Dipotassium Glycyrrhizinate

Dipotassium Glycyrrhizinate: Nature’s Potent Anti-Inflammatory & Pores and skin Soother | Zhonghong Bio

1. What is Dipotassium Glycyrrhizinate?

Dipotassium Glycyrrhizinate (DG) is the dipotassium salt of glycyrrhizic acid (GL), the first bioactive triterpenoid saponin derived from the roots and rhizomes of the licorice plant (Glycyrrhiza glabra or Glycyrrhiza uralensis). This water-soluble by-product is prized for its considerably enhanced bioavailability and decreased potential for the mineralocorticoid-like negative effects typically related to pure glycyrrhizic acid. DG is a cornerstone lively ingredient in superior skincare, cosmetics, prescribed drugs, and nutraceuticals resulting from its distinctive anti-inflammatory, antioxidant, soothing, and skin-brightening properties.

2. Product Supply, Chemical Id & Key Specs

• Supply: Roots/rhizomes of Glycyrrhiza glabra L. or Glycyrrhiza uralensis Fisch.

• Chemical Properties:

  • CAS Quantity: 68797-35-3

  • Molecular Components (MF): C₄₂H₆₀K₂O₁₆

  • Molecular Weight (MW): 899.12 g/mol

  • EINECS: 272-189-6

  • Look: Usually a tremendous white to off-white crystalline powder.

  • Solubility: Extremely soluble in water and aqueous alcohols; insoluble in non-polar natural solvents.

  • Stability: Steady below really useful storage situations (cool, dry). Delicate to robust acids, robust bases, and extended excessive warmth.

3. Why Zhonghong Bio’s Dipotassium Glycyrrhizinate is the Optimum Selection

Zhonghong Bio units the {industry} benchmark for premium Dipotassium Glycyrrhizinate via unwavering dedication to purity, efficacy, and scientific rigor.

• Key Ingredient: Excessive-Purity Dipotassium Glycyrrhizinate (>98% by HPLC).

• Core Efficacy & Well being Advantages (Compliant):

  • Potent Anti-Inflammatory: Masterfully inhibits key inflammatory mediators (NF-κB, COX-2, PGE₂, TNF-α, IL-6) by way of modulation of phospholipase A₂ and lipoxygenase pathways. Clinically confirmed to assuage pores and skin irritation, redness (erythema), and situations like eczema and psoriasis.

  • Superior Antioxidant: Scavenges free radicals (ROS), mitigating oxidative stress injury to pores and skin cells and macromolecules.

  • Pores and skin Soothing & Barrier Assist: Calms sensory irritation (stinging, itching) and enhances pores and skin resilience. Reveals anti-irritant results in opposition to surfactants and different aggressors.

  • Pores and skin Brightening: Inhibits tyrosinase exercise and melanin synthesis, successfully lowering hyperpigmentation and selling an excellent pores and skin tone.

  • Antiviral & Antimicrobial: Demonstrates exercise in opposition to sure enveloped viruses (e.g., HSV-1) and micro organism.

  • Hepatoprotective & Detox Assist: Helps liver perform and glutathione ranges, aiding detoxing processes (related in oral supplementation).

• Origin & Manufacturing: Sourced from premium licorice roots; extracted, purified, and meticulously processed in Zhonghong Bio’s state-of-the-art, ISO-certified services in China, adhering to stringent GMP requirements.

• Beneficial Utilization Ranges:

  • Topical (Skincare/Cosmetics): 0.1% – 2.0% (Typical efficient vary: 0.2% – 0.5%).

  • Oral (Dietary supplements/Practical Meals): Seek the advice of a healthcare skilled. Common steerage usually references limits for Glycyrrhizinic Acid (usually 100-200 mg/day max), with DG dosing adjusted accordingly based mostly on molecular weight equivalence. Essential to observe regional laws and product-specific security assessments.

