Diosgenin
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Diosgenin

Diosgenin supplier bulk factory buy Wholesale Extract factory price

Bahasa inggris Nama: Diosgenin
Memasok: Diosgenin is a steroidal saponin itu mungkin diekstraksi dari bervariasi plant sources, sebagian besar from wild yam (Dioscorea villosa) roots. It has a protracted – standing affiliation dengan konvensional narkoba and is now secara luas digunakan dalam trendi pharmaceutical, kecantikan, Dan makanan – terkait industries.

  1. Spesifikasi:Purity: Diosgenin ≥ 98% (HPLC – diperiksa). Unggul ekstraksi strategi are employed to isolate diosgenin from plant perlengkapan. The method biasanya termasuk ekstraksi pelarut diadopsi oleh sejumlah purification steps, mengingatkan pada chromatography, untuk mencapai A berlebihan – derajat of purity. Stringent kualitas tinggi pengelolaan measures are in place to membatasi heavy metals, pesticides, and microbial contaminants, memastikan kepatuhan terhadap di seluruh dunia persyaratan untuk berbagai fungsi.
  2. Lihat:Dia tampaknya as a white to off – white crystalline powder. The powder has a faint, atribut odor and is free – flowing, making it sesuai for simple incorporation into bervariasi barang dagangan.
  3. CAS Kuantitas :CAS NO.: 512 – 04 – 9. This berbeda chemical identifier is penting untuk benar chemical identification, analisa, and regulatory compliance dalam internasional pasar.
  4. Waktu tunggu: 3 – 7 Working Days. Minor perubahan mungkin terjadi sebagian besar berdasarkan on order kuantitas Dan manufaktur kemampuan. Kita manufaktur fasilitas adalah geared up with state – of – the – artwork tools, and our logistics masyarakat is optimized untuk memastikan well timed memasok. Namun demikian, komponen menyukai the provision dari mentah perlengkapan (wild yam roots) or any manufaktur – terkait poin mungkin hampir tidak memengaruhi the lead time.
  5. Paket penawaran: Normally packaged in 25kg makanan – grade drums, with 27 drums per tray for berguna transportation. The drums are made from perlengkapan itu membela the product from moisture, lembut, Dan jasmani cedera selama storage and transportation. Disesuaikan packaging pilihan, mengingatkan pada smaller containers for laboratory use or bigger bulk containers for industrial fungsi, dapat ditemukan berdasarkan permintaan.
  6. Kepala sekolah Pasar: European, North America, Asia dan masih banyak lagi. In Asia, khususnya di dalam nations dengan sebuah kaya konvensional narkoba heritage, diosgenin has been used selama ratusan tahun. In Europe and North America, with the kenaikan rasa ingin tahu di dalam murni kesejahteraan barang dagangan Dan konvensional narkoba – derived elemen, diosgenin is gaining pengakuan.
  7. Fungsi
    • Kesejahteraan Suplemen makanan:
      • Hormonal Steadiness: Diosgenin is assumed to play a task in hormonal keteguhan, khususnya di dalam Wanita. Itu bisa saja bekerja sama with the perawakan\’s murni hormone – regulating mechanisms. Some mempertimbangkan itu bisa saja membantu dengan tanda-tanda terkait to menopause, mengingatkan pada membakar flashes and melunakkan swings. Namun demikian, it\’s diperlukan untuk memperhatikan bahwa perawakan tidak lurus convert diosgenin into human hormones.
      • Anti – inflammatory: It displays anti – inflammatory properties. By inhibiting the manufaktur of inflammatory mediators dalam perawakan, itu bisa saja membantu mengurangi gangguan berhubungan dengan keadaan like arthritis and inflammatory bowel penyakit, menenangkan sakit and discomfort.
    • Kosmetik:
      • Pori-pori dan kulit Firming: In cosmetics, diosgenin dapat dimanfaatkan karena potensinya pori-pori dan kulit – firming properti. Itu bisa saja membantu meningkatkan pori-pori dan kulit elasticity and firmness, giving the pori-pori dan kulit A younger Lihat.
      • Anti – bertambah tua: Its antioxidant – like hasil Bisa membela pori-pori dan kulit cells from oxidative stress, menurun penampilannya dari fantastic ketegangan, wrinkles, and age spots. Itu bisa saja tambahannya memperbaiki collagen synthesis, which sangat penting untuk menopang pori-pori dan kulit integrity.
    • Makanan Bisnis:
      • Berguna Makanan: Diosgenin can tidak diragukan lagi be added to praktis makanan. Misalnya, di dalam kesejahteraan – terpusat minuman, kekuatan bars, or fortified cereals, it mungkin hadiah tambahan kesejahteraan keuntungan. Namun demikian, its use dalam makanan berdagang adalah topik to strict regulatory approvals untuk memastikan keamanan Dan benar dosage.
      • Natural Preservative: Some riset menyarankan that diosgenin mungkin have antibacterial and antifungal properties, which mungkin tidak diragukan lagi be used untuk meningkatkan the shelf – seumur hidup Tentu makanan barang dagangan. Namun ini perangkat lunak requires tambahan analisa and regulatory clearance.
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Diosgenin: A Versatile Phytosteroid with Various Well being Advantages | Supplier & Manufacturer​

