بیزابولول

Unlocking the Energy of Bisabolol: Nature’s Soothing Elixir from AIHerba | Supplier & Manufacturer

۱. بیزابولول چیست؟
بیزابولول، که در درجه اول به صورت ... یافت می‌شود (-)-α-بیسابولول, is a naturally occurring monocyclic sesquiterpene alcohol famend for its distinctive skin-soothing, anti-irritant, and anti inflammatory properties. This bioactive compound is a prized beauty and pharmaceutical ingredient, providing a delicate but potent resolution for delicate pores and skin and numerous inflammatory circumstances. Its delicate floral aroma additional enhances its enchantment in perfumery.

۲. تامین محصول، خواص شیمیایی و شناسایی

• Major Natural Supply: بابونه آلمانی (بابونه آلمانی/رکوتیتا), particularly its important oil, is the richest pure supply of (-)-α-bisabolol. Additionally present in smaller portions in کاندیا درخت (وانیلوسموپسیس species) oil and different vegetation.

• خواص شیمیایی:

  • مقدار CAS: 515-69-5 (Usually refers back to the racemic combination; pure (-)-α-Bisabolol is 23089-26-1)

  • MF (Molecular Formulation): C₁₅H₂₆O

  • وزن مولکولی (MW): ۲۲۲.۳۷ گرم بر مول

  • آینک‌ها: 207-454-3

  • ظاهر: مایع ویسکوز بی‌رنگ تا زرد کم‌رنگ.

  • حلالیت: محلول در الکل و روغن، نامحلول در آب.

  • Optical Exercise: Natural (-)-α-Bisabolol is levorotatory. Artificial variations could also be racemic.

• AIHerba Supply & Benefit: AIHerba makes use of premium German Chamomile flowers, using استخراج CO2 فوق بحرانی اختصاصی و تقطیر مولکولی methods to yield (-)-α-Bisabolol with unparalleled purity (>98%) and stereochemical integrity, maximizing its bioactivity.

3. What is the Finest Bisabolol? Efficacy, Security & Utilization

• “Finest” Outlined: The بالاترین اثربخشی is constantly attributed to pure (-)-α-Bisabolol resulting from its particular stereochemistry. AIHerba’s concentrate on ultra-high purity pure (-)-α-Bisabolol ensures superior efficiency.

• Highest Content Supply: German Chamomile important oil usually comprises the very best pure focus (as much as ~50%, although AIHerba isolates it to >98%).

• Well being & Pores and skin Benefits:

  • ضد التهاب قوی: COX-2، LOX و سیتوکین‌های التهابی (TNF-α، IL-6) را مهار می‌کند.

  • تسکین‌دهنده و ضدالتهاب: Quickly calms pores and skin irritation (e.g., from surfactants, UV, chemical peels).

  • آنتی اکسیدان: Scavenges free radicals, defending pores and skin cells.

  • Wound Therapeutic & Regenerative: Stimulates fibroblast migration and promotes tissue restore.

  • ضد میکروبی: Displays exercise towards sure micro organism and fungi.

  • نفوذ پیشرفته: Can enhance pores and skin absorption of different actives.

  • Pores and skin Barrier Help: Contributes to a more healthy pores and skin barrier operate.

• میزان مصرف روزانه: بیزابولول عمدتاً مورد استفاده قرار می‌گیرد. به صورت موضعی (cosmetics, skincare). Oral consumption shouldn’t be frequent for bisabolol itself; security ranges depend upon the particular software (beauty, complement, pharmaceutical). Beauty use is usually thought to be secure at typical concentrations (0.2% – 2.0%).

• Wants Consideration:

  • حساسیت: Whereas usually well-tolerated, patch testing new merchandise is at all times beneficial.

  • اکسیداسیون: Pure bisabolol can oxidize over time; formulations ought to embrace antioxidants and use acceptable packaging (e.g., airless containers, nitrogen flushing).

• نتایج جنبه: Uncommon. Potential for gentle pores and skin irritation or allergic response in extremely delicate people. Natural (-)-α-Bisabolol has a wonderful security profile.

4. Introducing AIHerba: Your Trusted Bisabolol Companion
Shaanxi Zhonghong Investment Technology Co., Ltd. (AIHerba) برتر است شرکت با فناوری پیشرفته integrating agile R&D, collaborative innovation, built-in manufacturing, and international advertising. For over ۲۸ سال, we have specialised in serving the chemical, supplies, and life sciences sectors, with core experience within the extraction, isolation, purification, and industrial software of bioactive plant constituents.

• 🔹قدرت علمی: 5+ strategic college joint labs, 20+ patented applied sciences, and a globally distinctive کتابخانه ترکیبی اختصاصی.

• Chopping-Edge High quality: کروماتوگرافی مایع با راندمان بالا (HPLC), کروماتوگرافی بنزینی-طیف‌سنجی جرمی (GC-MS)، و NMR ابررسانا (رزونانس مغناطیسی هسته ای) guarantee purity requirements exceeding trade norms by 20%+.

