Isatis Root Extract
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Isatis Root Extract

Isatis Indigotica Root Extract (Banlangen Extract)

  1. English Name: Isatis Indigotica Root Extract (it’s most commonly called “Banlangen Extract” in TCM and Asian markets—named after its Chinese herbal name “板蓝根，” which refers to the thick, fleshy roots of the Isatis indigotica plant)
  1. Specification
    • Active Content: Standardized to ≥ 5% indole alkaloids (HPLC tested—includes key compounds like indigotin and indirubin, which drive its immune benefits)
    • Solubility: Easily soluble in water and ethanol (perfect for herbal teas, liquid supplements, or throat sprays)
    • Moisture: ≤ 8% (keeps it dry, no clumping or losing its herbal potency)
    • Heavy Metals: ≤ 10 ppm (safe for oral use—meets strict TCM and food supplement standards)
    • Purity: No additives, sulfites, or artificial colors—just pure extract from dried Isatis indigotica roots
  1. Appearance: Brown to dark brown fine powder with a mild, earthy, slightly bitter aroma—definitely no chocolate aroma! It smells like dried Banlangen roots—familiar to anyone who’s had traditional Banlangen herbal tea, subtle and herbal.
  1. CAS NO.: N/A (it’s a mixed herbal extract with multiple active compounds; individual components like indigotin have CAS 482-89-3, but the full extract has no single CAS number)
  1. Lead time: 3-7 Working Days (we keep standard Banlangen extract in stock year-round, so you won’t wait long for this immune-support staple)
  1. Package: Small sizes: 100g/1kg resealable pouches (great for home herbal teas or small-batch products); bulk: 25kg paper drums (food-grade lined—locks in freshness and prevents moisture damage)
  1. Main Market: Asia (especially China, Japan, Korea), Europe, North America—anywhere people trust TCM or natural immune support! Super popular in cold/flu supplements, herbal teas, and throat care products.
  1. Application Scenarios

Key Features

  • TCM Immune Classic: Used in TCM for over 2,000 years to support immune health—especially for seasonal colds, sore throats, or mild fevers
  • Root-Sourced Potency: Extracted from mature Isatis indigotica roots (harvested after 2-3 years, when active compounds are most concentrated)
  • Gentle for Daily Use: Well-tolerated by kids and adults—no harsh side effects, even during short-term immune support
  • Easy to Use: Dissolves in hot water (makes instant Banlangen tea) or mixes into supplements—fits busy daily routines
  • Clean Label Friendly: 100% plant-based, vegan, gluten-free, and non-GMO—fits TCM traditions and modern “clean herbal” trends

Industry Applications

  1. Dietary Supplements
    • Immune Support Capsules/Powders: Most common use—500-1000mg per serving (taken at the first sign of colds or flu, or for seasonal immune maintenance)
    • Cold & Flu Blends: Mixed with other TCM herbs like honeysuckle (Lonicera japonica) or chrysanthemum (Chrysanthemum morifolium) for stronger throat and respiratory support
    • Kids’ Immune Products: Added to chewable tablets or fruit-flavored powders (masks slight bitterness—easy for kids to take during back-to-school season)
  1. Herbal Beverages
    • Banlangen Tea Bags: Pre-mixed into single-serve tea bags (steep in hot water for 5 minutes—classic way to use Banlangen for sore throats)
    • Wellness Shots: Diluted in “immune shots” (mixed with ginger or lemon to balance bitterness—quick on-the-go support)
    • Herbal Tonics: Added to warm tonics (paired with honey for sweetness—popular during winter cold seasons)
  1. Throat & Respiratory Care
    • Throat Sprays: 5-10% concentration in herbal throat sprays (soothes sore throats instantly—no alcohol burn)
    • Lozenges: Mixed into sugar-free lozenges (dissolves slowly in the mouth—provides long-lasting throat comfort)
    • Respiratory Syrups: Added to herbal cough syrups (supports immune health while easing mild coughs)
  1. Traditional Wellness Products
    • TCM Decoctions: A key ingredient in TCM liquid decoctions (simmered with other herbs for customized immune support—prescribed by TCM practitioners)
    • Herbal Pastes: Made into thick herbal pastes (mixed with brown sugar—traditional way to give Banlangen to kids or elderly)
  1. Pet Wellness
    • Pet Immune Powders: Tiny doses (50-100mg) in dog/cat immune supplements (supports pets’ natural defenses during cold weather—safe for small animals)
    • Pet Throat Care: Diluted in pet water additives (soothes mild throat irritation in dogs—especially after excessive barking)
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Isatis Root Extract: Premium Traditional Ingredient for Pharmaceutical & Nutraceutical Applications – Manufacturer & Exporter Guide

1. What is Isatis Root Extract?

For manufacturers in the pharmaceutical and nutraceutical industries seeking traditional Chinese medicine ingredients with modern scientific validation, Isatis Root Extract offers a powerful solution. Derived from the roots of Isatis indigotica Fort. (known as Ban Lan Gen in Traditional Chinese Medicine), this extract contains a complex profile of bioactive compounds that have been used for centuries in Eastern medicine. Today, it’s gaining global recognition for its unique properties and potential health benefits, making it an increasingly valuable ingredient for evidence-based formulations.

2. Source, Chemistry & Specifications

  • Source: Carefully extracted from the roots of Isatis indigotica Fort.

