Beta-Glucan: The Versatile Immunomodulating Polysaccharide Powerhouse|Supplier & Manufacturer

1. ¿Qué es el beta-glucano?

El beta-glucano (β-glucano) es un compuesto natural grupo heterogéneo de polímeros de glucosa characterised by enlaces β-glucosídicos enlazando monómeros de D-glucosa. Su bioactivity is critically depending on molecular construction: particularly, the linkage sort (β-(1,3), β-(1,4), β-(1,6)), diploma of branching, peso molecular (PM), solubilidad, y conformación terciaria (triple hélice). Primarily acknowledged as a potent organic response modifier (BRM), β-glucans exert profound results on the sistema inmunológico innato by interacting with particular receptors (e.g., dectin-1, receptor del complemento 3 (CR3), TLR-2/6) en macrófagos, células dendríticas y neutrófilos. Past immunology, they perform as fibras dietéticas solubles with established advantages for metabolic and cardiovascular well being.

2. Suministro de productos, propiedades químicas e identificadores

• Major Sources:

  • Levaduras y hongos: Saccharomyces cerevisiae (Baker’s/Brewer’s Yeast) – wealthy in β-(1,3)/(1,6)-glucanos (extremely immunomodulatory). Hongos medicinales (Reishi (Ganoderma lucidum), Shiitake (Lentinula edodes), Maitake (Grifola frondosa)) – complicated β-glucan constructions.

  • Cereales: Avena (Avena sativa), Cebada (Hordeum vulgare) – predominantemente β-(1,3)/(1,4)-glucanos (fibra soluble, reductora del colesterol).

  • Micro organism: Alcaligenes faecalis, Agrobacteria spp. – producir curdlan (β-(1,3)-glucano).

  • Alga: Euglena gracilis – Paramylon (β-(1,3)-glucano).

• Propiedades químicas:

  • Apariencia: Varies by supply. Yeast/fungal β-glucans: Off-white to mild tan powdersβ-glucanos de avena/cebada: Polvos blancos cremosos.

  • Solubilidad: Yeast/Fungal β-(1,3)/(1,6)-glucans are typically insoluble en agua however soluble in álcali (por ejemplo, NaOH 0,25 M) o DMSOLos β-(1,3)/(1,4)-glucanos de los cereales son extremely soluble in water, forming viscous options/gels. Solubility impacts performance and bioavailability.

  • Estabilidad: Typically steady. Cereal β-glucans can bear enzymatic degradation; requires cautious processing. Storage in cool, dry circumstances beneficial.

• Key Identifiers (Instance: Yeast β-(1,3)/(1,6)-Glucan):

  • Cantidad de registro CAS: 9012-72-0 (Basic for Glucans) / 160872-27-5 (derivado de Saccharomyces cerevisiae)

  • Formulación molecular (MF): (C6H10O5)n (Polímero – n varía)

  • Peso molecular (PM): Usually 100,000 – 2,000,000 Da (Excessive MW essential for immune exercise). Shaanxi Zhonghong provides particular MW ranges.

  • Cantidad EINECS: 232-739-3 (Para los glucanos)

3. Efficacy, Optimum Kinds, Well being Benefits, Dosage & Security

• “Greatest” Kind & Highest Purity: The “greatest” β-glucan is determined by the desired major perform:

  • Modulación inmunológica: Excessive-Molecular-Weight (>500 kDa), Insoluble Yeast/Fungal β-(1,3)/(1,6)-Glucan con excessive purity (>85%) y preserved triple-helix construction is taken into account the gold commonplace for maximal immune cell activation through dectin-1. Shaanxi Zhonghong makes use of Extracción patentada que preserva la conformación nativa.

  • Ldl cholesterol Administration & Blood Sugar Management: Excessive-Purity (>95%) Soluble Oat or Barley β-(1,3)/(1,4)-Glucan con excessive viscosity/molecular weight is best. Purity minimizes interference from different fibers/starch.

  • Wound Therapeutic/Topical: β-glucanos solubles de levadura o de hongo are sometimes most well-liked.

• Beneficios y mecanismos de bienestar:

  • Mejora del sistema inmunológico: Prompts macrophages (enhanced phagocytosis, reactive oxygen/nitrogen species manufacturing, cytokine/chemokine launch). Estimula la maduración de las células dendríticas.. Mejora la quimiotaxis y la citotoxicidad de los neutrófilos.. Primes Natural Killer (NK) cell exercise. Este “educated immunity” enhances host protection towards infections (bacterial, viral, fungal) and helps immune surveillance towards most cancers.

