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Berberine Hydrochloride Powder supplier Extract factory

  1. نام انگلیسی: Berberine Hydrochloride Powder
  1. مشخصات
    • خلوص: ≥ 98% (HPLC)
    • حلالیت: Sparingly soluble in water (0.12 g/100 mL at 25°C), more soluble in hot water; soluble in ethanol (≥ 5 g/100 mL)
    • مربوط به ظاهر: افت در هنگام خشک شدن ≤ 1.0%، فلزات سنگین ≤ 10 ppm، حلال‌های باقیمانده ≤ 0.5%
    • اندازه ذرات: ≤ 100 mesh (standard), can be customized according to requirements
  1. ظاهر
    • Bright yellow crystalline powder, odorless, with an intensely bitter taste, no relation to chocolate in terms of color or aroma
  1. شماره CAS：633 – 65 – 8
  1. زمان سرب: ۵ تا ۷ روز کاری
  1. بسته
    • کیسه فویل آلومینیومی ۱ کیلوگرمی، بشکه ۲۵ کیلوگرمی (کیسه پلی اتیلن دو لایه داخل بشکه مقوایی)
  1. بازار اصلی
    • Global market, with significant demand in Asia (China, India), Europe, and North America, mainly applied in pharmaceuticals, dietary supplements, veterinary medicine, and cosmetics industries
  1. سناریوهای کاربردی

خواص هسته

  • ساختار شیمیایی: An isoquinoline alkaloid with the molecular formula C₂₀H₁₈ClNO₄. Its unique heterocyclic structure endows it with multiple biological activities.
  • ویژگی‌های کلیدی
    • ضد میکروبی: Effective against a wide range of pathogens, including bacteria like اشریشیا کلی و استافیلوکوکوس اورئوس, fungi such as کاندیدا آلبیکنس, by disrupting cell membranes and inhibiting essential enzyme functions.
    • آنتی اکسیدان: Scavenges free radicals like hydroxyl and superoxide anions, protecting cells from oxidative damage and reducing the risk of aging – related diseases.
    • ضد التهاب: Suppresses the activation of inflammatory pathways, reducing the production of pro – inflammatory cytokines (TNF – α, IL – 6), which helps relieve inflammation – related symptoms.
    • Hypoglycemic: Regulates glucose metabolism by enhancing insulin sensitivity, inhibiting intestinal glucose absorption, and promoting cellular glucose uptake, making it useful for managing blood sugar.
    • Lipid – lowering: Reduces hepatic cholesterol synthesis and promotes cholesterol excretion, contributing to lower blood lipid levels.

سناریوهای کاربردی

1. صنعت داروسازی

  • داروهای خوراکی:
    • Used in tablets, capsules, and oral solutions for treating gastrointestinal infections, diarrhea caused by bacteria, and as an adjuvant treatment for mild to moderate type 2 diabetes to regulate blood glucose.
  • Topical Formulations:
    • Incorporated into creams, ointments, and gels for treating skin infections, acne, and eczema, leveraging its antimicrobial and anti – inflammatory properties.
  • تحقیقات بالینی:
    • Under investigation for potential applications in treating cardiovascular diseases, neurodegenerative disorders, and certain cancers due to its broad – spectrum bioactivity.

2. مکمل‌های غذایی

  • Health – Management Supplements:
    • Sold as standalone capsules or combined with other ingredients (e.g., gymnema sylvestre, chromium) to help individuals manage blood sugar, improve cardiovascular health, and boost immune function.

3. دامپزشکی

  • Animal Health Products:
    • Added to livestock and poultry feed or used in oral medications to treat digestive tract infections, diarrhea, and enteritis, and enhance animal growth performance.
  • مراقبت از حیوانات خانگی:
    • Prescribed for pets with bacterial infections, skin problems, or to support metabolic health in diabetic pets.

4. لوازم آرایشی و مراقبت شخصی

  • Anti – Acne Products:
    • Added to facial cleansers, toners, and spot – treatment creams (0.5 – 2% concentration) to combat acne – causing bacteria, reduce inflammation, and prevent breakouts.
  • Anti – Aging Products:
    • Some high – end anti – aging serums and creams contain berberine hydrochloride to protect skin from oxidative stress and reduce the appearance of fine lines and wrinkles.

روش‌های تشخیص

  • کروماتوگرافی مایع با کارایی بالا (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% phosphoric acid (30:70, v/v), Flow Rate: 1.0 mL/min, Detection Wavelength: 345 nm, for accurate quantification.
  • کروماتوگرافی مایع - طیف‌سنجی جرمی (LC - MS):
    • Ideal for analyzing berberine hydrochloride in complex samples, providing high sensitivity and the ability to detect trace amounts and identify impurities.
  • طیف‌سنجی مادون قرمز تبدیل فوریه (FTIR):
    • Analyzes the characteristic absorption peaks of functional groups to confirm the chemical structure, aiding in quality control during production.

