Biopérine

Bioperine®: The Gold Standard in Bioavailability Enhancement – A Manufacturer’s Guide

1. What is Bioperine®?

Let’s cut through the noise. Bioperine® is not just black pepper extract. It’s a patented, clinically-studied ingredient derived from the fruits of Piper nigrum L. (black pepper) and standardized to contain ≥95% piperine. Think of it as the key that unlocks the full potential of your supplements. Its primary, and most valuable, function is to significantly enhance the bioavailability of other active compounds, making your formulations more effective and efficient.

2. Source, composition chimique et spécifications

• Source: Sourced from the dried fruits of Piper nigrum L.

• Bioactif clé : Piperine (Standardized to ≥95%).

• Profil chimique :

  • N° CAS : 94-62-2

  • MF: C₁₇H₁₉NO₃

  • MW: 285.34 g/mol

  • EINECS : 202-348-0

• Apparence: Off-white to pale yellow crystalline powder.

• Solubilité: Soluble in ethanol and chloroform; sparingly soluble in water.

3. The Zhonghong Standard: Why Our Bioperine® is Best for B2B
Pour nutraceutical ingredients suppliers et private label supplement manufacturers, consistency and proof are everything. Here’s what defines a premium-grade Bioperine®:

• Key Ingredient & Potency: ≥95% Piperine. This high level of purity is non-negotiable for reliable and potent bioavailability enhancement.

• Proven Efficacy (Compliant Claims):

  • Bioavailability Enhancer: Clinically shown to increase the absorption of various nutrients (e.g., Curcumin, CoQ10, Vitamins, Selenium).

  • Thermogenic Activity: Supports metabolic rate and nutrient utilization.

  • (Note: This product is not intended to diagnose, treat, cure, or prevent any disease. Structure/function claims must be compliant with local regulations).

• Optimal Use Level: Typically used at a 1-5% ratio relative to the active compound it is enhancing (e.g., 5-10mg of Bioperine® per 500mg of Curcumin). Dosage should be finalized based on the specific formulation.

• Origine et qualité : Provenant de sources premium Piper nigrum and processed to meet stringent international standards.

• Application: Ideal for incorporation into tablets, capsules, and powder formulations for dietary supplements.

• Formulations cibles : Essential for private label supplement manufacturers creating products with high-value actives like turmeric/curcumin, resveratrol, multivitamins, and cognitive health blends.

• Safety & Considerations:

  • Généralement reconnu comme sûr (GRAS) : At recommended levels.

  • Interactions médicamenteuses : May affect the metabolism of certain pharmaceutical drugs by inhibiting cytochrome P450 enzymes and UDP-glucuronylation. Consult a medical expert if formulating for populations on medication.

  • Grossesse/Allaitement : Recommended to avoid high doses.

4. Zhonghong Biotech: Your Strategic Ingredient Partner
When you need a reliable bulk botanical extracts partner, you need more than a vendor. You need a technical expert. Shaanxi Zhonghong Investment Technology Co., Ltd. est certifié nutraceutical ingredients supplier with 28 years of experience in bioactive compound manufacturing.

• Expertise principale : We are specialists in the precision extraction and purification of plant-derived actives. Our portfolio is built for B2B:

  • Standardized Botanical Extracts (like Bioperine®)

  • Cosmetic Raw Material Supplier offerings

  • Ingrédients nutraceutiques for supplements and functional foods

  • API Intermediates

• Our B2B Value Proposition:

  • Innovation-Driven: 20+ patents and university collaborations ensure we are at the forefront of extraction technology.

  • Assurance qualité: Notre investissement dans Spectroscopie HPLC et RMN guarantees a purity standard that is consistently 20% above common industry specs, providing you with a uncontested competitive edge.

  • Global B2B Network: Nous fournissons extraits botaniques en gros et solutions personnalisées à OEM herbal extracts partners and major brands in over 80 countries.

5. Technical Insight: Mechanism of Action
Piperine’s primary mechanism is two-fold:

1. Inhibition of Metabolism: It inhibits the enzymes in the liver and intestine (e.g., CYP3A4, UGT) that would normally break down and eliminate other compounds before they enter the bloodstream.

2. Enhancing Absorption: It stimulates amino acid transporters in the intestinal lining and increases blood supply to the GI tract, facilitating greater uptake of co-administered supplements.

6. Uncompromising Quality Control: The COA
Our Quality Control is your formulation’s insurance policy. Every batch is rigorously tested.

