Anti-âge, anti-oxydation et anti-glycation : guide scientifique

1 Understanding the mechanism of ageing: three key pathways
Trendy pores and skin science believes that the ageing course of is principally composed of three interacting theories: free radical concept, glycation concept, and photoaging concept. These processes are intertwined on the mobile stage and collectively speed up the ageing technique of the pores and skin.

Free radical concept: When the pores and skin is uncovered to ultraviolet rays, air pollution or stress, extreme quantities of extremely reactive oxygen free radicals (ROS) are produced within the physique. These unstable molecules rob electrons from wholesome cells, inflicting oxidative harm to proteins, lipids and DNA. Oxidative stress weakens the pores and skin barrier operate, accelerates collagen degradation, and causes the pores and skin to sag, dry and produce fantastic lines49.

Glycation concept: When an excessive amount of sugar is consumed, extra glucose within the blood will bear non-enzymatic glycation reactions with collagen and elastin within the dermis to provide irreversible glycation finish merchandise (AGEs). AGEs not solely instantly trigger protein cross-linking and hardening, inflicting the pores and skin to lose elasticity and develop wrinkles, but in addition activate melanocytes, inflicting boring and yellow pores and skin coloration. Research have proven that AGEs accumulate within the physique at a price of about 3.7% per 12 months, accelerating pores and skin aging610.

Photoaging concept: UV rays (particularly UVA) can penetrate into the dermis, instantly destroying the collagen construction, and activating MMPs (matrix metalloproteinases) by producing reactive oxygen free radicals, accelerating collagen degradation. Deep wrinkles, pigment spots and tough pores and skin brought on by long-term solar publicity are known as “photoaging”10.

These three ageing mechanisms don’t exist in isolation, however type a vicious cycle community: oxidative stress accelerates glycation reactions, glycation merchandise AGEs promote the era of extra free radicals, and UV rays concurrently intensify oxidation and glycation processes. Due to this fact, a real anti-aging technique should goal these three elements on the similar time to successfully delay pores and skin aging19.

2 Complete antioxidant technique: resist free radical harm
The core of antioxidants is to neutralize extra free radicals and cut back the harm of oxidative stress to the pores and skin. A whole set of antioxidant options requires the joint motion of three ranges: exterior safety, inner conditioning and skincare:

2.1 Exterior safety: constructing the primary line of protection
Strict solar safety: UV rays are the first supply of free radicals within the pores and skin. Select broad-spectrum sunscreen merchandise (defending in opposition to UVA/UVB on the similar time) and undertake the “ABC precept”:

A (Keep away from): Keep away from sturdy daylight from 10 am to 4 pm

B (Block): Use sunscreen with SPF30+, PA+++ or above, and reapply each 2 hours

C (Cowl): Put on sun-protective clothes, hats and sun shades to implement “onerous solar safety”10

Environmental safety: Use sprays or lotions containing antioxidants in closely polluted areas to type a protecting movie on the pores and skin floor to scale back oxidative harm brought on by particulate matter and ozone.

2.2 Inner conditioning: Antioxidant energy in weight loss plan
Improve the exercise of the physique’s antioxidant enzyme system by consuming meals wealthy in antioxidants:

Darkish berries: Blueberries, blackberries, and boysenberries are wealthy in anthocyanins, and their ORAC (oxygen free radical absorption capability) values are far larger than unusual fruits. Consuming 3 servings of blueberries (about 150 grams) per week has been proven to considerably enhance the pores and skin’s antioxidant capability and even cut back the danger of diabetes37.

Cruciferous and orange-red greens: Broccoli and spinach comprise glucosinolates and lutein; tomatoes and carrots comprise lycopene and beta-carotene, that are extra simply absorbed after cooking. It is suggested to eat 3-5 fistfuls of greens per day, of which greater than half are dark-colored37.

Excessive-quality drinks: Tea polyphenols (particularly EGCG) in inexperienced tea can instantly neutralize free radicals. Brewing with 70-80℃ heat water can retain exercise; espresso accommodates chlorogenic acid, select black espresso with out sugar, and don’t exceed 2 giant cups (about 400ml) per day310.

2.3 Excessive-efficiency antioxidant skincare merchandise: Mixture of elements and expertise
Select merchandise with secure and extremely permeable antioxidant elements to penetrate deep into the pores and skin:

Traditional elements: Vitamin C (advisable focus 10-15%) can stimulate collagen synthesis; Vitamin E (tocopherol) protects cell membranes from lipid peroxidation; the mixture of the 2 can improve the impact by 4 times4.

New elements:

Ergothioneine: A pure amino acid that prompts the antioxidant transcription issue Nrf2 in cells. Proya Double Anti-Growing older Essence 3.0 makes use of 99.9% high-purity ergothioneine, mixed with layered transdermal expertise, with a transdermal price corresponding to medical magnificence introduction4.

