Gastrodia Phenolic Compounds
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Gastrodia Phenolic Compounds

Gastrodia Phenolic Compounds supplier bulk factory Wholesale Extract factory

  1. English Name: Gastrodia Phenolic Compounds
  1. Specification
    • Total Phenolic Content: ≥ 15 – 30% (Folin – Ciocalteu method)
    • Major Components: p – Hydroxybenzaldehyde ≥ 5% (HPLC), p – Hydroxybenzoic acid ≥ 3% (HPLC), vanillic acid ≥ 2% (HPLC)
    • Water – soluble Powder: Solubility ≥ 90% in water, moisture ≤ 5%
  1. Appearance
    • Light brown to yellowish – brown fine powder, mild herbal odor
  1. CAS NO.
    • p – Hydroxybenzaldehyde: 123 – 08 – 0
    • p – Hydroxybenzoic acid: 99 – 96 – 7
    • vanillic acid: 121 – 34 – 6
  1. Lead time: 3 – 7 Working Days
  1. Package
    • 1 kg/bag (aluminum foil bag), 25 kg/drum (double – layer PE bag inside cardboard drum)
  1. Main Market: Asia (China, Japan, South Korea), North America, Europe
  1. Application Scenarios

Core Properties

  • Molecular Structure: Composed of various phenolic acids and aldehydes with a benzene ring and hydroxyl groups
  • Solubility: Soluble in water, ethanol, and methanol; water – soluble formulations are ideal for beverage and pharmaceutical applications
  • Key Features
    • Antioxidant: Scavenges free radicals such as DPPH and hydroxyl radicals, with an ORAC (Oxygen Radical Absorbance Capacity) value of 2000 – 3500 μmol Trolox equivalents/g.
    • Anti – inflammatory: Inhibits the production of pro – inflammatory cytokines like TNF – α and IL – 6.
    • Neuroprotective: Protects neurons from oxidative stress and apoptosis, potentially beneficial for neurodegenerative diseases.
    • Antimicrobial: Exhibits inhibitory activity against certain bacteria and fungi, such as Staphylococcus aureus and Candida albicans.

Application Scenarios

1. Pharmaceuticals

  • Neurological Disorder Treatment:
    • Investigated for the treatment of stroke and epilepsy, as the neuroprotective properties help reduce brain damage and prevent seizure recurrence.
    • Used in combination with other drugs to enhance the treatment effect of Alzheimer’s disease by reducing oxidative stress in the brain.
  • Anti – inflammatory Formulations:
    • Incorporated into topical creams and ointments to relieve skin inflammation, such as eczema and dermatitis.

2. Dietary Supplements

  • Antioxidant Supplements:
    • Capsules or tablets containing 200 – 500 mg of phenolic compounds in Gastrodia, marketed for general health maintenance and anti – aging, often combined with other antioxidants like vitamin C and E.
  • Brain Health Formulas:
    • Added to nootropic supplements to support cognitive function, memory, and focus.

3. Cosmetics & Personal Care

  • Anti – aging Products:
    • Serums and moisturizers (2 – 5% concentration) to protect skin from UV – induced damage, reduce the appearance of fine lines and wrinkles, and promote skin elasticity.
  • Antibacterial Skincare:
    • Used in facial cleansers and acne treatments to inhibit the growth of acne – causing bacteria.

4. Functional Food & Beverages

  • Antioxidant – Rich Beverages:
    • Added to fruit juices, tea – based drinks, and energy drinks at 0.5 – 1% concentration to enhance the antioxidant capacity and extend shelf life.
  • Fortified Foods:
    • Incorporated into baked goods, cereals, and snacks to increase their nutritional value and provide health – promoting benefits.

Detection Methods

  • High – Performance Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% phosphoric acid (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 280 nm for p – Hydroxybenzaldehyde, 254 nm for p – Hydroxybenzoic acid, and 325 nm for vanillic acid.
  • Folin – Ciocalteu Assay:
    • A colorimetric method to determine the total phenolic content, measuring absorbance at 765 nm.
  • Mass Spectrometry (MS):
    • Used in combination with HPLC (HPLC – MS) to confirm the molecular structure and identify trace phenolic compounds.