  • Ldl cholesterol Discount: Soluble oat/barley β-glucan varieties a viscous gel within the intestine, unión de ácidos biliares and selling their excretion. This forces the liver to use blood ldl cholesterol to synthesize new bile acids, decreasing serum LDL (“dangerous”) ldl cholesterol. EFSA and FDA help well being claims (e.g., 3g/day oat β-glucan).

  • Modulación de la glucosa en sangre: Retrasa el vaciamiento gástrico y ralentiza la absorción de carbohidratos., lowering post-prandial blood glucose spikes and bettering insulin sensitivity.

  • Intestine Well being Promotion: Actúa como un prebiótico, stimulating development of helpful micro organism (e.g., Bifidobacteria, Lactobacilos). Mejora short-chain fatty acid (SCFA) manufacturing (butirato).

  • Wound Therapeutic & Pores and skin Well being: Por vía tópica, estimula proliferación de fibroblastos dérmicos, deposición de colágeno y migración de queratinocitos. Mejora macrophage recruitment to wound websites.

  • Adjuvant in Most cancers Remedy: Enhances efficacy and reduces negative effects of quimioterapia/radioterapia. Potential direct anti-tumor results through immune activation.

• Consumo diario:

  • Immune Help (Yeast/Fungal): Generalmente 100-500 mg/día de producto de alta pureza (>85%) y alto peso molecular.

  • Ldl cholesterol Administration (Oat/Barley): 3 gramos/día minimal, typically consumed in divided doses with meals. Requires constant consumption.

  • Blood Sugar Management (Oat/Barley): 3-4 gramos/comida.

  • Optimum dosing is determined by supply, purity, MW, and well being purpose. Seek the advice of a healthcare supplier.

• Precauciones y aspectos a considerar:

  • Typically Acknowledged as Secure (GRAS). Nicely-tolerated by most.

  • Potential Aspect Results: Excessive doses, particularly initially, could trigger gentle gastrointestinal signs (bloating, fuel, diarrhea) because of fermentation or fiber bulk. Begin with decrease doses and improve step by step.

  • Autoimmune Circumstances: Theoretical concern exists concerning immune stimulation exacerbating autoimmune illnesses (e.g., RA, lupus, MS). Seek the advice of doctor earlier than use.

  • Procedimiento quirúrgico: On account of potential immune-modulating results, discontinue use a minimum of 2 weeks earlier than scheduled surgical procedure.

  • Síntomas de alergia: Uncommon, however attainable sensitivity to supply (yeast, fungi, cereals). Keep away from if identified allergy.

  • Interacciones farmacológicas: Podría potentiate results of immunosuppressive medicine. Might gradual absorption of some medicines; take different meds 1 hour earlier than or 2-4 hours after β-glucan (particularly soluble varieties).

4. Premier Supply: Shaanxi Zhonghong Investment Technology Co., Ltd.

Shaanxi Zhonghong Investment Technology Co., Ltd. aprovecha 28 años de experiencia como un vertically built-in chief en bioactive polysaccharide manufacturingComo un licensed high-tech enterpriseNosotros conducimos agile R&D, collaborative innovation, precision manufacturing, and world distribution Para el chemical, materials science, and life science industries.

• Enfoque principal: Superior extraction, purification, and characterization of high-purity β-Glucans from numerous sources (yeast, fungi, oats, barley).

• Portafolio de productos: Polvos de β-glucano estandarizados (Yeast, Oat, Mushroom particular), complejos solubles, customized MW fractions, activos de belleza, sustancias nutracéuticas, research-grade supplies.

• Destreza científica (barrera de I+D):

  • College Alliances: Laboratorios conjuntos con 5 elite establishments Avances en la ciencia de los polisacáridos.

  • Cartera de propiedad intelectual: Más de 20 patentes masking hidrólisis enzimática patentada, fractionation strategies, y preservación de la bioactividad.

  • Distinctive Compound Library: World unique assortment of characterised polysaccharides.

• Manufacturing Excellence (Gear Edge):

  • Reducing-edge Analytics: HPLC-RID/ELSD/MS para purity/MW evaluation, GC-MS para el perfil de monosacáridos, FTIR/RMN para structural affirmation, SEC-MALS para absolute MW willpower.