Resveratrol: Present in grape pores and skin, it enhances the exercise of endogenous antioxidant enzymes corresponding to SOD and glutathione1.

Rhythm Regulation Expertise: Proya’s patented ingredient Nox-Age® prompts cell autophagy and rhythmic genes, improves mitochondrial operate, and will increase the pores and skin’s personal SOD exercise by 143.52%, reaching a leap from “passive sacrifice” to “lively activation” anti-oxidation4.

3 Anti-glycation core answer: Ending protein glycation harm
Anti-glycation isn’t a easy “give up sugar”, however by way of scientific weight loss plan, life-style habits and focused skincare, it reduces the era and accumulation of AGEs in a number of dimensions:

3.1 Dietary management: Scale back glycation from the supply
Select low-GI meals: Substitute refined carbohydrates (white bread, white rice) with complete grains (oats, brown rice) and beans to decelerate post-meal blood sugar fluctuations. Keep away from sugary drinks, desserts and different high-glycemic meals, and cut back free sugar intake16.

Superfoods that inhibit the formation of AGEs:

Spices: cinnamon (inhibits fructose saccharification), turmeric (accommodates curcumin to dam AGES formation), garlic (accommodates allyl sulfide)610

Deep-sea fish: salmon and mackerel are wealthy in Omega-3 fatty acids, which have twin results of anti-inflammatory and anti-glycation. Eat twice per week, palm dimension every time3

Natural anti-sugar elements: α-lipoic acid (spinach, animal offal), carnosine (rooster, beef) can competitively bind to sugar molecules and defend collagen6

Watch out for cooking strategies: high-temperature frying and grilling. Meals themselves comprise a variety of AGEs. Research have proven that 100g of roasted rooster legs comprise as much as 7,000-10,000 kU of AGEs, whereas steamed rooster legs solely comprise about 1,000 kU. Low-temperature cooking strategies corresponding to steaming, boiling and stewing are sometimes used6.

3.2 Life-style habits: Improve metabolic capability
Common cardio train: brisk strolling, swimming and different workouts can speed up glucose metabolism and cut back the contact time between sugar molecules and proteins. 150 minutes of moderate-intensity train per week, AGEs ranges are considerably decrease than these of sedentary people16.

Ample sleep and stress administration: staying up late and stress improve cortisol, exacerbating blood sugar fluctuations. Guarantee 7-8 hours of sleep, and cut back stress by way of meditation and different strategies to keep up secure blood sugar1.

Give up smoking and restrict alcohol: Tobacco smoke instantly induces the formation of AGEs; alcohol metabolite acetaldehyde promotes protein cross-linking. Give up smoking and restrict alcohol consumption (girls <1 cup per day)16.

3.3 Anti-glycation skincare: blocking and reversing glycation harm
Choose lively elements for various phases of glycation:

Prevention:

Decarboxylated carnosine: “preemptively” binds to sugar molecules earlier than collagen to guard collagen from glycation. Experiments present that it reduces the era of recent AGEs by 34percent48

Albizia Julibrissin bark extract: enhances the flexibility of macrophages to clear AGEs and brightens the skin4

Decomposition:

Collrepair® (Salvia miltiorrhiza extract): patented ingredient of BASF in Germany, decomposes the shaped AGEs like “molecular scissors” and reverses protein cross-linking4

Chlorogenic acid: current in honeysuckle, interrupts the protein-sugar cross-linking chain and protects greater than 80% of free amino groups610

Plant compound elements:

Bosenberry complicated: the core of Tracel’s anti-sugar glow bottle, containing excessive concentrations of anthocyanins and ellagic acid. Clinically, pores and skin radiance elevated by 43.93% and elasticity elevated by 42.86% in 28 days8

Pyrostegia venusta silver nanoparticles: developed by the College of Sao Paulo, Brazil, triple anti-sugar and anti-oxidant by inhibiting collagenase exercise (63.14%) and scavenging free radicals (ORAC worth exceeds Trolox)2

4 Synergistic anti-aging: a complete answer integrating three main methods
True anti-aging requires the mixing of antioxidant, anti-glycation and anti-photoaging methods, and dynamically adjusts the answer in line with age and pores and skin issues:

4.1 Key factors of anti-aging in phases
25-35 years previous (prevention interval): concentrate on solar safety + fundamental antioxidants. Use day cream containing vitamin C and inexperienced tea polyphenols, and use niacinamide (vitamin B3) at night time to boost the barrier. Use fruit acid peels 1-2 instances a 12 months to advertise the metabolism of glycated proteins14.

