Extracto de manzanilla
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Extracto de manzanilla

Chamomile Extract supplier bulk factory Wholesale buy Extract factory

  1. Nombre en inglés: Chamomile Extract
  1. Especificación
    • Contenido de compuestos activos:
      • Apigenin ≥ 2.0% (HPLC), Bisabolol ≥ 1.5% (HPLC), Chamazulene ≥ 0.5% (HPLC)
    • Solubilidad: Slightly soluble in water; highly soluble in ethanol (≥ 50 g/100 mL), propylene glycol, and most organic solvents
    • Apariencia – relacionada: Pérdida por secado ≤ 5%, Metales pesados ≤ 10 ppm, Disolventes residuales ≤ 0,5%
    • Tamaño de partícula: Standard powder ≤ 100 μm; micronized powder ≤ 5 μm for better dispersion
  1. Apariencia
    • Light yellow to yellow – brown fine powder, with a characteristic floral and herbal aroma, distinct from chocolate
  1. N.º CAS.
    • As a mixture, no single CAS number; individual components have separate numbers (e.g., Apigenin: 520 – 36 – 5, Chamazulene: 515 – 92 – 4)
  1. Plazo de entrega: 5 – 7 días laborables
  1. Paquete
    • 1 kg/bolsa (bolsa de aluminio), 25 kg/tambor (bolsa de PE de doble capa dentro de un tambor de cartón)
  1. Mercado principal: Global market, with significant demand in Europe (Germany, France), North America, and Asia (Japan, South Korea), especially in the food, pharmaceutical, and cosmetics industries
  1. Escenarios de aplicación

Propiedades principales

  • Componentes activos:
    • Apigenina: A flavonoid with potent antioxidant and anti – inflammatory properties.
    • α – Bisabolol: A sesquiterpene alcohol known for its soothing, antibacterial, and anti – irritant effects.
    • Chamazuleno: A blue – colored sesquiterpene with strong anti – inflammatory and wound – healing capabilities.
  • Características principales
    • Actividad antioxidante: Scavenges free radicals such as hydroxyl and superoxide anions, protecting cells from oxidative damage.
    • Antiinflamatorio: Inhibits the production of pro – inflammatory cytokines (e.g., TNF – α, IL – 6), reducing tissue inflammation.
    • Antimicrobiano: Exhibits inhibitory effects against bacteria (e.g., Estafilococo áureo) y hongos (por ejemplo, Candida albicans).
    • Skin – Soothing: Calms irritated skin, reduces redness, and promotes skin repair.

Escenarios de aplicación

1. Alimentos y bebidas

  • Beverage Ingredients:
    • Added to teas, herbal infusions, and fruit juices (0.1 – 0.5% concentration) for flavor enhancement and potential health benefits.
    • Used in functional beverages, such as stress – relief drinks, due to its calming properties.
  • Confectionery and Dairy Products:
    • Incorporated into candies, chocolates, and yogurt to impart a unique floral flavor and add antioxidant value.

2. productos farmacéuticos

  • Over – the – Counter (OTC) Medicines:
    • Used in topical creams, ointments, and lotions for treating minor skin irritations, rashes, and sunburns (2 – 5% concentration).
    • Available as oral supplements in capsule or tablet form (200 – 500 mg per serving) for promoting relaxation and reducing mild anxiety.
  • Remedios herbales:
    • A key ingredient in traditional herbal medicine for soothing digestive discomfort, such as indigestion and gastritis.

3. Cosméticos y cuidado personal

  • Productos para el cuidado de la piel:
    • Serums, moisturizers, and face masks (1 – 3% concentration) formulated to hydrate, soothe, and anti – age the skin. It helps reduce the appearance of fine lines and wrinkles by protecting against oxidative stress.
    • Used in sensitive – skin products due to its gentle and anti – inflammatory nature.
  • Cuidado del cabello:
    • Shampoos and conditioners containing chamomile extract can lighten hair naturally, as well as soothe the scalp and reduce dandruff.

4. Salud animal

  • Pet Care Products:
    • Added to pet shampoos and topical treatments to relieve itchy, irritated skin in dogs and cats.
    • Available as pet supplements to calm anxious pets during travel or stressful situations.
  • Aditivos para piensos de ganado:
    • Used in poultry and livestock feed (50 – 200 ppm) to improve feed palatability and enhance animal health through its antioxidant and anti – inflammatory effects.

