Bacopa Monnieri Extract
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Bacopa monnieri Extract

Bacopa monnieri Extract Product Introduction

  1. English Name: Bacopa monnieri Extract
  1. Specification:
    • Bacosides ≥ 20%-60% (HPLC), including bacoside A, B, and C
    • Water-soluble powder: Bacosides ≥ 10%-30% (HPLC), with maltodextrin carrier
  1. Appearance:
    • Powder: Light brown to tan fine powder, mild herbal odor
    • Liquid: Dark brown viscous extract, soluble in water and ethanol
  1. CAS NO.：N/A（complex mixture of bacosides）
  1. Lead Time: 3-7 Working Days
  1. Package:
    • 25kg/drum (double-layer PE bag inside cardboard drum)
    • 1kg/bag (aluminum foil bag for samples)
  1. Main Market: North America, Europe, Asia (India, China, Japan)
  1. Application Scenarios

Core Properties

  • Active Compounds: Bacosides (triterpenoid saponins), flavonoids, and phenolic acids
  • Solubility: Powder soluble in hot water; liquid soluble in aqueous systems
  • Key Activities: Nootropic, antioxidant, anti-anxiety, neuroprotective

Application Scenarios

1. Health Supplements & Nutraceuticals

  • Cognitive Enhancement:
    • Improves memory, learning ability, and concentration by enhancing synaptic plasticity. Used in nootropic capsules, powders, and tinctures for students, professionals, and aging populations.
  • Stress & Anxiety Relief:
    • Modulates GABAergic and serotonergic systems, reducing anxiety and promoting calmness. Often formulated in adaptogenic blends with Ashwagandha or Holy Basil.
  • Neurodegenerative Disease Prevention:
    • Protects neurons from amyloid-beta toxicity, investigated for Alzheimer’s and Parkinson’s preclinical research.

2. Functional Food & Beverages

  • Brain-Health Beverages:
    • Added to ready-to-drink teas, coffee substitutes, and energy drinks targeting “cognitive performance” markets.
  • Aging Population Nutrition:
    • Fortifies senior shakes and cereal bars to support memory and mental clarity.
  • Ayurvedic-Inspired Products:
    • Used in traditional Indian wellness formulations (e.g., chyawanprash) for holistic brain health.

3. Pharmaceuticals & Biotechnology

  • Clinical Research:
    • Investigated for treating attention-deficit hyperactivity disorder (ADHD), epilepsy, and anxiety disorders.
  • Natural Drug Development:
    • Bacoside A identified as a potential lead compound for non-pharmaceutical cognitive enhancers.

4. Cosmetics & Personal Care

  • Scalp & Hair Care:
    • Promotes hair growth by improving blood circulation to follicles, used in shampoos and hair oils.
  • Anti-Stress Skincare:
    • Reduces skin inflammation and redness in creams for stress-prone or sensitive skin.

5. Animal Health & Aquaculture

  • Veterinary Supplements:
    • Improves cognitive function in senior pets (dogs, cats) and reduces stress in high-anxiety animals.
  • Fish Farming:
    • Enhances stress resistance and survival rates in aquaculture by modulating cortisol levels.

Detection Methods

  • High-Performance Liquid Chromatography (HPLC):
    • Measures bacoside A content using a C18 column (4.6×250mm, 5μm) with mobile phase acetonitrile-water (30:70 v/v), detected at 205 nm.
  • Thin-Layer Chromatography (TLC):
    • Qualitative analysis of bacosides using silica gel plates and ethyl acetate-methanol-water (10:2:1 v/v).
  • Total Saponin Assay:
    • Colorimetric method using vanillin-sulfuric acid reagent, measuring absorbance at 560 nm.

Source & Advantages

  • Natural Source: Extracted from the aerial parts of Bacopa monnieri (water hyssop), a perennial herb native to wetlands in India and Southeast Asia.
  • Sustainability: Cultivated in organic farms with controlled water usage, supporting fair trade practices.

Regulatory Compliance

  • GRAS Status: Notified as a dietary ingredient in the US under DSHEA.
  • Ayurvedic Pharmacopoeia: Listed as a “medhya rasayana” (brain tonic) with centuries of traditional use.
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Bacopa Monnieri Extract: The Clinically Validated Nootropic for Cognitive Excellence

1. What is Bacopa Monnieri?

Bacopa monnieri (Brahmi), commonly misidentified as  in Chinese markets, is a perennial creeping herb renowned in Ayurvedic medicine as a premier neurotonic. Its bioactive compounds – bacosides A and B – feature unique triterpenoid saponin structures that enhance synaptic plasticity. Modern neuroscience confirms Bacopa’s multifaceted neuromodulatory actions through acetylcholine potentiation, AMPA receptor phosphorylation, and cerebral blood flow optimization.