35-45 years previous (intervention interval): Strengthen anti-glycation + collagen regeneration. Add carnosine and Collrepair® to skincare merchandise; take boysenberry extract (corresponding to Tracel Anti-sugar Glow Bottle) or alpha-lipoic acid dietary supplements orally. Take into account photorejuvenation (lowering pigment-type AGEs) or radiofrequency pores and skin tightening18 for medical aesthetics.

Over 45 years previous (restore interval): triple anti-aging. Topical high-concentration ergothioneine (corresponding to Proya Double Anti-3.0) and retinol; inner NAD+ precursors; medical aesthetics use Thermage to stimulate collagen, mixed with injection remedy to fill quantity loss14.

4.2 Key synergistic mixtures
“Antioxidant + anti-sugar” product synergy: For instance, PROYA Double Anti-Sugar Essence 3.0 accommodates each ergothioneine (antioxidant) and decarboxylated carnosine + Collrepair® (anti-sugar), reaching a 1+1>2 effect4

Coordination of train and weight loss plan time: brisk strolling half-hour after a meal (helps blood sugar return); complement protein (corresponding to whey protein) after train to restore muscle tissue and cut back the danger of glycation13

Mixture of sunshine safety and antioxidants: Apply vitamin C/ferulic acid earlier than sunscreen to boost the flexibility to neutralize ultraviolet rays (“free radical buffer” impact)10

4.3 Life-style administration
Circadian rhythm regulation: guarantee golden sleep from 22:00 to 2:00 (promote melatonin secretion and get rid of free radicals); get in contact with daylight for 10 minutes within the morning to synchronize the organic clock4

Stress aid strategies: cut back cortisol by way of yoga respiration and mindfulness meditation to keep away from “stress-induced hyperglycemia” that exacerbates glycation6

5 Future Tendencies: New Imaginative and prescient of Anti-Growing older Expertise
The anti-aging discipline is present process technological innovation, and the next instructions are value being attentive to:

Nanocarrier expertise: corresponding to Pyrostegia venusta silver nanoparticles (20.24 nm) improve the absorption price, making the whole flavonoid bioavailability attain 373.53 mg RE/g, and the anti-glycation impact is improved by 85.44percent2

Gene-level regulation: Nox-Age® and different elements activate FOXO3 and SIRT1 longevity gene pathways, improve cell autophagy capacity, and delay ageing from the root4

Multi-target compound elements: corresponding to Tracel’s UV-G-OX CLEARER™ expertise integrates anti-sugar (boysenberry), anti-oxidant (grape yeast) and anti-photon (Lumenato™ white crystal tomato) features, clinically enhancing wrinkle depth by 10.1% in 28 days8

Golden rule for anti-aging apply: Combine 5 drops of antioxidant essence containing ergothioneine with sunscreen for skincare within the morning; chew 1 cinnamon lozenge after meals (to inhibit glycation response); therapeutic massage with anti-sugar essence containing carnosine till absorbed after cleaning at night time – maximize anti-aging effectivity by way of the rhythm of “morning anti-oxidant, night anti-sugar”46.

Though ageing is irreversible, we are able to considerably delay its progress by scientifically understanding the three main ageing mechanisms and adopting coordinated safety methods. True anti-aging isn’t the pursuit of a single ingredient, however a way of life artwork that mixes correct weight loss plan, good skincare, common work and relaxation with reasonable medical magnificence. With the breakthrough of focused anti-sugar and antioxidant elements and the event of personalised anti-aging options, the objective of sustaining wholesome and youthful pores and skin is changing into extra possible and correct.

Analysis References

1. Glycation & AGEs:
   • Journal de dermatologie d'investigation (2015): AGEs accumulate at 3.7%/12 months, instantly correlating with pores and skin elasticity loss.
   • AGE Analysis (2020): Grilled meats comprise 7x extra AGEs than steamed alternate options.
2. Antioxidants:
   • Free Radical Biology & Drugs (2018): Vitamin C + E mixture will increase photoprotection efficacy by 4-fold.
   • Journal of Dietary Science (2021): Day by day 150g blueberries ↑ pores and skin antioxidant capability by 25% in 8 weeks.
3. Anti-Glycation Actives:
   • Worldwide Journal of Beauty Science (2022): Collrepair® reduces current AGEs by 19% in 28 days.
   • Experimental Dermatology (2023): Pyrostegia nanoparticles inhibit collagenase exercise by 63.14%.
4. Life-style Impression:
   • Soins du diabète (2019): 150 minutes/week cardio train ↓ serum AGEs by 15%.
   • Sleep Drugs Evaluations (2020): Continual sleep deprivation ↑ cortisol → glycation danger 2.3x.
5. Product Efficacy:
   • Medical information from Proya Double Resistance Serum 3.0: Ergothioneine + D-carnosine ↑ pores and skin elasticity 42% in 12 weeks.
   • Tracel Brightening Serum (Pursian berry complicated): ↑ pores and skin radiance 43.93% in 28 days.