शिसांद्रा अर्क

Schisandra Extract: Nature’s Adaptogenic Powerhouse | Premium Supplier Guide

1. What is Schisandra Extract?

Schisandra extract is a potent bioactive concentrate derived from the dried berries of शिसांद्रा चिनेंसिस (Chinese Magnolia Vine) or Schisandra sphenanthera. Revered for millennia in Traditional Chinese Medicine (TCM) as a premier adaptogen, it contains a unique complex of dibenzocyclooctadiene lignans—primarily schisandrin, deoxyschisandrin, γ-schisandrin, schisantherin A/B, and gomisins. These lignans are responsible for its characteristic “five flavors” (sweet, sour, salty, pungent, bitter) and its diverse physiological effects, particularly supporting hepatic function, cognitive performance, stress resilience, and cellular antioxidant defense.

2. उत्पाद स्रोत, रासायनिक गुण और पहचानकर्ता

• वानस्पतिक स्रोत: शिसांद्रा चिनेंसिस (Turcz.) Baill. berries.

• प्राथमिक सक्रिय घटक: Schisandra Lignans (≥1.5% – 10%+, standardized by HPLC).

• प्रमुख रासायनिक गुण:

  • उपस्थिति: Fine reddish-brown to brown powder.

  • घुलनशीलता: Soluble in ethanol, methanol; slightly soluble in water; insoluble in non-polar solvents.

  • स्थिरता: Sensitive to light, heat, and oxidation. Requires cool, dry storage.

• सीएएस: 7432-28-2 (Schisandra extract); Specific lignans have individual CAS (e.g., Schisandrin: 61281-37-6).

• एमएफ: Varies per compound (e.g., Schisandrin: C24H32O7).

• एमडब्ल्यू: Varies per compound (e.g., Schisandrin: 432.5 g/mol).

• ईआईएनईसीएस: 284-118-3 (Schisandra chinensis extract).

3. What is the Best Schisandra Extract? Key Considerations
Selecting the optimal Schisandra extract demands scrutiny across multiple parameters:

• Key Ingredient & Standardization: Premium extracts are standardized to Schisandra Lignans content (e.g., 5%, 9%, or higher). Lignan profile consistency is critical for efficacy. Look for HPLC-verified standardization.

• Efficacy & Compliance (Regulatory): Ensure compliance with target market regulations (e.g., FDA GRAS, EU Novel Food considerations, FSANZ, pharmacopoeial standards like USP/EP). Validated hepatoprotective, adaptogenic, and antioxidant effects are core.

• उत्पत्ति और खेती: Sustainably cultivated berries from pristine regions (e.g., Northeast China, Korea) are ideal. Certifications (Organic, GACP) enhance quality assurance. Traceability to origin is crucial.

• Method of Use: Common formats include powder (encapsulated, in blends), liquid extracts (tinctures), and functional food/beverage fortification. Typical oral dosage: 250mg – 1500mg daily, often divided. Consult product label and healthcare provider.

• लक्षित दर्शक: Adults seeking natural support for stress management, liver health, physical endurance, cognitive function, or general antioxidant protection. Not intended for children.

• Health Benefits (Science-Backed):

  • हेपेटोप्रोटेक्शन: Enhances liver detoxification enzymes (Phase I & II), protects hepatocytes from toxins (e.g., ethanol, CCl4), promotes regeneration.

  • Adaptogenic: Modulates HPA axis, reduces cortisol elevation under stress, improves resilience.

  • एंटीऑक्सीडेंट: Potent free radical scavenger, boosts endogenous glutathione (GSH) and superoxide dismutase (SOD).

  • न्यूरोप्रोटेक्शन: May improve cognitive function, focus, and protect against neuronal damage.

  • Physical Performance: Enhances endurance and reduces fatigue.

  • त्वचा स्वास्थ्य: Topical application may improve skin barrier function and combat oxidative stress.

• अनुशंसित दैनिक सेवन: 500mg – 1500mg of standardized extract (e.g., 9% lignans), dependent on application and individual needs. Start lower and adjust.

• सावधानियां एवं दुष्प्रभाव: Generally well-tolerated. Potential mild GI upset (heartburn, acid reflux). Contraindicated: Pregnancy, lactation. Caution: With anticoagulant/antiplatelet drugs (potential interaction), gastroesophageal reflux disease (GERD), epilepsy/seizure disorders. Consult physician before use if taking medications or have underlying conditions.

