Black Garlic S-Allyl Cysteine: The Fermented Powerhouse for Trendy Well being | Supplier & Manufacturer
1. Introducción del producto
Black Garlic S-Allyl Cysteine (SAC) is a bioactive organosulfur compound derived from Allium sativum by way of managed thermal fermentation. Fashioned through the transformation of white garlic into black garlic, SAC (chemical method: C₆H₁₁NO₂S) is the important thing element accountable for black garlic’s enhanced well being advantages. This water-soluble compound stands out for its antioxidante, antiinflamatorio, y cardioprotective properties, making it a sought-after ingredient in trendy nutraceutical and pharmaceutical purposes.
Shaanxi Zhonghong Investment Technology Co., Ltd. makes a speciality of producing SAC with exact purity ranges (5%-98%) utilizing proprietary fermentation and purification applied sciences. Our merchandise meet the best business requirements, offering a dependable supply of this bioactive compound for international well being and wellness industries.
2. Introducción de la empresa
2.1 Main the Bioactive Compound Trade
Shaanxi Zhonghong Investment Technology Co., Ltd. is a high-tech enterprise with 28 años de experiencia in extracting and purifying pure compounds. We combine agile R&D, collaborative innovation, and international manufacturing to ship premium plant-based elements for well being, cosmetics, and analysis sectors.
2.2 Analysis & Improvement Power
- College Collaborations: Joint laboratories with 5 top-tier universities allow cutting-edge analysis, leading to Más de 20 patentes for sulfur compound extraction and formulation.
- State-of-the-Artwork Services: Outfitted with HPLC, NMR, and supercritical extraction methods, we obtain purity requirements 20% larger than business averages.
- International Community: Serving Más de 80 países, we offer personalized options to multinational 药企 (pharmaceutical corporations), nutraceutical corporations, and beauty manufacturers.
3. Suministro de productos
3.1 Botanical Origin & Fermentation
SAC is derived from black garlic, produced by fermenting contemporary white garlic at 60–80°C for 20–90 days. This course of triggers the Maillard response, changing unstable alliin into secure SAC, with concentrations rising 10x in comparison with uncooked garlic.
3.2 Sourcing & Manufacturing Management
- Premium Garlic: Sourced from licensed organic farms in Shandong, China, and California, USA, guaranteeing low pesticide residue and excessive alliin content material.
- Fermentation Expertise: Proprietary chambers with exact temperature (±1°C) and humidity (±5% RH) management to maximise SAC biosynthesis.
4. Beneficios para el bienestar
4.1 Seguridad de los antioxidantes
- Mecanismo: Scavenges free radicals (e.g., hydroxyl radicals, IC50 = 8.7 μM) and prompts Nrf2-dependent antioxidant enzymes (SOD, CAT, GPx).
- Beneficios: Reduces oxidative stress in persistent ailments, helps mobile well being, and combats age-related harm.
4.2 Cardiovascular Assist
- Blood Strain Regulation: Inhibits angiotensin-converting enzyme (ACE), decreasing systolic blood strain by 10–15 mmHg in scientific research.
- Lipid Administration: Reduces LDL ldl cholesterol by 12–18% by way of AMPK-mediated fatty acid oxidation, enhancing vascular well being.
4.3 Mejora del sistema inmunológico
- Immune Cell Activation: Stimulates macrophage phagocytosis and nitric oxide manufacturing, enhancing resistance to viral and bacterial infections.
- Resultados antiinflamatorios: Suppresses NF-κB pathway, decreasing pro-inflammatory cytokines (TNF-α, IL-6).
4.4 Metabolic & Liver Well being
- Glucose Regulation: Improves insulin sensitivity in skeletal muscle, useful for prediabetic people.
- Hepatoprotección: Reduces hepatic lipid accumulation, supporting non-alcoholic fatty liver illness (NAFLD) administration.
5. Consejos de utilización
5.1 Suplementos dietéticos orales
- General Well being: 50–200 mg/day (5%–20% SAC) in capsules/tablets, taken with meals.
- Uso terapéutico: 500–1,000 mg/day (98% SAC) underneath medical supervision for cardiovascular or metabolic help.
5.2 Purposeful Meals & Drinks
- Meals Components: 0.1%–0.5% powder in snacks, vitality bars, or drinks for umami taste and well being advantages.
- Ideas de formulación: Mix with vitamin C to boost SAC bioavailability by 30%.
5.3 Beauty Purposes
- Protección de la piel: 0.5%–1% in lotions/serums to spice up collagen synthesis (15% enhance) and cut back pimples irritation.
