Berberine Hydrochloride
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Berberine Hydrochloride Powder​

Berberine Hydrochloride Powder supplier Extract factory

  1. English Name: Berberine Hydrochloride Powder
  1. Specification
    • Purity: ≥ 98% (HPLC)
    • Solubility: Sparingly soluble in water (0.12 g/100 mL at 25°C), more soluble in hot water; soluble in ethanol (≥ 5 g/100 mL)
    • Appearance – related: Loss on drying ≤ 1.0%, Heavy metals ≤ 10 ppm, Residual solvents ≤ 0.5%
    • Particle Size: ≤ 100 mesh (standard), can be customized according to requirements
  1. Appearance
    • Bright yellow crystalline powder, odorless, with an intensely bitter taste, no relation to chocolate in terms of color or aroma
  1. CAS NO.：633 – 65 – 8
  1. Lead time: 5 – 7 Working Days
  1. Package
    • 1 kg/aluminum foil bag, 25 kg/drum (double – layer PE bag inside cardboard drum)
  1. Main Market
    • Global market, with significant demand in Asia (China, India), Europe, and North America, mainly applied in pharmaceuticals, dietary supplements, veterinary medicine, and cosmetics industries
  1. Application Scenarios

Core Properties

  • Chemical Structure: An isoquinoline alkaloid with the molecular formula C₂₀H₁₈ClNO₄. Its unique heterocyclic structure endows it with multiple biological activities.
  • Key Features
    • Antimicrobial: Effective against a wide range of pathogens, including bacteria like Escherichia coli and Staphylococcus aureus, fungi such as Candida albicans, by disrupting cell membranes and inhibiting essential enzyme functions.
    • Antioxidant: Scavenges free radicals like hydroxyl and superoxide anions, protecting cells from oxidative damage and reducing the risk of aging – related diseases.
    • Anti – inflammatory: Suppresses the activation of inflammatory pathways, reducing the production of pro – inflammatory cytokines (TNF – α, IL – 6), which helps relieve inflammation – related symptoms.
    • Hypoglycemic: Regulates glucose metabolism by enhancing insulin sensitivity, inhibiting intestinal glucose absorption, and promoting cellular glucose uptake, making it useful for managing blood sugar.
    • Lipid – lowering: Reduces hepatic cholesterol synthesis and promotes cholesterol excretion, contributing to lower blood lipid levels.

Application Scenarios

1. Pharmaceutical Industry

  • Oral Medications:
    • Used in tablets, capsules, and oral solutions for treating gastrointestinal infections, diarrhea caused by bacteria, and as an adjuvant treatment for mild to moderate type 2 diabetes to regulate blood glucose.
  • Topical Formulations:
    • Incorporated into creams, ointments, and gels for treating skin infections, acne, and eczema, leveraging its antimicrobial and anti – inflammatory properties.
  • Clinical Research:
    • Under investigation for potential applications in treating cardiovascular diseases, neurodegenerative disorders, and certain cancers due to its broad – spectrum bioactivity.

2. Dietary Supplements

  • Health – Management Supplements:
    • Sold as standalone capsules or combined with other ingredients (e.g., gymnema sylvestre, chromium) to help individuals manage blood sugar, improve cardiovascular health, and boost immune function.

3. Veterinary Medicine

  • Animal Health Products:
    • Added to livestock and poultry feed or used in oral medications to treat digestive tract infections, diarrhea, and enteritis, and enhance animal growth performance.
  • Pet Care:
    • Prescribed for pets with bacterial infections, skin problems, or to support metabolic health in diabetic pets.

4. Cosmetics & Personal Care

  • Anti – Acne Products:
    • Added to facial cleansers, toners, and spot – treatment creams (0.5 – 2% concentration) to combat acne – causing bacteria, reduce inflammation, and prevent breakouts.
  • Anti – Aging Products:
    • Some high – end anti – aging serums and creams contain berberine hydrochloride to protect skin from oxidative stress and reduce the appearance of fine lines and wrinkles.

Detection Methods

  • High – Performance Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% phosphoric acid (30:70, v/v), Flow Rate: 1.0 mL/min, Detection Wavelength: 345 nm, for accurate quantification.
  • Liquid Chromatography – Mass Spectrometry (LC – MS):
    • Ideal for analyzing berberine hydrochloride in complex samples, providing high sensitivity and the ability to detect trace amounts and identify impurities.
  • Fourier Transform Infrared Spectroscopy (FTIR):
    • Analyzes the characteristic absorption peaks of functional groups to confirm the chemical structure, aiding in quality control during production.

