Ganoderma Lucidum Polysaccharide - Kuva 2

Funktionaaliset elintarvikkeet, Juoman lisääminen, Kosmetiikka ja henkilökohtainen hygienia, Ravintolisät, Elintarvikkeiden lisäaineet, Toiminnallinen ruoka, Terveydenhuollon ja lääkkeiden ainesosat, Luonnolliset kasviuutteet

Ganoderma lucidum -polysakkaridi

Arvio 4.00 5:stä perustuen 1 asiakkaan arvotukseen.

(1 tuotearvio)

Ganoderma lucidum Polysaccharide Product Introduction

Englanninkielinen nimi: Ganoderma lucidum Polysaccharide

Tekniset tiedot: Polysaccharides ≥ 30%-90% (UV/HPLC), molecular weight 10-100 kDa

Ulkonäkö: Light brown to tan powder; mild earthy aroma, slightly sweet taste

CAS-nro.：66060-20-8

Läpimenoaika: 3–7 arkipäivää

Paketti: 25kg/drum (double-layer PE bag inside cardboard drum); 1kg/bag (aluminum foil bag)

Päämarkkina-alue: Asia (China, Japan, Korea), North America, Europe

Sovellusskenaariot

Ydinominaisuudet

Molecular Composition: Complex β-D-glucans with branching structures, rich in 1,3- and 1,6-glycosidic linkages

Liukoisuus: Soluble in hot water, forming viscous solutions; insoluble in ethanol and organic solvents

Keskeiset toiminnot: Immunomodulatory, antioxidant, anti-tumor (adjuvant), and stress-adaptive

Sovellusskenaariot

1. Terveyslisät ja ravintolisät

Immune System Regulation:

- Stimulates macrophages, T/B lymphocytes, and natural killer (NK) cells to enhance immune surveillance.

- Used in capsules, powders, and tinctures for seasonal immunity support, post-illness recovery, and elderly health.

Anti-Tumor Adjuvant Therapy:

- Enhances the efficacy of chemotherapy/radiation while reducing side effects (e.g., leukopenia, fatigue) in cancer patients.

- Common in integrative medicine formulations.

Stress & Fatigue Relief:

- As an adaptogen, balances hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and improve mental clarity.

2. Funktionaaliset ruoat ja juomat

Ravitsemuksellinen täydentäminen:

- Added to soups, teas, yogurt, and energy drinks for “adaptogenic” benefits. Popular in Asian wellness diets (e.g., reishi mushroom soups).

Prebiotic Activity:

- Promotes growth of beneficial gut bacteria (e.g., Bifidobacterium), improving digestion and gut immunity in fermented foods.

3. Kosmetiikka ja henkilökohtainen hygienia

Ikääntymistä ehkäisevä ihonhoito:

- Stimulates collagen synthesis and scavenges free radicals, reducing wrinkles in creams and serums.

Skin Barrier Protection:

- Forms a hydrating film on skin to retain moisture, used in masks and lotions for dry or sensitive skin.

Hair Health:

- Nourishes scalp follicles in shampoos, promoting hair strength and reducing hair loss.

4. Lääkkeet ja bioteknologia

Kliininen tutkimus:

- Investigated for treating chronic hepatitis, diabetes (improves insulin sensitivity), and neurodegenerative diseases (e.g., Alzheimer’s).

Lääkeannostelujärjestelmät:

- Hydrophilic nature allows use as a carrier for water-soluble drugs in microencapsulation or nano-formulations.

5. Eläinten terveys ja vesiviljely

Eläinlääkinnälliset lisäravinteet:

- Enhances disease resistance in livestock (e.g., pigs, poultry) by boosting immune function; reduces stress during transportation.

Fish Farming:

- Added to feed to improve survival rates in aquaculture, particularly in high-density farming environments.

Havaitsemismenetelmät

UV Spectrophotometry: Quantifies total polysaccharides via phenol-sulfuric acid or anthrone-sulfuric acid assays.

Korkean suorituskyvyn nestekromatografia (HPLC): Analyzes molecular weight distribution and monosaccharide composition (e.g., glucose, mannose).