• Goal Viewers: Formulators of anti-aging serums, delicate skincare, zits therapies, brightening merchandise, soothing lotions/lotions, high-end cosmetics, pharmaceutical topical preparations, practical drinks, and dietary dietary supplements.

• Vital Precautions & Potential Aspect Results:

  • Topical: Usually well-tolerated at really useful ranges. Patch testing suggested for hypersensitive people. Uncommon potential for delicate irritation.

  • Oral: Important Warning Required. Excessive or extended oral consumption can result in pseudoaldosteronism: hypertension, hypokalemia, sodium/water retention, edema. Contraindicated in people with hypertension, hypokalemia, extreme renal/hepatic impairment, and through being pregnant/lactation until below medical supervision. Strictly adhere to established protected consumption ranges.

  • Drug Interactions: Potential interactions with diuretics, corticosteroids, cardiac glycosides (digoxin), and anti-hypertensives. Seek the advice of healthcare supplier earlier than oral use if on medicine.

• Why Zhonghong Bio is Greatest: Unmatched purity (>98%+), verified by superior analytical methods (HPLC, NMR), guaranteeing superior efficacy and batch-to-batch consistency. Rigorous management of residual solvents and undesirable glycyrrhetinic acid. Backed by complete technical dossiers and regulatory help.

4. Zhonghong Biotechnology Co., Ltd.: Your Trusted Associate in Bioactive Excellence

Zhonghong Bio is a vertically built-in, high-tech enterprise on the forefront of analysis, innovation, precision manufacturing, and world distribution inside the chemical, supplies, and life science sectors. We specialize within the superior extraction, isolation, purification, and software growth of potent plant-derived compounds.

• Core Focus: Natural Plant Extracts, Beauty Actives, Pharma/API Intermediates, Nutraceutical Components, Natural Colours & Sweeteners, Meals/Beverage Components.

• Scientific Prowess:

  • Strong R&D: Strategic partnerships with 5 main universities, fostering cutting-edge analysis in our Joint Innovation Laboratories.

  • Proprietary Expertise: Holder of 20+ patents and a globally distinctive compound library, driving innovation in purification and formulation.

• Manufacturing & High quality Supremacy:

  • Superior Infrastructure: Geared up with industry-leading analytical instrumentation together with Excessive-Efficiency Liquid Chromatography (HPLC/DAD/ELSD), Extremely-Efficiency Liquid Chromatography (UPLC), Gasoline Chromatography-Mass Spectrometry (GC-MS), and Superconducting Fourier Rework Nuclear Magnetic Resonance (FT-NMR).

  • Purity Benchmark: Our stringent high quality protocols persistently ship purity ranges exceeding {industry} requirements by 20% or extra.

• World Attain: An intensive distribution community serving over 80 international locations throughout Asia, Europe, and the Americas. We’re the popular associate for bespoke ingredient options amongst multinational pharmaceutical companies, analysis establishments, and premier beauty/formulation homes.

• Legacy of Experience: Leveraging 28 years of specialised expertise in bioactive compound sourcing, optimization, and commercialization.

5. Complete Certificates of Evaluation (COA) Specs

Zhonghong Bio ensures the utmost security and compliance of our Dipotassium Glycyrrhizinate via exhaustive testing:

Desk: Dipotassium Glycyrrhizinate COA Specs

(Observe: Full COA supplied with every batch. Specs topic to refinement based mostly on newest pharmacopoeial requirements and shopper necessities.)

6. Superior Manufacturing Course of

Zhonghong Bio employs a classy, multi-stage course of guaranteeing most purity and bioactivity:

1. Uncooked Materials Choice: Premium licorice roots sourced from licensed sustainable cultivators.

2. Extraction: Optimized aqueous or hydroalcoholic extraction below managed temperature/pH.

3. Main Purification: Macroporous resin adsorption chromatography to pay attention glycyrrhizic acid.

4. Acid Hydrolysis & Salt Formation: Managed hydrolysis adopted by response with potassium hydroxide to type Dipotassium Glycyrrhizinate.