Source & Advantages

  • Natural & Synthetic Sources: Extracted from plants like Coptis chinensis, Berberis vulgaris, and can also be synthesized chemically, ensuring a stable supply.
  • Versatile Applications: Its multifunctional bioactivity makes it valuable across multiple industries, meeting diverse health and beauty needs.
  • Market Growth: With the rising demand for natural remedies and preventive healthcare products, the market for berberine hydrochloride powder continues to expand.
  • Regulatory Oversight: Recognized and regulated in many regions for use in pharmaceuticals, supplements, and cosmetics, though regulations on dosage and claims vary by country.
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Berberine Hydrochloride Powder: Final Information by Zhonghong BioTech

1. What is Berberine Hydrochloride?
Berberine Hydrochloride is the stabilized, bioavailable salt type of berberine, a potent isoquinoline alkaloid naturally occurring in vegetation like Berberis vulgaris (Barberry), Coptis chinensis (Goldthread), and Hydrastis canadensis (Goldenseal). This vibrant yellow crystalline powder is famend for its broad-spectrum physiological actions, primarily focusing on metabolic pathways by way of AMPK activation.

2. Supply, Chemical Properties & Identification

  • Supply: Extracted from plant rhizomes/roots (e.g., Coptis, Phellodendron). Zhonghong makes use of sustainably sourced, premium-grade Coptis chinensis.

  • Chemical Properties:

    • CAS: 633-65-8

    • Molecular Components (MF): C₂₀H₁₈ClNO₄

    • Molecular Weight (MW): 371.81 g/mol

    • EINECS: 211-195-9

    • Look: Shiny Yellow to Orange-Yellow Crystalline Powder

    • Solubility: Soluble in water, barely soluble in ethanol, insoluble in non-polar solvents.

    • Melting Level: 200-203°C (decomposition)

    • Optical Rotation: -120° to -140° (c=2 in H₂O)

3. Premium Berberine HCl: Key Attributes (Zhonghong BioTech Customary)
Zhonghong BioTech units the benchmark for pharmaceutical-grade Berberine HCl:

  • Composition: ≥98% Berberine Hydrochloride (HPLC), minimizing minor alkaloids (e.g., jatrorrhizine, palmatine).

  • Efficacy (Compliance): Manufactured below cGMP, compliant with USP/EP monographs. Validated for key bioactivities:

    • Metabolic Well being: AMPK activation supporting wholesome glucose uptake & lipid metabolism (PMID: 25607236).

    • Microbiome Modulation: Selective inhibition of pathogenic intestine micro organism; promotes helpful species.

    • Cardiovascular Help: Modulates LDL-receptor expression & endothelial operate.

    • Mobile Well being: Reveals antioxidant and potential autophagy-enhancing properties.

  • Origin: Sourced & absolutely manufactured (extraction to micronization) in China, ISO 9001/22000 licensed amenities.

  • Utilization: Typical dose vary: 500mg-1500mg every day, divided (e.g., 500mg TID). Formulated in capsules, tablets, or useful meals. Seek the advice of a healthcare supplier.

  • Goal Viewers: Adults in search of metabolic/cardiovascular help. Not for youngsters.

  • Essential Precautions & Facet Results:

    • Contraindications: Being pregnant, lactation. Potent CYP3A4/P-gp inhibitor – keep away from with cyclosporine, tacrolimus, simvastatin, many antibiotics. Seek the advice of doctor if taking any remedy.

    • Facet Results: Usually delicate (dose-dependent): GI discomfort (constipation, cramping), uncommon potential for hypoglycemia.

    • Max Consumption: Don’t exceed 2000mg/day with out medical supervision. Begin low dose.

    • Testing: Suggest liver/kidney operate monitoring with long-term, high-dose use.

4. Zhonghong BioTech: Pioneering Plant Actives Since 1996
Shaanxi Zhonghong Investment Technology Co., Ltd. is a vertically built-in chief in high-purity botanical extracts and bioactive compounds. We serve international innovators in nutraceuticals, prescribed drugs, cosmeceuticals, and useful meals.

  • Scientific Edge: 5 College Joint Labs (e.g., CAS Institutes), 20+ Patents (e.g., Novel Purification, Polymorph Management), unique 10,000+ compound library.

