Quercetin
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Quercetin Supplements​

Quercetin Dietary supplements​ – Excessive-Purity Flavonoid Compound supplier bulk manufacturing unit Wholesale Extract manufacturing unit

  1. English Name: Quercetin
  1. Specification
    • Purity: Quercetin ≥ 98% (HPLC)
    • Water-soluble Kind: Quercetin glycosides (e.g., rutin) or nanoemulsion – primarily based formulations, solubility enhanced as much as 10 g/L by way of encapsulation
    • Particle Dimension: Commonplace powder ≤100 μm; micronized variations ≤5 μm for higher bioavailability
  1. Appearance
    • Powder: Yellow to orange – yellow crystalline powder, odorless, barely bitter style
  1. CAS NO.：117-39-5
  1. Lead time: 3 – 7 Working Days
  1. Package
    • 1 kg/bag (aluminum foil bag), 25 kg/drum (double – layer PE bag inside cardboard drum)
  1. Main Market: North America, Europe, Asia, South America
  1. Application Scenarios

Core Properties

  • Molecular Components: C₁₅H₁₀O₇
  • Solubility: Sparingly soluble in water (0.1 g/L at 25°C); soluble in ethanol, DMSO; water – soluble derivatives enhance usability in aqueous programs
  • Key Options
    • Potent Antioxidant: Scavenges free radicals (e.g., hydroxyl, superoxide), with an ORAC worth of ~5000 μmol Trolox equivalents/g.
    • Anti – inflammatory: Inhibits professional – inflammatory enzymes (COX – 2, iNOS) and cytokines (TNF – α, IL – 6).
    • Phytoestrogenic Exercise: Weak estrogen – like results, helpful for menopausal symptom administration.
    • Antimicrobial: Displays exercise towards micro organism (e.g., Staphylococcus aureus) and fungi (e.g., Candida albicans).

Application Scenarios

1. Dietary Dietary supplements

  • Basic Well being Formulation:
    • Capsules or tablets (250 – 500 mg per serving) bought as antioxidant and immune – boosting dietary supplements.
    • Usually mixed with vitamin C and zinc for enhanced efficacy throughout chilly and flu seasons.
  • Specialty Well being Merchandise:
    • Joint well being dietary supplements (500 – 1000 mg/day) to cut back irritation in arthritis sufferers.
    • Cardiovascular help formulation, as it could assist decrease blood stress and levels of cholesterol.

2. Practical Meals & Drinks

  • Antioxidant – Fortified Merchandise:
    • Added to juices, teas, and vitality drinks at 50 – 100 mg/L to extend antioxidant content material.
    • Utilized in “clear – label” snacks (e.g., granola bars) as a pure preservative and nutrient enhancer.
  • Plant – Based mostly Meat Alternate options:
    • Inhibits lipid oxidation, extending the shelf – lifetime of plant – primarily based proteins and bettering taste stability.

3. Cosmetics & Private Care

  • Anti – getting older Skincare:
    • Serums and lotions (0.5 – 2% focus) to guard towards UV – induced harm, cut back wrinkles, and promote collagen synthesis.
    • Soothing formulations for delicate pores and skin, leveraging its anti – inflammatory properties.
  • Hair Care:
    • Shampoos and conditioners to strengthen hair follicles and cut back dandruff by combating scalp irritation.

4. Prescribed drugs

  • Investigational Therapies:
    • Studied for its potential in treating neurodegenerative illnesses (e.g., Alzheimer’s, Parkinson’s) resulting from neuroprotective results.
    • Investigated as an adjuvant in most cancers therapy, enhancing the efficacy of chemotherapy whereas lowering unwanted side effects.
  • Over – the – Counter (OTC) Medicines:
    • Utilized in topical lotions for gentle pores and skin irritations and allergy symptoms, offering anti – inflammatory and antioxidant aid.

5. Animal Well being

  • Livestock Feed Components:
    • Added to poultry and swine feed (100 – 500 ppm) to enhance development efficiency, cut back oxidative stress, and improve meat high quality.
  • Pet Dietary supplements:
    • Formulated in chewable tablets for canine and cats to help joint well being and immune perform.

Detection Strategies

  • Excessive – Efficiency Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Cell Section: Acetonitrile – 0.1% phosphoric acid (35:65 v/v), Circulation Fee: 1.0 mL/min, Detection Wavelength: 360 nm.
  • Mass Spectrometry (MS):
    • Utilized in mixture with HPLC (HPLC – MS) to substantiate molecular construction and detect hint impurities.
  • FTIR Spectroscopy:
    • Identifies attribute purposeful teams (e.g., hydroxyl, carbonyl) to confirm product identification.

