The Definitive Guide to Nuciferine: Nature’s Lotus Alkaloid Powerhouse

1. What is Nuciferine?

Nuciferine is a prominent آلکالوئید آپورفین naturally found in the leaves and stems of the sacred نلومبو نوسیفره plant, commonly known as the lotus. This bioactive phytochemical is structurally characterized by its tetracyclic ring system and is increasingly recognized for its diverse physiological activities. It functions as a key signaling molecule within the plant and exhibits significant bioactive potential in mammalian systems, influencing metabolic, neurological, and inflammatory pathways.

۲. منبع محصول، خواص شیمیایی و شناسایی

• منبع: عمدتاً استخراج شده از نلومبو نوسیفره (Lotus) leaves using advanced techniques like استخراج با حلال و خالص‌سازی کروماتوگرافی.

• ماهیت شیمیایی: Nuciferine is classified as an aporphine isoquinoline alkaloid.

• شماره CAS: 475-83-2

• فرمول مولکولی (MF): C₁₉H₂₁NO₂

• وزن مولکولی (MW): ۲۹۵.۳۸ گرم بر مول

• شماره EINECS: 207-503-3

3. The Premium Nuciferine Standard: Key Attributes

Identifying the “best” nuciferine requires stringent criteria for quality, efficacy, and transparency:

• ماده‌ی کلیدی: High-purity نوسیفرین (typically ≥98% by HPLC).

• Proven Efficacy (Compliant): Research suggests potential benefits, however, specific health claims are regulated and require substantiation per jurisdiction. Current scientific focus includes:

  • سلامت متابولیک: Modulation of lipid metabolism, potential influence on glucose homeostasis via pathways like فعال‌سازی AMPK و PPARγ modulation.

  • Neurological Support: Interaction with dopaminergic و serotonergic receptors; potential anxiolytic and mood-modulating effects observed in preclinical models.

  • Anti-inflammatory & Antioxidant Activity: Reduction of pro-inflammatory cytokines (TNF-α, IL-6) and mitigation of oxidative stress markers.

• Optimal Origin: Sourced from premium نلومبو نوسیفره cultivars, ideally with documented traceability.

• Recommended Use: Primarily used as a dietary supplement ingredient یا research chemical. Typical formulations include capsules, tablets, or powder blends. Always follow manufacturer or research protocol guidelines.

• مخاطب هدف: Researchers, nutraceutical formulators, and consumers seeking advanced botanical ingredients (under professional guidance).

• Crucial Considerations:

  • مقدار مصرف: No established Recommended Dietary Allowance (RDA) exists. Human clinical data is limited. Preclinical studies use varying doses. Consulting a healthcare professional before use is essential.

  • ایمنی و عوارض جانبی: Generally considered safe at research doses, but comprehensive human safety data is lacking. Potential side effects are not well-documented but could relate to its pharmacology (e.g., mild sedation, gastrointestinal upset). Not evaluated by the FDA for disease diagnosis, treatment, cure, or prevention.

  • موارد منع مصرف: Avoid if pregnant, breastfeeding, or with known hypersensitivity. Potential interactions with medications (especially affecting liver enzymes CYP450 or neurotransmitter systems) warrant caution. Medical consultation is mandatory before use.

4. About Shaanxi Zhonghong Investment Technology Co., Ltd.
شرکت فناوری سرمایه‌گذاری شانشی ژونگ‌هونگ به عنوان برتر ایستاده است شرکت با فناوری پیشرفته متخصص در استخراج، جداسازی و خالص‌سازی of bioactive plant compounds. With 28 years of dedicated expertise در ترکیبات زیست فعال, the company integrates R&D, innovation, precision manufacturing, and global distribution to serve the chemical, material science, and life science sectors.

• شایستگی‌های اصلی: Advanced processing of عصاره‌های گیاهی طبیعی، از جمله botanical active ingredients برای لوازم آرایشی و بهداشتی, واسطه‌های دارویی, مواد مغذی (dietary supplements), natural pigments, افزودنی‌های غذایی, beverage enhancers، و شیرین‌کننده‌های گیاهی.

• Scientific Edge: Establishes significant technical barriers through collaborations with ۵ دانشگاه برتر از طریق آزمایشگاه‌های مشترک. Holds بیش از ۲۰ اختراع ثبت شده اختصاصی and maintains an exclusive کتابخانه مرکب جهانی.

