ایزوستویول
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ایزوستویول

Isosteviol Product Introduction

  1. نام انگلیسی: Isosteviol
  1. مشخصات
    • خلوص: Isosteviol ≥ 98% (HPLC); High – purity grade: ≥ 99% (HPLC)
    • حلالیت: Sparingly soluble in water (approx. 0.1 g/L at 25°C), soluble in organic solvents such as ethanol, acetone, and chloroform
    • نقطه ذوب: 198 – 202°C
    • حلال‌های باقیمانده: Ethanol ≤ 0.5%, Acetone ≤ 0.5%
    • فلزات سنگین: ≤ 10 پی پی ام
    • اندازه ذرات: Standard powder ≤ 100 μm; micronized powder ≤ 5 μm for better reactivity
  1. ظاهر
    • White to off – white crystalline powder, odorless
  1. شماره CAS：7979-62-4
  1. زمان سرب: ۵ تا ۷ روز کاری
  1. بسته
    • کیسه ۱ کیلوگرمی (کیسه فویل آلومینیومی)، بشکه ۲۵ کیلوگرمی (کیسه دو لایه PE داخل بشکه مقوایی)
  1. بازار اصلی: Global market, with significant demand in Asia (China, Japan, South Korea), North America, and Europe, especially in the food, pharmaceutical, and chemical industries
  1. سناریوهای کاربردی

خواص هسته

  • فرمول مولکولی: C₂₀H₂₈O₃
  • ساختار شیمیایی: A diterpenoid compound, derived from the hydrolysis and isomerization of steviol, featuring a complex ring structure with a carboxylic acid group and hydroxyl groups
  • ویژگی‌های کلیدی
    • Versatile Chemical Intermediate: Serves as a crucial building block for the synthesis of various bioactive compounds and industrial chemicals.
    • پایداری: Stable under normal storage conditions away from heat, light, and strong oxidizing agents.
    • زیست‌سازگاری: Generally low toxicity, making it suitable for applications in the food and pharmaceutical sectors with proper processing.
    • Modifiable Structure: Functional groups can be easily modified through chemical reactions, enabling the creation of derivatives with tailored properties.

سناریوهای کاربردی

1. صنایع غذایی و آشامیدنی

  • Sweetener Synthesis:
    • As a precursor for the production of high – intensity sweeteners. Isosteviol can be chemically modified to create sweeter derivatives with improved taste profiles, aiming to replace or supplement traditional stevia – based sweeteners.
  • Flavor and Fragrance Enhancement:
    • Some of its derivatives are used to enhance the flavor and aroma of food products, providing unique sensory experiences. For example, certain esters of isosteviol can impart pleasant, natural – like flavors.

2. صنعت داروسازی

  • Drug Synthesis:
    • Serves as an intermediate in the synthesis of anti – inflammatory, antioxidant, and antidiabetic drugs. Its chemical structure can be modified to create compounds with specific pharmacological activities. For instance, isosteviol – based derivatives are being investigated for their potential in treating metabolic disorders.
  • تحقیقات زیست پزشکی:
    • Used in research laboratories as a reference compound or starting material for the development of new drug delivery systems. Its biocompatibility allows for the exploration of novel carrier molecules for targeted drug delivery.

3. لوازم آرایشی و مراقبت شخصی

  • Anti – aging Formulations:
    • Incorporated into creams, serums, and lotions (0.5 – 2% concentration) due to its potential antioxidant and anti – inflammatory properties. It may help protect the skin from oxidative stress and reduce the signs of aging, such as wrinkles and fine lines.
  • Hair Care Products:
    • Added to shampoos and conditioners to improve hair texture, strength, and manageability. Some derivatives of isosteviol can act as conditioning agents, reducing static and enhancing shine.

4. Chemical Industry

  • Polymer Synthesis:
    • Utilized as a monomer or cross – linking agent in the production of biodegradable polymers. Isosteviol – based polymers have potential applications in packaging materials, where their biodegradability offers an environmentally friendly alternative.
  • Surfactant Production:
    • Its derivatives can be used to create surfactants with unique surface – active properties. These surfactants find applications in various industries, including detergents, emulsifiers, and wetting agents.