  • Purity Management: Nuestro β-Glucan purity requirements exceed trade norms by >20%, assured by pruebas ortogonales rigurosas.

• Logro mundial: Proporciona custom-made β-Glucan options a pharmaceutical giants, nutraceutical manufacturers, useful meals builders, and analysis organizations a lo largo de más de 80 naciones en Asia, Europa y las Américas.

5. Product Specs: Rigorous High quality Management

6. Superior Manufacturing Move (Yeast β-Glucan)

1. Elección de presión y fermentación: Uso de propiedad Saccharomyces cerevisiae presiones debajo managed fermentation circumstances.

2. Recolección e inactivación de células: Centrifugación/filtración, adopted by inactivación térmica o química.

3. Aislamiento de la pared celular: Disrupción mecánica (homogeneización a alta presión, molienda de perlas) o lisis enzimática to interrupt cells and isolate partitions.

4. Extracción alcalina: Remedy with sizzling alkali (e.g., 1-3M NaOH) para solubilizar manoproteínas y lípidos, dejando la matriz de β-glucano insoluble.

5. Lavado ácido: Acid remedy (e.g., acetic acid) to take away residual contaminants.

6. Neutralización y lavado: In depth diafiltración/ultrafiltración to impartial pH and low conductivity.

7. Fractionation & MW Management (Non-obligatory): Managed enzymatic hydrolysis o bodily shearing to realize goal MW vary. SEC preparativo for exact fractionation.

8. Solubilization (For Soluble Kinds): Derivatización (por ejemplo, carboximetilación) o particular enzymatic modification.

9. El secado: Secado por aspersión o liofilización to provide steady powder.

10. Lanzamiento de control de calidad estricto: Lleno id, purity, MW, contaminant, and microbiological testing per specs.

7. Escenarios de aplicación

• Nutracéuticos y suplementos dietéticos: Immune help capsules/tablets, cholesterol-lowering formulation, blood sugar administration blends, prebiotic dietary supplements, normal wellness powders.

• Comidas y bebidas con propósito: Cereales, barras y panes fortificados (β-glucano de avena), bebidas que refuerzan el sistema inmunológico, yogures (requires soluble varieties).

• Medicamentos recetados: Inmunoestimulantes (particularly post-surgery/chemo), adjuvant most cancers remedy, wound therapeutic gels/dressings, cholesterol-lowering medicine.

• Cosmecéuticos: Anti-aging lotions/serums (enhances pores and skin immunity, hydration, restore), wound therapeutic formulations, lociones calmantes.

• Animal Vitamin & Well being: Moduladores inmunitarios en piensos para ganado y aves de corral, companion animal dietary supplements.

• Análisis: Immunology research, drug supply techniques, biomateriales.

8. Complete High quality Management (QC) System

Shaanxi Zhonghong emplea a un multifaceted QC protocol exceeding pharmacopeial necessities Para asegurarse β-Glucan efficacy, security, and consistency:

• Id & Purity: HPLC coupled with Refractive Index (RID) or Evaporative Mild Scattering (ELSD) Detection quantifies β-glucan content material towards licensed requirements. Enzymatic strategies (Megazyme kits) present orthogonal affirmation. Dimension Exclusion Chromatography with Multi-Angle Mild Scattering (SEC-MALS) entrega peso molecular absoluto y distribución (MWD). Fourier Remodel Infrared Spectroscopy (FTIR) y Resonancia Magnética Nuclear (RMN – 1H, 13C) presente huella estructural definitiva and linkage affirmation.

• Gestión de contaminantes: Espectrometría de masas con plasma acoplado inductivamente (ICP-MS) logra detección ultrasensible de metales pesados at ppb ranges. Fuel Chromatography-Mass Spectrometry (GC-MS/MS) y Cromatografía líquida-espectrometría de masas en tándem (LC-MS/MS) display for pesticides, mycotoxins, and course of residuals. Ensayos microbiológicos validados guarantee compliance with stringent bioburden limits.

• Purposeful Characterization: Rheological evaluation medidas propiedades de viscosidad/gelificación de β-glucanos solubles. Ensayos de activación de macrófagos in vitro (e.g., cytokine launch, NO manufacturing) assess immunomodulatory efficiency for yeast/fungal merchandise. Solubility and water-binding capability are key bodily checks.