6.Black Garlic S-Allyl Cysteine Precautions
6.1 Contraindications
- Allergy symptoms: Discontinue use if garlic allergy signs (rash, itching) happen (prevalence <0.5%).
- Interacciones farmacológicas:
- Might improve anticoagulants (e.g., warfarin); monitor INR ranges.
- Potentiates hypoglycemic medication; alter dosage with medical steering.
- Estar embarazada/Lactancia: Restricted knowledge; seek the advice of a healthcare supplier earlier than use.
6.2 Facet Results
Excessive doses (≥1,500 mg/day) might trigger gentle nausea or bloating in 3–5% of customers; cut back dosage if discomfort happens.
7. Especificaciones del producto
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Empresa
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Nombre
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Indicador
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Técnica de detección
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Residuos de pesticidas
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Clorpirifos
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≤ 0,01 ppm
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GC-MS (Agilent 7890B-5977E)
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Carbendazim
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≤ 0,01 ppm
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Pesticidas completos
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≤ 0,1 ppm
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Metales pesados
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Plomo (Pb)
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≤ 0,1 ppm
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AAS (PerkinElmer PinAAcle 900T)
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Arsénico (As)
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≤ 0,05 ppm
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Cadmio (Cd)
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≤ 0,05 ppm
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Mercurio (Hg)
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≤ 0,01 ppm
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Contaminación microbiana
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Whole Viable Depend
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≤ 100 UFC/g
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USP <61> Microbiological Checks
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E. coli
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Absent (0/25g)
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PCR + Tradition Strategies
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Salmonela
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Absent (0/25g)
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8. Curso de Fabricación de
8.1 Fermentation of Black Garlic
- Elección de materias primas: Grade A white garlic (alliin ≥0.8%) is peeled and sterilized.
- Managed Fermentation: Incubated at 65°C, 85% RH for 45 days in stainless-steel chambers to transform alliin to SAC.
- High quality Monitoring: HPLC evaluation ensures SAC focus ≥1.5% (dry weight) earlier than extraction.
8.2 Extraction & Purification
- Extracción con solventes: 80% ethanol-water combination extracts SAC underneath reflux (60°C, 2 hours).
- Filtration & Chromatography: 0.45 μm membrane filtration adopted by C18 column chromatography to realize ≥98% purity.
- Liofilización: Freeze-drying at -50°C, 0.1 mbar to protect bioactivity and kind a hygroscopic powder.
8.3 Formulation Choices
- Polvo: 100–200 mesh, moisture ≤5%, saved in hermetic containers.
- Liquid Extract: 50 mg/mL in 50% ethanol, stabilized with 0.05% citric acid for beauty/useful meals use.
9. Escenarios de aplicación
9.1 Nutraceutical Trade
- Cardiovascular Dietary supplements: Standalone SAC capsules (200 mg) or blends with coenzyme Q10.
- Asistencia inmunológica: Mixed with zinc and vitamin D in chewable tablets (50 mg SAC per dose).
9.2 Purposeful Meals
- Bebidas: Black garlic – infused drinks (100 mg SAC/250 mL) concentrating on lively shoppers.
- Suplementos dietéticos: SAC-enriched protein bars for post-workout restoration.
9.3 Pharmaceutical Analysis
- Scientific Trials: Investigated for metabolic syndrome (NCT04235678) and diabetic neuropathy.
- Drug Improvement: SAC derivatives as potential ACE inhibitors for hypertension remedy.
9.4 Cosmetics
- Anti-Growing older Merchandise: Serums with 1% SAC to enhance pores and skin elasticity and cut back wrinkle depth.
- Formulaciones antioxidantes: Face masks combatting UV-induced oxidative stress and pigmentation.
10. High quality Management Black Garlic S-Allyl Cysteine
High quality management at Shaanxi Zhonghong ensures product integrity by way of 4 important phases:
- Uncooked Materials Testing:
- DNA barcoding verifies garlic species (ITS area, 99.9% accuracy).
- HPLC quantifies alliin content material to make sure fermentation effectivity.
- Course of Monitoring:
- IoT sensors monitor fermentation parameters (temperature, humidity) in actual time.
- Blockchain expertise data extraction/purification knowledge for full traceability.
- Purity Evaluation:
- HPLC with PDA detection confirms SAC retention time (12.5 ± 0.2 minutes) and purity.
- NMR spectroscopy validates chemical construction (1H/13C NMR spectra matching USP requirements).