Supply & Benefits

  • Natural Supply: Extracted from numerous vegetation, together with Sophora japonica flowers, onions, apples, and grapes.
  • Sustainability: Might be sourced from agricultural by – merchandise (e.g., onion skins), lowering waste.
  • Multi – purposeful: Its various bioactivities make it appropriate for functions throughout a number of industries.

Regulatory Compliance

  • US FDA: Regulated as a dietary complement ingredient underneath DSHEA (Dietary Complement Well being and Training Act).
  • EU Regulation: Permitted as a meals additive and dietary complement ingredient, topic to security evaluations.
  • China NMPA: Permitted to be used in purposeful meals and dietary dietary supplements, with particular utilization limits.
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Quercetin Dietary supplements​: The Premier Flavonoid Powerhouse – Final Information & Premium Supply| Supplier & Manufacturer

1. What is Quercetin?
Quercetin is a dietary flavonol belonging to the polyphenolic compounds subclass. As a potent plant pigment, it serves vital roles in UV safety and stress response in botanicals. In human physiology, it displays multifunctional bioactivity, appearing as a grasp antioxidant, anti-inflammatory agent, and mobile signaling modulator. Its distinctive catechol construction and α,β-unsaturated carbonyl group allow distinctive free radical scavenging and metallic chelation capabilities.

2. Supply, Chemical Properties & Identification

  • Main Natural Sources (Highest Concentrations):

    • Sophora japonica Buds: Richest supply (as much as 20% dry weight)

    • Onion Skins (Allium cepa): Significantly purple onions (1-1.5%)

    • Ginkgo biloba Leaves: Standardized extracts (22-26%)

    • Apple Peel (Malus domestica): Key supply of quercetin glycosides

    • Different Sources: Capers, lovage, elderberries, buckwheat, tea

  • Chemical Properties:

    • CAS Quantity: 117-39-5

    • Molecular Components: C₁₅H₁₀O₇

    • Molecular Weight: 302.24 g/mol

    • EINECS Quantity: 204-187-1

    • Appearance: Yellow crystalline powder

    • Solubility: Insoluble in water; soluble in ethanol, DMSO, lipids (when complexed)

    • Stability: Delicate to UV mild and alkaline circumstances; degrades above 160°C

3. Benefits, Efficacy, Dosage & Security

  • Optimum Sources & Bioavailability: Sophora japonica extracts ship the very best pure concentrations (95-98% purity). Bioavailability is enhanced by phospholipid complexation (Quercetin Phytosome®) or liposomal encapsulation, growing absorption by 5-20x vs. commonplace powder.

  • Validated Well being Benefits & Mechanisms:

    • Systemic Antioxidant Protection: Modulates Nrf2/ARE pathway, upregulating glutathione synthesis and superoxide dismutase (SOD)

    • Anti-Inflammatory Motion: Inhibits COX-2, LOX, and NF-κB signaling pathways, decreasing pro-inflammatory cytokines (TNF-α, IL-6)

    • Immune Modulation: Stabilizes mast cells, reduces histamine launch through cAMP phosphodiesterase inhibition

    • Cardiometabolic Assist: Improves endothelial perform by eNOS activation, inhibits LDL oxidation

    • Viral Protection: Demonstrated 3CL protease inhibition in opposition to coronaviruses in vitro

  • Medical Dosage:

    Formulation Each day Dose Length
    Commonplace Powder 500-1000 mg 8-12 weeks
    Phytosome® 250-500 mg Steady
    Acute Immune Assist As much as 3000 mg ≤5 days

  • Security Profile:

    • GRAS standing (FDA)

    • Keep away from concomitant use with CYP3A4 substrates (cyclosporine, warfarin)

    • Potential renal toxicity at >5g/day

    • Being pregnant Class C

4. Shaanxi Zhonghong: Quercetin Excellence
Leveraging 28 years in bioactive phytochemistry, Shaanxi Zhonghong Investment Technology Co., Ltd. pioneers quercetin manufacturing by:

  • Core Improvements:

    • Glycoside-to-Aglycone Conversion: Patented enzymatic hydrolysis for >98% aglycone purity

    • Nanocrystallization Know-how: 200nm particle measurement for enhanced solubility

    • Phytosome® Manufacturing: Validated complexation with sunflower phospholipids

  • High quality Infrastructure:

    • UPLC-QTOF-MS for isomer profiling

    • cGMP and ISO 22000 licensed amenities

    • Batch traceability through blockchain expertise

5. Product Specification (Pharmaceutical Grade)

Class Parameter Specification Check Technique
Purity Quercetin Aglycone ≥98.0% HPLC-DAD (EP 10.0)
Heavy Metals Lead (Pb) ≤1.0 ppm ICP-MS (USP <233>)
Cadmium (Cd) ≤0.5 ppm ICP-MS
Arsenic (As) ≤1.0 ppm ICP-MS
Pesticides Chlorpyrifos ≤0.01 ppm GC-MS/MS
Cypermethrin ≤0.02 ppm GC-MS/MS
Complete 186 Pesticides Detrimental EU SANTE/11813/2017
Microbiology Complete Cardio Depend ≤1000 CFU/g USP <61>
Yeast & Mildew ≤100 CFU/g USP <61>
Enterobacteriaceae Absent/10g ISO 21528-2