  • Analytical Management: State-of-the-art QC: UHPLC-DAD-ELSD, GC-MS, ICP-MS, NMR. Purity requirements exceed USP by ≥20% (sometimes ≥98.5% Berberine HCl).

  • International Attain: cGMP-compliant provide to 80+ nations, providing bespoke options for Tier-1 Pharma and analysis establishments.

5. Well being Advantages & Mechanisms

  • Glucose Homeostasis: Prompts AMPK, enhances insulin sensitivity, inhibits hepatic gluconeogenesis (glucose-6-phosphatase), mimics insulin motion.

  • Lipid Regulation: Upregulates hepatic LDLR expression, modulates PCSK9, prompts AMPK→ACC inhibition.

  • Intestine Well being: Disrupts bacterial biofilm formation, inhibits virulence elements (e.g., E. coli LT/ST toxins), fosters Akkermansia/Bifidobacterium progress.

  • Cardioprotection: Improves endothelial NO synthesis, reduces LOX-1 expression, attenuates ox-LDL uptake.

  • Mobile Resilience: Modulates Nrf2/KEAP1 pathway, enhances endogenous antioxidants (SOD, GSH); potential mTOR inhibition influencing autophagy.

6. Utilization Tips

  • Customary Dose: 500mg taken 2-3 instances every day earlier than meals. Bioavailability enhancers (e.g., liposomal, with piperine) might permit decrease doses.

  • Formulation: Excellent for strong dosage varieties (tablets, capsules). Guarantee compatibility with excipients (hygroscopic).

  • Synergists: Usually mixed with Silymarin (liver help), Chromium Picolinate, or Alpha-Lipoic Acid.

7. Essential Precautions

  • Drug Interactions: STRONG CYP3A4/P-glycoprotein inhibition. Contraindicated with immunosuppressants, statins, most macrolides/fluoroquinolones, antifungals, SSRIs, Ca²⁺ channel blockers, sedatives. Necessary HCP session if medicated.

  • Medical Circumstances: Keep away from in hypotension, bradycardia, renal/hepatic impairment. Monitor blood glucose intently in diabetics.

  • Length: Restricted long-term human security knowledge. Take into account biking (e.g., 8 weeks on, 2-4 weeks off).

8. Product Specification & Certificates of Evaluation (COA)

Parameter Class Check Merchandise Specification Check Methodology
Pesticide Residues Chlorpyrifos ≤ 0.01 ppm GC-MS/MS (EU 396/2005)
Cypermethrin ≤ 0.05 ppm GC-MS/MS (EU 396/2005)
Whole DDTs ≤ 0.05 ppm GC-MS/MS (EU 396/2005)
Whole BHCs ≤ 0.05 ppm GC-MS/MS (EU 396/2005)
Heavy Metals Lead (Pb) ≤ 1.0 mg/kg ICP-MS (USP <232>/<233>)
Arsenic (As) ≤ 1.0 mg/kg ICP-MS (USP <232>/<233>)
Cadmium (Cd) ≤ 0.5 mg/kg ICP-MS (USP <232>/<233>)
Mercury (Hg) ≤ 0.1 mg/kg ICP-MS/CVAAS (USP <232>/<233>)
Microbiological Whole Cardio Rely ≤ 1000 CFU/g USP <61>
Yeast & Mould ≤ 100 CFU/g USP <61>
E. coli Absent in 1g USP <62>
Salmonella spp. Absent in 10g USP <62>
Staph. aureus Absent in 1g USP <62>
Assay (HPLC) Berberine Hydrochloride ≥ 98.0% USP Chromatographic

9. Superior Manufacturing Move

  1. Uncooked Materials QC: Species authentication (HPTLC, DNA barcoding), heavy metallic/pesticide screening.

  2. Extraction: Optimized acidified ethanol percolation (pH 2-3, 60°C).

  3. Macroporous Resin Purification: Selective adsorption/desorption to take away polysaccharides, pigments.

  4. Crystallization: pH-controlled anti-solvent crystallization (Ethanol/H₂O system) for outlined particle measurement distribution.