5. Crystallization & Recrystallization: Excessive-purity crystallization steps to isolate DG crystals.

6. Ultrafiltration/Nanofiltration: Removing of excessive molecular weight impurities and endotoxins.

7. Superior Chromatography (Non-obligatory): Preparative HPLC or Counter-Present Chromatography (CCC) for ultra-high purity (>99%) grades.

8. Lyophilization (Freeze-Drying): Mild drying to protect molecular integrity and guarantee powder traits.

9. Milling & Mixing: Managed particle dimension discount and homogenization.

10. Stringent QC Launch: Each batch undergoes full COA testing in opposition to rigorous specs.

7. Various Software Eventualities

• Cosmetics & Skincare: Calming serums/lotions, anti-redness therapies, after-sun care, delicate pores and skin formulations, anti-acne merchandise (lowering irritation), brightening/whitening lotions, anti-aging formulations (combating irritation & oxidative stress), soothing shaving merchandise, child care.

• Prescription drugs: Topical gels/lotions for eczema, psoriasis, dermatitis, herpes simplex lesions (chilly sores); potential ingredient in oral mucosal protectants or throat lozenges (for soothing); adjunct in hepatoprotective formulations.

• Nutraceuticals & Practical Meals: Oral dietary supplements concentrating on liver well being, irritation modulation (requires cautious dosing), detoxing help; practical drinks with soothing/anti-inflammatory claims.

• Oral Care: Toothpaste and mouthwash for gum soothing and anti inflammatory advantages.

8. Uncompromising High quality Management (QC)

High quality is embedded in each step at Zhonghong Bio. Our QC paradigm integrates:

• Strict Uncooked Materials Qualification: Incoming licorice root undergoes identification (HPLC, TLC, macroscopic/microscopic) and contaminant (heavy metals, pesticides) testing in opposition to permitted specs.

• In-Course of Controls (IPC): Rigorous monitoring at essential course of levels (e.g., extraction yield, intermediate purity by HPLC, pH, solvent ranges) ensures course of consistency and early deviation detection.

• Stability Research: Actual-time and accelerated stability research (ICH pointers) decide shelf life, really useful storage situations (usually 2-8°C, desiccated), and packaging suitability.

• State-of-the-Artwork Analytics: Our laboratories make the most of HPLC-UV/DAD/ELSD for assay and associated substances, UPLC-MS/MS for hint impurity profiling, GC-MS for residual solvents, ICP-MS for heavy metals, validated microbiological strategies (USP/EP), FT-NMR (1H, 13C) for definitive structural affirmation and purity evaluation, and Polarimetry for optical rotation. Methodology validation per ICH Q2(R1) ensures accuracy, precision, specificity, linearity, vary, LOD/LOQ, and robustness.

• Documentation & Traceability: Complete documentation adhering to ALCOA+ rules (Attributable, Legible, Contemporaneous, Unique, Correct + Full, Constant, Enduring, Out there) ensures full batch traceability from uncooked materials to completed product launch.

9. Safe Packaging & World Logistics

• Packaging: Out there in pharmaceutical-grade, multi-layered choices:

  • Commonplace: 1kg/5kg double HDPE luggage inside sealed foil-lined kraft paper luggage, positioned in sturdy cartons.

  • Premium: 1kg/5kg vacuum-sealed in aluminum foil luggage with desiccant, inside HDPE containers.

  • Bulk: 25kg fiber drums with double poly-bag liners.

  • Customized packaging (e.g., smaller aliquots, nitrogen flushing) obtainable upon request.

• Storage: Retailer in a cool (2-8°C really useful), dry place, protected against mild and moisture in tightly sealed containers. Preserve managed ambient situations throughout transport.

• Logistics: Environment friendly world delivery by way of air freight (DAP, DDP) or sea freight (FOB, CIF, CFR). Experience in dealing with customs clearance and regulatory documentation worldwide. Chilly chain choices obtainable.