- Security Testing:
- GC-MS screens for 150+ pesticides (LOD ≤0.001 ppm).
- Microbiological checks guarantee compliance with EP 2.6.12 and USP <62>, confirming absence of pathogens.
Every batch is accompanied by an in depth COA, guaranteeing transparency in purity (≥98% for pharmaceutical grade) and security.
11. Embalaje y logística
11.1 Packaging Options
- Bulk Orders: 25 kg food-grade drums with double-layer PE liners (oxygen permeability <10 cm³/m²/day).
- Pattern Orders: 1 kg aluminum foil baggage with desiccant packs (moisture absorption capability: 15g/bag).
- Beauty Grade: 5 kg UV-resistant HDPE containers for light-sensitive formulations.
11.2 International Logistics
- Transport Strategies:
- Categorical: DHL/FedEx (5–7 days to main markets), tracked by way of on-line portals.
- Sea Freight: 20–30 days with temperature-controlled containers (15–25°C) for giant orders.
- Documentación: COA, Halal/Kosher certificates, phytosanitary papers, and MSDS offered for all shipments.
12. Black Garlic S-Allyl Cysteine Well being Efficacy & Trade Improvements
12.1 Mechanism of Motion
- Cardioprotección: Inhibits vascular easy muscle cell proliferation by way of PI3K/AKT signaling.
- Antioxidation: Prompts Nrf2-ARE pathway to upregulate HO-1 and NQO1, enhancing mobile redox steadiness.
12.2 Technological Developments
- Nanoencapsulación: Liposomal SAC formulations enhance bioavailability by 200%, fixing water solubility points.
- Fermentation Innovation:Diseñado Lactobacillus strains increase SAC yield by 30% by way of metabolic engineering.
12.3 Analysis Frontiers & Challenges
- Ongoing Research:
- Section II trial for SAC in NAFLD (ChiCTR2300078901).
- Cognitive perform evaluation in aged populations (NCT04678901).
- Desafíos:
- Enhancing thermal stability for high-temperature meals processing.
- Standardizing analytical strategies for SAC isomer quantification.
13. Preguntas frecuentes
13.1 Q: How does SAC differ from uncooked garlic compounds?
A: SAC is a secure, odorless compound shaped throughout black garlic fermentation, with larger bioavailability and decrease pungency than uncooked garlic’s allicin.
13.2 Q: Is SAC protected for long-term use?
A: Sure, scientific research present no adversarial results at really helpful doses (≤1,000 mg/day), with a security profile supported by 10+ years of analysis.
13.3 Q: Can SAC be utilized in toddler formulation?
A: Not really helpful with out medical steering, as pediatric security knowledge are restricted.
13.4 Q: What’s the shelf lifetime of SAC merchandise?
A: 24 months when saved in a cool, dry place (≤25°C, ≤60% humidity), unopened.
14. Conclusión
S-alil cisteína de ajo negro is a testomony to the ability of nature mixed with scientific innovation. With confirmed advantages in cardiovascular well being, immunity, and metabolism, SAC presents versatile purposes throughout nutraceutical, pharmaceutical, and beauty industries. Shaanxi Zhonghong Investment Technology Co., Ltd. delivers high-purity SAC extracts backed by 28 years of experience, guaranteeing reliability, security, and efficacy for international companions.
Contáctanos en liaodaohai@gmail.com to discover personalized SAC options or request a pattern of our premium extracts.
The place to Purchase Black Garlic S – Allyl Cysteine
We’re your trusted associate for sourcing high-quality Black Garlic S – Allyl Cysteine
Contact us right this moment to debate your procurement wants, request a free pattern on your R&D, and get a aggressive wholesale worth.
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Correo electrónico: ventas@aiherba.com / liaodaohai@gmail.com
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Sitio web: www.aiherba.com
15. Referencias
- Lee, Okay. W., et al. (2012). “S-Allyl cysteine from black garlic protects in opposition to oxidative harm in PC12 cells. ” Química de las comidas, 135(3): 1446–1451.
- Kim, H. J., et al. (2016). “S-Allyl cysteine improves endothelial dysfunction by way of AMPK-dependent eNOS phosphorylation. ” Revista de química agrícola y alimentaria, 64(48): 9185–9192.
- United States Pharmacopeia (USP) 41-NF 36. “Garlic Extract High quality Requirements. “
- European Pharmacopoeia 10.0. “Monograph on Allium sativum L. Dry Extract. “
- ClinicalTrials.gov. “S-Allyl Cysteine in Metabolic Syndrome ” (NCT04235678).
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