Certificate of Analysis (COA) Summary – Bioperine® (≥95% Piperine)

7. Processus de production avancé
Our GMP-compliant process ensures unmatched purity:

1. Sourcing et préparation : Selection and cleaning of premium Piper nigrum fruits.

2. Extraction: Solvent extraction optimized for maximum piperine yield.

3. Filtration & Concentration: Removal of impurities and concentration of the extract.

4. Crystallization & Purification: Further refinement to achieve the ≥95% purity benchmark.

5. Standardisation: Precise adjustment to meet the exact specification.

6. Séchage et broyage : Conversion into a fine, free-flowing powder.

7. Libération du contrôle qualité : The batch is only released after passing all critical quality parameters.

8. Application in Nutraceutical Formulations
This ingredient is a cornerstone for effective supplement design. Its primary application is in:

• Enhanced Absorption Formulas: Curcumin supplements, multivitamins, coenzyme Q10, resveratrol, and antioxidant blends.

• Weight Management Products: Leveraging its mild thermogenic properties.

• Nutrition sportive : To improve the uptake of amino acids and other performance nutrients.

9. B2B Packaging & Logistics

• Conditionnement: Standard 25kg/fiber drum with double polyethylene liners. Customized packaging available for de gros et en gros ordres.

• Stockage: Store in a cool, dry place away from strong light.

• Durée de conservation : 24 months when stored correctly.

• Logistique: We handle global shipping and all export documentation (COA, MSDS, Certificate of Origin) for seamless delivery to OEM partners worldwide.

10. Associez-vous à nous pour vos besoins en ingrédients en vrac
Zhonghong isn’t just a fournisseur; we’re your innovation partner. We provide:

• Prix de gros compétitifs : Obtenez un direct prix d'usine pour les commandes à volume élevé.

• Personnalisation et OEM : Nous offrons OEM herbal extracts et solutions personnalisées tailored to your specific formulation requirements.

• Technical Support: Leverage our 28 years of expertise for your product development.

Contactez-nous pour un devis ou pour demander un échantillon !

• Web: www.aiherba.com

• E-mail: ventes@aiherba.com; liaodaohai@gmail.com

• Mots-clés: Bioperine supplier, bulk piperine, nutraceutical ingredients supplier, cosmetic raw material supplier, wholesale botanical extracts, private label supplement manufacturer, OEM herbal extracts, bulk organic ingredients.

11. FAQ pour les clients B2B

• Q: What is your Minimum Order Quantity (MOQ) for bulk orders?
  R : Contactez-nous pour obtenir des informations précises sur la quantité minimale de commande. Nous proposons des conditions flexibles pour de gros et en gros partenaires.

• Q: Can you provide custom standardization for private label?
  A: Absolutely. As an OEM herbal extracts partner, we specialize in solutions personnalisées to meet your specific product specs.

• Q: Do you offer technical documentation and regulatory support?
  A: Yes. We provide full documentation (COA, MSDS) and can support with regulatory data for your market.

• Q : Quel est le délai de livraison pour les commandes importantes ?
  A: Lead times vary based on order size. We maintain strategic stock for popular items and provide clear timelines for custom productions.

• Q: How do I start the qualification process?
  A : Envoyez-nous un e-mail à ventes@aiherba.com pour demander un échantillon gratuit and discuss your specific needs. Our technical team will guide you through the process.

12. Conclusion
In the competitive world of supplement manufacturing, ingredient efficacy is paramount. Bioperine® is a proven, powerful tool to differentiate your products and guarantee customer results. Sourcing from a technically advanced, reliable fabricant is critical. Zhonghong Biotech, with its scientific rigor, proven quality, and global B2B supply capability, is the optimal partner for nutraceutical ingredients suppliers et private label brands. Contact us today to discuss your project and request a sample.

Références :

• Majeed, M., et al. (1999). Piperine, a bioavailability enhancer. US Patent 5,972,382.

• Shoba, G., et al. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Plante Médicale, 64(4), 353-356.

• Badmaev, V., et al. (2000). Piperine, an alkaloid derived from black pepper, increases serum response of beta-carotene during 14-days of oral supplementation. Nutrition Research, 20(3), 381-388.

• Johnson, J. J., et al. (2011). Enhancing the bioavailability of resveratrol by combining it with piperine. Recherche en nutrition moléculaire et en alimentation, 55(8), 1169-1176.