منبع و مزایا

  • Natural & Synthetic Sources: Extracted from plants like قبطی چینی, زرشک سیاه, and can also be synthesized chemically, ensuring a stable supply.
  • کاربردهای متنوع: Its multifunctional bioactivity makes it valuable across multiple industries, meeting diverse health and beauty needs.
  • Market Growth: With the rising demand for natural remedies and preventive healthcare products, the market for berberine hydrochloride powder continues to expand.
  • Regulatory Oversight: Recognized and regulated in many regions for use in pharmaceuticals, supplements, and cosmetics, though regulations on dosage and claims vary by country.
دسته: , , ,

Berberine Hydrochloride Powder: Final Information by Zhonghong BioTech

1. What is Berberine Hydrochloride?
Berberine Hydrochloride is the stabilized, bioavailable salt type of berberine, a potent isoquinoline alkaloid naturally occurring in vegetation like زرشک سیاه (زرشک)، قبطی چینی (Goldthread), and هیدراستیس کانادنسیس (Goldenseal). This vibrant yellow crystalline powder is famend for its broad-spectrum physiological actions, primarily focusing on metabolic pathways by way of AMPK activation.

۲. تامین، خواص شیمیایی و شناسایی

  • عرضه: Extracted from plant rhizomes/roots (e.g., Coptis, Phellodendron). Zhonghong makes use of sustainably sourced, premium-grade قبطی چینی.

  • خواص شیمیایی:

    • CAS: 633-65-8

    • اجزای مولکولی (MF): C₂₀H₁₈ClNO₄

    • وزن مولکولی (MW): 371.81 g/mol

    • آینک‌ها: 211-195-9

    • نگاه کنید: Shiny Yellow to Orange-Yellow Crystalline Powder

    • حلالیت: Soluble in water, barely soluble in ethanol, insoluble in non-polar solvents.

    • سطح ذوب: 200-203°C (decomposition)

    • Optical Rotation: -120° to -140° (c=2 in H₂O)

3. Premium Berberine HCl: Key Attributes (Zhonghong BioTech Customary)
Zhonghong BioTech units the benchmark for pharmaceutical-grade Berberine HCl:

  • ترکیب: ≥98% Berberine Hydrochloride (HPLC), minimizing minor alkaloids (e.g., jatrorrhizine, palmatine).

  • اثربخشی (انطباق): Manufactured below cGMP, compliant with USP/EP monographs. Validated for key bioactivities:

    • سلامت متابولیک: AMPK activation supporting wholesome glucose uptake & lipid metabolism (PMID: 25607236).

    • Microbiome Modulation: Selective inhibition of pathogenic intestine micro organism; promotes helpful species.

    • کمک به قلب و عروق: Modulates LDL-receptor expression & endothelial operate.

    • Mobile Well being: Reveals antioxidant and potential autophagy-enhancing properties.

  • مبدا: Sourced & absolutely manufactured (extraction to micronization) in China, ISO 9001/22000 licensed amenities.

  • کاربرد: Typical dose vary: 500mg-1500mg every day, divided (e.g., 500mg TID). Formulated in capsules, tablets, or useful meals. Seek the advice of a healthcare supplier.

  • بینندگان گل: Adults in search of metabolic/cardiovascular help. Not for youngsters.

  • Essential Precautions & Facet Results:

    • موارد منع مصرف: Being pregnant, lactation. Potent CYP3A4/P-gp inhibitor – keep away from with cyclosporine, tacrolimus, simvastatin, many antibiotics. Seek the advice of doctor if taking any remedy.

    • نتایج وجهی: Usually delicate (dose-dependent): GI discomfort (constipation, cramping), uncommon potential for hypoglycemia.

    • Max Consumption: Don’t exceed 2000mg/day with out medical supervision. Begin low dose.

    • Testing: Suggest liver/kidney operate monitoring with long-term, high-dose use.

4. Zhonghong BioTech: Pioneering Plant Actives Since 1996
Shaanxi Zhonghong Investment Technology Co., Ltd. is a vertically built-in chief in high-purity botanical extracts and bioactive compounds. We serve international innovators in nutraceuticals, prescribed drugs, cosmeceuticals, and useful meals.

  • Scientific Edge: 5 College Joint Labs (e.g., CAS Institutes), 20+ Patents (e.g., Novel Purification, Polymorph Management), unique 10,000+ compound library.

  • Analytical Management: State-of-the-art QC: UHPLC-DAD-ELSD, GC-MS, ICP-MS, NMR. Purity requirements exceed USP by ≥20% (sometimes ≥98.5% Berberine HCl).