• Cutting-Edge Facilities: استخدام می‌کند ابزار دقیق تحلیلی پیشرفته از جمله کروماتوگرافی مایع با کارایی بالا (HPLC), Ultraconducting Nuclear Magnetic Resonance (NMR)، اطمینان حاصل کردن استانداردهای خلوص تا سال 20%+ از هنجارهای صنعت فراتر می‌رود.

• دسترسی جهانی: Maintains a robust شبکه تأمین بین‌المللی پوشا بیش از ۸۰ کشور در سراسر آسیا، اروپا و آمریکا، ارائه دهنده customized raw material solutions به شرکت‌های داروسازی چندملیتی و موسسات تحقیقاتی.

5. Nuciferine Benefits for Health
Nuciferine’s emerging profile as a multi-target bioactive alkaloid is underpinned by mechanistic research:

• Metabolic Syndrome Management: Modulates key regulators (AMPK, PPARγ, SREBP-1c) involved in lipid biosynthesis, fatty acid oxidation، و adipocyte differentiation, showing promise in preclinical models of dyslipidemia و insulin resistance.

• Neuroprotection & Mood Support: Exhibits affinity for 5-HT1A, 5-HT2A/2C, D1/D2 گیرنده‌ها, suggesting potential roles in anxiety reduction, depression mitigation, and possibly neurodegenerative disease pathwaysآن antioxidant capacity further supports neuronal health.

• Anti-inflammatory & Immunomodulatory Actions: Suppresses activation of سیگنالینگ NF-κB and downstream pro-inflammatory mediators (مثلاً، COX-2, iNOS), beneficial in models of chronic inflammation.

• Antioxidant Defense: Directly scavenges گونه‌های فعال اکسیژن (ROS) and enhances endogenous antioxidant enzyme systems (مثلاً، SOD, GSH), protecting cells from oxidative damage.

6. Nuciferine Usage Guidelines

• فرم: Primarily available as a standardized extract powder or in encapsulated/tableted supplements.

• کاربرد: Incorporated into مکمل‌های غذایی, functional foods/beverages، و cosmeceutical formulations targeting metabolic, cognitive, or anti-aging benefits. Also vital for pharmacological research.

• دوز مصرفی: Specific human dosage is not established. Preclinical studies range widely. Adherence to product labeling or research protocols is crucial. Consultation with a qualified healthcare provider is essential before personal use.

7. Nuciferine Safety & Important Precautions

• Toxicology Profile: Generally displays low acute toxicity in animal studies. Chronic toxicity and comprehensive human safety data are areas of ongoing research.

• Potential Adverse Effects: Based on its mechanism, possible side effects might include drowsiness, dizziness, dry mouth, or digestive discomfort. Theoretical risk of hepatotoxicity یا interactions exists.

• اقدامات احتیاطی بحرانی:

  • Consult a Physician: Especially if pregnant, nursing, under 18, have pre-existing medical conditions (liver/kidney disease, mental health disorders), or are taking medications (antidepressants, antipsychotics, hypoglycemics, statins).

  • کیفیت حرف اول را می‌زند: Source only from reputable suppliers (مانند Shaanxi Zhonghong) providing full گواهی‌های تجزیه و تحلیل (CoA) to ensure purity and absence of contaminants.

  • Avoid Self-Diagnosis/Treatment: Not a substitute for professional medical care.

8. Nuciferine Product Specification & Certificate of Analysis (CoA)
Shaanxi Zhonghong guarantees quality through rigorous testing per international standards. A typical CoA includes:

Certificate of Analysis (CoA) Summary: Nuciferine (Lot: [Example])

*(Note: This is a representative example. Actual specifications and test items may vary per batch and specific customer requirements. Always request the full CoA for the specific lot.)

۹. فرآیند تولید پیشرفته
Shaanxi Zhonghong employs a sophisticated, vertically integrated nuciferine extraction protocol:

1. تامین مواد اولیه و کنترل کیفیت: پریمیوم نلومبو نوسیفره leaves, sustainably sourced, undergo strict incoming inspection (ID, moisture, contaminants).

2. پیش تصفیه: Leaves are cleaned, dried (low-temperature لیوفیلیزاسیون preferred), and milled.

3. استخراج انتخابی: بهره می‌برد patented solvent systems (مثلاً، acidified ethanol/water mixtures) optimized for alkaloid yield از طریق maceration یا counter-current extraction.

4. تصفیه اولیه: Initial liquid-liquid partitioning یا جذب رزین ماکرومتخلخل to remove impurities.

