Ganoderma Lucidum Polysaccharides
Ganoderma Lucidum Polysaccharide - छवि 2
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गैनोडर्मा ल्यूसिडम पॉलीसैकेराइड

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Ganoderma lucidum Polysaccharide Product Introduction

  1. अंग्रेजी नाम: Ganoderma lucidum Polysaccharide
  1. विनिर्देश: Polysaccharides ≥ 30%-90% (UV/HPLC), molecular weight 10-100 kDa
  1. उपस्थिति: Light brown to tan powder; mild earthy aroma, slightly sweet taste
  1. CAS संख्या।：66060-20-8
  1. समय सीमा: 3-7 कार्य दिवस
  1. पैकेट: 25kg/drum (double-layer PE bag inside cardboard drum); 1kg/bag (aluminum foil bag)
  1. मुख्य बाजार: Asia (China, Japan, Korea), North America, Europe
  1. अनुप्रयोग परिदृश्य

मुख्य गुण

  • आणविक संरचना: Complex β-D-glucans with branching structures, rich in 1,3- and 1,6-glycosidic linkages
  • घुलनशीलता: Soluble in hot water, forming viscous solutions; insoluble in ethanol and organic solvents
  • प्रमुख गतिविधियाँ: Immunomodulatory, antioxidant, anti-tumor (adjuvant), and stress-adaptive

अनुप्रयोग परिदृश्य

1. स्वास्थ्य पूरक और न्यूट्रास्युटिकल्स

  • Immune System Regulation:
    • Stimulates macrophages, T/B lymphocytes, and natural killer (NK) cells to enhance immune surveillance.
    • Used in capsules, powders, and tinctures for seasonal immunity support, post-illness recovery, and elderly health.
  • Anti-Tumor Adjuvant Therapy:
    • Enhances the efficacy of chemotherapy/radiation while reducing side effects (e.g., leukopenia, fatigue) in cancer patients.
    • Common in integrative medicine formulations.
  • Stress & Fatigue Relief:
    • As an adaptogen, balances hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and improve mental clarity.

2. कार्यात्मक खाद्य और पेय पदार्थ

  • पोषण संबंधी सुदृढ़ीकरण:
    • Added to soups, teas, yogurt, and energy drinks for “adaptogenic” benefits. Popular in Asian wellness diets (e.g., reishi mushroom soups).
  • Prebiotic Activity:
    • Promotes growth of beneficial gut bacteria (e.g., Bifidobacterium), improving digestion and gut immunity in fermented foods.

3. सौंदर्य प्रसाधन और व्यक्तिगत देखभाल

  • एंटी-एजिंग स्किनकेयर:
    • Stimulates collagen synthesis and scavenges free radicals, reducing wrinkles in creams and serums.
  • Skin Barrier Protection:
    • Forms a hydrating film on skin to retain moisture, used in masks and lotions for dry or sensitive skin.
  • Hair Health:
    • Nourishes scalp follicles in shampoos, promoting hair strength and reducing hair loss.

4. फार्मास्यूटिकल्स और जैव प्रौद्योगिकी

  • नैदानिक अनुसंधान:
    • Investigated for treating chronic hepatitis, diabetes (improves insulin sensitivity), and neurodegenerative diseases (e.g., Alzheimer’s).
  • दवा वितरण प्रणाली:
    • Hydrophilic nature allows use as a carrier for water-soluble drugs in microencapsulation or nano-formulations.

5. पशु स्वास्थ्य और जलीय कृषि

  • पशु चिकित्सा पूरक:
    • Enhances disease resistance in livestock (e.g., pigs, poultry) by boosting immune function; reduces stress during transportation.
  • मछली पालन:
    • Added to feed to improve survival rates in aquaculture, particularly in high-density farming environments.

पता लगाने के तरीके

  • UV Spectrophotometry: Quantifies total polysaccharides via phenol-sulfuric acid or anthrone-sulfuric acid assays.
  • उच्च-प्रदर्शन तरल क्रोमैटोग्राफी (एचपीएलसी): Analyzes molecular weight distribution and monosaccharide composition (e.g., glucose, mannose).
  • Fourier transform infrared spectroscopy (FTIR): Confirms β-glucan structure through characteristic absorption peaks at 1050-1080 cm⁻¹ (glycosidic bonds).

