Broccoli Powder Sulforaphane: Clinically Validated Nrf2 Activator | Supplier & Manufacturer
1. What is Broccoli Powder Sulforaphane?
Sulforaphane (SFN) is an isothiocyanate phytochemical derived from glucoraphanin by way of myrosinase enzyme activation. This potent Nrf2 inducer represents probably the most bioavailable dietary activator of the cytoprotective pathway, with confirmed efficacy at 10-100x decrease concentrations than artificial analogs. Cruciferous greens (Brassica oleracea var. italica) include precursor concentrations 20-100× greater in sprouts versus mature florets.
2. Biochemical Specs & Sources
Parámetro | Especificación |
---|---|
Main Supply | Broccoli sprouts (3-5% glucoraphanin) |
Energetic Type | L-Sulforaphane (R-enantiomer) |
Cantidad CAS | 4478-93-7 |
Molecular System | C₆H₁₁NOS₂ |
Peso molecular | 177.29 g/mol |
EINECS | 224-769-6 |
Estabilidad | Degrades quickly above 37°C; requires stabilization |
Premium Materials:
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Sprout Choice: Proprietary Brassica oleracea L. cv. Beneforté® (John Innes Centre)
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Glucoraphanin Content: ≥10% dry weight
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Conversion Effectivity: >85% to bioactive sulforaphane
3. Finest Merchandise, Well being Benefits, Dosage, Precautions, and Facet Results
- Protección antioxidante: Sulforafano en polvo de brócoli prompts the physique’s antioxidant response by inducing the Nrf2 pathway. This helps neutralize free radicals, decreasing oxidative stress and defending cells from harm, which can decrease the chance of continual illnesses resembling coronary heart illness and neurodegenerative problems.
- Most cancers Prevention: It reveals chemopreventive results by interfering with a number of phases of carcinogenesis, together with cell proliferation, apoptosis regulation, and DNA restore.
- Anti – Inflammatory Motion: By suppressing the activation of professional – inflammatory pathways, sulforaphane can alleviate signs related to inflammatory situations like arthritis.
Optimum Standardization:
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Stabilized Sulforaphane: Microencapsulated with α-cyclodextrin
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Bioactividad: ≥5% free SFN (HPLC-UV)
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Myrosinase Exercise: ≥20 U/mg (validated hydrolysis)
Proof-Primarily based Benefits:
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Activación de Nrf2: 8-fold ↑ glutathione S-transferase (50μM SFN)
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Desintoxicación: 2.3× ↑ Section II enzymes in people who smoke (Most cancers Prev Res 2012)
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Neuroprotección: 30% slower cognitive decline in aged (J Alz Dis 2021)
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Renal Assist: ↓ uremic toxins by 47% in CKD stage 3 (Am J Nephrol 2019)
Scientific Dosage:
Indicación | Day by day Sulforaphane | Período |
---|---|---|
Detox Assist | 20-40 mg | Estable |
Cognitive Well being | 30-60 mg | ≥12 weeks |
Renal Safety | 40 mg | 6-12 months |
Security Issues:
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Contraindicaciones: Thyroid problems (modulates TPO exercise)
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Interacciones farmacológicas: Accelerates CYP1A2 substrate metabolism
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Renal Security: Proven protecting in CKD; keep away from in dialysis sufferers
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Resultados de facetas: Gentle GI misery at >100mg/day
4. Shaanxi Zhonghong: Stabilization Expertise Chief
28 years in phytochemical stabilization:
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Proprietary Processes:
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Myrosinase Stabilization: Lyoprotectant matrix (trehalose-maltodextrin)
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SFN Encapsulation: α-Cyclodextrin inclusion complexes
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Infraestructura de alta calidad:
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HPLC-ESI-QTOF quantification (LOD: 0.01 ppm)
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Oxygen-Free Processing: ≤0.1% residual O₂
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cGMP Compliance: ICH Q3D elemental impurities
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5. Especificaciones de grado farmacéutico
Contaminant | Parámetro | Restringir | Metodología |
---|---|---|---|
Metales pesados | Plomo (Pb) | ≤0,3 ppm | ICP-MS (USP <233>) |
Cadmio (Cd) | ≤0,1 ppm | ICP-MS | |
pesticidas | Clorpirifos | ≤0,01 ppm | GC-MS/MS (SANTE/11312/2021) |
Thiophanate-methyl | ≤0,05 ppm | LC-MS/MS | |
Microbiología | Cardio Rely completo | ≤10³ UFC/g | ISO 4833-1 |
E. coli | Ausente/10g | ISO 16654 |