روش‌های تشخیص

  • کروماتوگرافی مایع با کارایی بالا (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – water (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 210 nm for quantification.
  • کروماتوگرافی گازی - طیف‌سنجی جرمی (GC - MS):
    • Used for the identification and quantification of isosteviol in complex mixtures, especially when analyzing volatile derivatives. GC – MS provides detailed information about the molecular structure and impurities.
  • طیف‌سنجی مادون قرمز تبدیل فوریه (FTIR):
    • Helps in confirming the chemical structure of isosteviol by analyzing the characteristic absorption peaks of its functional groups. It is a quick and effective method for quality control and product identification.

منبع و مزایا

  • منبع طبیعی: Derived from stevia leaves, a renewable plant resource. The extraction process involves isolation from steviol, which is further processed to obtain isosteviol.
  • Sustainable Chemistry: Enables the development of green and sustainable chemical processes, especially in the production of biodegradable materials and natural – based products.
  • Economic Potential: As a valuable intermediate, it offers opportunities for the creation of high – value – added products, driving innovation in multiple industries.

انطباق با مقررات

  • سازمان غذا و داروی آمریکا (FDA): For food and pharmaceutical applications, products containing isosteviol must comply with relevant regulations. As a food additive precursor, it needs to meet safety standards set by the FDA.
  • مقررات اتحادیه اروپا: Regulated under REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals) for industrial applications. In the food and cosmetic sectors, it must adhere to specific EU directives regarding safety and labeling.
  • چین NMPA: Approved for use in certain industrial and consumer products, with strict quality control and safety requirements in place to ensure compliance with national standards.
دسته: , , , ,

Unlocking the Potential of Isosteviol: Nature’s Zero-Calorie Sweetener Powerhouse

1. What is Isosteviol?

Isosteviol is a diterpenoid carboxylic acid derived from its precursor, steviol glycosides, the intensely sweet compounds found in the leaves of the Stevia rebaudiana Bertoni plant. Through a specific acid hydrolysis process, the glucose moieties of stevioside are cleaved off, yielding isosteviol. Unlike its parent glycosides, isosteviol itself is non-caloric but possesses only mild sweetness. Its significance lies primarily in its role as a key metabolic intermediate and, increasingly, in its own distinct and promising bioactive properties, making it a compound of significant interest in food science, nutraceuticals, and pharmaceutical research.

۲. منبع محصول، خواص شیمیایی و شناسه‌ها

  • منبع: Synthesized via chemical modification (hydrolysis) of steviol glycosides extracted from Stevia rebaudiana leaves.

  • خواص شیمیایی:

    • Chemical Name: ent-16-Ketobeyeran-19-oic acid or 13-Hydroxyent-kaur-16-en-19-oic acid

    • فرمول مولکولی: C₂₀H₃₀O₃

    • وزن مولکولی: 318.45 g/mol

    • ظاهر: Typically a fine, white to off-white crystalline powder.

    • حلالیت: Exhibits lipophilic characteristics, soluble in organic solvents like ethanol, methanol, chloroform, and dimethyl sulfoxide (DMSO), but exhibits low solubility in water.

    • پایداری: Chemically stable under typical storage conditions. Resistant to heat and pH changes encountered in food processing.

  • شناسه‌های کلیدی:

    • شماره ثبت CAS: 471-80-7

    • شماره EC (EINECS): 207-442-5

    • م.ف: C₂₀H₃₀O₃

    • مگاوات: 318.45

3. Benefits, Purity, Dosage & Safety Considerations

  • “Best” & Highest Purity: The “best” isosteviol prioritizes exceptional purity (>98%), rigorous absence of residual solvents، و undetectable levels of contaminants (heavy metals, pesticides, microbes). Reputable suppliers like Shaanxi Zhonghong Investment Technology Co., Ltd. achieve this through proprietary purification techniques (e.g., multi-stage crystallization, preparative HPLC) exceeding standard industry purity benchmarks.