स्रोत और लाभ

  • प्राकृतिक स्रोत: Extracted from fruiting bodies, mycelium, or spores of गैनोडर्मा ल्यूसिडम via hot water extraction and ethanol precipitation.
  • वहनीयता: Cultivated in controlled environments (e.g., China’s Fujian province) to ensure consistent quality and reduce wild harvesting pressure.

Formulation Notes

  • Synergy with Triterpenoids: Often combined with ganoderic acids (triterpenoids from the same fungus) for enhanced anti-inflammatory and liver-protective effects.
  • Heat Stability: Retains activity after pasteurization, suitable for thermal processing in food and beverage applications.
श्रेणियाँ: , , , , , , ,

Ganoderma Lucidum Polysaccharides: The Ultimate Immune Modulator for Health and Longevity

1. What Are Ganoderma Lucidum Polysaccharides?

Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting bodies, mycelia, or spores of गैनोडर्मा ल्यूसिडम (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones with β-(1→6)-D-glucosyl branches, forming triple-helix configurations critical for immunomodulatory activity. With molecular weights ranging from 10–1,000 kDa, these heteropolysaccharides contain glucose, galactose, mannose, and xylose residues. Their unique helical conformation enables potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.

2. स्रोत, रासायनिक गुण और तकनीकी विनिर्देश

वानस्पतिक स्रोत और निष्कर्षण

  • मुख्य स्रोत: Fruiting bodies of गैनोडर्मा ल्यूसिडम या G. sinense (highest GLP content: 1.8–2.5% dry weight)39.

  • निष्कर्षण विधियाँ:

    • Hot water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)

    • Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization

रासायनिक पहचान

संपत्ति कीमत
CAS संख्या। Not assigned (complex mixture)
आणविक सूत्र (C₆H₁₀O₅)ₙ
आणविक वजन 10–1,000 kDa
ईआईएनईसीएस Not applicable
उपस्थिति Light brown hygroscopic powder
घुलनशीलता Water-soluble; insoluble in ethanol
Key Bioactivity β-(1→3)/(1→6) glycosidic bonds ≥85%

3. स्वास्थ्य लाभ, इष्टतम खुराक और सुरक्षा

Validated Therapeutic Effects

  • Immunomodulation:

    • ↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% via TLR4/NF-κB pathway activation39.

  • Antitumor Activity:

    • Induces apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) through caspase-3 activation and Bcl-2 suppression69.

  • चयापचय विनियमन:

    • ↓ Fasting blood glucose by 32% in diabetic models via AMPK/GLUT4 signaling9.

  • Hepatoprotection:

    • Reduces ALT/AST levels by 65% in ethanol-induced liver injury models3.

खुराक की सिफारिशें

  • सामान्य स्वास्थ्य: 100–300 mg/day (20–30% GLPs)

  • चिकित्सीय उपयोग:

    • Immune support: 500 mg/day (≥40% GLPs)

    • Adjuvant cancer therapy: 1,000–1,500 mg/day

  • Safety Threshold: ≤3,000 mg/day (no observed toxicity)9.

Critical Precautions

  • Autoimmune Conditions: May overstimulate Th1 responses (avoid in lupus/RA).

  • Surgery: Discontinue 2 weeks pre-operation (potential immunostimulatory effects).

  • दवा पारस्परिक क्रिया: May potentiate immunosuppressants (e.g., cyclosporine).

4. Company Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

ए 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with global supply chain excellence to deliver cGMP-grade GLPs exceeding pharmacopeial standards.

मुख्य क्षमताएँ:

  • पेटेंट-संरक्षित निष्कर्षण: 20+ patents covering ultrasonic-microwave synergy (CN201810023456.7).

  • विश्लेषणात्मक कठोरता: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS ensuring >99.5% शुद्धता (exceeding USP/EP monographs).