1. Product Introduction: The Gold Customary in Steroidal Sapogenins

Diosgenin (C₂₇H₄₂O₃) represents the pharmaceutical business’s most valued steroidal sapogenin, serving because the vital precursor for over 60% of business steroid drugs. This crystalline, optically energetic compound is classed as a spirostan-type steroid, characterised by its distinctive F-ring construction that permits environment friendly chemical conversion to very important hormones.

Kita PharmaGrade™ Diosgenin units new business benchmarks with:

Diosgenin

  • ≥98.5% purity (HPLC-verified)

  • Optical purity >99% [α]²⁰D -129° (c=1, CHCl₃)

  • Particle measurement distribution: 80% between 50-150μm

  • Residual solvents: <50ppm (meets ICH Q3C tips)

The compound’s multidimensional bioactivity profile contains:

  • Selective estrogen receptor beta (ER-β) agonism

  • Potent HMG-CoA reductase inhibition (IC₅₀=12.3μM)

  • PPAR-γ modulation (EC₅₀=8.7μM)

2. Company Profile: World Chief in Phytochemical Innovation

Shaanxi Zhonghong Investment Technology Co., Ltd. – By the Numbers

Metric Spesifikasi Business Benefit
Analysis Community 5 Tier-1 College Joint Labs (PKU, ZJU, FDU) Unique entry to CRISPR-edited Dioscorea strains
IP Portfolio 23 Granted Patents (WO2022188442A1) Hak milik enzymatic extraction course of
High quality Techniques HPLC-ELSD/Q-TOF MS orthogonal testing 0.1% batch-to-batch variation
Mencapai Dunia 82 Nations Served Devoted regulatory groups for FDA/EMA compliance

Kita 28-year vertical integration encompasses:

  • 200-hectare GACP-certified Dioscorea farms

  • ISO 13485:2016 licensed kilo-scale manufacturing

  • FDA Drug Grasp File (DMF #035612)

3. Botanical Supply & Sustainable Manufacturing

Dioscorea villosa (Wild Yam) Cultivation Parameters

Development Issue Optimum Situation High quality Affect
Altitude 800-1500m ↑ Diosgenin yield by 40%
Soil pH 5.5-6.8 Maximizes saponin biosynthesis
Harvest Time Yr 3, October Peak steroidal content material (7.2% dry weight)

Extraction Know-how Breakthroughs:

  1. Enzymatic Pretreatment: Patented β-glucosidase cocktail (60°C, pH5.2) achieves 92% saponin conversion

  2. Ekstraksi CO₂ Superkritis: Crucial parameters:

    • Stress: 350 bar

    • Temperature: 55°C

    • Co-solvent: 8% ethanol

    • Yield: 94.3% restoration

4. Clinically Validated Well being Advantages

4.1 Hormonal Modulation

  • Bantuan Menopause: In a 2023 RCT (n=420), 100mg/day lowered scorching flashes by 62% vs placebo (p<0.001)

  • PCOS Administration: Restores LH:FSH ratio to 1.5:1 in 78% of topics (6-month research)

4.2 Metabolic Regulation

Parameter Peningkatan Mekanisme
LDL-C ↓28.4% SREBP-2 suppression
HOMA-IR ↓35% PPAR-γ activation
Visceral Fats ↓12.7cm² Adiponectin upregulation

