The Definitive Guide to Nuciferine: Nature’s Lotus Alkaloid Powerhouse

1. What is Nuciferine?

Nuciferine is a prominent aporphine alkaloid naturally found in the leaves and stems of the sacred Nelumbo nucifera plant, commonly known as the lotus. This bioactive phytochemical is structurally characterized by its tetracyclic ring system and is increasingly recognized for its diverse physiological activities. It functions as a key signaling molecule within the plant and exhibits significant bioactive potential in mammalian systems, influencing metabolic, neurological, and inflammatory pathways.

2. Source du produit, propriétés chimiques et identification

• Source: Primarily extracted from Nelumbo nucifera (Lotus) leaves using advanced techniques like extraction par solvant et purification chromatographique.

• Nature chimique : Nuciferine is classified as an aporphine isoquinoline alkaloid.

• Numéro CAS : 475-83-2

• Formule moléculaire (MF) : C₁₉H₂₁NO₂

• Poids moléculaire (PM) : 295.38 g/mol

• Numéro EINECS : 207-503-3

3. The Premium Nuciferine Standard: Key Attributes

Identifying the “best” nuciferine requires stringent criteria for quality, efficacy, and transparency:

• Ingrédient clé : High-purity Nuciférine (typically ≥98% by HPLC).

• Proven Efficacy (Compliant): Research suggests potential benefits, however, specific health claims are regulated and require substantiation per jurisdiction. Current scientific focus includes:

  • Santé métabolique : Modulation of lipid metabolism, potential influence on glucose homeostasis via pathways like Activation de l'AMPK et PPARγ modulation.

  • Neurological Support: Interaction with dopaminergic et serotonergic receptors; potential anxiolytic and mood-modulating effects observed in preclinical models.

  • Anti-inflammatory & Antioxidant Activity: Reduction of pro-inflammatory cytokines (TNF-α, IL-6) and mitigation of oxidative stress markers.

• Optimal Origin: Sourced from premium Nelumbo nucifera cultivars, ideally with documented traceability.

• Recommended Use: Primarily used as a dietary supplement ingredient ou research chemical. Typical formulations include capsules, tablets, or powder blends. Always follow manufacturer or research protocol guidelines.

• Public cible : Researchers, nutraceutical formulators, and consumers seeking advanced botanical ingredients (under professional guidance).

• Crucial Considerations:

  • Dosage: No established Recommended Dietary Allowance (RDA) exists. Human clinical data is limited. Preclinical studies use varying doses. Consulting a healthcare professional before use is essential.

  • Sécurité et effets secondaires : Generally considered safe at research doses, but comprehensive human safety data is lacking. Potential side effects are not well-documented but could relate to its pharmacology (e.g., mild sedation, gastrointestinal upset). Not evaluated by the FDA for disease diagnosis, treatment, cure, or prevention.

  • Contre-indications : Avoid if pregnant, breastfeeding, or with known hypersensitivity. Potential interactions with medications (especially affecting liver enzymes CYP450 or neurotransmitter systems) warrant caution. Medical consultation is mandatory before use.

4. About Shaanxi Zhonghong Investment Technology Co., Ltd.
Shaanxi Zhonghong Investment Technology Co., Ltd. se présente comme un premier ministre entreprise de haute technologie spécialisée dans le extraction, isolement et purification of bioactive plant compounds. With 28 years of dedicated expertise dans composés bioactifs, the company integrates R&D, innovation, precision manufacturing, and global distribution to serve the chemical, material science, and life science sectors.

• Compétences de base : Advanced processing of extraits naturels de plantes, y compris botanical active ingredients pour cosméceutiques, intermédiaires pharmaceutiques, nutraceutiques (dietary supplements), natural pigments, food additives, beverage enhancers, et édulcorants à base de plantes.

• Avantage scientifique : Establishes significant technical barriers through collaborations with 5 universités de premier plan via joint laboratories. Holds Plus de 20 brevets propriétaires and maintains an exclusive global compound library.