Métodos de detección

  • Cromatografía líquida de alta resolución (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% formic acid (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 254 nm (for apigenin) and 230 nm (for chamazulene).
  • Cromatografía de gases – Espectrometría de masas (GC – MS):
    • Used for the identification and quantification of volatile components like bisabolol, providing detailed information about the extract’s chemical profile.
  • Espectroscopía infrarroja por transformada de Fourier (FTIR):
    • Helps in confirming the chemical structure of the active compounds by analyzing characteristic absorption peaks, ensuring product quality and authenticity.

Origen y ventajas

  • Fuente natural: Extracted from the flowers of Matricaria recutita (German chamomile) or Chamaemelum nobile (Roman chamomile), which are widely cultivated in Europe, North America, and Asia.
  • Producción sostenible: Chamomile is an easily – grown crop, and modern extraction techniques, such as supercritical CO₂ extraction, ensure high – quality products with minimal environmental impact.
  • Demanda del mercado: Its dual function as a flavoring agent and a bioactive ingredient drives high demand across multiple industries, making it a valuable natural product.

Cumplimiento normativo

  • FDA de EE. UU.: Regulated as a food additive and dietary supplement ingredient. Meets Good Manufacturing Practice (GMP) requirements for pharmaceutical – grade products.
  • Reglamento de la UE: Approved as a food flavoring substance and permitted for use in cosmetics under the Cosmetics Regulation (EC) No 1223/2009.
  • NMPA de China: Permitted for use in food, pharmaceuticals, and cosmetics, subject to strict quality control and safety standards.
Categorías: , , , ,

Chamomile Extract: Nature’s Golden Elixir | Premium Standardized Ingredients

1. What is Chamomile Extract?

Chamomile Extract is a concentrated bioactive fraction derived primarily from the flowers of Matricaria chamomilla L. (German Chamomile) or Chamaemelum nobile L. (Roman Chamomile). This complex phytochemical matrix is prized for its apigenin-rich composition, essential oils (including bisabolol oxides and chamazulene), and other bioactive flavonoids. It represents one of the most scientifically validated and globally utilized botanical extracts, with applications spanning nutracéuticos, cosmecéuticos, y alimentos funcionales.

2. Source, Chemical Properties & Key Identifiers

  • Fuente botánica primaria: Flowers of Matricaria chamomilla L. (German Chamomile – highest apigenin content) or Chamaemelum nobile L. (Roman Chamomile).

  • Propiedades químicas:

    • Key Constituents: Apigenin (and its glycosides, e.g., apigenin-7-O-glucoside), Apigenin-7-O-glucoside, α-Bisabolol, Chamazulene (blue derivative from matricin), Bisabolol oxides A & B, Flavonoids (luteolin, quercetin), Coumarins.

    • Clase química: Flavonoids (Apigenin), Sesquiterpenes (Bisabolols, Chamazulene), Coumarins.

    • Solubilidad: Water-soluble extracts (standardized for apigenin glycosides), oil-soluble fractions (essential oils, CO2 extracts), or standardized powders (spray-dried).

    • Estabilidad: Light- and heat-sensitive (especially chamazulene). Requires cool, dark storage and often antioxidants/stabilizers.

  • Key Identifiers (Representative):

    • CAS Registry Number (Apigenin): 520-36-5

    • Molecular Formula (Apigenin): C₁₅H₁₀O₅

    • Molecular Weight (Apigenin): 270.24 g/mol

    • EINECS (Apigenin): 208-292-1

    • (Note: Full extract has no single CAS/EINECS; identifiers apply to specific markers)

3. Potencia, beneficios para la salud, dosis y seguridad

  • Contenido “mejor” y de mayor calidad: The “best” extract depends on the application. Standardized Apigenin (4-6%) extracts are preferred for calmative and GI benefits. CO2 Supercritical Extracts (2-10% total sesquiterpenes/azulenes) excel in topical anti-inflammatory applications. Shaanxi Zhonghong offers diverse specifications (e.g., 4% Apigenin, 10:1 Concentrate, Essential Oil, Full Spectrum).

  • Health Benefits (Evidence-Based):

    • Calming & Sleep Support: Modulates GABA_A receptors (apigenin), reduces anxiety, improves sleep quality.

    • GI Health: Soothes gastrointestinal irritation (bisabolol/chamazulene), reduces spasms, alleviates symptoms of dyspepsia.