10. Deep Dive: Well being Mechanisms, Innovation & Analysis Frontiers

• Mechanism of Motion:

  • Anti-inflammatory: Potently inhibits Phospholipase A₂ (PLA₂), the enzyme initiating the arachidonic acid cascade, thereby suppressing downstream manufacturing of pro-inflammatory prostaglandins (PGE₂ by way of COX-2 inhibition) and leukotrienes (by way of 5-LOX inhibition). Modulates NF-κB signaling, lowering TNF-α, IL-1β, and IL-6 synthesis. Enhances cortisol’s anti-inflammatory results at websites of irritation by inhibiting 11β-HSD2.

  • Antioxidant: Immediately scavenges superoxide anion radicals (O₂⁻), hydroxyl radicals (OH⁻), and peroxynitrite (ONOO⁻). Chelates pro-oxidant metallic ions. Upregulates endogenous antioxidant enzymes (SOD, CAT, GPx) by way of Nrf2 pathway activation.

  • Pores and skin Brightening: Competitively inhibits tyrosinase, the rate-limiting enzyme in melanin synthesis. Downregulates microphthalmia-associated transcription issue (MITF) expression. Reduces UVB-induced hyperpigmentation.

  • Antiviral: Interferes with viral attachment, penetration, and replication (e.g., disrupts HSV-1 envelope glycoproteins). Stimulates interferon manufacturing.

• Industrial Functions & Zhonghong’s Innovation: DG is driving innovation in “cosmeceuticals” and dermatologicals. Zhonghong Bio focuses on:

  • Enhanced Supply Programs: Creating liposomal, nanoemulsion, and ethosomal DG formulations for superior pores and skin penetration and focused supply.

  • Synergistic Complexes: Creating patented complexes with different bioactives (e.g., alpha-bisabolol, niacinamide, tranexamic acid) for amplified soothing, brightening, or anti-aging results.

  • Stability Optimization: Superior encapsulation methods to guard DG from degradation in difficult formulations (e.g., excessive pH).

  • Sustainable Extraction: Implementing inexperienced chemistry rules (e.g., subcritical water extraction) to cut back environmental influence.

• Analysis Frontiers & Challenges:

  • Frontiers: Exploring DG’s potential in wound therapeutic acceleration, atopic dermatitis administration, rosacea, scalp well being (anti-dandruff, soothing), oral mucositis, neuroprotective results, and metabolic syndrome modulation (requiring exact dosing options).

  • Challenges: Balancing potent anti-inflammatory results with the necessity for absolute security in oral functions (pseudoaldosteronism threat). Overcoming formulation stability challenges (pH sensitivity, potential for discoloration). Establishing definitive scientific dosing pointers for systemic results. Scaling novel supply programs cost-effectively. Assembly evolving world regulatory necessities for pure actives.

11. Continuously Requested Questions (FAQ)

• Q1: What is the distinction between Glycyrrhizic Acid and Dipotassium Glycyrrhizinate?

  • A: Glycyrrhizic Acid (GL) is the pure saponin. Dipotassium Glycyrrhizinate (DG) is its water-soluble potassium salt by-product. DG presents considerably higher solubility in aqueous beauty formulations and probably decrease threat of systemic negative effects in comparison with excessive oral doses of GL.

• Q2: Is Dipotassium Glycyrrhizinate protected for delicate pores and skin?

  • A: Sure, it’s usually very well-tolerated topically at concentrations as much as 2% and is famend for its soothing properties, making it extremely appropriate for delicate, reactive, and compromised pores and skin sorts. All the time patch take a look at new merchandise.

• Q3: Can I take advantage of Dipotassium Glycyrrhizinate orally?