• Estabilidad y almacenamiento: ICH Q1A(R2) compliant stability research (accelerated: 40°C/75% RH; long-term: 25°C/60% RH) decide shelf-life. Merchandise are usually saved in sealed containers at ambient temperature, shielded from moisture.

• Trazabilidad y cumplimiento: Certificados completos de evaluación (CoA) con batch-specific knowledge. Digital Batch Information (EBR) y Sistema de gestión de la información de límites garantizar trazabilidad completaAdherencia a cGMP, ISO 9001, ISO 22000/FSSC 22000, Kosher, Halal.

9. Embalaje seguro y logística mundial

• Embalaje principal: Multi-layered, foil-lined luggage with zipper closures and desiccant positioned inside bidones de fibra o contenedores de HDPE.

• Embalaje secundario: Strong cajas de cartón de calidad de exportación.

• Etiquetado: Etiquetado claro con product title, supply, CAS (if relevant), batch no., expiry date, internet weight, storage circumstances, GMP standing, allergen assertion (if required).

• Logística: World delivery through air/sea. Experience in logística de temperatura ambiente. Actual-time cargo monitoring. Paquete completo de documentación de exportación (Industrial Bill, Packing Listing, CoA, MSDS, Certificates of Origin, Well being Certificates). Customs brokerage help.

10. Well being Efficacy & Mechanism Analysis, Purposes & Innovation, Analysis Frontiers

• Profundidad mecanicista: Ongoing analysis focuses on cascadas detalladas de señalización de receptores (p.ej, Vía Syk/CARD9 aguas abajo de la dectina-1), modulation of educated immunity (epigenetic reprogramming), affect on gut-immune axis, y interplay with the complement system.

• Increasing Scientific Purposes: Energetic investigation in oncology immunotherapy mixtures, administration of sepsis and important sickness, adyuvanticidad de la vacuna, inflammatory bowel illness (IBD), allergy/bronchial asthma modulation, y intervenciones para el síndrome metabólico.

• Trade Purposes & Tech Innovation: Key areas embrace nanoparticulate β-glucan for focused drug/vaccine supply, improvement of extremely purified soluble β-(1,3)/(1,6)-glucans with preserved bioactivity, microencapsulation for meals/beverage stability, chemically outlined derivatives with tailor-made properties, y sustainable manufacturing through fermentation optimization.

• Análisis Fronteras y Desafíos: Main challenges contain estandarización de ensayos de bioactividad throughout numerous constructions, Comprensión de las relaciones estructura-actividad (SAR) con precisión atómica, bettering oral bioavailability of insoluble varieties, conducting large-scale long-term medical trials, guaranteeing constant supply materials high quality, y addressing regulatory complexities for well being claims. Interacciones del microbioma y metabolitos de β-glucano are rising frontiers.

11. Preguntas frecuentes (FAQ)

• Q: What is the distinction between yeast, mushroom, and oat beta-glucan?

  • A: Supply and Construction: El β-glucano de levadura es principalmente β-(1,3)-enlazado con ramas β-(1,6), insoluble, y extremely immunomodulatory. Mushroom β-glucans range however typically have complicated β-(1,3)/ (1,6) constructions; algunos son inmunogénicos. El β-glucano de avena/cebada es linear/barely branched β-(1,3)/(1,4)-linked, soluble, y actúa principalmente como un fibra soluble que reduce el colesterol with some immune results through the intestine.

• Q: Which beta-glucan is greatest for immune help?

  • A: Excessive-purity (>85%), Excessive-Molecular-Weight (>500 kDa) Yeast or Mushroom (e.g., Reishi, Shiitake) β-(1,3)/(1,6)-Glucan is mostly thought-about essentially the most potent for direct immune cell activation through receptors like dectin-1. Preservation of the native triple-helix construction is crucial.

• Q: How a lot beta-glucan ought to I take day by day?

  • A: Dose is determined by the supply and function:

    • Inmune (levadura/hongo): 100-500 mg/día de extracto de alta calidad.

    • Ldl cholesterol (Oat/Barley): At the least 3 grams/day, consumido con las comidas.

    • Azúcar en sangre (avena/cebada): 3-4 gramos por comida.
      Seek the advice of a healthcare skilled for personalised recommendation.