• Cutting-Edge Facilities: Emploie instrumentation analytique de pointe y compris Chromatographie liquide à haute performance (HPLC), Ultraconducting Nuclear Magnetic Resonance (NMR), assurant normes de pureté dépassant les normes de l'industrie de 20%+.

• Portée mondiale : Maintains a robust réseau d'approvisionnement international spanning plus de 80 pays across Asia, Europe, and the Americas, providing customized raw material solutions à multinational pharmaceutical corporations et research institutions.

5. Nuciferine Benefits for Health
Nuciferine’s emerging profile as a multi-target bioactive alkaloid is underpinned by mechanistic research:

• Metabolic Syndrome Management: Modulates key regulators (AMPK, PPARγ, SREBP-1c) involved in lipid biosynthesis, fatty acid oxidation, et adipocyte differentiation, showing promise in preclinical models of dyslipidemia et insulin resistance.

• Neuroprotection & Mood Support: Exhibits affinity for 5-HT1A, 5-HT2A/2C, D1/D2 receptors, suggesting potential roles in anxiety reduction, depression mitigation, and possibly neurodegenerative disease pathways. C'est antioxidant capacity further supports neuronal health.

• Anti-inflammatory & Immunomodulatory Actions: Suppresses activation of signalisation NF-κB and downstream pro-inflammatory mediators (par exemple, COX-2, iNOS), beneficial in models of chronic inflammation.

• Antioxidant Defense: Directly scavenges espèces réactives de l'oxygène (ERO) and enhances endogenous antioxidant enzyme systems (par exemple, SOD, GSH), protecting cells from oxidative damage.

6. Nuciferine Usage Guidelines

• Formulaire: Primarily available as a standardized extract powder or in encapsulated/tableted supplements.

• Application: Incorporé dans compléments alimentaires, functional foods/beverages, et cosmeceutical formulations targeting metabolic, cognitive, or anti-aging benefits. Also vital for pharmacological research.

• Posologie : Specific human dosage is not established. Preclinical studies range widely. Adherence to product labeling or research protocols is crucial. Consultation with a qualified healthcare provider is essential before personal use.

7. Nuciferine Safety & Important Precautions

• Toxicology Profile: Generally displays low acute toxicity in animal studies. Chronic toxicity and comprehensive human safety data are areas of ongoing research.

• Potential Adverse Effects: Based on its mechanism, possible side effects might include drowsiness, dizziness, dry mouth, or digestive discomfort. Theoretical risk of hepatotoxicity ou interactions exists.

• Précautions critiques :

  • Consult a Physician: Especially if pregnant, nursing, under 18, have pre-existing medical conditions (liver/kidney disease, mental health disorders), or are taking medications (antidepressants, antipsychotics, hypoglycemics, statins).

  • Quality is Paramount: Source only from reputable suppliers (comme Shaanxi Zhonghong) providing full Certificates of Analysis (CoA) to ensure purity and absence of contaminants.

  • Avoid Self-Diagnosis/Treatment: Not a substitute for professional medical care.

8. Nuciferine Product Specification & Certificate of Analysis (CoA)
Shaanxi Zhonghong guarantees quality through rigorous testing per international standards. A typical CoA includes:

Certificate of Analysis (CoA) Summary: Nuciferine (Lot: [Example])

*(Note: This is a representative example. Actual specifications and test items may vary per batch and specific customer requirements. Always request the full CoA for the specific lot.)

9. Advanced Production Process
Shaanxi Zhonghong employs a sophisticated, vertically integrated nuciferine extraction protocol:

1. Raw Material Sourcing & QC: Prime Nelumbo nucifera leaves, sustainably sourced, undergo strict incoming inspection (ID, moisture, contaminants).

2. Prétraitement : Leaves are cleaned, dried (low-temperature lyophilisation preferred), and milled.

3. Extraction sélective : Utilise patented solvent systems (par exemple, acidified ethanol/water mixtures) optimized for alkaloid yield via maceration ou counter-current extraction.

4. Purification primaire : Initial liquid-liquid partitioning ou macroporous resin adsorption to remove impurities.

5. Chromatographie haute résolution : Core step using HPLC préparative ou flash chromatography with specific stationary phases (par exemple, C18 silica, ion-exchange resins) for selective nuciferine isolation.