    • Antiinflamatorio y antioxidante: Potently inhibits COX-2, LOX, and pro-inflammatory cytokines (TNF-α, IL-6); scavenges free radicals.

    • Salud de la piel: Anti-irritant, wound healing (α-Bisabolol), antimicrobial, soothes eczema/dermatitis.

    • Antimicrobiano: Activity against Staph aureus, Candida albicans.

    • Potential Metabolic Support: Emerging evidence for blood glucose regulation.

  • Typical Daily Intake (Oral): 220-1100 mg daily of standardized extract (e.g., 4% Apigenin), often divided. Tea: 1-4 cups daily (2-3g dried flowers/cup). Follow product label or practitioner guidance.

  • Precauciones y efectos secundarios:

    • Generalmente reconocido como seguro (GRAS). Rare mild GI upset or drowsiness.

    • Alergia: Contraindicated in individuals with known allergy to Asteraceae/Compositae family plants (ragweed, chrysanthemums, marigolds).

    • Coumarin Content: Potential interaction with anticoagulants (warfarin). Use caution.

    • Pregnancy: Traditionally used but limited modern safety data; consult physician.

    • Imperativo de calidad: Risk of pyrrolizidine alkaloid (PA) contamination in non-premium sources necessitates stringent testing by suppliers like Shaanxi Zhonghong.

4. Trusted Global Supplier: Shaanxi Zhonghong Investment Technology Co., Ltd.
Tecnología de inversión Shaanxi Zhonghong Co., Ltd. apalancamientos 28 years of phytochemistry expertise to deliver premium, research-backed Chamomile Extracts. As a vertically integrated empresa de alta tecnología, we master the entire value chain from sustainable sourcing to advanced purification under cGMP compliance.

  • Core Strengths:

    • Scientific Innovation: 5 strategic university partnerships fuel cutting-edge extraction R&D. Más de 20 patentes protect proprietary isolation techniques.

    • Pureza inigualable: HPLC-DAD-MS/MS y GC-MS quantification ensures apigenin/bisabolol standards exceed industry norms by 20%. ICP-MS guarantees ultra-low heavy metals.

    • Cumplimiento global: Suministros pharma-grade ingredients meeting USP/EP/FCC standards to más de 80 países across nutraceutical, cosmetic, and functional food industries.

    • Integración vertical: Controls quality from DNA-authenticated botanicals a ISO 9001:2015 certified manufacturing.

  • Portafolio de productos: Apigenin-Standardized Extract (4%, 6%), Full Spectrum Extract (10:1), Organic Chamomile CO2 Extract, Chamomile Essential Oil, Chamomile Water.

5. Chamomile Extract Benefits: A Scientific Summary
Chamomile Extract delivers multisystem benefits validated by pharmacology:

  • Neuroscience: GABAergic modulation promotes calmness & restful sleep.

  • Gastroenterology: Spasmolytic & anti-inflammatory actions support comodidad digestiva.

  • Dermatología: Bisabolol/chamazulene enhance skin barrier repair & reduce erythema.

  • Immunology: Dual antimicrobial & anti-inflammatory activity.

  • Metabolismo: Emerging role in glycemic control pathways.

6. Instrucciones de uso

  • Nutracéuticos: Capsules, tablets, tinctures, sleep blends, digestive aids.

  • Cosmecéuticos: Calming serums, after-sun products, sensitive skin creams, baby care.

  • Alimentos/bebidas funcionales: Teas, relaxation drinks, functional confectionery.

  • Dosificación: Adhere to formulation-specific recommendations based on standardization.

7. Critical Safety Notes

  • Absolute Contraindication: Asteraceae/Compositae allergy.

  • Use With Caution: Concurrent anticoagulant therapy (monitor INR).

  • Embarazo/Lactancia: Consult healthcare provider despite traditional use.

  • Seguro de calidad: Partner with certified suppliers (p.ej, Shaanxi Zhonghong) para PA-free, contaminant-tested extracts.