4. Premium Supplier: Shaanxi Zhonghong Investment Technology Co., Ltd.
Shaanxi Zhonghong Investment Technology Co., Ltd. stands as a vertically integrated उच्च तकनीक उद्यम at the forefront of plant extraction technology. For over 28 years, we have specialized in the advanced extraction, isolation, purification, and global commercialization of high-purity bioactive compounds for the chemical, materials, and जीवन विज्ञान उद्योग.

• मूल दक्षताएं:

  • Advanced Botanical Extraction: Expertise in supercritical CO2 extraction, molecular distillation, preparative HPLC, membrane separation for unparalleled purity.

  • Broad Product Portfolio: High-grade शिसांद्रा अर्क, other standardized botanical extracts, cosmetic actives, nutraceutical ingredients (dietary supplements), pharmaceutical intermediates, natural pigments, food & beverage additives, plant-based sweeteners.

  • Global Sourcing: Importation of premium raw materials under strict quality protocols.

• Scientific & Technological Barriers:

  • Joint Innovation Labs: Collaborative R&D with 5 अग्रणी विश्वविद्यालय, driving innovation in phytochemistry and process optimization.

  • आईपी पोर्टफोलियो: Holder of 20+ मालिकाना पेटेंट और एक विश्व स्तर पर अद्वितीय यौगिक पुस्तकालय.

  • अत्याधुनिक QC: Investment in HPLC-DAD/ELSD/CAD, UPLC-QTOF-MS, GC-MS, ICP-MS, and 600MHz NMR ensures purity standards 20%+ तक उद्योग मानदंडों को पार करना. Full identity, purity, and potency verification.

• विश्वव्यापी पहुँच: Trusted B2B supplier to multinational pharmaceutical companies, research institutions, and manufacturers across 80+ countries in Asia, Europe, and the Americas. Experts in अनुकूलित वनस्पति घटक समाधान.

5. Comprehensive Certificate of Analysis (COA) Specifications
Our Schisandra Extract undergoes rigorous testing to meet international safety standards. Below is a summary table of key specifications:

Table: Schisandra Extract Standard COA Specifications

6. Advanced Production Workflow
Our manufacturing adheres to cGMP and integrates cutting-edge technology:

1. Sourcing & Identification: Raw berries sourced from qualified growers; authenticated via macroscopic/microscopic evaluation & TLC/HPLC fingerprinting.

2. पूर्व प्रसंस्करण: Cleaning, drying (<40°C), milling under controlled humidity.

3. चयनात्मक निष्कर्षण: Optimized ethanol/water solvent systems using dynamic counter-current extraction or pressurized low-temperature extraction (PLTE) to preserve thermolabile lignans.

4. प्राथमिक शुद्धिकरण: Macroporous resin adsorption chromatography for targeted lignan enrichment and removal of polysaccharides/sugars.

5. उन्नत पृथक्करण: Employing preparative HPLC or high-speed counter-current chromatography (HSCCC) for isolation of specific high-purity fractions if required.

6. सांद्रण एवं सुखाना: Low-temperature vacuum concentration followed by spray drying (inlet/outlet temp controlled) or freeze-drying.

7. मानकीकरण: Precise blending to achieve guaranteed lignan content (HPLC-controlled).

8. कठोर QC: Full battery of identity, purity, potency, and safety tests (as per COA above) before release.

7. विविध अनुप्रयोग परिदृश्य

• न्यूट्रास्युटिकल्स और आहार पूरक: Capsules, tablets, softgels, powders for liver support, stress relief, energy, and antioxidant formulas.

• कार्यात्मक खाद्य एवं पेय पदार्थ: Fortified juices, health drinks, energy bars, confectionery.

• कॉस्मेटिक्स: Active ingredient in anti-aging, antioxidant, and protective skincare serums, creams, lotions (topical antioxidant, collagen protection).

• फार्मास्युटिकल इंटरमीडिएट्स: Source of purified lignans (e.g., Schisandrin C) for drug discovery and development.

• Traditional Herbal Products: TCM formulations and granules.

8. Rigorous Quality Control 
Quality is embedded in every stage at Shaanxi Zhonghong. Our ISO 17025 accredited QC laboratory, से सुसज्जित Agilent 1290 Infinity II UPLC-DAD-QTOF, Shimadzu HPLC-ELSD/CAD, PerkinElmer ICP-MS NexION 2000, and Bruker Avance III HD 600MHz NMR, provides unparalleled analytical capability. We implement a multipronged QC strategy:

• Incoming Material Control: Strict vendor qualification, Certificate of Analysis review, and full identity/purity testing on all raw materials using compendial methods (EP, USP, ChP) and advanced spectroscopy (FTIR, NMR for structure confirmation).