Source & Advantages

  • Natural Source: Extracted from the rhizomes of Gastrodia elata Blume, a traditional Chinese medicinal herb.
  • Multi – functional Benefits: Their diverse bioactivities make them suitable for various applications from medicine to consumer products.
  • Traditional Use Validation: With a long history of use in traditional Chinese medicine, it provides a reliable foundation for modern applications.

Regulatory Compliance

  • China NMPA: Approved as a dietary supplement ingredient and used in traditional Chinese medicine formulations.
  • US FDA: Regulated as a dietary ingredient when used in supplements, subject to Good Manufacturing Practice (GMP) requirements.
  • EU Cosmetic Regulation: Allowed as a cosmetic ingredient, with restrictions on maximum concentration in different product types.
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Gastrodia Phenolic Compounds: The Neuroprotective Powerhouse from Tian Ma

1. What Are Gastrodia Phenolic Compounds?

Gastrodia phenolic compounds are a bunch of bioactive phytochemicals primarily derived from Gastrodia elata Blume (天麻/Tian Ma), a revered medicinal orchid in Conventional Chinese language Medication (TCM). These compounds, together with gastrodin, parishins, and vanillyl alcohol derivatives, are clinically validated for his or her neuroprotective, antioxidant, and anti inflammatory properties, making them invaluable in fashionable nutraceuticals, prescription drugs, and cosmeceuticals.

2. Supply, Chemical Properties & Key Identifiers

Major Supply

  • Botanical Origin: Gastrodia elata Blume (Orchidaceae household)

  • Plant Half Used: Dried rhizomes (underground stems)

  • Geographical Distribution: Yunnan, Guizhou, and Sichuan provinces (China) yield the highest-quality specimens

Key Chemical Constituents

Compound Chemical Class Relative Abundance
Gastrodin Phenolic glycoside 40-60% of complete phenolics
Parishin A/B/C Gastrodin oligomers 15-25%
Vanillyl alcohol Easy phenol 5-10%
4-Hydroxybenzyl alcohol Benzyl spinoff 3-8%

Physicochemical Properties

  • Appearance: White to mild yellow crystalline powder (gastrodin), brown viscous extract (complete phenolics)

  • Solubility: Water-soluble (gastrodin), ethanol-soluble (parishins)

  • Stability: Delicate to UV mild and oxidation; requires antioxidant safety

Regulatory Identifiers

Parameter Gastrodin Whole Phenolics
CAS Quantity 62499-27-8 Not assigned (combination)
Molecular Method C₁₃H₁₈O₇ Variable
Molecular Weight 286.28 g/mol 200-1000 Da
EINECS 263-618-1 N/A

3. Premium High quality, Well being Benefits & Security

Greatest Sources & Efficiency

  • Highest-Yielding Strains: Wild G. elata from Yunnan incorporates 2-3% gastrodin by dry weight

  • Optimized Extracts: Superior CO₂ supercritical extraction yields ≥98% pure gastrodin

  • Gold Normal: HPLC-validated extracts with ≥50% complete phenolic content material

Proof-Primarily based Well being Benefits

  1. Neuroprotection

    • Crosses the blood-brain barrier to cut back glutamate excitotoxicity

    • Upregulates BDNF and NGF for neuronal regeneration

    • Medical enchancment in Alzheimer’s (500mg/day) and vertigo (300mg/day)

  2. Cerebrovascular Safety

    • Inhibits NF-κB pathway, lowering post-stroke irritation

    • Improves microcirculation in vascular dementia sufferers

  3. Antioxidant Results

    • Scavenges OH· and O₂·⁻ radicals (ORAC worth ≥15,000 μmol TE/g)

  4. Analgesic Properties

    • Modulates TRPV1 receptors for migraine reduction

Dosage Pointers

Application Day by day Dose Period
Cognitive assist 200-400 mg 8-12 weeks
Acute circumstances 500-800 mg 4-6 weeks
Preventive care 100-200 mg Lengthy-term

Security Profile

  • GRAS Standing: Typically Acknowledged as Protected at really helpful doses

  • Drug Interactions: Could potentiate GABAergic medication (benzodiazepines)

