Compléments alimentaires, Cosmétiques et soins personnels, Aliments fonctionnels, Ingrédients de santé et pharmaceutiques, Extraits naturels de plantes

Extrait de camomille

Chamomile Extract supplier bulk factory Wholesale buy Extract factory

Nom anglais: Chamomile Extract

Spécification

- Teneur en composés actifs:

- - Apigenin ≥ 2.0% (HPLC), Bisabolol ≥ 1.5% (HPLC), Chamazulene ≥ 0.5% (HPLC)

- Solubilité: Slightly soluble in water; highly soluble in ethanol (≥ 50 g/100 mL), propylene glycol, and most organic solvents

- Apparence – liée: Perte à la dessiccation ≤ 5%, Métaux lourds ≤ 10 ppm, Solvants résiduels ≤ 0,5%

- Taille des particules: Standard powder ≤ 100 μm; micronized powder ≤ 5 μm for better dispersion

Apparence

- Light yellow to yellow – brown fine powder, with a characteristic floral and herbal aroma, distinct from chocolate

N° CAS

- As a mixture, no single CAS number; individual components have separate numbers (e.g., Apigenin: 520 – 36 – 5, Chamazulene: 515 – 92 – 4)

Délai de mise en œuvre: 5 à 7 jours ouvrables

Emballer

- 1 kg/sac (sac en aluminium), 25 kg/fût (sac PE double couche à l'intérieur d'un fût en carton)

Marché principal: Global market, with significant demand in Europe (Germany, France), North America, and Asia (Japan, South Korea), especially in the food, pharmaceutical, and cosmetics industries

Scénarios d'application

Propriétés de base

Composants actifs:

- Apigénine: A flavonoid with potent antioxidant and anti – inflammatory properties.

- α – Bisabolol: A sesquiterpene alcohol known for its soothing, antibacterial, and anti – irritant effects.

- Chamazulene: A blue – colored sesquiterpene with strong anti – inflammatory and wound – healing capabilities.

Caractéristiques principales

- Activité antioxydante: Scavenges free radicals such as hydroxyl and superoxide anions, protecting cells from oxidative damage.

- Anti-inflammatoire: Inhibits the production of pro – inflammatory cytokines (e.g., TNF – α, IL – 6), reducing tissue inflammation.

- Antimicrobien: Exhibits inhibitory effects against bacteria (e.g., Staphylococcus aureus) et les champignons (par exemple, Candida albicans).

- Skin – Soothing: Calms irritated skin, reduces redness, and promotes skin repair.

Scénarios d'application

1. Alimentation et boissons

Beverage Ingredients:

- Added to teas, herbal infusions, and fruit juices (0.1 – 0.5% concentration) for flavor enhancement and potential health benefits.

- Used in functional beverages, such as stress – relief drinks, due to its calming properties.

Confectionery and Dairy Products:

- Incorporated into candies, chocolates, and yogurt to impart a unique floral flavor and add antioxidant value.

2. Médicaments

Over – the – Counter (OTC) Medicines:

- Used in topical creams, ointments, and lotions for treating minor skin irritations, rashes, and sunburns (2 – 5% concentration).

- Available as oral supplements in capsule or tablet form (200 – 500 mg per serving) for promoting relaxation and reducing mild anxiety.

Herbal Remedies:

- A key ingredient in traditional herbal medicine for soothing digestive discomfort, such as indigestion and gastritis.

3. Cosmétiques et soins personnels

Produits de soins de la peau:

- Serums, moisturizers, and face masks (1 – 3% concentration) formulated to hydrate, soothe, and anti – age the skin. It helps reduce the appearance of fine lines and wrinkles by protecting against oxidative stress.

- Used in sensitive – skin products due to its gentle and anti – inflammatory nature.

Soins capillaires:

- Shampoos and conditioners containing chamomile extract can lighten hair naturally, as well as soothe the scalp and reduce dandruff.

4. Santé animale

Pet Care Products:

- Added to pet shampoos and topical treatments to relieve itchy, irritated skin in dogs and cats.

- Available as pet supplements to calm anxious pets during travel or stressful situations.

Additifs pour l'alimentation du bétail:

- Used in poultry and livestock feed (50 – 200 ppm) to improve feed palatability and enhance animal health through its antioxidant and anti – inflammatory effects.