  • دستاوردهای بین‌المللی: cGMP-compliant provide to 80+ nations, providing bespoke options for Tier-1 Pharma and analysis establishments.

5. Well being Advantages & Mechanisms

  • هموستاز گلوکز: Prompts AMPK, enhances insulin sensitivity, inhibits hepatic gluconeogenesis (glucose-6-phosphatase), mimics insulin motion.

  • Lipid Regulation: Upregulates hepatic LDLR expression, modulates PCSK9, prompts AMPK→ACC inhibition.

  • Intestine Well being: Disrupts bacterial biofilm formation, inhibits virulence elements (e.g., E. coli LT/ST toxins), fosters Akkermansia/Bifidobacterium progress.

  • Cardioprotection: Improves endothelial NO synthesis, reduces LOX-1 expression, attenuates ox-LDL uptake.

  • Mobile Resilience: Modulates Nrf2/KEAP1 pathway, enhances endogenous antioxidants (SOD, GSH); potential mTOR inhibition influencing autophagy.

6. Utilization Tips

  • Customary Dose: 500mg taken 2-3 instances every day earlier than meals. Bioavailability enhancers (e.g., liposomal, with piperine) might permit decrease doses.

  • فرمولاسیون: Excellent for strong dosage varieties (tablets, capsules). Guarantee compatibility with excipients (hygroscopic).

  • سینرژیست‌ها: Usually mixed with Silymarin (liver help), Chromium Picolinate, or Alpha-Lipoic Acid.

۷. اقدامات احتیاطی ضروری

  • تداخلات دارویی: STRONG CYP3A4/P-glycoprotein inhibition. Contraindicated with immunosuppressants, statins, most macrolides/fluoroquinolones, antifungals, SSRIs, Ca²⁺ channel blockers, sedatives. Necessary HCP session if medicated.

  • Medical Circumstances: Keep away from in hypotension, bradycardia, renal/hepatic impairment. Monitor blood glucose intently in diabetics.

  • Length: Restricted long-term human security knowledge. Take into account biking (e.g., 8 weeks on, 2-4 weeks off).

8. Product Specification & Certificates of Evaluation (COA)

کلاس پارامتر کالا را بررسی کنید مشخصات روش‌شناسی بررسی
بقایای آفت‌کش‌ها کلرپیریفوس ≤ 0.01 ppm GC-MS/MS (EU 396/2005)
سیپرمترین ≤ 0.05 ppm GC-MS/MS (EU 396/2005)
DDT های کامل ≤ 0.05 ppm GC-MS/MS (EU 396/2005)
Whole BHCs ≤ 0.05 ppm GC-MS/MS (EU 396/2005)
فلزات سنگین سرب (Pb) ≤ ۱.۰ میلی‌گرم بر کیلوگرم دستگاه ICP-MS (USP <232>/<233>)
آرسنیک (As) ≤ ۱.۰ میلی‌گرم بر کیلوگرم دستگاه ICP-MS (USP <232>/<233>)
کادمیوم (Cd) ≤ 0.5 میلی‌گرم بر کیلوگرم دستگاه ICP-MS (USP <232>/<233>)
جیوه (Hg) ≤ 0.1 میلی‌گرم بر کیلوگرم ICP-MS/CVAAS (USP <232>/<233>)
میکروبیولوژیکی تکیه کامل بر تمرینات قلبی عروقی ≤ ۱۰۰۰ واحد تشکیل کلونی در گرم USP <61>
مخمر و کپک ≤ ۱۰۰ واحد تشکیل کلونی در گرم USP <61>
ای. کولی در ۱ گرم وجود ندارد USP <62>
سالمونلا گونه‌های در 10 گرم وجود ندارد USP <62>
استافیلوکوکوس اورئوس در ۱ گرم وجود ندارد USP <62>
سنجش (HPLC) بربرین هیدروکلراید ≥ ۹۸.۰۱TP3T USP Chromatographic

9. Superior Manufacturing Move

  1. Uncooked Materials QC: Species authentication (HPTLC, DNA barcoding), heavy metallic/pesticide screening.

  2. استخراج: Optimized acidified ethanol percolation (pH 2-3, 60°C).

  3. Macroporous Resin Purification: Selective adsorption/desorption to take away polysaccharides, pigments.

  4. تبلور: pH-controlled anti-solvent crystallization (Ethanol/H₂O system) for outlined particle measurement distribution.

  5. Recrystallization: Excessive-purity solvent system for remaining polymorph management (Anhydrous type).

  6. میکرونیزه کردن: Jet milling to focus on D90 < 45µm for optimum dissolution.

