Berberina

Berberine Extract | High-Purity Botanical Ingredient Supplier | AIHerba® 

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1. Descripción general del producto

Nombre en inglés: Extracto de berberina
Fuente botánica: Berberis aristata, Coptis chinensis (Coptis root), or Phellodendron amurense ladrar
Ingrediente activo: Berberine Hydrochloride / Berberine Sulfate
Especificación: 97% Berberine (HPLC)
Apariencia: polvo cristalino amarillo
N.º CAS: 633-65-8
Fórmula molecular: C₂₀H₁₈NO₄⁺
Fabricante: Shaanxi Zhonghong Investment Technology Co., Ltd. (AIHerba®)
Certificates: GMP, ISO9001, ISO22000, HACCP, HALAL, KOSHER

Berberine is a natural isoquinoline alkaloid extracted from Coptis chinensis and other Berberis plants. With potent bioactivity and a long history in traditional Chinese medicine, it is widely used in pharmaceuticals, dietary supplements, and functional food formulations for its glucose-regulating, antimicrobial, and metabolic benefits.

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2. Source & Production

AIHerba® sources premium Coptis chinensis roots and Berberis aristata barks from pollution-free mountain regions in China.
Production utilizes modern water-ethanol extraction, supercritical CO₂ purification, y membrane separation to ensure:

• ≥97% purity (HPLC verified)
• Low heavy metal and pesticide residue levels
• Consistent batch-to-batch quality
• Full traceability from raw herb to final extract

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3. Health Benefits & Functions

(1) Key Bioactive Benefits

• Regulación del azúcar en sangre: Supports insulin sensitivity and lowers fasting glucose levels.
• Metabolismo lipídico: Reduces LDL cholesterol and triglycerides while increasing HDL.
• Gut Microbiome Support: Balances intestinal flora and improves digestive function.
• Anti-Inflammatory & Antioxidant: Reduces systemic inflammation and oxidative stress.
• Salud cardiovascular: Promotes endothelial function and circulation.

(2) Scientifically Supported Health Effects

Clinical studies (NIH, PubMed) have shown berberine’s comparable effects to metformin in managing Type 2 diabetes and metabolic syndrome.

• NIH Study on Berberine & Glucose Control
• FDA Reference on Herbal Alkaloids

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4. Traditional Applications

Used for centuries in Medicina Tradicional China (MTC) as “Huang Lian,” berberine was prescribed to treat gastrointestinal infections, fever, and inflammation. In Ayurveda, Berberis aristata (Tree Turmeric) was known for its cleansing and antimicrobial effects.

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5. Recommended Dosage & Usage

Solicitud	Dosis típica	Usage Form
Suplementos dietéticos	500–1500 mg/day	Capsules, Tablets, Powders
Bebidas funcionales	100–300 mg/serving	Dissolved or mixed in drink bases
Pharmaceutical Formulations	Personalizado	Per regulatory and formulation requirements

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6. Best Formulation Combinations

Berberine is often combined with:

• Milk Thistle Extract (Silymarin): Enhances liver detoxification.
• Alpha Lipoic Acid: Boosts glucose metabolism.
• Cinnamon Extract: Improves insulin sensitivity.
• Probiotics: Supports microbiota balance and absorption efficiency.

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7. Safety & Precautions

• Avoid during pregnancy or lactation without medical supervision.
• May interact with diabetic medications—consult a physician before use.
• Store in a cool, dry place away from direct light and moisture.