  • Health Benefits (Emerging Research):

    • Cardiometabolic Health: Shows potential in modulating glucose homeostasis (improving insulin sensitivity), managing dyslipidemia (reducing triglycerides, LDL), and supporting healthy blood pressure via effects on vascular tone and endothelial function. Acts partly through AMPK activation و PPARγ modulation.

    • ضد التهاب و آنتی اکسیدان: Exhibits significant reactive oxygen species (ROS) scavenging ability and modulates key inflammatory pathways (e.g., NF-κB, MAPK signaling).

    • Renal Protection: Research suggests protective effects against renal fibrosis و glomerular damage in experimental models, potentially via TGF-β/Smad pathway inhibition و oxidative stress reduction. (Note: While nattokinase is researched for cardiovascular benefits, its direct impact on kidney health is less established compared to the emerging renal protective data for isosteviol).

    • پتانسیل محافظت عصبی: Preliminary studies indicate possible benefits in neurodegenerative conditions by reducing neuroinflammation and oxidative damage.

  • Daily Intake & Usage Guidelines: Currently, no established ADI (Acceptable Daily Intake) exists specifically for isosteviol. Dosing in research varies significantly. Crucially consult a healthcare professional before supplementation. Usage depends heavily on the application (food additive, supplement, research chemical). Follow specific product labeling or research protocols meticulously.

  • اقدامات احتیاطی و عوارض جانبی:

    • Limited Human Safety Data: Comprehensive long-term human studies are still needed.

    • Potential Drug Interactions: Theoretical interactions exist due to effects on CYP450 enzymes and blood pressure/glucose; caution with antihypertensives, antidiabetics, and anticoagulants.

    • Pregnancy & Lactation: Avoid use due to insufficient safety data.

    • Reported Side Effects: Generally well-tolerated in research, but high doses could potentially cause gastrointestinal discomfort. Allergic reactions are rare but possible.

    • Quality is Paramount: Underscores the necessity of sourcing ultra-pure isosteviol from GMP-compliant manufacturers to minimize contaminant risks.

4. Introducing Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Isosteviol Partner

Shaanxi Zhonghong Investment Technology Co., Ltd. stands as a premier شرکت با فناوری پیشرفته dedicated to excellence in ترکیب زیست فعال research, development, and manufacturing. We specialize in the advanced استخراج، جداسازی و خالص‌سازی of potent phytochemicals, serving global markets in nutraceuticals, pharmaceuticals, cosmeceuticals, food additives (natural sweeteners, colors), and research chemicals.

  • Core Competencies & Differentiation:

    • Unmatched Scientific Prowess (The Research Barrier): Strategic academic-industry partnerships with 5 elite universities underpin our innovation. We possess a formidable IP portfolio exceeding 20 patents and maintain a کتابخانه مرکب انحصاری جهانی, driving cutting-edge discovery.

    • Analytical Leadership (Equipment Dominance): ما state-of-the-art QC infrastructure features High-Performance Liquid Chromatography (HPLC/UHPLC), Gas Chromatography-Mass Spectrometry (GC-MS), Superconducting Fourier Transform Nuclear Magnetic Resonance (FT-NMR)، و طیف‌سنجی جرمی پلاسمای جفت‌شده القایی (ICP-MS). This enables stringent purity verification (>98% standard, exceeding industry norms by 20%) and comprehensive contaminant profiling.

    • Global Supply Chain Excellence: We reliably serve a diverse clientele across بیش از ۸۰ کشور throughout Asia, Europe, and the Americas, providing custom synthesis و راهکارهای سفارشی برای مواد تشکیل دهنده to multinational pharmaceutical corporations, research institutions, and supplement brands.

    • Legacy of Expertise: اهرم سازی 28 years of specialized experience in the isolation and application of bioactive natural compounds.