  7. Strict QC: In-process checks & remaining launch per COA specs. Stability research (ICH Q1A).

10. Software Situations

  • مواد مغذی: Metabolic well being capsules, blood sugar help blends, weight administration formulation.

  • داروهای تجویزی: API for anti-diabetic, anti-dyslipidemia, or antimicrobial formulations (analysis stage).

  • Purposeful Meals/Drinks: Fortified powders, well being drinks (requires taste-masking).

  • لوازم آرایشی و بهداشتی: Pimples topical therapies (antibacterial/anti-inflammatory), anti-aging serums.

  • تحلیل: Molecular biology (AMPK pathway research), microbiology (antimicrobial mechanisms).

11. Stringent High quality Management
Zhonghong employs a multi-tiered QC technique: Identification (FTIR, NMR fingerprinting), Assay (Validated RP-UHPLC with DAD/ELSD detection), Associated Substances (HPLC for jatrorrhizine, palmatine <1.0%), Residual Solvents (GC-MS per ICH Q3C), Heavy Metals (ICP-MS), Microbiology (fast strategies & compendial), Particle Measurement (Laser diffraction), XRD (Polymorph verification). Our stability program (25°C/60% RH, 40°C/75% RH) ensures 36-month shelf life in alu-foil luggage. Batch traceability is paramount.

۱۲. بسته‌بندی و لجستیک

  • اصلی: Double HDPE luggage with food-grade PE liner. Elective vacuum packing.

  • ثانویه: Sealed in moisture-proof, light-resistant fiber drums (25kg web).

  • لجستیک: Ambient delivery globally. MSDS, Certificates of Origin, Full COA offered. DDP/DAP phrases accessible. Quick EU/US warehouse dispatch.

13. Analysis & Innovation

  • مکانیسم‌های سلامت: Ongoing analysis explores NLRP3 inflammasome modulation, gut-brain axis impression, and mitochondrial biogenesis results.

  • Tech Innovation: Zhonghong focuses on:

    • فراهمی زیستی افزایش یافته: Novel nanoemulsions, phospholipid complexes.

    • زیست‌شناسی مصنوعی: Engineered microbial biosynthesis of berberine precursors.

    • Derivatization: Novel berberine salts/esters for improved solubility/focusing on.

  • چالش‌ها: Overcoming low oral bioavailability (~<5%), managing DDIs, establishing definitive long-term medical outcomes.

14. Regularly Requested Questions (FAQ)

  • Q: Is Berberine HCl higher than Berberine Sulfate? A: HCl typically affords increased solubility and bioavailability than sulfate salts.

  • Q: Can I take Berberine HCl long-term? A: Whereas typically protected for intervals of 3-6 months in research, focus on long-term use and biking along with your healthcare supplier. Monitor liver/kidney operate.

  • Q: Does it trigger weight reduction? A: It helps metabolic well being and will help weight administration as a part of a wholesome life-style, primarily by way of AMPK results on metabolism.

  • Q: How lengthy to see advantages? A: Metabolic results (glucose/lipids) typically noticed inside 4-8 weeks.

  • Q: Is Zhonghong’s Berberine non-GMO & Allergen-Free? A: Sure, licensed non-GMO, gluten-free, soy-free, dairy-free. Kosher/Halal accessible.

  • س: آیا می‌توانم الگو بگیرم؟ A: Sure! Request beneath.

15. Sourcing & Samples
Supply Premium Berberine Hydrochloride Powder:

  • وب‌سایت: https://www.aiherba.com

  • تماس: Mr. Liao DaoHai

  • ایمیل: liaodaohai@gmail.com

  • درخواست: Inquire for bulk pricing, technical file (TDS, CoA, MSDS), and FREE 20g SAMPLES (qualifying B2B shoppers).

نتیجه‌گیری
Berberine Hydrochloride Powder represents a strong software in metabolic well being help. Selecting a provider with uncompromising high quality, scientific rigor, and regulatory experience like Zhonghong BioTech is vital for product efficacy and security. Our vertically managed course of, from validated botanical sourcing to cutting-edge purification and QC, delivers berberine HCl of remarkable purity (>98%) and constant organic exercise. Contact us as we speak to raise your formulations.

References (Illustrative)

  1. Imenshahidi M, Hosseinzadeh H. Berberine and barberry (Berberis vulgaris): A medical assessment. فیتوتر رز. 2019.

  2. Pang B, et al. Software of berberine on treating kind 2 diabetes mellitus. Int J Endocrinol. 2015.

  3. Koppen LM, et al. Efficacy of berberine in heart problems threat discount. Nutr Metab Cardiovasc Dis. 2020.

  4. ICH Q7: Good Manufacturing Observe Information for Energetic Pharmaceutical Substances.

  5. USP-NF Monograph: Berberine Hydrochloride. (Accessed July 2025).

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