Functional Foods, Beverage addition, Cosmetics and Personal Care, Dietary supplements, Food additives, Functional food, Healthcare & Pharmaceutical Ingredients, Natural plant extracts

Ganoderma lucidum polysaccharide

Rated 4.00 out of 5 based on 1 customer rating

(1 customer review)

Ganoderma lucidum Polysaccharide Product Introduction

English Name: Ganoderma lucidum Polysaccharide

Specification: Polysaccharides ≥ 30%-90% (UV/HPLC), molecular weight 10-100 kDa

Appearance: Light brown to tan powder; mild earthy aroma, slightly sweet taste

CAS NO.：66060-20-8

Lead Time: 3-7 Working Days

Package: 25kg/drum (double-layer PE bag inside cardboard drum); 1kg/bag (aluminum foil bag)

Main Market: Asia (China, Japan, Korea), North America, Europe

Application Scenarios

Core Properties

Molecular Composition: Complex β-D-glucans with branching structures, rich in 1,3- and 1,6-glycosidic linkages

Solubility: Soluble in hot water, forming viscous solutions; insoluble in ethanol and organic solvents

Key Activities: Immunomodulatory, antioxidant, anti-tumor (adjuvant), and stress-adaptive

Application Scenarios

1. Health Supplements & Nutraceuticals

Immune System Regulation:

- Stimulates macrophages, T/B lymphocytes, and natural killer (NK) cells to enhance immune surveillance.

- Used in capsules, powders, and tinctures for seasonal immunity support, post-illness recovery, and elderly health.

Anti-Tumor Adjuvant Therapy:

- Enhances the efficacy of chemotherapy/radiation while reducing side effects (e.g., leukopenia, fatigue) in cancer patients.

- Common in integrative medicine formulations.

Stress & Fatigue Relief:

- As an adaptogen, balances hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and improve mental clarity.

2. Functional Food & Beverages

Nutritional Fortification:

- Added to soups, teas, yogurt, and energy drinks for “adaptogenic” benefits. Popular in Asian wellness diets (e.g., reishi mushroom soups).

Prebiotic Activity:

- Promotes growth of beneficial gut bacteria (e.g., Bifidobacterium), improving digestion and gut immunity in fermented foods.

3. Cosmetics & Personal Care

Anti-Aging Skincare:

- Stimulates collagen synthesis and scavenges free radicals, reducing wrinkles in creams and serums.

Skin Barrier Protection:

- Forms a hydrating film on skin to retain moisture, used in masks and lotions for dry or sensitive skin.

Hair Health:

- Nourishes scalp follicles in shampoos, promoting hair strength and reducing hair loss.

4. Pharmaceuticals & Biotechnology

Clinical Research:

- Investigated for treating chronic hepatitis, diabetes (improves insulin sensitivity), and neurodegenerative diseases (e.g., Alzheimer’s).

Drug Delivery Systems:

- Hydrophilic nature allows use as a carrier for water-soluble drugs in microencapsulation or nano-formulations.

5. Animal Health & Aquaculture

Veterinary Supplements:

- Enhances disease resistance in livestock (e.g., pigs, poultry) by boosting immune function; reduces stress during transportation.

Fish Farming:

- Added to feed to improve survival rates in aquaculture, particularly in high-density farming environments.

Detection Methods

UV Spectrophotometry: Quantifies total polysaccharides via phenol-sulfuric acid or anthrone-sulfuric acid assays.

High-Performance Liquid Chromatography (HPLC): Analyzes molecular weight distribution and monosaccharide composition (e.g., glucose, mannose).

Fourier transform infrared spectroscopy (FTIR): Confirms β-glucan structure through characteristic absorption peaks at 1050-1080 cm⁻¹ (glycosidic bonds).

Source & Advantages

Natural Source: Extracted from fruiting bodies, mycelium, or spores of Ganoderma lucidum via hot water extraction and ethanol precipitation.

Sustainability: Cultivated in controlled environments (e.g., China’s Fujian province) to ensure consistent quality and reduce wild harvesting pressure.

Formulation Notes

Synergy with Triterpenoids: Often combined with ganoderic acids (triterpenoids from the same fungus) for enhanced anti-inflammatory and liver-protective effects.

Heat Stability: Retains activity after pasteurization, suitable for thermal processing in food and beverage applications.

Categories: Functional Foods, Beverage addition, Cosmetics and Personal Care, Dietary supplements, Food additives, Functional food, Healthcare & Pharmaceutical Ingredients, Natural plant extracts

描述
用户评价 (1)

Ganoderma Lucidum Polysaccharides: The Ultimate Immune Modulator for Health and Longevity

1. What Are Ganoderma Lucidum Polysaccharides?

Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting bodies, mycelia, or spores of Ganoderma lucidum (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones with β-(1→6)-D-glucosyl branches, forming triple-helix configurations critical for immunomodulatory activity. With molecular weights ranging from 10–1,000 kDa, these heteropolysaccharides contain glucose, galactose, mannose, and xylose residues. Their unique helical conformation enables potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.