5. کروماتوگرافی با وضوح بالا: Core step using HPLC مقدماتی یا flash chromatography with specific stationary phases (مثلاً، C18 silica, ion-exchange resins) for selective nuciferine isolation.

6. تبلور و خشک کردن: Purified fractions undergo تبلور یا vacuum concentration به دنبال آن خشک کردن پاششی یا freeze drying to obtain powder.

7. Final Purification (Optional): Recrystallization یا preparative TLC for ultra-high purity (>99%).

8. ترکیب و استانداردسازی: Batches are blended to ensure consistent nuciferine potency as per specification.

۱۰. سناریوهای کاربردی متنوع

• مکمل‌های غذایی و دارویی: Key ingredient in formulations targeting مدیریت وزن, metabolic health support, stress relief، و cognitive function.

• Functional Food & Beverages: Incorporated into health drinks, bars, or fortified foods for added bioactive benefits.

• لوازم آرایشی و بهداشتی: مورد استفاده در ضد پیری و anti-inflammatory skincare products (serums, creams) for its antioxidant and potential collagen-protective effects.

• Pharmaceutical Research: Valuable reference standard و lead compound for drug discovery in metabolic disorders, CNS diseases، و inflammation.

• تحقیقات دانشگاهی: Used in در شرایط آزمایشگاهی (in vitro) و در داخل بدن studies exploring pharmacology, toxicology, and molecular mechanisms.

11. Stringent Quality Control (QC)
Shaanxi Zhonghong implements a cGMP-aligned quality management system اطمینان از نوسیفرین integrity from seed to shipment:

• صلاحیت مواد اولیه: سختگیرانه supplier auditing و incoming QC با استفاده از HPLC fingerprinting and contaminant screening.

• کنترل‌های حین فرآیند (IPC): Critical parameters (extraction yield, solvent residues, intermediate purity) monitored via HPLC-UV, جی سی، و تی ال سی at defined stages.

• Final Product Testing: جامع release testing against full CoA specifications (Identity, Assay, Residual Solvents, Heavy Metals, Pesticides, Microbiology) using روش‌های معتبر (HPLC-DAD/ELSD/CAD, ICP-MS, GC-MS/MS, Microbiological assays per USP/EP).

• مطالعات پایداری: هدایت accelerated و real-time stability under ICH guidelines to establish shelf-life and optimal storage conditions.

• اعتبارسنجی روش: All analytical procedures are fully validated برای specificity, accuracy, precision, linearity, range, LOD/LOQ, and robustness.

• مستندسازی و ردیابی: کامل batch records و electronic data capture ensure complete traceability and audit readiness.

۱۲. بسته‌بندی ایمن و لجستیک جهانی

• بسته بندی: High-purity عصاره نوکیفرین is typically packaged in double-sealed, food-grade polyethylene bags درون fiber drums یا stainless-steel containers. Nitrogen flushing یا vacuum sealing minimizes oxidation. Labels include critical data (Product Name, CAS#, Batch/Lot #, MF, MW, Date, Net Weight, Storage Conditions, COA link/QR code).

• ذخیره سازی: Recommended long-term storage در -20 درجه سانتیگراد در یک dry, dark environment. Short-term storage at ۲-۸ درجه سانتی‌گراد is acceptable for most applications. خشک‌کننده‌ها are included.

• لجستیک: Shaanxi Zhonghong leverages its global network for efficient shipping via air freight or sea cargo. Options include DDP (Delivered Duty Paid) و EXW (Ex Works)جامع cold chain solutions are available for temperature-sensitive shipments. All packages include MSDS (Material Safety Data Sheet) و Certificate of Origin.

13. Research Frontiers, Applications & Challenges

• مکانیسم‌های سلامت: تحقیقات مداوم، عمیق‌تر به این موضوع می‌پردازد nuciferine’s molecular targets (e.g., specific GPCRs, nuclear receptors, kinases) and signaling pathways (AMPK/mTOR, NF-κB/NLRP3 inflammasome, autophagy regulation) relevant to NAFLD, دیابت, neuroinflammation، و پیشگیری شیمیایی از سرطان.

• کاربردهای صنعتی: Innovation focuses on enhancing bioavailability (via nanocarriers, کمپلکس‌های فسفولیپیدی, salt formation), developing synthetic biology routes (enzymatic synthesis, fermentation), and creating value-added derivatives with improved potency or selectivity.