5. Product Specifications: Rigorous Quality Assurance

دسته بندی آلاینده ها پارامتر محدودیت مشخصات روش آزمون
بقایای آفت‌کش‌ها گلیفوسات ≤ 0.05 میلی‌گرم بر کیلوگرم LC-MS/MS
کلرپیریفوس ≤ 0.01 میلی‌گرم بر کیلوگرم کروماتوگرافی گازی-طیف‌سنجی جرمی/طیف‌سنجی جرمی
سیپرمترین ≤ 0.05 میلی‌گرم بر کیلوگرم GC-ECD
Total Other Pesticides ≤ 0.1 mg/kg (each) Multi-residue Methods (GC/LC)
فلزات سنگین سرب (Pb) ≤ ۱.۰ میلی‌گرم بر کیلوگرم ICP-MS/AAS
آرسنیک (As) ≤ 0.5 میلی‌گرم بر کیلوگرم ICP-MS / HG-AAS
کادمیوم (Cd) ≤ 0.5 میلی‌گرم بر کیلوگرم ICP-MS / GFAAS
جیوه (Hg) ≤ 0.1 میلی‌گرم بر کیلوگرم ICP-MS / CVAAS
میکروبیولوژیکی تعداد کل صفحات ≤ ۱۰۰۰ واحد تشکیل کلونی در گرم USP <61>
مخمر و کپک ≤ ۱۰۰ واحد تشکیل کلونی در گرم USP <61>
ای. کولی منفی در 10 گرم USP <62>
سالمونلا گونه‌های Negative in 375g USP <62>
استافیلوکوکوس اورئوس منفی در ۱ گرم USP <62>
General Isosteviol Purity ≥ 98.0% (HPLC) HPLC-ELSD/UV
افت در خشک شدن ≤ 2.0% USP <731>
باقی مانده در احتراق ≤ 0.2% USP <281>
حلال‌های باقیمانده Meets ICH Q3C Guidelines GC-FID/HS-GC

6. Advanced Production Process
Our isosteviol production employs a vertically integrated, GMP-compliant workflow:

  1. Sourcing & Authentication: Premium Stevia rebaudiana leaves undergo botanical verification (macroscopic/microscopic, DNA barcoding).

  2. استخراج اولیه: Supercritical CO2 extraction یا food-grade solvent extraction yields crude steviol glycosides.

  3. Hydrolysis: Controlled acid-catalyzed hydrolysis selectively cleaves glycosidic bonds, converting stevioside/rebaudioside A to isosteviol.

  4. تصفیه: Multi-stage liquid-liquid extraction، و به دنبال آن activated carbon decolorization و multi-step fractional crystallization under precise temperature control. HPLC مقدماتی is employed for ultra-high purity (>99%) batches.

  5. Drying & Milling: Lyophilization (freeze-drying) یا vacuum belt drying ensures stability, followed by micronization to desired particle size distribution.

  6. کنترل کیفیت دقیق: هر دسته دستخوش تغییراتی می‌شود comprehensive analytical profiling against stringent specifications before release.

۷. سناریوهای کاربردی متنوع

  • مکمل‌های غذایی و دارویی: Formulated in capsules, tablets, softgels, and powders targeting metabolic health, cardiovascular support, antioxidant defense, and anti-aging.

  • غذاها و نوشیدنی‌های کاربردی: Incorporated as a non-caloric functional ingredient in health-focused drinks, snacks, and meal replacements, leveraging its bioactivity beyond sweetness.

  • Pharmaceutical Research: A crucial reference standard, pharmacophore، و lead compound in drug discovery for diabetes, hypertension, inflammation, and neurodegeneration.

  • لوازم آرایشی و بهداشتی: Explored in topical formulations for ضد پیری (combating oxidative stress/inflammation) and skin-brightening اثرات.

  • Sweetener Intermediate: Key precursor in the synthesis of next-generation steviol glycosides with improved taste profiles.

۸. کنترل کیفیت دقیق (QC)
Quality is embedded at every stage. Our ISO 9001 and cGMP-aligned QC system mandates:

  • تأیید هویت: FT-NMR و HPLC-UV/ELSD fingerprint matching against reference standards.

  • Purity & Potency: HPLC-ELSD/UV quantification of isosteviol content (≥98%), monitoring for related compounds (steviol, steviol glycosides).

  • کنترل آلاینده‌ها: GC-MS/MS/LC-MS/MS screens for >500 pesticide residues. ICP-MS ensures heavy metals compliance. آزمایش میکروبیولوژیکی (aerobic count, pathogens) follows validated USP/EP methods.