Méthodes de détection

Chromatographie liquide à haute performance (HPLC):

- Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% formic acid (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 254 nm (for apigenin) and 230 nm (for chamazulene).

Chromatographie en phase gazeuse – Spectrométrie de masse (GC – MS):

- Used for the identification and quantification of volatile components like bisabolol, providing detailed information about the extract’s chemical profile.

Spectroscopie infrarouge à transformée de Fourier (FTIR):

- Helps in confirming the chemical structure of the active compounds by analyzing characteristic absorption peaks, ensuring product quality and authenticity.

Source et avantages

Source naturelle: Extracted from the flowers of Matricaire recutita (German chamomile) or Chamaemelum nobile (Roman chamomile), which are widely cultivated in Europe, North America, and Asia.

Sustainable Production: Chamomile is an easily – grown crop, and modern extraction techniques, such as supercritical CO₂ extraction, ensure high – quality products with minimal environmental impact.

Demande du marché: Its dual function as a flavoring agent and a bioactive ingredient drives high demand across multiple industries, making it a valuable natural product.

Conformité réglementaire

FDA américaine: Regulated as a food additive and dietary supplement ingredient. Meets Good Manufacturing Practice (GMP) requirements for pharmaceutical – grade products.

Règlement de l'UE: Approved as a food flavoring substance and permitted for use in cosmetics under the Cosmetics Regulation (EC) No 1223/2009.

NMPA de Chine: Permitted for use in food, pharmaceuticals, and cosmetics, subject to strict quality control and safety standards.

Catégories : Compléments alimentaires, Cosmétiques et soins personnels, Aliments fonctionnels, Ingrédients de santé et pharmaceutiques, Extraits naturels de plantes

Description
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Chamomile Extract: Nature’s Golden Elixir | Premium Standardized Ingredients

1. What is Chamomile Extract?

Chamomile Extract is a concentrated bioactive fraction derived primarily from the flowers of Matricaire camomille L. (German Chamomile) or Chamaemelum nobile L. (Roman Chamomile). This complex phytochemical matrix is prized for its apigenin-rich composition, essential oils (including bisabolol oxides and chamazulene), and other bioactive flavonoids. It represents one of the most scientifically validated and globally utilized botanical extracts, with applications spanning nutraceutiques, cosméceutiques, et functional foods.

2. Source, propriétés chimiques et identifiants clés

Primary Botanical Source: Flowers of Matricaire camomille L. (German Chamomile – highest apigenin content) or Chamaemelum nobile L. (Roman Chamomile).
Propriétés chimiques :
- Key Constituents: Apigenin (and its glycosides, e.g., apigenin-7-O-glucoside), Apigenin-7-O-glucoside, α-Bisabolol, Chamazulene (blue derivative from matricin), Bisabolol oxides A & B, Flavonoids (luteolin, quercetin), Coumarins.
- Chemical Class: Flavonoids (Apigenin), Sesquiterpenes (Bisabolols, Chamazulene), Coumarins.
- Solubilité: Water-soluble extracts (standardized for apigenin glycosides), oil-soluble fractions (essential oils, CO2 extracts), or standardized powders (spray-dried).
- Stabilité: Light- and heat-sensitive (especially chamazulene). Requires cool, dark storage and often antioxidants/stabilizers.
Key Identifiers (Representative):
- CAS Registry Number (Apigenin): 520-36-5
- Molecular Formula (Apigenin): C₁₅H₁₀O₅
- Molecular Weight (Apigenin): 270.24 g/mol
- EINECS (Apigenin): 208-292-1
- (Note: Full extract has no single CAS/EINECS; identifiers apply to specific markers)