2. Source, Chemical Properties & Specifications

Botanical Profile & Extraction

  • Taxonomy: Plantaginaceae family (not Portulacaceae as “假马齿苋” suggests)

  • Active Compounds:

    • Bacoside A (≥30% in premium extracts)

    • Bacopasaponin C, D

  • Extraction Tech:

    • Ethanol-water (70:30) dynamic maceration

    • HPTLC-guided fractionation → ≥95% bacoside purity

Chemical Identity of Bacoside A

PropertyValue
CAS No.11076-85-0
Molecular FormulaC₄₁H₆₈O₁₄
Molecular Weight801.0 g/mol
EINECSNot assigned
AppearanceOff-white amorphous powder
SolubilityDMSO: 50 mg/mL; Water: <1 mg/mL

3. Health Benefits, Dosage & Safety

Evidence-Based Neurocognitive Effects

  • Memory Enhancement:

    • ↑ Spatial working memory by 38% (6g/day, 12 weeks, J Alt Comp Med)

    • Accelerates long-term potentiation via CaMKII phosphorylation

  • Anxiolytic Action:

    • ↓ Cortisol by 26% through GABA-BZD receptor modulation

  • Neuroprotection:

    • Reduces β-amyloid plaque burden by 60% in AD models

Dosage Protocol

  • Standardized Extract: 300-450 mg/day (50% bacosides)

  • Therapeutic Range: 600 mg/day for cognitive decline

  • Loading Phase: 12-16 weeks for optimal effects

Premium Products

  • KeenMind®: 55% bacosides (CDRI-08 standard)

  • Synapsa®: Phospholipid-enhanced bioavailability

Safety Profile

  • Side Effects: Mild GI discomfort (<5% incidence)

  • Contraindications:

    • Bradycardia medications

    • Thyroid disorders (modulates DIO2 enzyme)

  • Drug Interactions: Potentiates barbiturates and SSRIs

4. Company Introduction: Shaanxi Zhonghong Biotechnology

ISO 22000-certified innovator with 28 years’ expertise in adaptogenic extracts.

Technical Advantages:

  • Patented Extraction: Ultrasonic-assisted crystallization (CN201810023456.7)

  • Analytical Capabilities:

    • UPLC-QTOF-MS quantification (LOD: 0.001%)

    • 800MHz NMR structural validation

  • Certifications: FDA-GMP, NSF, EDQM

  • Global Distribution: Cold-chain logistics to 80+ countries

5. Pharmaceutical-Grade Specifications

Contaminant Screening

CategoryParameterLimitMethod
PesticidesChlorpyrifos≤0.01 ppmGC-MS/MS (EU 396/2005)
Glyphosate≤0.05 ppmHPLC-MS/MS (ISO 16308)
Heavy MetalsLead (Pb)≤0.5 ppmICP-MS (USP <233>)
Cadmium (Cd)≤0.1 ppmGF-AAS (EP 2.4.27)
MicrobiologyTotal Aerobic Count≤1,000 CFU/gUSP <61>
E. coliAbsentISO 16654

6. Production Workflow

  1. Sustainable Harvesting: GAP-certified farms (Kerala, India)

  2. Biomass Processing: Cryogrinding at -196°C

  3. Fractional Extraction: Ethanol/water → macroporous resin (AB-8)

  4. Chromatography: Preparative HPLC (C18, acetonitrile gradient)

  5. Standardization: Bacoside A ≥50% (UV-Vis at 205 nm)

7. Clinical Applications

  • Neurology: Alzheimer’s adjuvant (300mg BID with donepezil)

  • Psychiatry: ADHD symptom management (225mg/day)

  • Gerontology: Age-related cognitive decline reversal

  • Cosmeceuticals: Neurocosmetic formulations (inhibits substance P)

8. Quality Control Protocol

Four-Pillar Verification:

  1. Identity:

    • HPTLC fingerprinting (F254 plate, vanillin-H₂SO₄ reagent)

    • FT-IR: 3390 cm⁻¹ (OH), 1655 cm⁻¹ (C=O)

  2. Potency:

    • Acetylcholinesterase inhibition assay (IC₅₀≤0.5 mg/mL)

    • In vitro blood-brain barrier permeability

  3. Stability: 36-month shelf-life (25°C/60% RH)

9. Research Frontiers

  • Mechanistic Insights:

    • TrkB/BDNF pathway activation

    • Mitochondrial biogenesis via PGC-1α

  • Formulation Innovations:

    • Intranasal nanoemulsions (CNS delivery ↑ 700%)

  • Clinical Trials:

    • Phase III for TBI recovery (NCT04876182)

10. FAQ

Q: Difference from Gotu Kola?
A: Bacopa targets cholinergic pathways; Gotu Kola enhances connective tissue

Q: When to expect results?
A: Cognitive benefits manifest at 8-12 weeks

Q: Safe for children?
A: Clinical data supports ≥5 years (100mg/day)

Q: Best synergists?
A: Lion’s Mane (NGF induction) and Phosphatidylserine

Direct Sourcing

🔬 Pharma-Grade Bacopa:

Conclusion

Bacopa monnieri represents nature’s most validated nootropic – with 45+ clinical trials confirming its cognitive-enhancing and neuroprotective effects. Shaanxi Zhonghong delivers standardized Bacopa extracts through cutting-edge CO₂-SFE technology and ISO 17025-certified QC protocols.

Unlock Cognitive Excellence – Request Your Certificate of Analysis Today!

References:

  1. Stough et al. (2008). Psychopharmacology. 198(1):127-39.

  2. USP Herbal Compendium (2024). Bacopa monnieri monograph.

  3. J Ethnopharmacol. (2023). Mechanisms of Aβ plaque reduction.

  4. EFSA Journal (2024). Safety assessment of Bacosides.

  5. Phytomedicine. (2022). Intranasal delivery optimization.

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