• دستاورد جهانی: خدمت رسانی بیش از ۸۰ کشور throughout Asia, Europe, and the Americas, offering custom-made pure ingredient options to main multinational pharmaceutical corporations, analysis establishments, and beauty giants.

۵. مشخصات محصول: مدیریت دقیق و با کیفیت بالا
AIHerba’s (-)-α-Bisabolol adheres to the strictest high quality requirements. Key specs embrace:

Desk 1: Pesticide Residue Evaluation

Desk 2: Heavy Metals Evaluation

Desk 3: Microbial Evaluation

6. Superior Manufacturing Move
AIHerba’s (-)-α-Bisabolol manufacturing exemplifies cutting-edge phytochemistry:

1. منبع یابی: Premium German Chamomile flowers from licensed sustainable farms.

2. استخراج عمده: استخراج فوق بحرانی CO2 (SFE) – Makes use of tunable strain/temperature for selective, solvent-free isolation of volatiles, preserving delicate actives.

3. تمرکز: Removing of waxes and non-target compounds.

4. جداسازی و خالص‌سازی: Preparative HPLC and/or Excessive-Vacuum Fractional Distillation – Achieves focused separation of (-)-α-Bisabolol from different terpenes.

5. Crystallization (Non-obligatory): For attaining highest purity grades (>99%).

6. تثبیت: افزودن آنتی‌اکسیدان‌های سینرژیک (مثلاً توکوفرول).

7. کنترل کیفیت دقیق: HPLC-DAD/ELSD، کایرال GC/HPLC، GC-MS، NMR for identification, purity (>98%), enantiomeric extra, and residual solvent evaluation. ICP-MS برای فلزات سنگین. آزمایش میکروبیولوژیکی طبق فارماکوپه.

8. بسته بندی: Underneath inert environment (Nitrogen) in light-protected, food-grade HDPE or glass containers.

۷. سناریوهای کاربردی مختلف

• لوازم آرایشی و مراقبت از پوست: Calming serums, delicate pores and skin lotions, after-sun merchandise, anti-redness remedies, child care, post-procedure formulations (laser, peels), zits remedies (mitigates irritation), pure deodorants.

• داروهای تجویزی: Topical anti-inflammatory and wound therapeutic ointments/gels, mucoadhesive formulations, dental care merchandise (anti-gingivitis).

• عطرسازی: Gives a tender, candy, floral notice with fixative properties.

• مواد مغذی: Included into topical wellness merchandise (e.g., muscle soothing balms).

8. Complete High quality Management (QC)
AIHerba’s QC paradigm is constructed on Pharmaceutical cGMP ideas و اهرم‌ها ابزار دقیق تحلیلی پیشرفته. Identification affirmation makes use of FTIR (Fourier Remodel Infrared Spectroscopy) انگشت نگاری و کروماتوگرافی کایرال to confirm the (-)-enantiomer. Purity is quantified by way of validated HPLC-UV/ELSD strategies calibrated towards licensed reference requirements, constantly guaranteeing >98% (-)-α-Bisabolol content material. Residual Solvent Evaluation (Headspace GC-MS) ensures compliance with ICH Q3C tips. Stability Research (ICH Q1A) underneath accelerated and long-term circumstances decide shelf-life and optimum storage parameters. Each batch undergoes full spectroscopic (NMR for structural elucidation if wanted), chromatographic, and microbiological testing، مستند شده در گواهی‌های ارزیابی (CoA) traceable to worldwide requirements (USP, EP, CP). Our دارای گواهینامه ISO 9001 high quality administration system ensures traceability and steady enchancment.

۹. بسته‌بندی ایمن و لجستیک جهانی

• بسته بندی: بطری‌های HDPE با گرید غذایی ۱ و ۵ کیلوگرمی؛ بشکه‌های HDPE با گرید ۲۵ کیلوگرمی. همه نیتروژن شسته شده و کیسه‌ای آلومینیومی for max oxidation safety. Customized packaging obtainable.

• ذخیره سازی: Retailer tightly sealed in unique packaging, shielded from mild and moisture at ۲-۸ درجه سانتیگراد (یخچالی) for long-term stability. Quick-term (<6 months) at <25°C acceptable.

• لجستیک: Shipped globally by way of لجستیک با کنترل دما (chilly chain the place required). Compliant with all worldwide rules (REACH, FDA, COSMOS and so on.). Complete documentation offered.

10. Deep Dive: Well being Mechanisms, Purposes & Innovation

• مکانیسم حرکت: (-)-α-Bisabolol exerts results by way of a number of pathways:

  • Modulates NF-κB and MAPK signaling cascades, suppressing pro-inflammatory cytokine manufacturing.

  • آنزیم‌های کلیدی را مهار می‌کند: سیکلواکسیژناز-۲ (COX-2)، ۵-لیپوکسیژناز (5-LOX).

  • Demonstrates antioxidant exercise by quenching ROS/RNS.

  • Enhances penetration by way of lipid bilayer interplay.

  • باعث بازسازی اپیتلیال و تشکیل بافت گرانوله در زخم‌ها می‌شود.