3. Puissance, bienfaits pour la santé, dosage et sécurité

“Best” & Highest Content: The “best” extract depends on the application. Standardized Apigenin (4-6%) extracts are preferred for calmative and GI benefits. CO2 Supercritical Extracts (2-10% total sesquiterpenes/azulenes) excel in topical anti-inflammatory applications. Shaanxi Zhonghong offers diverse specifications (e.g., 4% Apigenin, 10:1 Concentrate, Essential Oil, Full Spectrum).
Health Benefits (Evidence-Based):
- Calming & Sleep Support: Modulates GABA_A receptors (apigenin), reduces anxiety, improves sleep quality.
- GI Health: Soothes gastrointestinal irritation (bisabolol/chamazulene), reduces spasms, alleviates symptoms of dyspepsia.
- Anti-inflammatoire et antioxydant : Potently inhibits COX-2, LOX, and pro-inflammatory cytokines (TNF-α, IL-6); scavenges free radicals.
- Santé de la peau : Anti-irritant, wound healing (α-Bisabolol), antimicrobial, soothes eczema/dermatitis.
- Antimicrobien : Activity against Staph aureus, Candida albicans.
- Potential Metabolic Support: Emerging evidence for blood glucose regulation.
Typical Daily Intake (Oral): 220-1100 mg daily of standardized extract (e.g., 4% Apigenin), often divided. Tea: 1-4 cups daily (2-3g dried flowers/cup). Follow product label or practitioner guidance.
Précautions et effets secondaires :
- Generally Recognized as Safe (GRAS). Rare mild GI upset or drowsiness.
- Allergy: Contraindicated in individuals with known allergy to Asteraceae/Compositae family plants (ragweed, chrysanthemums, marigolds).
- Coumarin Content: Potential interaction with anticoagulants (warfarin). Use caution.
- Pregnancy: Traditionally used but limited modern safety data; consult physician.
- Impératif de qualité : Risk of pyrrolizidine alkaloid (PA) contamination in non-premium sources necessitates stringent testing by suppliers like Shaanxi Zhonghong.

4. Trusted Global Supplier: Shaanxi Zhonghong Investment Technology Co., Ltd.
Shaanxi Zhonghong Investment Technology Co., Ltd. leviers 28 years of phytochemistry expertise to deliver premium, research-backed Chamomile Extracts. As a vertically integrated entreprise de haute technologie, we master the entire value chain from sustainable sourcing to advanced purification under Conformité aux BPF.

Core Strengths:
- Scientific Innovation: 5 strategic university partnerships fuel cutting-edge extraction R&D. 20+ brevets protect proprietary isolation techniques.
- Unmatched Purity: HPLC-DAD-MS/MS et GC-MS quantification ensures apigenin/bisabolol standards exceed industry norms by 20%. ICP-MS guarantees ultra-low heavy metals.
- Conformité mondiale : Fournitures pharma-grade ingredients meeting USP/EP/FCC standards to plus de 80 pays across nutraceutical, cosmetic, and functional food industries.
- Intégration verticale : Controls quality from DNA-authenticated botanicals à ISO 9001:2015 certified manufacturing.
Portefeuille de produits : Apigenin-Standardized Extract (4%, 6%), Full Spectrum Extract (10:1), Organic Chamomile CO2 Extract, Chamomile Essential Oil, Chamomile Water.

5. Chamomile Extract Benefits: A Scientific Summary
Chamomile Extract delivers multisystem benefits validated by pharmacology:

Neuroscience: GABAergic modulation promotes calmness & restful sleep.
Gastroenterology: Spasmolytic & anti-inflammatory actions support digestive comfort.
Dermatologie: Bisabolol/chamazulene enhance skin barrier repair & reduce erythema.
Immunology: Dual antimicrobial & anti-inflammatory activity.
Metabolism: Emerging role in glycemic control pathways.

6. Usage Guidelines

Nutraceutiques : Capsules, tablets, tinctures, sleep blends, digestive aids.
Cosméceutiques : Calming serums, after-sun products, sensitive skin creams, baby care.
Aliments/boissons fonctionnels : Teas, relaxation drinks, functional confectionery.
Dosage: Adhere to formulation-specific recommendations based on standardization.

7. Critical Safety Notes

Absolute Contraindication: Asteraceae/Compositae allergy.
Use With Caution: Concurrent anticoagulant therapy (monitor INR).
Pregnancy/Nursing: Consult healthcare provider despite traditional use.
Assurance qualité: Partner with certified suppliers (par exemple, Shaanxi Zhonghong) pour PA-free, contaminant-tested extracts.