• In-Process Control (IPC): Critical process parameters (CPPs – solvent ratio, temp, pressure, time) and critical quality attributes (CQAs – intermediate lignan profile, residual solvents) are monitored in real-time using PAT (Process Analytical Technology) tools like inline NIR spectroscopy and automated HPLC sampling. This ensures process consistency and enables immediate corrective actions.

• Finished Product Release: Every batch undergoes exhaustive testing per a comprehensive, validated specification (Identity by TLC/HPLC fingerprint vs. reference standard; Assay for lignan content by HPLC-UV; Purity – Residual solvents by GC-HS-FID, Heavy metals by ICP-MS; Safety – Pesticides by GC-MS/MS & LC-MS/MS, Microbiology per USP/EP; Physical tests – LOD, Ash, Bulk Density, Particle Size Distribution). स्थिरता अध्ययन (ICH Q1A) under accelerated and long-term conditions define shelf-life and storage requirements. Our commitment to data integrity (ALCOA+ principles) and continuous method validation ensures results are reliable and defensible globally.

9. सुरक्षित पैकेजिंग और वैश्विक रसद

• प्राथमिक पैकेजिंग: Food-grade polyethylene-lined kraft paper bags (5kg, 10kg, 25kg) or UN-certified HDPE drums (25kg, 50kg). Optional vacuum packing or nitrogen flushing for oxygen-sensitive extracts. Tamper-evident seals standard.

• द्वितीयक पैकेजिंग: Sturdy export cartons or fiber drums.

• लेबलिंग: Compliant with destination regulations. Includes Product Name, Batch #, MFG/EXP Date, Net Weight, Lignan Content %, COA QR Code, GMP/ISO Certifications.

• भंडारण: Store in a cool (<25°C), dry place (RH <60%), protected from light. -20°C long-term storage available for high-value fractions.

• रसद: Expertise in global shipping (DDP, DAP, FOB). Documentation includes Commercial Invoice, Packing List, Certificate of Analysis, Certificate of Origin, Health Certificate (if required), MSDS. Compliant with international hazardous goods (if applicable) and customs regulations.

10. Deep Dive: Health Efficacy, Research & Industry Trends

• कार्रवाई की प्रणाली: Schisandra lignans exert effects via multiple pathways:

  • हेपेटोप्रोटेक्शन: Induction of Phase II detox enzymes (GST, UGT), upregulation of antioxidant genes via Nrf2 pathway, inhibition of CYP450-mediated toxin activation, stabilization of hepatocyte membranes.

  • Adaptogenic: Modulation of HPA axis, reduction of plasma cortisol and NO under stress, regulation of heat shock proteins (HSP70).

  • एंटीऑक्सीडेंट: Direct ROS scavenging, regeneration of vitamins C & E, elevation of intracellular GSH and SOD/GPx activity.

  • न्यूरोप्रोटेक्शन: Reduction of glutamate excitotoxicity, inhibition of MAO-B, potential enhancement of BDNF signaling, anti-neuroinflammatory effects.

  • Anti-fatigue: Enhancement of mitochondrial function and ATP synthesis, reduction of lactic acid accumulation.

• Industry Applications & Innovation: Beyond supplements, research explores Schisandra in:

  • Hepatology: Adjunctive therapy in NAFLD, chemical hepatotoxicity, viral hepatitis.

  • Oncology: Chemopreventive potential via antioxidant/anti-inflammatory pathways; adjunct to reduce chemotherapy side effects (e.g., cisplatin nephrotoxicity).

  • न्यूरोडीजेनेरेटिव रोग: Potential in Alzheimer’s (Aβ aggregation inhibition) and Parkinson’s (dopaminergic protection).

  • चयापचय स्वास्थ्य: Improving insulin sensitivity, lipid profile modulation.

  • Advanced Delivery Systems: Liposomal encapsulation, nanoemulsions, phytosome complexes (e.g., Schisandra Phytosome®) to enhance bioavailability of hydrophobic lignans.

• अनुसंधान सीमाएँ एवं चुनौतियाँ:

  • सीमाएँ: Elucidating specific receptor targets of individual lignans; large-scale human clinical trials for specific indications (e.g., cognitive decline, NAFLD); exploring synergistic effects in multi-botanical formulations; microbiome interactions.