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8. Technical Specifications (COA Summary)

Categoría	Artículo	Especificación	Método de prueba
Apariencia	polvo cristalino amarillo	Conforme	Visual
Assay (Berberine)	≥97.0%	HPLC
Pérdida por secado	≤5.0%	105°C, 2h
Contenido de cenizas	≤2.0%	Gravimétrico
Solvent Residue	≤5000 ppm	GC

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Pruebas de residuos de pesticidas

Artículo	Límite (ppm)	Método
DDT	<0.05	GC-ECD
BHC	<0.05	GC-ECD
Paratión	<0.05	GC-MS
Carbofuran	<0.05	LC-MS/MS
Clorpirifos	<0.05	GC-MS

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Pruebas de metales pesados

Metal	Límite	Método
Plomo (Pb)	≤3,0 mg/kg	ICP-MS
Arsénico (As)	≤2,0 mg/kg	ICP-MS
Mercurio (Hg)	≤0,1 mg/kg	ICP-MS
Cadmio (Cd)	≤1,0 mg/kg	ICP-MS

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Pruebas microbiológicas

Parámetro	Límite	Método
Recuento total de placa	≤1000 UFC/g	USP <61>
Levadura y moho	≤100 UFC/g	USP <61>
E. coli	Negativo	USP <62>
Salmonela	Negativo	USP <62>
Estafilococo áureo	Negativo	USP <62>

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9. Manufacturing Process

1. Selección de materia prima →
2. Crushing & Pre-treatment →
3. Water-Ethanol Extraction →
4. Filtración y concentración →
5. Purification (Membrane & Chromatography) →
6. Drying (Spray or Vacuum Drying) →
7. Grinding & Sieving →
8. Quality Inspection & Packaging

All steps follow GMP, ISO, and HACCP standards with full traceability.

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10. Almacenamiento, vida útil y embalaje

• Almacenamiento: Store below 25°C, in a tightly sealed container, protected from light and humidity.
• Duración: 24 months from production date.
• Embalaje: 25 kg/drum (inner double PE bag + outer fiber drum).
• Muestras: Free 20–50 g samples available upon request.
• Cantidad mínima de pedido: 1 kg (for trial order).

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11. Logistics & Delivery

• Plazo de entrega: 3–7 working days for standard specifications.
• Métodos de envío: DHL, FedEx, UPS, or air/sea freight.
• Documentación aduanera: COA, MSDS, TDS, Non-GMO statement, and Origin Certificate available.

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12. Application Industries

Industria	Aplicaciones
Nutracéuticos	Blood sugar control, lipid management supplements
productos farmacéuticos	Metabolic and anti-inflammatory formulations
Alimentos funcionales	Metabolic health beverages, herbal tonics
Productos cosméticos	Antibacterial and anti-inflammatory skin formulations
Veterinary & Feed Additives	Natural antimicrobial ingredient

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13. Why Choose AIHerba®?

✅ Professional Factory: Encima 28 años of production experience in botanical extracts.
✅ Certificaciones: GMP, ISO9001, ISO22000, HALAL, KOSHER.
✅ OEM/ODM Solutions: Custom formulations for global brands.
✅ Global Clients: Trusted by 1,000+ health and cosmetic companies.
✅ Trazabilidad completa: Raw material to final batch with transparent quality control.

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14. Preguntas frecuentes (FAQ)

Q1: Is berberine water-soluble?
A1: Berberine hydrochloride is slightly soluble in water but dissolves better in ethanol and methanol.

Q2: Can I get customized specifications (e.g., 85% Berberine)?
A2: Yes. We provide tailored purity levels and formulation bases according to client needs.

Q3: What is the lead time for bulk orders?
A3: Typically 5–10 days depending on quantity and specification.

Q4: Can AIHerba provide third-party testing reports?
A4: Yes. We can provide SGS, Eurofins, or Intertek reports upon request.

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15. Referencias

1. Yin, J. et al. “Efficacy of Berberine in Type 2 Diabetes Mellitus: A Meta-analysis.” Metabolismo (2008). PubMed Link
2. NIH: Berberine — Herbal Supplement Information. NIH.gov
3. FDA Botanical Drug Development Guidance. FDA.gov

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Contáctenos
📧 Correo electrónico: ventas@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 Sitio web: www.aiherba.com
🏭 Fábrica: Tecnología de inversión Shaanxi Zhonghong Co., Ltd.
AIHerba® – Your Trusted GMP-Certified Natural Plant Extract Supplier in China