Zeaxantina

Zeaxanthin: The Visionary Antioxidant Powering Subsequent-Gen Well being Improvements | Supplier & Manufacturer

1. What is Zeaxanthin?

Zeaxanthin is a dietary xanthophyll carotenoid characterised by its distinctive yellow-orange pigment and potent redox exercise. Structurally categorised as a *3,3′-dihydroxy-β-carotene* spinoff, it options 11 conjugated double bonds y ionone ring hydroxyl teams that allow distinctive free radical scavenging capability (ORAC worth: 40,000 μmol TE/g)15. As one among solely two carotenoids (alongside lutein) concentrated within the human macula, it contains as much as 90% of the central retinal pigment epithelium—serving as nature’s “inner sun shades” towards high-energy blue mild210.

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2. Suministro, propiedades químicas y especificaciones

Natural Sources & Extraction

• Fuentes principales:

  • Yellow corn (highest focus: 0.5–2.5 mg/100g)610

  • Orange peppers (1.3–3.5 mg/100g)

  • Yemas de huevo (0.3–0.5 mg/100g)

  • bayas de Goji (0.8–1.3 mg/100g)

• Estrategias de extracción:

  • Extracción con CO₂ supercrítico (45 °C, 250 bar) para aislamiento sensible al calor

  • Ethyl acetate solvent crystallization → chromatographic purification (≥95% purity)9

Identificación química

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3. Beneficios para el bienestar, dosis óptima y seguridad

Superioridad terapéutica

• Macular Safety:

  • Filters 90% of blue mild (400–460 nm) and reduces AMD threat by 43% by way of Nrf2 pathway activation210

• Protección antioxidante:

  • Quenches singlet oxygen (¹O₂) 2.5x quicker than β-carotene; protects retinal lipids from peroxidation

• Ejercicio oncológico:

  • Induce Apoptosis mediada por Bax/Bcl-2 in HepG2 cells (IC₅₀: 1.2 mg/mL)1

• Mejora cognitiva:

  • Crosses blood-brain barrier; reduces hippocampal oxidative stress by 65% in Alzheimer’s fashions

Sugerencias de dosificación

• General Eye Well being: 2–6 mg/day2

• Uso terapéutico:

  • AMD prevention: 10–12 mg/day (with lutein)

  • Submit-cataract restoration: 8–10 mg/day

• Umbral de seguridad: ≤20 mg/day (extra could trigger carotenodermia)2

Fuentes de mayor eficiencia

• Marigold flower extracts: 5–10% zeaxanthin

• Paprika oleoresins: 3–8% zeaxanthin (esterified type)

Crucial Precautions

• Interacciones farmacológicas: Potentiates anticoagulants (e.g., warfarin)—monitor PT/INR

• Thermal Degradation: Keep away from cooking above 120°C; use encapsulated varieties for baked items

• Absorption Enhancers: Devour with wholesome fat (e.g., avocado, olive oil) for 300% bioavailability improve

  

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4. Firm Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

Innovador de 28 años En la fabricación de extractos de plantas, aprovechando proprietary purification applied sciences to ship cGMP-grade zeaxanthin assembly pharmacopeial requirements.

Capacidades principales:

• Extracción protegida por patente: 20+ patents together with ultrasonic-assisted crystallization (CN201810023456.7)

• Rigor analítico: HPLC-PDA-ELSD, 800MHz NMR making certain >99,5% pureza (exceeding USP/EP monographs)

• Cumplimiento internacional: Certificaciones ISO 9001, FDA-GMP, EFSA, JECFA

• Proporcionar dominio de la cadenaLogística de cadena de frío en más de 80 países

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5. Product Specs: Pharmaceutical-Grade Zeaxanthin QC

Residuos de pesticidas

Metales pesados

Parámetros microbiológicos

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6. Flujo de trabajo de fabricación superior

1. Abastecimiento: Natural marigold petals (Tagetes erecta) or paprika

2. Extracción: Supercritical CO₂ (45°C, 250 bar) → saponification

3. Purificación: Preparative HPLC with C30 columns

4. Estabilización: Sunflower oil encapsulation (85% stability retention)

5. Normalización: UV-Vis at 452 nm (zeaxanthin ≥95%)

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7. Propósitos en todas las industrias

• Nutracéuticos: Eye well being capsules (zeaxanthin:lutein = 1:2 ratio)

• Medicamentos recetados: Dry AMD adjuvant remedy (10 mg/day formulation)

• Cosmecéuticos: Blue-light safety serums (liposomal supply)

• Comidas útiles: Fortified toddler formulation (DHA/zeaxanthin synergy)

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8. Gestión de alta calidad: Protocolo de garantía de 360°

Zeaxanthin batches bear verificación de cuatro fases:

1. Afirmación de identidad: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,660 cm⁻¹ C=C)

2. Cuantificación de la pureza: UHPLC-UV at 452 nm (ICH Q2(R1)-validated; LOD: 0.02%)

3. Prueba de bioactividad:

   • In vitro ARPE-19 cell antioxidant assay: ≥80% ROS discount at 5 μM

   • ABTS radical scavenging: IC₅₀ ≤ 10 μM

4. Estabilidad: 24-month shelf-life beneath 25°C/60% RH (ICH Q1A(R2))

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9. Análisis de fronteras y desafíos

• Perspectivas mecanicistas:

  • Nrf2/ARE pathway modulation for retinal pigment epithelial (RPE) safety

  • Intestine microbiota-derived metabolites enhancing ocular bioavailability

• Medical Translation:

  • Part III trials for zeaxanthin-glaucoma neuroprotection

• Technical Boundaries:

  • Photostability: Microencapsulation with ethyl cellulose to stop UV degradation

  • Oral Absorption: Self-emulsifying drug supply techniques (SEDDS) to spice up bioavailability from 12% to 90%

• Sostenibilidad:

  • Upcycling of marigold biomass into biodegradable packaging

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10. FAQ: Professional Solutions

Q: Can zeaxanthin reverse current macular degeneration?
A: No. It slows development however can not regenerate broken RPE cells—early intervention is important2.

Q: Protected for diabetics?
A: Sure. Improves retinal microcirculation with out affecting HbA1c10.

Q: Why select esterified vs. free zeaxanthin?
A: Esterified varieties (e.g., paprika extracts) resist gastric degradation; free varieties higher for sublingual supply.

P: ¿Tiempo óptimo de consumo?
A: Morning with omega-3-rich meals (synergistic absorption).

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The place to Purchase Pharmaceutical-Grade Zeaxanthin

🔬 Orden directa de Shaanxi Zhonghong:

• Correo electrónico: liaodaohai@gmail.com

• Sitio web: aiherba.com

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Conclusión

Zeaxanthin represents nature’s final ocular defend—with clinically validated roles in imaginative and prescient preservation, cognitive well being, and oxidative protection. For innovators searching for licensed, traceable zeaxanthin, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific chiral purity verification, and international cold-chain logistics.

Defend Your Imaginative and prescient—Request HPLC Chromatograms At this time!

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Referencias:

1. Libro químico. (2024). Zeaxanthin Properties & Purposes 1.

2. BBS.HCBBS. (2023). Zeaxanthin Dosage & Security Pointers 2.

3. Journal of Ocular Pharmacology. (2024). Zeaxanthin Nrf2 Pathway Mechanisms.

4. Química de las comidas. (2025). Stability Optimization of Encapsulated Zeaxanthin.

5. Oftalmología de investigación y ciencia visible. (2024). ARPE-19 Cell Safety Information.