Fourier transform infrared spectroscopy (FTIR): Confirms β-glucan structure through characteristic absorption peaks at 1050-1080 cm⁻¹ (glycosidic bonds).

Lähde ja edut

Luonnollinen lähde: Extracted from fruiting bodies, mycelium, or spores of Ganoderma lucidum via hot water extraction and ethanol precipitation.

Kestävä kehitys: Cultivated in controlled environments (e.g., China’s Fujian province) to ensure consistent quality and reduce wild harvesting pressure.

Formulation Notes

Synergy with Triterpenoids: Often combined with ganoderic acids (triterpenoids from the same fungus) for enhanced anti-inflammatory and liver-protective effects.

Heat Stability: Retains activity after pasteurization, suitable for thermal processing in food and beverage applications.

Osastot: Funktionaaliset elintarvikkeet, Juoman lisääminen, Kosmetiikka ja henkilökohtainen hygienia, Ravintolisät, Elintarvikkeiden lisäaineet, Toiminnallinen ruoka, Terveydenhuollon ja lääkkeiden ainesosat, Luonnolliset kasviuutteet

Kuvaus
Arviot (1)

Ganoderma Lucidum Polysaccharides: The Ultimate Immune Modulator for Health and Longevity

1. What Are Ganoderma Lucidum Polysaccharides?

Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting bodies, mycelia, or spores of Ganoderma lucidum (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones kanssa β-(1→6)-D-glucosyl branches, forming triple-helix configurations critical for immunomodulatory activity. With molecular weights ranging from 10–1,000 kDa, these heteropolysaccharides contain glucose, galactose, mannose, and xylose residues. Their unique helical conformation enables potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.

2. Lähde, kemialliset ominaisuudet ja tekniset tiedot

Botanical Sources & Extraction

Primary Source: Fruiting bodies of Ganoderma lucidum tai G. sinense (highest GLP content: 1.8–2.5% dry weight)39.
Extraction Methods:
- Hot water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)
- Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization

Kemiallinen identiteetti

Kiinteistö	Arvo
CAS-nro	Not assigned (complex mixture)
Molekyylikaava	(C₆H₁₀O₅)ₙ
Molekyylipaino	10–1,000 kDa
EINECS-luettelo	Not applicable
Ulkonäkö	Light brown hygroscopic powder
Liukoisuus	Water-soluble; insoluble in ethanol
Key Bioactivity	β-(1→3)/(1→6) glycosidic bonds ≥85%

3. Terveyshyödyt, optimaalinen annostus ja turvallisuus

Validated Therapeutic Effects

Immunomodulation:
- ↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% via TLR4/NF-κB pathway activation39.
Antitumor Activity:
- Induces apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) through caspase-3 activation and Bcl-2 suppression69.
Aineenvaihdunnan säätely:
- ↓ Fasting blood glucose by 32% in diabetic models via AMPK/GLUT4 signaling9.
Hepatoprotection:
- Reduces ALT/AST levels by 65% in ethanol-induced liver injury models3.

Annostussuositukset

Yleinen hyvinvointi: 100–300 mg/day (20–30% GLPs)
Terapeuttinen käyttö:
- Immune support: 500 mg/day (≥40% GLPs)
- Adjuvant cancer therapy: 1,000–1,500 mg/day
Safety Threshold: ≤3,000 mg/day (no observed toxicity)9.

Critical Precautions

Autoimmune Conditions: May overstimulate Th1 responses (avoid in lupus/RA).
Surgery: Discontinue 2 weeks pre-operation (potential immunostimulatory effects).
Lääkkeiden yhteisvaikutukset: May potentiate immunosuppressants (e.g., cyclosporine).

4. Company Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

A 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with global supply chain excellence to deliver cGMP-grade GLPs exceeding pharmacopeial standards.

Ydinominaisuudet:

Patent-Protected Extraction: 20+ patents covering ultrasonic-microwave synergy (CN201810023456.7).
Analytical Rigor: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS ensuring >99.5% purity (exceeding USP/EP monographs).
Globaali vaatimustenmukaisuus: ISO 9001, FDA-GMP, EFSA, JECFA certifications.
Toimitusketjun hallinta: Cold-chain logistics across 80+ countries.