  • A: Oral use requires excessive warning {and professional} steerage because of the threat of pseudoaldosteronism (hypertension, hypokalemia). It ought to solely be utilized in oral merchandise the place the dosage is strictly managed to remain nicely under established protected consumption ranges for glycyrrhizinic acid (usually 100-200 mg/day max). Not really useful for self-supplementation with out medical recommendation. Seek the advice of relevant laws (e.g., FDA GRAS, EFSA, FOSHU).

• This fall: Does DG trigger pores and skin photosensitivity?

  • A: No, Dipotassium Glycyrrhizinate itself is just not a photosensitizer. The truth is, its antioxidant properties could supply some safety in opposition to UV-induced injury.

• Q5: What is the everyday efficient focus in skincare?

  • A: Important results are sometimes seen between 0.1% and 0.5%. Concentrations as much as 2.0% can be utilized for enhanced soothing/anti-inflammatory results, supported by stability and formulation compatibility.

• Q6: How does DG examine to hydrocortisone?

  • A: DG is a potent non-steroidal anti-inflammatory. Whereas usually much less potent than prescription-strength topical corticosteroids, it presents a positive security profile for long-term use with out the dangers related to steroids (pores and skin thinning, telangiectasia). It is a wonderful different or complement for managing mild-moderate irritation.

• Q7: Does Zhonghong Bio supply customized specs or formulations?

  • A: Completely. We focus on growing customized purity grades, particle sizes, and synergistic complexes tailor-made to your particular software and efficiency necessities.

12. Supply Premium Dipotassium Glycyrrhizinate

Able to formulate with best-in-class Dipotassium Glycyrrhizinate?

• Buy: Contact our gross sales crew for aggressive quotations (MOQ applies) and seamless world supply.

• Request FREE Samples: Expertise the Zhonghong Bio distinction firsthand. Request your complimentary pattern for R&D analysis.

• Contact:

  • E mail: liaodaohai@gmail.com

  • Web site: https://aiherba.com (Discover our full catalog of premium botanical actives)

13. Conclusion

Dipotassium Glycyrrhizinate stands as a scientifically validated, multi-functional powerhouse ingredient derived from nature. Its distinctive anti-inflammatory, soothing, antioxidant, and brightening properties make it indispensable in high-performance skincare, cosmetics, and focused topical prescribed drugs. Zhonghong Bio distinguishes itself because the premier world supply via its relentless pursuit of unparalleled purity (>98%), cutting-edge extraction and purification know-how, unwavering dedication to GMP and QC excellence, and deep 28-year experience in bioactive compounds. By selecting Zhonghong Bio’s Dipotassium Glycyrrhizinate, formulators achieve entry to a persistently superior, reliably protected, and extremely efficacious ingredient, backed by complete technical help and world logistics capabilities – the optimum basis for creating progressive, market-leading merchandise. Contact us at this time to raise your formulations.

14. References

1. European Pharmacopoeia (Ph. Eur.) Monographs.

2. United States Pharmacopeia (USP) Monographs.

3. Kao, T. C., et al. (2014). “The Anti-Inflammatory Exercise of Glycyrrhiza glabra L. (Licorice) Derivatives.” Journal of Conventional and Complementary Medication.

4. Ploeger, B., et al. (2000). “Pharmacokinetics of Glycyrrhizic Acid and its Metabolite.” Scientific Pharmacokinetics.

5. Saeedi, M., et al. (2003). “The Therapy of Atopic Dermatitis with Licorice Gel.” Journal of Dermatological Therapy.

6. Wang, Z. Y., & Nixon, D. W. (2001). “Licorice and Most cancers.” Diet and Most cancers.

7. ICH Pointers: Q3C (Residual Solvents), Q2(R1) (Validation of Analytical Procedures), Q1A(R2) (Stability Testing).

8. Beauty Ingredient Evaluate (CIR) Skilled Panel Assessments on Licorice-Derived Components.

9. EFSA Scientific Opinions on Glycyrrhizinic Acid and Ammonium Salt.

10. Zhonghong Bio Inside Analysis & Technical Dossiers.