  5. Recrystallization: Excessive-purity solvent system for remaining polymorph management (Anhydrous type).

  6. Micronization: Jet milling to focus on D90 < 45µm for optimum dissolution.

  7. Strict QC: In-process checks & remaining launch per COA specs. Stability research (ICH Q1A).

10. Software Situations

  • Nutraceuticals: Metabolic well being capsules, blood sugar help blends, weight administration formulation.

  • Prescription drugs: API for anti-diabetic, anti-dyslipidemia, or antimicrobial formulations (analysis stage).

  • Purposeful Meals/Drinks: Fortified powders, well being drinks (requires taste-masking).

  • Cosmeceuticals: Pimples topical therapies (antibacterial/anti-inflammatory), anti-aging serums.

  • Analysis: Molecular biology (AMPK pathway research), microbiology (antimicrobial mechanisms).

11. Stringent High quality Management
Zhonghong employs a multi-tiered QC technique: Identification (FTIR, NMR fingerprinting), Assay (Validated RP-UHPLC with DAD/ELSD detection), Associated Substances (HPLC for jatrorrhizine, palmatine <1.0%), Residual Solvents (GC-MS per ICH Q3C), Heavy Metals (ICP-MS), Microbiology (fast strategies & compendial), Particle Measurement (Laser diffraction), XRD (Polymorph verification). Our stability program (25°C/60% RH, 40°C/75% RH) ensures 36-month shelf life in alu-foil luggage. Batch traceability is paramount.

12. Packaging & Logistics

  • Main: Double HDPE luggage with food-grade PE liner. Elective vacuum packing.

  • Secondary: Sealed in moisture-proof, light-resistant fiber drums (25kg web).

  • Logistics: Ambient delivery globally. MSDS, Certificates of Origin, Full COA offered. DDP/DAP phrases accessible. Quick EU/US warehouse dispatch.

13. Analysis & Innovation

  • Well being Mechanisms: Ongoing analysis explores NLRP3 inflammasome modulation, gut-brain axis impression, and mitochondrial biogenesis results.

  • Tech Innovation: Zhonghong focuses on:

    • Enhanced Bioavailability: Novel nanoemulsions, phospholipid complexes.

    • Artificial Biology: Engineered microbial biosynthesis of berberine precursors.

    • Derivatization: Novel berberine salts/esters for improved solubility/focusing on.

  • Challenges: Overcoming low oral bioavailability (~<5%), managing DDIs, establishing definitive long-term medical outcomes.

14. Regularly Requested Questions (FAQ)

  • Q: Is Berberine HCl higher than Berberine Sulfate? A: HCl typically affords increased solubility and bioavailability than sulfate salts.

  • Q: Can I take Berberine HCl long-term? A: Whereas typically protected for intervals of 3-6 months in research, focus on long-term use and biking along with your healthcare supplier. Monitor liver/kidney operate.

  • Q: Does it trigger weight reduction? A: It helps metabolic well being and will help weight administration as a part of a wholesome life-style, primarily by way of AMPK results on metabolism.

  • Q: How lengthy to see advantages? A: Metabolic results (glucose/lipids) typically noticed inside 4-8 weeks.

  • Q: Is Zhonghong’s Berberine non-GMO & Allergen-Free? A: Sure, licensed non-GMO, gluten-free, soy-free, dairy-free. Kosher/Halal accessible.

  • Q: Can I get a pattern? A: Sure! Request beneath.

15. Sourcing & Samples
Supply Premium Berberine Hydrochloride Powder:

Conclusion
Berberine Hydrochloride Powder represents a strong software in metabolic well being help. Selecting a provider with uncompromising high quality, scientific rigor, and regulatory experience like Zhonghong BioTech is vital for product efficacy and security. Our vertically managed course of, from validated botanical sourcing to cutting-edge purification and QC, delivers berberine HCl of remarkable purity (>98%) and constant organic exercise. Contact us as we speak to raise your formulations.

References (Illustrative)

  1. Imenshahidi M, Hosseinzadeh H. Berberine and barberry (Berberis vulgaris): A medical assessment. Phytother Res. 2019.

  2. Pang B, et al. Software of berberine on treating kind 2 diabetes mellitus. Int J Endocrinol. 2015.

  3. Koppen LM, et al. Efficacy of berberine in heart problems threat discount. Nutr Metab Cardiovasc Dis. 2020.

  4. ICH Q7: Good Manufacturing Observe Information for Energetic Pharmaceutical Substances.

  5. USP-NF Monograph: Berberine Hydrochloride. (Accessed July 2025).

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