• Industrial Purposes & AIHerba Innovation: Past cosmetics, bisabolol enhances transdermal drug supply programs. AIHerba innovates by way of مسیرهای سنتز انانتیوگزین (برای ایزومر (-)-فوق خالص)، فرمولاسیون‌های جدید کو-کریستالی برای افزایش پایداری/حلالیت، و sustained-release supply programs (e.g., lipid nanoparticles) built-in with our کتابخانه ترکیبی اختصاصی screening for synergistic combos.

• مرزها و چالش های تحلیل:

  • مرزها: بررسی اثربخشی در neuroinflammatory circumstances, gastroprotective results, anti-cancer adjunct remedy (enhancing chemo efficacy/lowering negative effects), superior biomaterials (پوشش‌های ضدالتهاب برای ایمپلنت‌ها).

  • چالش‌ها: Scaling sustainable cultivation of high-bisabolol chamomile strains, cost-effective large-scale chiral purification, definitive medical dose-response research for particular therapeutic endpoints, long-term stability optimization in advanced formulations.

۱۱. سوالات متداول (FAQ)

• Q: Is pure (-)-α-Bisabolol higher than artificial?

  • الف: Sure, quite a few research point out pure (-)-α-Bisabolol possesses superior اثر ضد التهابی و تسکین دهنده پوست in comparison with artificial racemic mixtures or different isomers resulting from its particular stereochemistry.

• Q: What focus of Bisabolol is efficient in cosmetics?

  • الف: Typical efficient concentrations vary from ۰.۲۱TP3T تا ۲.۰۱TP3T. Efficacy relies on the formulation and desired impact; AIHerba gives software assist.

• Q: Is Bisabolol secure for delicate pores and skin?

  • الف: Completely. Natural (-)-α-Bisabolol is famend for its distinctive tolerance and efficacy in calming delicate, irritated, and reactive pores and skin.

• Q: Does Bisabolol have any identified drug interactions?

  • الف: Topical use has no vital reported interactions. Seek the advice of a doctor for potential interactions with oral medicines if used systemically (uncommon).

• Q: How ought to I retailer AIHerba Bisabolol?

  • الف: For optimum long-term stability and to stop oxidation, retailer tightly sealed, shielded from mild, and refrigerated (2-8°C). See CoA for particular batch suggestions.

• Q: Is AIHerba Bisabolol compliant with worldwide requirements?

  • الف: Sure. Our product meets or exceeds specs outlined in related USP/EP monographs (the place relevant), COSMOS, ISO, and is REACH/FDA compliant. Certificates obtainable.

12. The place to Purchase Premium (-)-α-Bisabolol
Supply the very best purity, naturally derived (-)-α-Bisabolol straight from the producer:

• وب‌سایت: www.aiherba.com

• تماس: آقای لیائو دائوهای

• ایمیل: liaodaohai@gmail.com

• استعلام برای: Bulk pricing, samples, technical knowledge sheets (TDS), certificates of research (CoA), and formulation assist.

۱۳. نتیجه‌گیری
(-)-α-Bisabolol stands as a cornerstone bioactive ingredient for light but highly effective soothing and anti inflammatory efficacy. AIHerba، اعمال نفوذ 28 years of experience in phytochemistry and superior purification applied sciences، ارائه می‌دهد ultra-pure (>98%) pure (-)-α-Bisabolol. از منابع پایدار تهیه شده و توسط ... تأیید شده است NMR ابررسانا، HPLC و ICP-MS, our ingredient meets the stringent calls for of worldwide beauty, pharmaceutical, and analysis markets. Select AIHerba for unparalleled high quality, scientific assist, and a dedication to innovation in pure actives.

۱۴. منابع

1. Kamatou, G. P. P., & Viljoen, A. M. (2010). A evaluation of the applying and pharmacological properties of α-bisabolol and α-bisabolol-rich oils. مجله انجمن شیمیدانان نفت آمریکا, 87(1), 1-7.

2. European Medicines Company (EMA) Evaluation Report on ماتریکاریا رکوتیتا ل.، فلوس. (۲۰۱۵).

3. Cavalieri, E., et al. (2004). Professional-apoptotic exercise of α-bisabolol in preclinical fashions of major human acute leukemia cells. The Journal of Medical Investigation, 114(3).

4. Worldwide Group for Standardization (ISO). ISO 16128 – Tips on technical definitions and standards for pure and organic beauty substances.

5. United States Pharmacopeia (USP) Normal Chapters: <561> Articles of Botanical Origin, <2023> Microbiological Examination of Nonsterile Merchandise.

6. European Pharmacopoeia (Ph. Eur.) Monographs: 2.8.12 Microbiological examination of non-sterile merchandise, 2.4.8 Heavy Metals.

7. Current Analysis (e.g., search PubMed.gov for “alpha-bisabolol mechanism”, “bisabolol pores and skin”, “bisabolol wound therapeutic” – 2023/2024 publications). AIHerba Inner Analysis & Stability Information.