6. Superior Manufacturing Workflow

  1. Botanical Sourcing: DNA-authenticated Sophora japonica buds

  2. Multistage Extraction: Ethanol/water (70:30) at 45°C with microwave help

  3. Macroporous Resin Chromatography: AB-8 resin for flavonoid isolation

  4. Enzymatic Bioconversion: β-glucosidase remedy (45°C, pH 5.0)

  5. Crystallization Management: Anti-solvent precipitation at 4°C

  6. Nanomilling: Moist-milling to D90 < 250nm

  7. Phospholipid Complexation (Optionally available): 1:1 ratio with phosphatidylcholine

  8. Lyophilization: -40°C main drying

7. Application Matrix

Business Formulation Examples Useful Position
Nutraceuticals Immune complexes, sports activities formulation Oxidative stress discount
Prescription drugs Antiviral adjuvants, cardioprotectives Endothelial perform modulation
Cosmeceuticals Anti-pollution serums, UV protectants MMP inhibition
Useful Meals Stability-enhanced drinks Shelf-life extension

8. Mechanism & Medical Proof

  • Mitochondrial Biogenesis: Prompts SIRT1/PGC-1α pathway (5-15% improve in ATP manufacturing)

  • Senescence Modulation: Reduces p16INK4a expression in human fibroblasts

  • Viral Inhibition: IC₅₀ = 7.6 μM in opposition to SARS-CoV-2 3CL protease

  • Cardiometabolic Results: 12% LDL discount in hyperlipidemic sufferers (500mg/day, 8 weeks)

9. Technological Frontiers

  • Bioavailability Options:

    • Quercetin-β-cyclodextrin complexes (water solubility: 35 mg/mL)

    • Strong lipid nanoparticles (90% oral bioavailability)

  • Inexperienced Chemistry:

    • Subcritical water extraction (SWE) at 120°C/50 bar

    • Enzyme-assisted deep eutectic solvent techniques

10. Analysis Challenges

  • Pharmacokinetics: Quick plasma half-life (3-4 hours)

  • Medical Translation: Restricted Part III trials for immune claims

  • Regulatory Standing: Novel Meals authorization required in EU

11. FAQ

  1. Q: Why select Sophora japonica-derived quercetin?
    A: Superior focus profile (98% vs. 70% in onion extracts) and decrease pesticide danger.

  2. Q: The best way to overcome bioavailability limitations?
    A: Our phytosome expertise achieves Cₘₐₓ 4.3x greater than commonplace powder.

  3. Q: Validated immune help dosage?
    A: 500-1000mg/day prophylactic; 3000mg/day acute part (max 5 days).

  4. Q: Stability in formulations?
    A: Nanoencapsulated type retains >90% efficiency at 25°C/60% RH for twenty-four months.

  5. Q: GMP compliance?
    A: Manufactured underneath ICH Q7 pointers with ISO 17025 accredited QC.

12. Procurement Info

  • Technical Dossiers: liaodaohai@gmail.com

  • Order Portal: aiherba.com/quercetin

  • MOQ: 1kg (R&D), 10kg (business)

  • Logistics: -20°C validated chilly chain transport

13. Conclusion
Quercetin represents the apex of flavonoid bioactivity with clinically validated impacts on immune competence, metabolic well being, and oxidative resilience. Shaanxi Zhonghong’s vertically built-in manufacturing—from DNA-verified Sophora japonica to nanoparticle-enhanced supply techniques—ensures unprecedented purity (≥98%) and bioavailability. Our patented enzymatic conversion expertise and cGMP-compliant manufacturing ship benchmark materials compliant with USP, EP, and JP monographs. Accomplice with our 28-year experience for quercetin options powering next-generation nutraceuticals, prescription drugs, and useful meals.

14. References

  1. Li Y, et al. (2021). Molecules. 26(9):2507. [Bioavailability]

  2. Colunga Biancatelli RML, et al. (2020). Entrance Immunol. 11:1451. [Antiviral]

  3. EFSA Panel (2020). EFSA Journal. 18(1):e05993.

  4. Anand David AV, et al. (2016). J Meals Sci. 81(10):R2501. [Metabolism]

  5. Zhonghong Technical File QRC-2024. aiherba.com/docs/QRC-Spec

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