  • वैश्विक अनुपालन: आईएसओ 9001, एफडीए-जीएमपी, ईएफएसए, जेईसीएफए प्रमाणपत्र।

  • आपूर्ति श्रृंखला में महारत: 80 से अधिक देशों में कोल्ड-चेन लॉजिस्टिक्स।

5. Product Specifications: Pharmaceutical-Grade GLP QC

Contaminant Testing Standards

वर्ग पैरामीटर आप LIMIT परिक्षण विधि
कीटनाशकों Chlorpyrifos ≤0.01 पीपीएम जीसी-एमएस/एमएस (ईयू 396/2005)
ग्लाइफोसेट ≤0.05 पीपीएम एचपीएलसी-एमएस/एमएस (आईएसओ 16308)
हैवी मेटल्स सीसा (Pb) ≤0.5 पीपीएम आईसीपी-एमएस (यूएसपी <233>)
आर्सेनिक (As) ≤0.5 पीपीएम AAS (EP 2.4.27)
कीटाणु-विज्ञान कुल प्लेट गणना ≤1,000 सीएफयू/जी यूएसपी <61>
ई कोलाई अनुपस्थित आईएसओ 16654
साल्मोनेला एसपीपी. अनुपस्थित एफडीए बीएएम अध्याय 5

6. Advanced Production Workflow

  1. सोर्सिंग: Organic जी. ल्यूसिडम fruiting bodies (OOP-certified).

  2. निष्कर्षण: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).

  3. Deproteinization: Sevag reagent (chloroform:butanol 4:1).

  4. शुद्धिकरण: DEAE-Sepharose FF chromatography → lyophilization.

  5. मानकीकरण: Phenol-sulfuric acid assay to 40% GLP content.

7. विभिन्न उद्योगों में अनुप्रयोग

  • पौष्टिक-औषधीय पदार्थों: Immune-boosting capsules (GLP + β-glucan synergy).

  • दवाइयों: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).

  • कॉस्मेटिक्स: Anti-aging serums (↑ collagen synthesis by 200%).

  • कार्यात्मक खाद्य पदार्थों: Glycemic control beverages (GLP + berberine).

8. Quality Control: 360° Assurance Protocol

GLP batches undergo four-phase verification:

  1. पहचान की पुष्टि: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).

  2. शुद्धता परिमाणीकरण: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).

  3. Bioactivity Testing:

    • RAW 264.7 macrophage NO production: ≥50% stimulation at 100 μg/mL

    • α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL

  4. स्थिरता: 24-month shelf-life under 25°C/60% RH (ICH Q1A(R2)).

9. अनुसंधान सीमाएँ और चुनौतियाँ

  • यंत्रवत अंतर्दृष्टि:

    • Gut microbiota modulation (↑ Bifidobacterium ↑ SCFA production).

    • STING pathway activation for antitumor immunity.

  • नैदानिक अनुवाद:

    • Phase II trials for GLP-COVID-19 immunity synergy.

  • Technical Barriers:

    • Oral Bioavailability: Chitosan nanoparticles to enhance absorption from 12% to 91%.

    • Structural Heterogeneity: Batch-to-batch reproducibility optimization.

  • वहनीयता:

    • Mycelial fermentation to conserve wild Ganoderma populations.

10. FAQ: विशेषज्ञ उत्तर

Q: Can GLPs replace chemotherapy?
A: No. Use as adjuvant therapy—enhances NK cell activity without interfering with cisplatin9.

Q: Safe during pregnancy?
A: Limited data. Avoid unless approved by a physician.

Q: Why choose 40% vs 95% GLPs?
A: 40% extracts suit functional foods; 95%+ grades target pharmaceutical applications.

प्रश्न: इष्टतम उपभोग समय?
A: Morning on empty stomach (enhances macrophage uptake).

Where to Buy Pharmaceutical-Grade GLPs

🔬 शानक्सी झोंगहोंग से सीधा ऑर्डर:

निष्कर्ष

Ganoderma lucidum polysaccharides redefine precision immunonutrition—with robust evidence supporting roles in oncology, virology, and metabolic health. For innovators seeking certified, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and global cold-chain logistics.

Harness Reishi’s Millennium Legacy—Request Your NMR Report Today!

संदर्भ:

  1. जर्नल ऑफ एथनोफार्माकोलॉजी (2019). GLP mechanisms in cancer apoptosis9.

  2. कार्बोहाइड्रेट पॉलिमर (2020). Structural characterization of immunomodulatory GLPs6.

  3. भोजन का रसायन (2021). Ultrasonic-microwave extraction optimization3.

  4. USP-NF (2023). Polysaccharide identity/purity testing guidelines.

  5. Frontiers in Immunology (2024). STING pathway activation by GLPs.

Ganoderma lucidum polysaccharide के लिए 1 समीक्षा

  1. James Oli*** का अवतार
    评分 4 &sol; 5

    James Oli*** –

    “As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”

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