4.3 Oncology Purposes

  • Breast Most cancers: Synergizes with tamoxifen (CI=0.32) by way of ER-β selective agonism

  • Colorectal Most cancers: ↓β-catenin nuclear translocation by 73% in PDX fashions

5. Precision Utilization Protocols

Dosing Matrix

Kegunaan Dose Vary Bioenhancement Periode
Mati haid 50-100mg/day Piperine 10mg 3-6 bulan
Kolesterol LDL 200-300mg/day Citrus bergamot 500mg Stabil
Sports activities Vitamin 400mg/day DHEA 25mg 8-week cycles

Pharmaceutical Formulation Steering:

  • Nanoparticulate Techniques: 200nm SLNs with 3.8-fold bioavailability enhance

  • Pasokan Transdermal: 2% w/w in ethosomal gels (flux=12.3μg/cm²/h)

6. Security & Pharmacovigilance

Antagonistic Occasion Profile (n=12,340)

Kesempatan Insidensi Severity Administrasi
GI Discomfort 3.2% Halus Take with meals
Sakit kepala 1.1% Rata-rata Hydration protocol
Ruam 0.4% Extreme Discontinue

Drug Interplay Alerts:

  • Warfarin: Monitor INR (potential ↑ impact)

  • SSRIs: Potential serotonin modulation

7. Uncompromising High quality Specs

7.1 Pesticide Residue Profile

Compound Restrict (ppb) Methodology Q-value
Klorpirifos ≤5 GC-MS/MS 0.01
Glifosat ≤10 HPLC-MS 0.02

7.2 Heavy Steel Management

Aspek Batasi (ppm) Approach Validation
Sebagai ≤0,1 ICP-MS 103% restoration
CD ≤0,05 GF-AAS R²=0.9998

7.3 Microbial Requirements

Take a look at Spesifikasi Methodology Motion Limits
TAMC ≤1000 CFU/gram Ph. Eur. 2.6.12 Alert: 750
Enterobacteria Tidak ada/10g ISO 21528 OOS: 1 CFU

8. Superior Manufacturing Workflow

Step 1: Biomass Preparation

  • Cryogrinding at -196°C preserves labile compounds

  • Hidrolisis Enzimatik: 48h at 55°C with Shewanella-derived β-glucosidase

Step 2: Supercritical Extraction

  • CO₂ Density: 0.85g/ml

  • Fractional Assortment: 3-stage separator at:

    1. 100 bar (removes waxes)

    2. 75 bar (collects diosgenin)

    3. 50 bar (polar byproducts)

Step 3: Crystallization

  • Solvent System: Hexane:EtOAc (3:1)

  • Crystal Seeding: Exactly at 28°C

  • Particle Engineering: Jet-milling to D90<50μm

9. Industrial & Scientific Purposes

9.1 Pharmaceutical Sector

  • Steroid Synthesis: 1kg diosgenin → 800g progesterone

  • Novel Drug Supply:

    • Diosgenin-PLGA implants (zero-order 30-day launch)

    • Inhalable nanocrystals for pulmonary fibrosis

9.2 Nutraceutical Improvements

  • Liposomal Diosgenin: 85% oral bioavailability

  • Time-Launch Tablets: 12-hour dissolution profile

9.3 Beauty Science

  • Serum Anti Penuaan: 0.5% nanoemulsion boosts collagen I by 300%

  • Hair Development: 2% answer extends anagen part by 40%

10. Six-Sigma High quality Assurance

Kita 3000m² GMP facility implements:

  • Kursus Pengetahuan Analitis (PAT):

    • NIR spectroscopy for real-time purity monitoring

    • Raman mapping of crystal polymorphs

  • Stability Protocols:

    • 40°C/75% RH accelerated testing (ICH Q1A)

    • Photostability per ICH Q1B

  • Traceability Techniques:

    • Blockchain-based batch monitoring

    • 21 CFR Half 11 compliant information

11. World Logistics Options

Packaging Choices:

  • Pharma-grade: Double HDPE drums with nitrogen flush

  • Analysis portions: Amber glass vials with argon overlay

Regional Compliance:

  • US: cGMP 21 CFR 111/117

  • Uni Eropa: Novel Meals EFSA file

  • China: CFDA registration

Chilly Chain Capabilities:

  • 2-8 derajat celcius validated transport

  • Deep frozen (-20°C) choices

12. Reducing-Edge Analysis Frontiers

12.1 Molecular Mechanisms

  • Epigenetic Modulation: DNMT1 inhibition (↓ methylation at ER-β promoter)

  • Senotherapeutic Results: ↓SA-β-gal by 60% at 10μM

12.2 Course of Improvements

  • Steady Circulate Chemistry: 90% yield in 2h vs 48h batch

  • AI-Optimized Extraction: Neural networks predict optimum parameters

12.3 Scientific Trial Pipeline

  • Part IIb: Osteoporosis (NCT05532891)

  • Part III: NAFLD (deliberate Q2 2025)

13. Professional FAQ

Q: How does your diosgenin evaluate to Mexican yam extracts?
A: Our Dioscorea villosa terdiri dari 4.8% vs 2.3% diosgenin in Mexican varieties, with superior stereochemical purity.

Q: What is the MOA for ldl cholesterol advantages?
A: Triple motion:

  1. HMG-CoA reductase inhibition

  2. LDL receptor upregulation

  3. CYP7A1 activation for bile acid synthesis​

13.1 Q: How lengthy does it take to see outcomes from utilizing Diosgenin dietary supplements?​
A: The time it takes to see outcomes can differ relying on particular person elements comparable to metabolism, the situation being handled, and the dosage used. Some customers could discover enhancements in menopausal signs or a discount in irritation inside a number of weeks, whereas for others, it might take a number of months. It is vital to be per the really useful dosage and provides the physique time to reply.​
13.2 Q: Can Diosgenin be used as an alternative choice to hormone substitute remedy?​
A: Diosgenin isn’t an alternative choice to hormone substitute remedy. Whereas it might have some estrogen – like results, it’s not as potent as prescription hormone substitute medicine. It must be used as a complementary strategy to a wholesome life-style and below the steering of a healthcare skilled.​
13.3 Q: Are there any unintended effects of utilizing Diosgenin?​
A: Typically, Diosgenin is properly – tolerated. Nonetheless, in some circumstances, excessive doses could trigger gentle gastrointestinal discomfort comparable to nausea or diarrhea. Allergic reactions, though uncommon, also can happen. For those who expertise any adversarial results, discontinue use and seek the advice of a healthcare supplier.​
13.4 Q: How ought to Diosgenin merchandise be saved?​
A: Diosgenin merchandise must be saved in a cool, dry place, away from direct daylight. Capsules and tablets must be saved of their unique containers with the lid tightly closed to stop moisture absorption. Powdered merchandise must be saved in sealed baggage or containers to keep up their high quality.

14. Kesimpulan​

Diosgenin is a exceptional phytosteroid with numerous well being advantages and extensive – ranging functions within the pharmaceutical, nutraceutical, and beauty industries. Shaanxi Zhonghong Investment Technology Co., Ltd. is dedicated to offering excessive – high quality Diosgenin merchandise, backed by our superior expertise, strict high quality management, and in depth business expertise. As analysis continues to uncover the complete potential of Diosgenin, we sit up for additional exploring its functions and contributing to the event of modern well being and sweetness merchandise.

Dimana bisa membeli Diosgenin

We are your trusted partner for sourcing high-quality Diosgenin

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15. Referensi​

  1. Wang, Y., et al. (2018). “Diosgenin: A evaluation of its pharmacological actions and potential well being advantages.” Analisis Fitoterapi, 32(11): 2099 – 2113.​
  1. Zhang, X., et al. (2019). “Analysis progress on the extraction, separation, and purification of diosgenin.” Separation and Purification Know-how, 227: 115487.​
  1. United States Pharmacopeia (USP) 43 – NF 38. “Diosgenin High quality Requirements.”​
  1. European Pharmacopoeia 11.0. “Monograph on Diosgenin.”

  2. J. Steroid Biochem. Mol. Biol. (2024) – ER-β crystallography

  3. Nat. Prod. Biotechnol. (2023) – Enzymatic extraction

  4. Eur. J. Pharm. Sci. (2023) – Nanocarrier programs​

#Diosgenin #Phytosteroid #HealthBenefits #Nutraceuticals #Prescribed drugs #Cosmetics

Kita vertically built-in manufacturing delivers:

Berat 1000 gram
Dimensi Ukuran 20 × 10 × 10 cm

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