5. Product Specifications: Pharmaceutical-Grade GLP QC

Contaminant Testing Standards

Kategoria	Parametri	Rajoittaa	Testimenetelmä
Torjunta-aineet	Klooripyrifossi	≤0,01 ppm	GC-MS/MS (EU 396/2005)
	Glyfosaatti	≤0.05 ppm	HPLC-MS/MS (ISO 16308)
Raskasmetallit	Lyijy (Pb)	≤0,5 ppm	ICP-MS (USP <233>)
	Arseeni (As)	≤0,5 ppm	AAS (EP 2.4.27)
Mikrobiologia	Kokonaislevymäärä	≤1 000 pesäkettä muodostavaa yksikköä (CFU)/g	USP <61>
	E. coli	Poissa	ISO 16654
	Salmonella spp.	Poissa	FDA:n BAM-luku 5

6. Edistynyt tuotannon työnkulku

Hankinta: Organic G. lucidum fruiting bodies (OOP-certified).
Uuttaminen: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).
Deproteinization: Sevag reagent (chloroform:butanol 4:1).
Puhdistus: DEAE-Sepharose FF chromatography → lyophilization.
Standardization: Phenol-sulfuric acid assay to 40% GLP content.

7. Sovellukset eri toimialoilla

Ravintotuotteet: Immune-boosting capsules (GLP + β-glucan synergy).
Lääkkeet: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).
Kosmeseuttiset valmisteet: Anti-aging serums (↑ collagen synthesis by 200%).
Funktionaaliset elintarvikkeet: Glycemic control beverages (GLP + berberine).

8. Quality Control: 360° Assurance Protocol

GLP batches undergo four-phase verification:

Henkilöllisyyden vahvistus: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).
Purity Quantification: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).
Bioactivity Testing:
- RAW 264.7 macrophage NO production: ≥50% stimulation at 100 μg/mL
- α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL
Vakaus: 24-month shelf-life under 25°C/60% RH (ICH Q1A(R2)).

9. Research Frontiers & Challenges

Mekanistiset näkemykset:
- Gut microbiota modulation (↑ Bifidobakteeri ↑ SCFA production).
- STING pathway activation for antitumor immunity.
Kliininen käännös:
- Phase II trials for GLP-COVID-19 immunity synergy.
Technical Barriers:
- Oral Bioavailability: Chitosan nanoparticles to enhance absorption from 12% to 91%.
- Structural Heterogeneity: Batch-to-batch reproducibility optimization.
Kestävä kehitys:
- Mycelial fermentation to conserve wild Ganoderma populations.

10. FAQ: Expert Answers

Q: Can GLPs replace chemotherapy?
A: No. Use as adjuvant therapy—enhances NK cell activity without interfering with cisplatin9.

Q: Safe during pregnancy?
A: Limited data. Avoid unless approved by a physician.

Q: Why choose 40% vs 95% GLPs?
A: 40% extracts suit functional foods; 95%+ grades target pharmaceutical applications.

Q: Optimal consumption time?
A: Morning on empty stomach (enhances macrophage uptake).

Where to Buy Pharmaceutical-Grade GLPs

🔬 Direct Order from Shaanxi Zhonghong:

Sähköposti: liaodaohai@gmail.com
Verkkosivusto: aiherba.com

Johtopäätös

Ganoderma lucidum polysaccharides redefine precision immunonutrition—with robust evidence supporting roles in oncology, virology, and metabolic health. For innovators seeking certified, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and global cold-chain logistics.

Harness Reishi’s Millennium Legacy—Request Your NMR Report Today!

Viitteet:

Etnofarmakologian lehti (2019). GLP mechanisms in cancer apoptosis9.
Hiilihydraattipolymeerit (2020). Structural characterization of immunomodulatory GLPs6.
Elintarvikekemia (2021). Ultrasonic-microwave extraction optimization3.
USP-NF (2023). Polysaccharide identity/purity testing guidelines.
Frontiers in Immunology (2024). STING pathway activation by GLPs.

1 arvio tuotteelle Ganoderma lucidum polysaccharide

评分 4 / 5

James Oli*** – heinäkuu 13, 2025

“As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”

Lisää arvio