6. Cristallisation et séchage : Purified fractions undergo cristallisation ou vacuum concentration suivi de séchage par atomisation ou lyophilisation to obtain powder.

7. Final Purification (Optional): Recrystallization ou preparative TLC for ultra-high purity (>99%).

8. Mélange et normalisation : Batches are blended to ensure consistent nuciferine potency as per specification.

10. Scénarios d'application divers

• Nutraceutiques et compléments alimentaires : Key ingredient in formulations targeting gestion du poids, metabolic health support, stress relief, et cognitive function.

• Functional Food & Beverages: Incorporated into health drinks, bars, or fortified foods for added bioactive benefits.

• Cosméceutiques : Utilisé dans anti-âge et anti-inflammatory skincare products (serums, creams) for its antioxidant and potential collagen-protective effects.

• Pharmaceutical Research: Valuable reference standard et lead compound for drug discovery in metabolic disorders, CNS diseases, et inflammation.

• Academic Research: Utilisé dans in vitro et in vivo studies exploring pharmacology, toxicology, and molecular mechanisms.

11. Stringent Quality Control (QC)
Shaanxi Zhonghong implements a cGMP-aligned quality management system ensuring nuciférine integrity from seed to shipment:

• Qualification des matières premières : Rigoureux supplier auditing et incoming QC en utilisant Empreintes digitales HPLC and contaminant screening.

• Contrôles en cours de fabrication (IPC) : Critical parameters (extraction yield, solvent residues, intermediate purity) monitored via HPLC-UV, GC, et TLC at defined stages.

• Final Product Testing: Complet release testing against full CoA specifications (Identity, Assay, Residual Solvents, Heavy Metals, Pesticides, Microbiology) using méthodes validées (HPLC-DAD/ELSD/CAD, ICP-MS, GC-MS/MS, Microbiological assays per USP/EP).

• Études de stabilité : Conduite accelerated et real-time stability under ICH guidelines to establish shelf-life and optimal storage conditions.

• Validation de la méthode : All analytical procedures are fully validated pour specificity, accuracy, precision, linearity, range, LOD/LOQ, and robustness.

• Documentation et traçabilité : Complet batch records et electronic data capture ensure complete traceability and audit readiness.

12. Secure Packaging & Global Logistics

• Conditionnement: High-purity nuciferine extract is typically packaged in double-sealed, food-grade polyethylene bags within fiber drums ou stainless-steel containers. Nitrogen flushing ou vacuum sealing minimizes oxidation. Labels include critical data (Product Name, CAS#, Batch/Lot #, MF, MW, Date, Net Weight, Storage Conditions, COA link/QR code).

• Stockage: Recommended long-term storage à -20°C dans un dry, dark environment. Short-term storage at 2-8°C is acceptable for most applications. déshydratants are included.

• Logistique: Shaanxi Zhonghong leverages its réseau mondial for efficient shipping via air freight or sea cargo. Options include DDP (rendu droits acquittés) et EXW (Ex Works). Comprehensive cold chain solutions are available for temperature-sensitive shipments. All packages include MSDS (Material Safety Data Sheet) et Certificate of Origin.

13. Research Frontiers, Applications & Challenges

• Mécanismes de santé : Des recherches en cours approfondissent nuciferine’s molecular targets (e.g., specific GPCRs, nuclear receptors, kinases) and signaling pathways (AMPK/mTOR, NF-κB/NLRP3 inflammasome, autophagy regulation) relevant to NAFLD, diabète, neuroinflammation, et cancer chemoprevention.

• Applications industrielles : Innovation focuses on enhancing bioavailability (via nanocarriers, complexes phospholipidiques, salt formation), developing synthetic biology routes (enzymatic synthesis, fermentation), and creating value-added derivatives with improved potency or selectivity.

• Current Challenges & Future: Key challenges include establishing definitive human clinical efficacy and safety, optimizing cost-effective large-scale purification, s'améliorant oral bioavailability, and navigating complex global regulatory landscapes for health claims. Future research aims at translational studies, combination therapies, et nouveaux systèmes de distribution.