  • चुनौतियाँ: Standardization complexities due to diverse lignan profiles; optimizing bioavailability of high-MW lignans; securing sustainable wildcrafting/cultivation; navigating complex global regulatory landscapes for health claims; cost-effective production of ultra-high purity (>98%) single lignans.

11. अक्सर पूछे जाने वाले प्रश्न (एफएक्यू)

• Q: What makes your Schisandra Extract superior? A: Our extract boasts industry-leading purity (>99.5% solvent-free, minimal impurities), guaranteed high lignan standardization (HPLC-verified), absence of harmful residues (full compliance testing), and is produced under strict cGMP using state-of-the-art extraction technology (PLTE, HSCCC) and QC (HPLC-MS, NMR).

• Q: Is Schisandra Extract safe? A: Generally safe for adults at recommended dosages. Possible mild GI upset. Contraindicated in pregnancy/lactation. Consult a doctor if taking anticoagulants, have GERD, epilepsy, or underlying health conditions. See Precautions (Section 3).

• Q: What is the recommended daily dosage? A: Typically 500mg – 1500mg daily of a standardized extract (e.g., 9% lignans), often divided. Start at the lower end. Follow product label or healthcare provider advice.

• Q: How long does it take to see benefits? A: Effects like stress resilience may be noticeable within weeks. Liver protective or significant cognitive benefits may require consistent use over several months.

• Q: Can it be used topically? A: Yes, Schisandra extract is valued in cosmetics for its antioxidant and protective properties, helping combat skin aging and environmental damage.

• प्रश्न: क्या यह दवाओं के साथ परस्पर क्रिया करता है? A: Potential interaction with blood thinners (warfarin, clopidogrel) and drugs metabolized by CYP3A4/CYP2C9 enzymes. Consult your physician.

• Q: Is it Organic or Non-GMO? A: We offer both conventional and certified organic (e.g., USDA, EU) Schisandra Extract. All are Non-GMO. Specify your requirement.

12. नमूने कहां से खरीदें और मांगें
Source premium, certified Schisandra Extract directly from the manufacturer: शानक्सी झोंगहोंग निवेश प्रौद्योगिकी कं, लिमिटेड

• Contact for Quotes & Customization: liaodaohai@gmail.com

• Explore Our Portfolio: www.aiherba.com

• अपना निःशुल्क नमूना अनुरोध करें: Email us (liaodaohai@gmail.com) with your company details, intended use, and desired specification (e.g., Lignan %). Experience the Zhonghong quality difference.

13. निष्कर्ष
Schisandra extract, standardized for its bioactive lignans, represents a scientifically validated adaptogen with significant benefits for liver health, stress management, cognitive function, and antioxidant defense. Choosing a high-quality extract is paramount for efficacy and safety. Shaanxi Zhonghong Investment Technology Co., Ltd., with its 28-year legacy, cutting-edge extraction and analytical technology, unwavering commitment to cGMP quality, and global supply chain expertise, stands as a trusted partner for premium Schisandra Extract. We provide not just an ingredient, but a commitment to purity, potency, and scientific rigor for demanding nutraceutical, cosmetic, and pharmaceutical applications.

14. संदर्भ

1. Panossian, A., & Wikman, G. (2008). Pharmacology of Schisandra chinensis Bail.: An overview of Russian research and uses in medicine. Journal of Ethnopharmacology, 118(2), 183-212. (Mechanisms, Adaptogenic Effects)

2. Lu, Y., & Chen, D. F. (2009). Analysis of Schisandra chinensis and Schisandra sphenanthera. Journal of Chromatography A, 1216(11), 1980-1990. (Analytical Methods, Lignan Profiles)

3. Nowak, A., Zakłos-Szyda, M., Błasiak, J., Nowak, A., Zhang, Z., & Zhang, B. (2019). Potential of Schisandra chinensis (Turcz.) Baill. in Human Health and Nutrition: A Review. Current Issues in Molecular Biology, 31(1), 1-24. (Comprehensive Health Benefits Review)

4. EMA. (2016). Assessment report on शिसांद्रा चिनेंसिस (Turcz.) Baill., fructus. European Medicines Agency. (Regulatory Perspective, Traditional Uses)

5. USP-NF. (2023). United States Pharmacopeia and National Formulary. (General Quality Standards)

6. ICH Q7. Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients. (GMP Standards)

7. ICH Q1A(R2). Stability Testing of New Drug Substances and Products. (Stability Guidelines)

8. Shaanxi Zhonghong Internal Research Data & Process Validation Reports. (Proprietary Extraction & QC Data – Available under NDA).