  • Key Bioactive Compounds:

    • Indirubin: Potent anti-inflammatory and anti-proliferative properties

    • Indigo: Natural pigment with therapeutic benefits

    • Isatan B: Precursor to indigo with biological activity

    • Polysaccharides: Immune-modulating effects

  • Chemical Profile: As a complex botanical extract, it contains multiple active compounds rather than a single molecule

  • Appearance: Brown to dark brown fine powder

  • Solubility: Water-soluble and alcohol-soluble components

3. The Professional Standard: Why Our Isatis Root Extract Excels
For B2B clients in pharmaceutical and nutraceutical manufacturing, our Isatis Root Extract delivers consistent quality and efficacy:

  • Key Advantages:

    • Standardized Active Compounds: Consistent levels of indirubin and other markers

    • Traditional Knowledge + Modern Science: Combines historical use with contemporary research

    • Multi-Target Action: Works through multiple biological pathways

  • Research-Supported Benefits:

    • Immune System Support: Modulates immune response

    • Anti-inflammatory Effects: Reduces inflammatory markers

    • Antioxidant Protection: Scavenges free radicals

    • Respiratory Health: Supports respiratory system function

  • Recommended Usage: 100-500 mg daily in supplements; specific dosage depends on formulation goals

  • Certifications Available: cGMP, ISO 9001, Organic, Kosher

  • Target Applications: Immune support supplements, respiratory health products, anti-inflammatory formulations

  • Safety Profile: Generally well-tolerated with proper usage; consult healthcare professional for specific cases

4. Zhonghong Biotech: Your Traditional Medicine Expert
Sourcing authentic, high-quality Isatis Root Extract requires specialized expertise. Shaanxi Zhonghong Investment Technology Co., Ltd. combines 28 years of traditional medicine knowledge with modern extraction technology to deliver superior botanical extracts to global markets.

  • Technical Capabilities:

    • Authenticity Verification: Botanical authentication and traceability

    • Advanced Extraction: Optimized extraction methods for maximum bioactive retention

    • Quality Assurance: Comprehensive testing from raw material to finished product

  • Global Compliance: Full documentation meeting international regulatory requirements

5. Scientific Validation: Mechanism of Action
Isatis Root Extract’s efficacy stems from its complex phytochemical profile:

  • Modulates NF-κB and other inflammatory pathways

  • Enhances immune cell activity and cytokine production

  • Provides antioxidant protection through multiple mechanisms

  • Supports respiratory health through various biological actions

6. Pharmaceutical-Grade Quality Assurance
Our rigorous quality control ensures every batch meets the highest standards:

Certificate of Analysis (COA) Summary – Isatis Root Extract

Category Parameter Specification Test Method
Identity HPLC Fingerprint Matches Reference HPLC-DAD
Assay Total Flavonoids ≥ 10.0% UV-Vis
Safety Heavy Metals ≤ 10 ppm ICP-MS
Pesticide Residues Meet EPA Standards GC-MS/MS
Microbiology Total Plate Count ≤ 10,000 CFU/g USP <61>
Yeast/Mold ≤ 100 CFU/g USP <61>
Pathogens Absent USP <62>

7. Advanced Manufacturing Process
Our optimized processing ensures maximum bioactive preservation:

  1. Raw Material Selection: Authenticated Isatis indigotica roots from certified growers

  2. Extraction: Optimized solvent extraction for maximum yield

  3. Concentration: Low-temperature vacuum concentration

  4. Purification: Removal of impurities while retaining actives

  5. Spray Drying: Conversion to stable powder form

  6. Quality Control: Comprehensive analytical testing

8. Professional Applications

  • Pharmaceuticals: Immune support formulations, respiratory health products

  • Nutraceuticals: Dietary supplements, health products

  • Traditional Medicine: TCM formulations and products

  • Cosmeceuticals: Anti-inflammatory skincare products

9. Global Supply Chain Excellence

  • Packaging: 1kg double-bagged with oxygen absorbers, 25kg fiber drums

  • Storage: Cool, dry conditions away from direct light

  • Shelf Life: 24 months when stored properly

  • Logistics: Global shipping with full documentation support

10. Partnership Opportunities
We offer:

  • Custom extract ratios and standardizations

  • Private labeling and custom formulations

  • Technical support for product development

  • Regulatory documentation for market access

Contact Our Team:

11. Technical FAQ

  • Q: What’s the difference between your extract and others on the market?
    A: Our extract maintains the full spectrum of active compounds while ensuring consistent standardization

  • Q: Can you provide different standardizations?
    A: Yes, we can customize extracts based on specific marker compounds

  • Q: What documentation do you provide?
    A: Full COA, MSDS, and regulatory support documents

  • Q: Do you offer organic certification?
    A: Yes, we offer both conventional and certified organic options

  • Q: What’s your minimum order quantity?
    A: MOQ is 1kg for samples, 25kg for production quantities

12. Professional Conclusion
Isatis Root Extract represents a unique combination of traditional wisdom and modern scientific validation. Zhonghong’s expertise in traditional medicine extraction and quality control ensures consistent, high-quality material for pharmaceutical and nutraceutical applications.

Contact us today for technical specifications and samples.

References:

  1. Lin, C.W., et al. (2018). Anti-inflammatory effects of Isatis indigotica root extracts. Journal of Ethnopharmacology

  2. Ho, Y.L., et al. (2020). Immunomodulatory effects of Isatis indigotica. Phytomedicine

  3. Chinese Pharmacopoeia Commission. (2020). Pharmacopoeia of the People’s Republic of China

  4. World Health Organization. (2019). WHO monographs on selected medicinal plants

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