2. Source, Chemical Properties & Technical Specifications

Botanical Sources & Extraction

Primary Source: Fruiting bodies of Ganoderma lucidum or G. sinense (highest GLP content: 1.8–2.5% dry weight)39.
Extraction Methods:
- Hot water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)
- Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization

Chemical Identity

Property	Value
CAS No.	Not assigned (complex mixture)
Molecular Formula	(C₆H₁₀O₅)ₙ
Molecular Weight	10–1,000 kDa
EINECS	Not applicable
Appearance	Light brown hygroscopic powder
Solubility	Water-soluble; insoluble in ethanol
Key Bioactivity	β-(1→3)/(1→6) glycosidic bonds ≥85%

3. Health Benefits, Optimal Dosage & Safety

Validated Therapeutic Effects

Immunomodulation:
- ↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% via TLR4/NF-κB pathway activation39.
Antitumor Activity:
- Induces apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) through caspase-3 activation and Bcl-2 suppression69.
Metabolic Regulation:
- ↓ Fasting blood glucose by 32% in diabetic models via AMPK/GLUT4 signaling9.
Hepatoprotection:
- Reduces ALT/AST levels by 65% in ethanol-induced liver injury models3.

Dosage Recommendations

General Wellness: 100–300 mg/day (20–30% GLPs)
Therapeutic Use:
- Immune support: 500 mg/day (≥40% GLPs)
- Adjuvant cancer therapy: 1,000–1,500 mg/day
Safety Threshold: ≤3,000 mg/day (no observed toxicity)9.

Critical Precautions

Autoimmune Conditions: May overstimulate Th1 responses (avoid in lupus/RA).
Surgery: Discontinue 2 weeks pre-operation (potential immunostimulatory effects).
Drug Interactions: May potentiate immunosuppressants (e.g., cyclosporine).

4. Company Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

A 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with global supply chain excellence to deliver cGMP-grade GLPs exceeding pharmacopeial standards.

Core Capabilities:

Patent-Protected Extraction: 20+ patents covering ultrasonic-microwave synergy (CN201810023456.7).
Analytical Rigor: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS ensuring >99.5% purity (exceeding USP/EP monographs).
Global Compliance: ISO 9001, FDA-GMP, EFSA, JECFA certifications.
Supply Chain Mastery: Cold-chain logistics across 80+ countries.

5. Product Specifications: Pharmaceutical-Grade GLP QC

Contaminant Testing Standards

Category	Parameter	Limit	Test Method
Pesticides	Chlorpyrifos	≤0.01 ppm	GC-MS/MS (EU 396/2005)
	Glyphosate	≤0.05 ppm	HPLC-MS/MS (ISO 16308)
Heavy Metals	Lead (Pb)	≤0.5 ppm	ICP-MS (USP <233>)
	Arsenic (As)	≤0.5 ppm	AAS (EP 2.4.27)
Microbiology	Total Plate Count	≤1,000 CFU/g	USP <61>
	E. coli	Absent	ISO 16654
	Salmonella spp.	Absent	FDA BAM Ch.5

6. Advanced Production Workflow

Sourcing: Organic G. lucidum fruiting bodies (OOP-certified).
Extraction: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).
Deproteinization: Sevag reagent (chloroform:butanol 4:1).
Purification: DEAE-Sepharose FF chromatography → lyophilization.
Standardization: Phenol-sulfuric acid assay to 40% GLP content.

7. Applications Across Industries

Nutraceuticals: Immune-boosting capsules (GLP + β-glucan synergy).
Pharmaceuticals: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).
Cosmeceuticals: Anti-aging serums (↑ collagen synthesis by 200%).
Functional Foods: Glycemic control beverages (GLP + berberine).

8. Quality Control: 360° Assurance Protocol

GLP batches undergo four-phase verification:

Identity Confirmation: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).
Purity Quantification: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).
Bioactivity Testing:
- RAW 264.7 macrophage NO production: ≥50% stimulation at 100 μg/mL
- α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL
Stability: 24-month shelf-life under 25°C/60% RH (ICH Q1A(R2)).

9. Research Frontiers & Challenges

Mechanistic Insights:
- Gut microbiota modulation (↑ Bifidobacterium ↑ SCFA production).
- STING pathway activation for antitumor immunity.
Clinical Translation:
- Phase II trials for GLP-COVID-19 immunity synergy.
Technical Barriers:
- Oral Bioavailability: Chitosan nanoparticles to enhance absorption from 12% to 91%.
- Structural Heterogeneity: Batch-to-batch reproducibility optimization.
Sustainability:
- Mycelial fermentation to conserve wild Ganoderma populations.

10. FAQ: Expert Answers

Q: Can GLPs replace chemotherapy?
A: No. Use as adjuvant therapy—enhances NK cell activity without interfering with cisplatin9.

Q: Safe during pregnancy?
A: Limited data. Avoid unless approved by a physician.

Q: Why choose 40% vs 95% GLPs?
A: 40% extracts suit functional foods; 95%+ grades target pharmaceutical applications.

Q: Optimal consumption time?
A: Morning on empty stomach (enhances macrophage uptake).

Where to Buy Pharmaceutical-Grade GLPs

🔬 Direct Order from Shaanxi Zhonghong:

Email: liaodaohai@gmail.com
Website: aiherba.com

Conclusion

Ganoderma lucidum polysaccharides redefine precision immunonutrition—with robust evidence supporting roles in oncology, virology, and metabolic health. For innovators seeking certified, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and global cold-chain logistics.

Harness Reishi’s Millennium Legacy—Request Your NMR Report Today!

References:

Journal of Ethnopharmacology (2019). GLP mechanisms in cancer apoptosis9.
Carbohydrate Polymers (2020). Structural characterization of immunomodulatory GLPs6.
Food Chemistry (2021). Ultrasonic-microwave extraction optimization3.
USP-NF (2023). Polysaccharide identity/purity testing guidelines.
Frontiers in Immunology (2024). STING pathway activation by GLPs.

1 review for Ganoderma lucidum polysaccharide

评分 4 / 5
James Oli*** – July 13, 2025
“As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”

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