• Q: Are there any negative effects?

  • A: El β-glucano es typically very secure. Excessive preliminary doses, particularly soluble oat/barley, could trigger gentle fuel or bloating; begin low and improve step by step. Theoretical immune stimulation threat in energetic autoimmune illness or pre-surgery – seek the advice of your physician. Uncommon yeast/mould allergy symptoms attainable.

• Q: Is your beta-glucan gluten-free? (Oat supply)

  • A: Nuestro Beta-glucano de avena proviene de licensed gluten-free oats y procesado en un devoted gluten-free facility, examined to satisfy <20 ppm de gluten requirements. Yeast/Mushroom β-glucans are inherentemente libre de gluten.

• Q: Is it KOSHER/HALAL licensed?

  • A: Sure, particular grades can be found with Certificación KOSHER y HALAL. Por favor pregunte.

• Q: Are you able to present customized specs (MW, Purity, Solubility)?

  • A: Completely. Shaanxi Zhonghong focuses on customized β-glucan options, junto con particular MW ranges, purity ranges (as much as >95%), solubilized varieties, non-public labeling, y technical help. Contact us to debate.

12. The place to Purchase Excessive-High quality Beta-Glucan

Suministrar premium β-Glucan substances (Yeast, Oat, Mushroom Particular) from Shaanxi Zhonghong Investment Technology Co., Ltd.:

• Correo electrónico: liaodaohai@gmail.com

• Sitio web: https://aiherba.com

• Contacto: Attain out through electronic mail or our web site for technical dossiers, samples, quotations, and customized venture discussions.

13. Conclusión

El beta-glucano se destaca como un polisacárido bioactivo notablemente versátil, providing unparalleled advantages for immune well being, metabolic regulation, and past. Shaanxi Zhonghong Investment Technology Co., Ltd., aprovechando 28 years of specialised experience, state-of-the-art expertise, and uncompromising high quality techniques, entrega β-glucanos de alta pureza y bien caracterizados tailor-made to satisfy the demanding necessities of the world nutraceutical, pharmaceutical, useful meals, and analysis markets. Our dedication to scientific rigor, superior purification (exceeding trade purity by >20%), and dependable world provide chain administration positions us because the accomplice of alternative for innovators searching for premium β-Glucan substances. Empower your subsequent well being product with nature’s highly effective immunomodulator.

14. Referencias

1. Vetvicka, V., & Vetvickova, J. (2021). β-Glucans as Natural Organic Response Modifiers. Endocrine, Metabolic & Immune Problems – Drug Targets, 21(2), 216-228. (Mecanismos).

2. EFSA Panel on Dietetic Merchandise, Vitamin and Allergy symptoms (NDA). (2011). Scientific Opinion on the substantiation of well being claims associated to beta-glucans from oats and barley… Revista de la EFSA, 9(6), 2207. (Ldl cholesterol Declare).

3. Goodridge, HS, et al. (2009). La estimulación de Dectin-1 por la levadura Candida albicans o zimosano desencadena la activación de NFAT en macrófagos y células dendríticas. La Revista de Inmunología, 182(12), 7497-7504. (Señalización del receptor).

4. Akramiene, D., et al. (2007). Results of beta-glucans on the immune system. Medicina (Kaunas), 43(8), 597-606. (Immune Results Evaluate).

5. El Khoury, D., et al. (2012). Beta glucan: well being advantages in weight problems and metabolic syndrome. Journal of Vitamin and Metabolism, 2012, 851362. (Metabolic Well being).

6. Zekovic, D. B., et al. (2005). Natural and modified (1→3)-β-D-glucans in well being promotion and illness alleviation. Essential Evaluations in Biotechnology, 25(4), 205-230. (Supply & Construction Comparisons).

7. US Pharmacopeia-Nationwide Formulary (USP-NF). Basic Chapters: <1059> Excipient Efficiency, <2021> Identification of Articles of Botanical Origin by HPTLC.

8. AOAC Official Strategies of Evaluation (e.g., 995.16, 2011.25 – Beta-Glucan Assay).

9. Synytsya, A., & Novak, M. (2014). Structural range of fungal glucans. Polímeros de carbohidratos, 92(1), 792-809. (Structural Evaluation).

10. Shaanxi Zhonghong Inside Methodology Validations, Stability Research & Product Dossiers.