8. Premium Product Specifications

Table 1: Shaanxi Zhonghong Chamomile Extract Quality Standards (Example: 4% Apigenin)

Catégorie	Projet	Spécification	Méthode d'essai
Résidus de pesticides	Chlorpyrifos	≤ 0,01 ppm	GC-MS/MS (EU SANTE 11312/2021)
	Cyperméthrine	≤ 0,05 ppm	GC-MS/MS
	Propargite	≤ 0,01 ppm	GC-MS/MS
	DDT total	≤ 0,05 ppm	GC-μECD
	Pyrrolizidine Alkaloids (PAs)	< 1.0 ppb Total PAs	LC-MS/MS (USP <223>)
Métaux lourds	Arsenic (As)	≤ 1,0 ppm	ICP-MS (USP <232>/ICH Q3D)
	Plomb (Pb)	≤ 3,0 ppm	ICP-MS
	Cadmium (Cd)	≤ 0,5 ppm	ICP-MS
	Mercure (Hg)	≤ 0,1 ppm	CV-AAS
Microbiologique	Compte aérobie total	≤ 10⁴ CFU/g	USP <61>
	Levures et moisissures	≤ 10² UFC/g	USP <61>
	E. coli	Absent dans 1 g	USP <62>
	Salmonella espèces	Absent dans 10 g	ISO 6579-1
	Staphylococcus aureus	Absent dans 1 g	USP <62>
Chemical Markers	Apigénine	≥ 4.0%	HPLC-DAD (Validated USP/EP)
	α-bisabolol	≥ 5.0% (in CO2 Extracts)	GC-FID
	Perte au séchage	≤ 6.0%	USP <731>
	Total Ash	≤ 8,0%	USP <281>
	Résidus de solvants	Conforms to USP <467>	GC-HS-FID

9. Flux de production avancé

Sustainable Sourcing: Partner farms (EU/Organic certified) supply identity-preserved Matricaire camomille flowers. HPTLC/DNA barcoding verification.
Gentle Drying: Low-temperature air drying (<40°C) preserves thermolabile actives.
Precision Extraction: Optimisé hydroethanolic percolation (apigenin) or Extraction au CO2 supercritique (sesquiterpenes/oils). Extraction d'eau sous-critique employed for high-yield fractions.
Multistage Purification: Adsorption chromatography (macroporous resin) enriches apigenin. distillation moléculaire refines essential oil fractions.
Standardization & Stabilization: Precise HPLC-guided blending achieves target potency. Microencapsulation (cyclodextrins) enhances apigenin stability in powders.
cGMP Processing: Closed-system spray drying (inlet ≤ 120°C) for powders; nitrogen-flushed packaging for oils.
Contrôle qualité complet : Batch-specific CoA via UPLC-QTOF-MS (full metabolomics), GC×GC-TOFMS (volatiles), ICP-MS/MS (elementals), validated microbiological assays.

10. Scénarios d'application divers

Stress & Sleep Supplements: Nighttime formulas, anxiety relief capsules.
GI Health Products: IBS support, digestive bitters, anti-spasmodic blends.
Dermocosmetics: Rosacea creams, baby shampoo, post-procedure soothing gels, anti-aging serums (apigenin antioxidant).
Functional Beverages: Relaxation teas, sleep-inducing tonics.
Oral Care: Anti-gingivitis mouthwashes.
Animal Health: Pet calming chews, equine wound gels.

11. Pharmaceutical-Grade Quality Control
Shaanxi Zhonghong’s QC protocol exceeds pharmacopeial standards: Raw material authentication via DNA metabarcoding (ITS2, matK) ensures species authenticity. In-process controls monitor critical quality attributes (CQAs): solvent ratios, temperature profiles, intermediate marker content (TLC/HPLC). Finished product release requires validated UPLC-PDA methods (ICH Q2(R1)) for apigenin quantification and LC-MS/MS for PA screening (LOD < 0.1 ppb). Stability chambers (ICH Q1A) conduct accelerated (40°C/75% RH) and long-term (25°C/60% RH) studies. Method transfer/verification supports global client audits. Laboratoire accrédité ISO 17025 underpins data integrity (ALCOA+).

12. Protective Packaging & Global Logistics

Conditionnement: Light-resistant amber glass bottles (oils), triple-layer foil-aluminum pouches (powders – 25kg), or nitrogen-flushed double drums (bulk). US FDA/EC 1935-compliant materials.
Stockage: Ambiance contrôlée (15-25°C), <60% RH. Oils stored at 4-8°C.
Logistique: Cold chain solutions for temperature-sensitive extracts (2-8°C transport). DDP (rendu droits acquittés) expertise to 80+ countries. Full documentation suite: CoA, GC-MS/HPLC chromatograms, MSDS, Certificate of Origin, Non-GMO/Allergen/PA-Free Statements.