  • حلال‌های باقیمانده: GC-FID/HS-GC analysis per ICH Q3C guidelines.

  • Physical & Chemical Tests: افت در خشک شدن (LOD), باقیمانده پس از احتراق (خاکستر سولفاته), pH, Specific Rotation.

  • مطالعات پایداری: Ongoing ICH Q1A(R2) compliant accelerated و long-term stability studies to define shelf life and storage conditions. مستندسازی و ردیابی: کامل گواهی تجزیه و تحلیل (CoA) per batch, adhering to ALCOA+ principles for data integrity.

۹. بسته‌بندی ایمن و لجستیک جهانی

  • بسته بندی: درجه غذایی double HDPE bags با integrity liners, sealed inside robust, tamper-evident fiber drums (25kg standard). Smaller R&D quantities use glass bottles. Custom packaging (vacuum-sealed, nitrogen-flushed) available.

  • ذخیره سازی: ذخیره در cool, dry place (<25°C), protected from light and moisture. Maintain original sealed packaging.

  • لجستیک: Efficient global shipping via air freight, sea freight, or express couriers. Expertise in handling ترخیص کالا از گمرک و regulatory documentation for international markets. Cold chain options available.

10. Health Efficacy, Mechanism & Research

  • Mechanism Insights: Isosteviol exerts effects via multiple pathways:

    • AMPK Activation: Enhances glucose uptake, fatty acid oxidation.

    • PPARγ Modulation: Influences adipogenesis, insulin sensitivity, inflammation.

    • K+ Channel Activation (Vascular): Promotes vasodilation, lowering blood pressure.

    • TGF-β1/Smad Pathway Inhibition: Key mechanism in reducing renal fibrosis.

    • NF-κB & MAPK Suppression: Reduces pro-inflammatory cytokine production (TNF-α, IL-6).

    • ROS Scavenging: Direct antioxidant activity and upregulation of endogenous antioxidants (SOD, GSH).

  • Industry Applications & Innovation: Driving innovation in functional sweeteners, metabolic syndrome therapeutics, natural preservatives، و cosmeceutical actives. Zhonghong’s patented enzymatic bioconversion و continuous chromatography technologies enhance yield and purity.

  • مرزها و چالش‌های پژوهشی:

    • مرزها: Exploring isosteviol derivatives for enhanced bioavailability/activity; ترجمه بالینی of preclinical benefits; combination therapies.

    • چالش‌ها: Establishing human-specific ADI; definitive large-scale human clinical trials; optimizing delivery systems for poor water solubility; navigating complex global regulatory landscapes (GRAS, Novel Food, etc.).

۱۱. سوالات متداول (FAQ)

  • Q1: Is Isosteviol the same as Stevia?

    • الف: No. Stevia refers to the plant or its sweet leaf extracts (steviol glycosides like stevioside, rebaudioside A). Isosteviol is a specific metabolite/derivative produced by chemically modifying those glycosides. It has different properties (mildly sweet/non-sweet, distinct bioactivity).

  • Q2: Is Isosteviol safe?

    • الف: Existing preclinical and limited human data suggest a good safety profile at researched doses. However, long-term, large-scale human studies are ongoing. Always choose high-purity (>98%) isosteviol from reputable suppliers adhering to GMP and consult your healthcare provider before use, especially if pregnant, breastfeeding, taking medication, or have underlying conditions.

  • Q3: What are the main health benefits of Isosteviol?

    • الف: Research highlights potential for supporting healthy blood sugar metabolism, cardiovascular function (blood pressure, lipids), reducing inflammation and oxidative stress, and protecting kidney health. More human trials are needed to confirm efficacy for specific conditions.

  • Q4: What is the recommended daily dosage of Isosteviol?

    • الف: There is no universally established daily intake (ADI). Dosages used in research vary widely. Crucially, consult your doctor or a qualified healthcare practitioner for personalized advice based on your health goals and circumstances. Follow product-specific labeling.

  • Q5: How does Isosteviol compare to Nattokinase for kidney health?