• Current Challenges & Future: Key challenges include establishing definitive human clinical efficacy and safety, optimizing cost-effective large-scale purification، بهبود oral bioavailability, and navigating complex global regulatory landscapes for health claims. Future research aims at translational studies, combination therapies، و novel delivery systems.

14. Frequently Asked Questions (FAQ)

• Q: Is nuciferine safe? A: Preclinical data suggests safety at research doses, but comprehensive human safety studies are limited. Consult your doctor before use. Quality and purity are critical.

• Q: What are nuciferine’s main benefits? A: Research highlights potential for سلامت متابولیک, محافظت عصبی، و اثرات ضد التهابی, but these are not FDA-approved claims. Human evidence is evolving.

• Q: How much nuciferine should I take daily? الف: There is no established daily intake. Dosage in research varies widely. Follow product label instructions if applicable, or research protocols. Medical advice is essential.

• Q: Where does nuciferine come from? A: Primarily extracted from the leaves of the lotus plant (Nelumbo nucifera).

• Q: Does nuciferine have side effects? A: Potential side effects based on its action may include drowsiness or digestive upset, but are not well-documented in humans. Consult a healthcare provider.

• Q: Can I take nuciferine with my medications? A: Potential for drug interactions exists (e.g., with CNS drugs, metabolized by CYP enzymes). Absolutely consult your doctor or pharmacist.

• Q: How do I ensure I’m buying high-quality nuciferine? A: Source from reputable suppliers مانند Shaanxi Zhonghong who provide comprehensive گواهی‌های تجزیه و تحلیل (CoA) verifying identity, purity (>98%), and safety (contaminant levels).

15. Source Premium Nuciferine & Request Samples
شرکت فناوری سرمایه‌گذاری شانشی ژونگ‌هونگ is your trusted global partner for high-purity عصاره نوکیفرین and custom botanical active ingredients.

• Purchase Inquiries & Free Sample Requests:

  • ایمیل: liaodaohai@gmail.com

  • وب‌سایت: https://aiherba.com (برای مشاهده کاتالوگ کامل محصولات و اطلاعات شرکت به ادامه مطلب مراجعه کنید)

• Contact for: Bulk pricing, custom specifications (purity, particle size), CoAs, MSDS, and collaborative development opportunities.

۱۶. نتیجه‌گیری
نوسیفرین, the principal alkaloid of نلومبو نوسیفره, represents a fascinating ترکیب زیست فعال with significant and growing scientific interest, particularly in سلامت متابولیک و neurological support. While preclinical data is promising, robust human clinical trials are the critical next step to fully validate its therapeutic potential and safety profile. For researchers and formulators, sourcing high-purity, well-characterized nuciferine from an experienced and quality-focused manufacturer like شرکت فناوری سرمایه‌گذاری شانشی ژونگ‌هونگ is paramount. Their commitment to advanced extraction technology, stringent QC exceeding industry standards, and global supply chain expertise ensures reliable access to this intriguing natural product for innovation in مواد مغذی, لوازم آرایشی و بهداشتی، و pharmaceutical research.

۱۷. منابع
(Key research areas – illustrative examples)

1. Liu, S., et al. (2019). Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozotocin-induced diabetic mice through a PPARα/PPARγ coactivator-1α pathway. مجله شیمی کشاورزی و مواد غذایی, 67(42), 11637-11646. (Metabolic Effects)

2. Sugimoto, Y., et al. (2010). Serotonin receptor subtypes involved in the discriminative stimulus effects of nuciferine in rats. روان‌داروشناسی, 208(1), 23-30. (Neuropharmacology)

3. Kashiwada, Y., et al. (2005). Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of نلومبو نوسیفره, and structure–activity correlations with related alkaloids. شیمی دارویی و بیوارگانیک, 13(2), 443-448. (Bioactivity)

4. Yan, Z., et al. (2021). Nuciferine protects against LPS-induced acute lung injury via inhibiting MAPK/NF-κB activation and NLRP3 inflammasome signaling pathway. ایمونوفارماکولوژی بین‌المللی, 100, 108137. (Anti-inflammatory)

5. Wang, J., et al. (2022). Nuciferine: A review of its pharmacology, pharmacokinetics, toxicity and clinical application. مجله طب قومی, 298, 115650. (Review)

6. ICH Q7: Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients.

7. USP-NF General Chapters: <561> Articles of Botanical Origin, <62> Microbiological Examination of Nonsterile Products, <232> Elemental Impurities—Limits, <467> Residual Solvents.

8. European Pharmacopoeia (Ph. Eur.) Monographs on Herbal Drugs and Extracts.

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