13. Mechanism of Action & Industry Innovation

Pharmacology:
- GABA_A Receptor Modulation: Apigenin binds benzodiazepine site → Cl⁻ influx → neuronal hyperpolarization.
- Anti-inflammatoire: α-Bisabolol inhibits NF-κB & TNF-α; chamazulene scavenges leukotrienes.
- GI Smooth Muscle Relaxation: Apigenin blocks Ca²⁺ influx → spasmolytic effect.
- Antimicrobien : Sesquiterpene lactones disrupt microbial membranes.
Innovation industrielle :
- Amélioration de la biodisponibilité : Nanoémulsions et complexes phospholipidiques boost apigenin absorption (5-10x).
- Chimie verte : Enzyme-assisted extraction (cellulase/pectinase) increases yield while reducing solvent use.
- Stability Technology: Antioxidant synergies (Rosemary CO2 extract + Tocopherols) extend shelf-life.
Frontières de la recherche :
- Oncologie: Apigenin’s pro-apoptotic effects (PI3K/Akt pathway inhibition) in preclinical cancer models.
- Neuroprotection : Mitigation of Aβ-induced toxicity in Alzheimer’s models.
- Microbiome Interactions: Impact on gut-brain axis signaling.
- Standardization Complexity: Correlating specific chemotypes (bisabolol oxide A vs B ratios) with clinical efficacy.

14. Foire aux questions (FAQ)

Q: What’s the difference between German and Roman Chamomile extract?
- UN: German (Matricaria) is richer in apigenin/chamazulene, preferred for anti-inflammatoire effects. Roman (Chamaemelum) has higher esters (angelates), valued for aromatherapy/milder action.
Q: Is Chamomile Extract safe for children?
- UN: Generally safe in age-appropriate doses (e.g., teething gels). Verify PA-free status and avoid with Asteraceae allergy.
Q: Can I take Chamomile with blood thinners?
- UN: Consult your doctor. Coumarin content may potentiate warfarin; close INR monitoring required.
Q: Why choose Shaanxi Zhonghong’s Chamomile Extract?
- UN: Guaranteed PA-free (<1ppb), HPLC-standardized actives (apigenin/bisabolol), cGMP/ISO 9001 manufacturing, 28 ans d'expertise, R&D soutenue par l'université, global regulatory support.
Q: Where to buy premium Chamomile Extract?
- UN: Contact Shaanxi Zhonghong for B2B sales: Email: liaodaohai@gmail.com | Website: aiherba.com.

15. Conclusion: The Gold Standard in Calmative Botanicals
Chamomile Extract remains a cornerstone of evidence-based phytotherapy. Its multimodal benefits—spanning neurological calm, GI comfort, and dermatological soothing—are unlocked only through scientifically rigorous production. Shaanxi Zhonghong Investment Technology Co., Ltd. sets the global benchmark with PA-free extracts, chromatographic standardization exceeding pharmacopeia, et vertically integrated quality control. Notre 28-year legacy in bioactive compounds, 5 university alliances, et Plus de 20 technologies brevetées deliver Chamomile ingredients of uncompromising purity and efficacy for premium health applications worldwide.

Source Pharmaceutical-Grade Chamomile Extract:

E-mail: liaodaohai@gmail.com
Site web: aiherba.com

16. Select References

Srivastava, J.K., et al. (2010). Chamomile: A herbal medicine of the past with bright future. Molecular Medicine Reports, *3*(6), 895-901.
Amsterdam, J.D., et al. (2009). Chamomile (Matricaire recutita) may provide antidepressant activity… Journal of Clinical Psychopharmacology, *29*(4), 378-382.
McKay, D.L., & Blumberg, J.B. (2006). A review of the bioactivity and potential health benefits of chamomile tea… Recherche en phytothérapie, *20*(7), 519-530.
European Medicines Agency (EMA). (2015). Assessment report on Matricaria recutita L., flos.
USP-NF Monographs: Chamomile Flower, German.
Avonto, C., et al. (2017). In Chemico Evaluation of Tea Tree Essential Oils and Chamomile Extracts for Pyrrolizidine Alkaloids. J. Agric. Food Chem., *65*(14), 3087–3093.
ICH Guidelines: Q1A(R2) Stability Testing, Q2(R1) Validation of Analytical Procedures.
ISO 9271:2022 – Aromatic natural raw materials – Vocabulary. (Specific pharmacopeial methods and clinical studies should be referenced in formal product documentation).

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