8. Premium Product Specifications

Table 1: Shaanxi Zhonghong Chamomile Extract Quality Standards (Example: 4% Apigenin)

Categoría Proyecto Especificación Método de prueba
Residuos de pesticidas Clorpirifos ≤ 0,01 ppm GC-MS/MS (EU SANTE 11312/2021)
Cipermetrina ≤ 0,05 ppm GC-MS/MS
Propargite ≤ 0,01 ppm GC-MS/MS
DDT total ≤ 0,05 ppm GC-μECD
Pyrrolizidine Alkaloids (PAs) < 1.0 ppb Total PAs LC-MS/MS (USP <223>)
Metales pesados Arsénico (As) ≤ 1,0 ppm ICP-MS (USP <232>/ICH Q3D)
Plomo (Pb) ≤ 3,0 ppm ICP-MS
Cadmio (Cd) ≤ 0,5 ppm ICP-MS
Mercurio (Hg) ≤ 0,1 ppm CV-AAS
Microbiológico Recuento aeróbico total ≤ 10⁴ CFU/g USP <61>
Levadura y moho ≤ 10² UFC/g USP <61>
E. coli Ausente en 1g USP <62>
Salmonela especies Ausente en 10g ISO 6579-1
Estafilococo áureo Ausente en 1g USP <62>
Chemical Markers Apigenina ≥ 4.0% HPLC-DAD (Validated USP/EP)
α-Bisabolol ≥ 5.0% (in CO2 Extracts) GC-FID
Pérdida por secado ≤ 6.0% USP <731>
Total Ash ≤ 8.0% USP <281>
Residuos de disolventes Conforms to USP <467> GC-HS-FID

9. Flujo de trabajo de producción avanzado

  1. Sustainable Sourcing: Partner farms (EU/Organic certified) supply identity-preserved Matricaria chamomilla flowers. HPTLC/DNA barcoding verification.

  2. Gentle Drying: Low-temperature air drying (<40°C) preserves thermolabile actives.

  3. Precision Extraction: Optimizado hydroethanolic percolation (apigenin) or Extracción de CO2 supercrítico (sesquiterpenes/oils). Extracción de agua subcrítica employed for high-yield fractions.

  4. Multistage Purification: Cromatografía de adsorción (macroporous resin) enriches apigenin. Molecular distillation refines essential oil fractions.

  5. Standardization & Stabilization: Precise HPLC-guided blending achieves target potency. Microencapsulation (cyclodextrins) enhances apigenin stability in powders.

  6. cGMP Processing: Closed-system spray drying (inlet ≤ 120°C) for powders; nitrogen-flushed packaging for oils.

  7. Comprehensive QC: Batch-specific CoA a través de UPLC-QTOF-MS (full metabolomics), GC×GC-TOFMS (volatiles), ICP-MS/MS (elementals), validated microbiological assays.

10. Diversos escenarios de aplicación

  • Stress & Sleep Supplements: Nighttime formulas, anxiety relief capsules.

  • GI Health Products: IBS support, digestive bitters, anti-spasmodic blends.

  • Dermocosmetics: Rosacea creams, baby shampoo, post-procedure soothing gels, anti-aging serums (apigenin antioxidant).

  • Functional Beverages: Relaxation teas, sleep-inducing tonics.

  • Oral Care: Anti-gingivitis mouthwashes.

  • Animal Health: Pet calming chews, equine wound gels.

11. Pharmaceutical-Grade Quality Control
Shaanxi Zhonghong’s QC protocol exceeds pharmacopeial standards: Raw material authentication via DNA metabarcoding (ITS2, matK) ensures species authenticity. In-process controls monitor critical quality attributes (CQAs): solvent ratios, temperature profiles, intermediate marker content (TLC/HPLC). Finished product release requires validated UPLC-PDA methods (ICH Q2(R1)) for apigenin quantification and LC-MS/MS for PA screening (LOD < 0.1 ppb). Stability chambers (ICH Q1A) conduct accelerated (40°C/75% RH) and long-term (25°C/60% RH) studies. Method transfer/verification supports global client audits. Laboratorio acreditado según la norma ISO 17025 underpins data integrity (ALCOA+).

12. Protective Packaging & Global Logistics

  • Embalaje: Light-resistant amber glass bottles (oils), triple-layer foil-aluminum pouches (powders – 25kg), or nitrogen-flushed double drums (bulk). US FDA/EC 1935-compliant materials.

  • Almacenamiento: Ambiente controlado (15-25°C), <60% RH. Oils stored at 4-8°C.

  • Logística: Cold chain solutions for temperature-sensitive extracts (2-8°C transport). DDP (Delivered Duty Paid) expertise to 80+ countries. Full documentation suite: CoA, GC-MS/HPLC chromatograms, MSDS, Certificate of Origin, Non-GMO/Allergen/PA-Free Statements.