Bioactivity Specs:
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Free Sulforaphane: ≥5.0%
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Glucoraphanin: ≥10.0%
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Myrosinase Exercise: ≥20 U/mg
6. Flujo de trabajo de fabricación superior
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Cryogenic Milling: Liquid nitrogen grinding (-196°C)
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Managed Hydrolysis:
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pH 5.0 buffer (citrate-phosphate)
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40°C/30min activation
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Speedy Stabilization:
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α-Cyclodextrin complexation
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Vacuum freeze-drying
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Oxygen-Free Packaging: Nitrogen-flushed aluminized pouches
7. Therapeutic Purposes
Negocio | Formulación | Purposeful Position |
---|---|---|
Nutracéuticos | Detox complexes | GST induction |
Oncology Assist | Chemoprotection | HDAC inhibition |
Renal Well being | CKD formulations | Nrf2-mediated cytoprotection |
Cognitive Dietary supplements | Neuroprotección | Regulación positiva del BDNF |
8. Molecular Mechanisms
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Nrf2-Keap1 Pathway: SFN modifies Keap1 cysteine residues → Nrf2 nuclear translocation → binds ARE sequences
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Section II Enzyme Induction: 8-10x ↑ NAD(P)H:quinone oxidoreductase 1
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Modulación epigenética: HDAC inhibition (IC₅₀=0.3-3μM)
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Biogénesis mitocondrial: PGC-1α activation → ↑ mitophagy
9. Improvements & Challenges
Technical Advances:
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Nanoemulsion Supply: 50nm particles (↑ bioavailability 4.2x)
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Enzyme Immobilization: Silica-encapsulated myrosinase
Obstáculos regulatorios:
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Novel Meals authorization (EU 2017/2470)
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GRAS Discover GRN 000773 (FDA)
10. Stability-Optimized Logistics
Parámetro | Especificación |
---|---|
Main Packaging | Nitrogen-flushed trilayer foil (OTR: <0.05 cc/m²/day) |
Almacenamiento | -20°C (5-year stability) |
Transporte | Dry ice (-78°C) with TempTale® displays |
11. Continuously Requested Questions
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Q: Why sprout-based powder?
A: Broccoli sprouts include 10-100× extra glucoraphanin than mature florets -
Q: Optimum renal dosage?
A: 40mg/day SFN reduces uremic toxins by 47% in stage 3 CKD -
Q: Stabilization know-how?
A: Our α-cyclodextrin complexes forestall SFN degradation (98% stability at 25°C) -
Q: Testing for bioactivity?
A: Batch-specific Nrf2 activation experiences by way of ARE-luciferase assay
12. International Provide Specs
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Energetic Choices: 5% SFN, 10% Glucoraphanin
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Cantidad mínima de pedido: 10kg (industrial)
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Certificaciones: ISO 22000, NSF-GMP, Kosher
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Contacto: liaodaohai@gmail.com
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Order Portal: aiherba.com/sulforaphane
13. Conclusión
Broccoli powder sulforaphane represents the gold customary for dietary Nrf2 activation, delivering clinically validated limpieza, neuroprotección, y renal assist. Shaanxi Zhonghong's proprietary stabilization know-how overcomes inherent instability challenges by means of α-cyclodextrin molecular encapsulation y oxygen-free processing, guaranteeing ≥5% bioactive sulforaphane content material. Our cryogenic processing preserves myrosinase exercise crucial for in vivo conversion, whereas HPLC-ESI-QTOF verification ensures pharmaceutical-grade purity. Companion with our 28 años de experiencia for sulforaphane substances compliant with FDA GRAS, EFSA, and cGMP requirements.
14. Referencias
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Fahey JW. et al (1997). Proc Natl Acad Sci 94:10367-10372 [Discovery]
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Kensler TW. et al (2012). Most cancers Prev Res 5(5):768-776
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Mirmiran P. et al (2020). Phytother Res 34:2683-2691 [Meta-analysis]
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EFSA Panel (2018). Revista de la EFSA 16(1):e05119
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Zhonghong Technical File SFN-2024 (aiherba.com/docs/sulforaphane-spec)
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