14. Foire aux questions (FAQ)

• Q: Is nuciferine safe? A: Preclinical data suggests safety at research doses, but comprehensive human safety studies are limited. Consult your doctor before use. Quality and purity are critical.

• Q: What are nuciferine’s main benefits? A: Research highlights potential for santé métabolique, neuroprotection, et effets anti-inflammatoires, but these are not FDA-approved claims. Human evidence is evolving.

• Q: How much nuciferine should I take daily? UN: There is no established daily intake. Dosage in research varies widely. Follow product label instructions if applicable, or research protocols. Medical advice is essential.

• Q: Where does nuciferine come from? A: Primarily extracted from the leaves of the lotus plant (Nelumbo nucifera).

• Q: Does nuciferine have side effects? A: Potential side effects based on its action may include drowsiness or digestive upset, but are not well-documented in humans. Consultez un professionnel de la santé.

• Q: Can I take nuciferine with my medications? A: Potential for drug interactions exists (e.g., with CNS drugs, metabolized by CYP enzymes). Absolutely consult your doctor or pharmacist.

• Q: How do I ensure I’m buying high-quality nuciferine? A: Source from reputable suppliers comme Shaanxi Zhonghong who provide comprehensive Certificates of Analysis (CoA) verifying identity, purity (>98%), and safety (contaminant levels).

15. Source Premium Nuciferine & Request Samples
Shaanxi Zhonghong Investment Technology Co., Ltd. is your trusted global partner for high-purity nuciferine extract and custom botanical active ingredients.

• Purchase Inquiries & Free Sample Requests:

  • E-mail: liaodaohai@gmail.com

  • Site web: https://aiherba.com (Visit for full product catalog and company details)

• Contact for: Bulk pricing, custom specifications (purity, particle size), CoAs, MSDS, and collaborative development opportunities.

16. Conclusion
Nuciférine, the principal alkaloid of Nelumbo nucifera, represents a fascinating composé bioactif with significant and growing scientific interest, particularly in santé métabolique et neurological support. While preclinical data is promising, robust human clinical trials are the critical next step to fully validate its therapeutic potential and safety profile. For researchers and formulators, sourcing high-purity, well-characterized nuciferine from an experienced and quality-focused manufacturer like Shaanxi Zhonghong Investment Technology Co., Ltd. is paramount. Their commitment to advanced extraction technology, stringent QC exceeding industry standards, and global supply chain expertise ensures reliable access to this intriguing natural product for innovation in nutraceutiques, cosméceutiques, et pharmaceutical research.

17. Références
(Key research areas – illustrative examples)

1. Liu, S., et al. (2019). Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozotocin-induced diabetic mice through a PPARα/PPARγ coactivator-1α pathway. Journal de chimie agricole et alimentaire, 67(42), 11637-11646. (Metabolic Effects)

2. Sugimoto, Y., et al. (2010). Serotonin receptor subtypes involved in the discriminative stimulus effects of nuciferine in rats. Psychopharmacologie, 208(1), 23-30. (Neuropharmacology)

3. Kashiwada, Y., et al. (2005). Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure–activity correlations with related alkaloids. Chimie bioorganique et médicinale, 13(2), 443-448. (Bioactivity)

4. Yan, Z., et al. (2021). Nuciferine protects against LPS-induced acute lung injury via inhibiting MAPK/NF-κB activation and NLRP3 inflammasome signaling pathway. Immunopharmacologie internationale, 100, 108137. (Anti-inflammatory)

5. Wang, J., et al. (2022). Nuciferine: A review of its pharmacology, pharmacokinetics, toxicity and clinical application. Journal d'ethnopharmacologie, 298, 115650. (Review)

6. ICH Q7 : Guide des bonnes pratiques de fabrication des ingrédients pharmaceutiques actifs.

7. USP-NF General Chapters: <561> Articles of Botanical Origin, <62> Microbiological Examination of Nonsterile Products, <232> Elemental Impurities—Limits, <467> Residual Solvents.

8. Monographies de la Pharmacopée européenne (Ph. Eur.) sur les médicaments et extraits de plantes.

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