13. Mechanism of Action & Industry Innovation

  • Pharmacology:

    • GABA_A Receptor Modulation: Apigenin binds benzodiazepine site → Cl⁻ influx → neuronal hyperpolarization.

    • Antiinflamatorio: α-Bisabolol inhibits NF-κB & TNF-α; chamazulene scavenges leukotrienes.

    • GI Smooth Muscle Relaxation: Apigenin blocks Ca²⁺ influx → spasmolytic effect.

    • Antimicrobiano: Sesquiterpene lactones disrupt microbial membranes.

  • Innovación industrial:

    • Mejora de la biodisponibilidad: Nanoemulsiones y complejos de fosfolípidos boost apigenin absorption (5-10x).

    • Química verde: Enzyme-assisted extraction (cellulase/pectinase) increases yield while reducing solvent use.

    • Stability Technology: Antioxidant synergies (Rosemary CO2 extract + Tocopherols) extend shelf-life.

  • Fronteras de la investigación:

    • Oncología: Apigenin’s pro-apoptotic effects (PI3K/Akt pathway inhibition) in preclinical cancer models.

    • Neuroprotección: Mitigation of Aβ-induced toxicity in Alzheimer’s models.

    • Microbiome Interactions: Impact on gut-brain axis signaling.

    • Complejidad de estandarización: Correlating specific chemotypes (bisabolol oxide A vs B ratios) with clinical efficacy.

14. Preguntas frecuentes (FAQ)

  • Q: What’s the difference between German and Roman Chamomile extract?

    • A: German (Matricaria) is richer in apigenin/chamazulene, preferred for antiinflamatorio effects. Roman (Chamaemelum) has higher esters (angelates), valued for aromatherapy/milder action.

  • Q: Is Chamomile Extract safe for children?

    • A: Generally safe in age-appropriate doses (e.g., teething gels). Verify PA-free status and avoid with Asteraceae allergy.

  • Q: Can I take Chamomile with blood thinners?

    • A: Consult your doctor. Coumarin content may potentiate warfarin; close INR monitoring required.

  • Q: Why choose Shaanxi Zhonghong’s Chamomile Extract?

    • A: Guaranteed PA-free (<1ppb), HPLC-standardized actives (apigenin/bisabolol), cGMP/ISO 9001 manufacturing, 28 años de experiencia, I+D respaldada por la universidad, global regulatory support.

  • Q: Where to buy premium Chamomile Extract?

    • A: Contacto Shaanxi Zhonghong for B2B sales: Email: liaodaohai@gmail.com | Website: aiherba.com.

15. Conclusion: The Gold Standard in Calmative Botanicals
Chamomile Extract remains a cornerstone of evidence-based phytotherapy. Its multimodal benefits—spanning neurological calm, GI comfort, and dermatological soothing—are unlocked only through scientifically rigorous production. Tecnología de inversión Shaanxi Zhonghong Co., Ltd. sets the global benchmark with PA-free extracts, chromatographic standardization exceeding pharmacopeia, y vertically integrated quality control. Nuestro 28-year legacy in bioactive compounds, 5 university alliances, y Más de 20 tecnologías patentadas deliver Chamomile ingredients of uncompromising purity and efficacy for premium health applications worldwide.

Source Pharmaceutical-Grade Chamomile Extract:

16. Select References

  1. Srivastava, J.K., et al. (2010). Chamomile: A herbal medicine of the past with bright future. Informes de medicina molecular, *3*(6), 895-901.

  2. Amsterdam, J.D., et al. (2009). Chamomile (Matricaria recutita) may provide antidepressant activity… Revista de psicofarmacología clínica, *29*(4), 378-382.

  3. McKay, D.L., & Blumberg, J.B. (2006). A review of the bioactivity and potential health benefits of chamomile tea… Investigación en fitoterapia, *20*(7), 519-530.

  4. European Medicines Agency (EMA). (2015). Assessment report on Matricaria recutita L., flos.

  5. USP-NF Monographs: Chamomile Flower, German.

  6. Avonto, C., et al. (2017). In Chemico Evaluation of Tea Tree Essential Oils and Chamomile Extracts for Pyrrolizidine Alkaloids. J. Agric. Food Chem., *65*(14), 3087–3093.

  7. ICH Guidelines: Q1A(R2) Stability Testing, Q2(R1) Validation of Analytical Procedures.

  8. ISO 9271:2022 – Aromatic natural raw materials – Vocabulary. (Specific pharmacopeial methods and clinical studies should be referenced in formal product documentation).

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