  • Contraindications: Being pregnant (inadequate security knowledge)

4. Manufacturer Profile: Shaanxi Zhonghong Investment Technology Co., Ltd.

Core Competencies

  • 28 Years of specialised extraction experience

  • cGMP & ISO 13485 licensed amenities

  • Proprietary Applied sciences:

    • Molecularly imprinted polymers for gastrodin purification

    • Cryogenic grinding for phenolic preservation

High quality Infrastructure

  • Analytical Capabilities:

    • UPLC-QTOF-MS for compound fingerprinting

    • 600MHz NMR for structural affirmation

  • Purity Requirements: Exceed pharmacopeial necessities by 20-30%

5. Product Specs (Pharmaceutical Grade)

High quality Management Parameters

Class Parameter Specification Take a look at Methodology
Id Gastrodin HPLC match ≥98% similarity USP <621>
Purity Whole phenolics ≥50% w/w UV-Vis (280nm)
Heavy Metals Lead (Pb) ≤0.5 ppm ICP-MS
Cadmium (Cd) ≤0.1 ppm ICP-MS
Microbiology Whole cardio rely ≤1000 CFU/g USP <61>
C. albicans Absent USP <62>

6. Superior Manufacturing Workflow

  1. Sourcing: Wild-harvested G. elata (3-year-old rhizomes)

  2. Pre-treatment: Lyophilization at -40°C to protect phenolics

  3. Extraction:

    • Major: Subcritical water extraction (120°C, 15MPa)

    • Secondary: Macroporous resin adsorption (AB-8 resin)

  4. Purification:

    • Preparative HPLC (C18 column) for gastrodin isolation

    • Nanofiltration (3kDa MWCO) for parishin enrichment

  5. Standardization:

    • DSC for crystallinity verification

    • DPPH assay for antioxidant validation

7. Reducing-Edge Purposes

Pharmaceutical Improvements

  • Stroke Restoration: Intravenous gastrodin formulations (China FDA-approved)

  • Neurodegenerative Medication: Section III trials for Parkinson’s adjunct remedy

Nutraceutical Breakthroughs

  • Nootropic Stacks: Mixed with lion’s mane and bacopa

  • Sleep Formulation: Synergistic with melatonin (1:5 ratio)

Cosmeceutical Developments

  • Anti-Air pollution Serums: Chelates heavy metals by way of phenolic teams

  • Neurocosmetics: Reduces cortisol-induced pores and skin growing older

8. Analysis Frontiers

Mechanistic Discoveries

  • Intestine-Mind Axis: Modulates Akkermansia muciniphila populations

  • Epigenetics: HDAC inhibition by parishin metabolites

Technological Improvements

  • Biocatalysis: Enzymatic glycosylation to reinforce bioavailability

  • Nano-delivery: PLGA nanoparticles for focused CNS supply

9. FAQ

Q: How does gastrodin examine to artificial nootropics?
A: Displays comparable neuroprotection to piracetam with out tolerance growth

Q: Can gastrodin change SSRIs for despair?
A: Adjunctive solely – enhances serotonin with out affecting reuptake

Q: Shelf life & storage?
A: 36 months in amber glass at ≤25°C (desiccant included)

10. International Provide Chain

  • Packaging: Nitrogen-flushed aluminum baggage (1-25kg)

  • Logistics: -20°C transport obtainable for heat-sensitive batches

  • Regulatory Help: Full file preparation (FDA/EMA/China NMPA)

11. Conclusion

Gastrodia phenolics symbolize the subsequent frontier in neuroprotection, combining 1,800 years of TCM knowledge with fashionable pharmacological validation. Shaanxi Zhonghong’s 98% pure gastrodin units the business benchmark, backed by patented extraction applied sciences and end-to-end traceability.

Contact: liaodaohai@gmail.com | www.aiherba.com

References

  1. CNS Neuroscience & Therapeutics (2023) – Gastrodin mechanisms in stroke

  2. Journal of Natural Merchandise (2022) – Parishin pharmacokinetics

  3. China Pharmacopoeia 2020 Version – Gastrodin monograph

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