    • الف: While both are researched for health benefits, their mechanisms differ. Isosteviol shows direct anti-fibrotic and antioxidant effects in kidney tissue in preclinical models, primarily via TGF-β inhibition. Nattokinase is a fibrinolytic enzyme primarily studied for cardiovascular benefits (blood flow, clot prevention); its direct impact on kidney structure/function is less established. Neither replaces medical treatment for kidney disease.

  • Q6: Why choose Zhonghong’s Isosteviol?

    • الف: Zhonghong delivers ultra-high purity (>98%), industry-leading contaminant control, batch-to-batch consistency, backed by 20+ patents, cutting-edge analytical capabilities (HPLC, NMR, ICP-MS), GMP compliance، و ۲۸ سال تخصص در زمینه ترکیبات زیست فعال. We offer customization و global regulatory support.

12. Where to Buy High-Purity Isosteviol?
Source premium Isosteviol directly from the manufacturer:

  • وب‌سایت: Explore products and specifications at aiherba.com

  • تماس: Reach our sales team via email: liaodaohai@gmail.com

  • Inquiry: Request a detailed گواهی تجزیه و تحلیل (CoA), MSDS، و competitive quotation for your specific needs (bulk, research samples).

13. Conclusion: Isosteviol – A Versatile Bioactive with Significant Promise
Isosteviol, derived from the natural sweetener stevia, transcends its origins as a metabolic intermediate. Its compelling portfolio of bioactivities – spanning cardiometabolic regulation, renoprotection, anti-inflammation, and antioxidant defense – positions it as a highly promising compound for the nutraceutical, functional food, and pharmaceutical industries. While further robust human clinical validation is essential, the existing scientific foundation is strong. The critical factor for efficacy and safety lies in sourcing ultra-pure, meticulously characterized isosteviol. Shaanxi Zhonghong Investment Technology Co., Ltd., with its scientific rigor, advanced purification technology, and unwavering commitment to quality, stands as the premier global partner for unlocking the full potential of this remarkable diterpenoid. Contact us today to discuss your isosteviol requirements.

۱۴. منابع

  1. Wang, J., et al. (2014). Isosteviol reduces plasma glucose levels in diabetic Goto-Kakizaki rats by enhancing insulin sensitivity and improving glucose metabolism. European Journal of Pharmacology, 734, 50-55. DOI: 10.1016/j.ejphar.2014.03.036

  2. Liu, J. C., et al. (2010). Antihypertensive effects of isosteviol in spontaneously hypertensive rats. Molecular and Cellular Biochemistry, 340(1-2), 55-60. DOI: 10.1007/s11010-010-0401-1

  3. Mizushina, Y., et al. (2005). Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors. علوم زیستی, 77(17), 2127-2140. DOI: 10.1016/j.lfs.2005.03.022

  4. Chen, T. H., et al. (2016). Isosteviol protects against endotoxin-induced acute kidney injury by inhibiting NF-κB and MAPK signaling pathways. مجله شیمی کشاورزی و مواد غذایی, 64(34), 6669-6677. DOI: 10.1021/acs.jafc.6b02895

  5. International Stevia Council. (2023). Stevia Production & Science. https://internationalsteviacouncil.org/

  6. EFSA Panel on Food Additives and Flavourings (FAF). (2021). Safety of use of steviol glycosides. مجله EFSA, 19(1), e06336. DOI: 10.2903/j.efsa.2021.6336

  7. FDA GRAS Notices: GRN No. 252 (Steviol Glycosides), GRN No. 667 (Reb M). https://www.fda.gov/food/gras-notice-inventory

  8. JECFA (Joint FAO/WHO Expert Committee on Food Additives). (2016). Steviol glycosides. WHO Food Additives Series 71. https://apps.who.int/food-additives-contaminants-jecfa-database/

  9. ICH Quality Guidelines (Q1A(R2), Q2(R1), Q3C). https://www.ich.org/page/quality-guidelines

  10. USP-NF General Chapters: <61> Microbiological Examination, <62> Microbiological Procedures, <731> Loss on Drying, <281> Residue on Ignition. https://www.usp.org/

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