Pine Bark Extract: Premium OPC Complement for Cardiovascular & Antioxidant Help| Provider & Producer | Supplier & Manufacturer

1. What is Pine Bark Extract?

Pine bark extract is a bioactive focus derived from the internal bark of Pinus pinaster (Maritime Pine), standardized to include proanthocyanidines oligomères (OPC) – potent polyphenols with clinically validated antioxidant properties. In contrast to artificial antioxidants, OPCs exhibit superior biodisponibilité et synergistic exercise with endogenous free radical scavengers like nutritional vitamins C and E.

2. Approvisionnement, propriétés chimiques et identification

• Fournitures botaniques : Pinus pinaster Aiton (Pinaceae household), sustainably harvested from cultivated European forests

• Energetic Constituents:

  • Procyanidins (85-90%)

  • Taxifolin

  • Catechin/epicatechin monomers

  • Phenolic acids

• Quantité CAS : 85596-91-0 (for proanthocyanidin-rich extract)

• Système moléculaire (MF) : Variable polymer constructions (C30H26O12 for dimers)

• Poids moléculaire (PM) : 500-3,000 Da (oligomeric vary)

• EINECS : 287-476-3

• Apparence: Reddish-brown hygroscopic powder

• Solubilité: Water-soluble (>50mg/mL), ethanol-soluble

3. High quality Gradients, Well being Benefits & Scientific Efficacy
Premium High quality Indicators:

• OPC Content: High-grade extracts include ≥90% procyanidins by UV-HPLC (vs. 70% in industrial grades)

• Polymerization Diploma: Oligomers (DP 2-7) present optimum absorption – validated by GPC-SEC evaluation

• Bioactivity Markers: A- & B-type interflavan linkages quantified by way of phloroglucinolysis-HPLC

Proof-Based mostly Well being Benefits:
✓ Cardioprotection:

• Blood Stress Modulation: Vital discount in systolic BP (-3.8 mmHg, p<0.01) by way of ACE inhibition et endothelial NO synthase activation (Luzzi et al., 2021)

• Arterial Elasticity: ↑28% flow-mediated dilation in hypertensive sufferers (Fitzpatrick et al., 1998)

✓ Antioxydant et anti-inflammatoire :

• 50x stronger free radical scavenging vs. vitamin E (ORAC assay)

• ↓CRP (-35%) and ↑SOD exercise in metabolic syndrome (Devaraj et al., 2002)

✓ Stabilité hormonale :

• Testosterone Affect: No direct impact on testosterone synthesis. Could assist hormonal well being not directly by way of oxidative stress discount in Leydig cells.

Dosing & Security:

• Day by day Consumption: 100-300 mg standardized extract (morning dose)

• Contre-indications : Keep away from with anticoagulants (warfarin), autoimmune situations

• Résultats des facettes : Uncommon (<2% incidence) – gentle gastrointestinal discomfort reported

• Being pregnant: Not beneficial (inadequate teratogenicity knowledge)

4. Shaanxi Zhonghong: Business Chief in Premium Botanicals

Excellence scientifique :

• College Collaborations: Joint R&D with Peking College, ETH Zurich specializing in OPC bioavailability enhancement

• Proprietary Extraction: Patented low-temperature turbulent-flow chromatography (CN104945367A) preserves thermolabile phenolics

• Capacités analytiques :

  • Triple-quad LC-MS/MS quantification of 37 procyanidin isomers

  • qNMR purity verification (≥98.5% OPCs)

International Provide Chain:

• Uncooked materials traceability by way of blockchain-enabled sourcing from PEFC-certified forests

• cGMP manufacturing (FDA DMF #033451)

5. Product Specs: Pharmaceutical-Grade High quality Management

6. Flux de travail de fabrication supérieur

1. Cryogenic Milling: Liquid nitrogen grinding (-196°C) prevents thermal degradation

2. Pressurized Low-Polarity Water Extraction: 120°C/15MPa for optimum polyphenol yield

3. Adsorption Chromatography: Polyamide resin separation of procyanidin fractions

4. Nanofiltration: 200Da membranes focus OPCs >95% purity

5. Freeze Drying: Lyophilization at -45°C/0.1mBar preserves thermolabile compounds

7. Matrice d'application

8. Reducing-Edge High quality Assurance

Shaanxi Zhonghong implements QbD (Haute qualité par conception) protocols throughout manufacturing. Actual-time PAT (Course of Analytical Expertise) displays important high quality attributes by way of:

• Inline NIR Spectroscopy: Tracks procyanidin focus throughout extraction

• UPLC-PDA-ELSD: Twin-detection system for fingerprinting 58 phenolic compounds

• Accelerated Stability: ICH Q1A-compliant 6-month research at 40°C/75% RH
  All batches embody genetic authentication (DNA barcoding) and isotope ratio evaluation (δ13C) for geographical verification.

9. Clinically Validated Mechanisms

• Vasodilation: ↑NO bioavailability by way of eNOS phosphorylation (Akt/PI3K pathway)

• Antioxidant Recycling: Regenerates oxidized vitamin E (tocopheroxyl radical discount)

• Anti-inflammatoire: Suppresses NF-κB translocation and COX-2 expression

10. Technical FAQs

Q: Does pine bark extract enhance testosterone?
A: No scientific proof helps direct testosterone elevation. It might scale back oxidative stress in gonadal tissues however is not an androgen modulator.

Q: Optimum dosage for hypertension?
*A: 150-300mg every day standardized to ≥90% OPCs. Results manifest in 8-12 weeks.*

Q : Stabilité dans les formulations ?
A: Use enteric coating for oral merchandise. In topicals, mix with chelators (EDTA) to forestall Fe³⁺-catalyzed degradation.

11. International Distribution

Ordering Data:

• Contact: Mr. Liao Daohai (Director of International Gross sales)

• Courrier électronique : liaodaohai@gmail.com

• Site web: https://www.aiherba.com

• Minimal Order: 1kg (R&D samples), 25kg (manufacturing batches)

• Logistique: -20°C transport for bulk OPC concentrates

12. Conclusion

Pine bark extract represents a gold-standard botanical for cardiovascular and antioxidant assist when sourced from respected suppliers like Shaanxi Zhonghong. Their vertically built-in management from sustainable forestry à purification chromatographique ensures pharmaceutical-grade OPC concentrates with clinically related bioactivity.

Références

1. Rohdewald P. (2002). Int J Clin Pharmacol Ther

2. Luzzi R. et al. (2021). Analyse de l'hypertension

3. Grimm T. et al. (2006). Free Radical Bio Med

4. USP-NF <2029> Botanical Extracts

5. European Patent EP2895210B1 – Extraction technique