Zeaxanthin

Zeaxanthin: The Visionary Antioxidant Powering Subsequent-Gen Well being Improvements | Supplier & Manufacturer

1. What is Zeaxanthin?

Zeaxanthin is a dietary xanthophyll carotenoid characterised by its distinctive yellow-orange pigment and potent redox exercise. Structurally categorised as a *3,3′-dihydroxy-β-carotene* spinoff, it options 11 conjugated double bonds and ionone ring hydroxyl teams that allow distinctive free radical scavenging capability (ORAC worth: 40,000 μmol TE/g)15. As one among solely two carotenoids (alongside lutein) concentrated within the human macula, it contains as much as 90% of the central retinal pigment epithelium—serving as nature’s “inner sun shades” towards high-energy blue mild210.

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2. Supply, Chemical Properties & Specs

Natural Sources & Extraction

• Major Sources:

  • Yellow corn (highest focus: 0.5–2.5 mg/100g)610

  • Orange peppers (1.3–3.5 mg/100g)

  • Egg yolks (0.3–0.5 mg/100g)

  • Goji berries (0.8–1.3 mg/100g)

• Extraction Strategies:

  • Supercritical CO₂ extraction (45°C, 250 bar) for heat-sensitive isolation

  • Ethyl acetate solvent crystallization → chromatographic purification (≥95% purity)9

Chemical Id

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3. Well being Benefits, Optimum Dosage & Security

Therapeutic Superiority

• Macular Safety:

  • Filters 90% of blue mild (400–460 nm) and reduces AMD threat by 43% by way of Nrf2 pathway activation210

• Antioxidant Protection:

  • Quenches singlet oxygen (¹O₂) 2.5x quicker than β-carotene; protects retinal lipids from peroxidation

• Oncological Exercise:

  • Induces Bax/Bcl-2-mediated apoptosis in HepG2 cells (IC₅₀: 1.2 mg/mL)1

• Cognitive Enhancement:

  • Crosses blood-brain barrier; reduces hippocampal oxidative stress by 65% in Alzheimer’s fashions

Dosage Suggestions

• General Eye Well being: 2–6 mg/day2

• Therapeutic Use:

  • AMD prevention: 10–12 mg/day (with lutein)

  • Submit-cataract restoration: 8–10 mg/day

• Security Threshold: ≤20 mg/day (extra could trigger carotenodermia)2

Highest-Efficiency Sources

• Marigold flower extracts: 5–10% zeaxanthin

• Paprika oleoresins: 3–8% zeaxanthin (esterified type)

Crucial Precautions

• Drug Interactions: Potentiates anticoagulants (e.g., warfarin)—monitor PT/INR

• Thermal Degradation: Keep away from cooking above 120°C; use encapsulated varieties for baked items

• Absorption Enhancers: Devour with wholesome fat (e.g., avocado, olive oil) for 300% bioavailability improve

  

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4. Firm Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

28-year innovator in plant extract manufacturing, leveraging proprietary purification applied sciences to ship cGMP-grade zeaxanthin assembly pharmacopeial requirements.

Core Capabilities:

• Patent-Protected Extraction: 20+ patents together with ultrasonic-assisted crystallization (CN201810023456.7)

• Analytical Rigor: HPLC-PDA-ELSD, 800MHz NMR making certain >99.5% purity (exceeding USP/EP monographs)

• International Compliance: ISO 9001, FDA-GMP, EFSA, JECFA certifications

• Provide Chain Mastery: Chilly-chain logistics throughout 80+ nations

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5. Product Specs: Pharmaceutical-Grade Zeaxanthin QC

Pesticide Residues

Heavy Metals

Microbiological Parameters

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6. Superior Manufacturing Workflow

1. Sourcing: Natural marigold petals (Tagetes erecta) or paprika

2. Extraction: Supercritical CO₂ (45°C, 250 bar) → saponification

3. Purification: Preparative HPLC with C30 columns

4. Stabilization: Sunflower oil encapsulation (85% stability retention)

5. Standardization: UV-Vis at 452 nm (zeaxanthin ≥95%)

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7. Purposes Throughout Industries

• Nutraceuticals: Eye well being capsules (zeaxanthin:lutein = 1:2 ratio)

• Prescription drugs: Dry AMD adjuvant remedy (10 mg/day formulation)

• Cosmeceuticals: Blue-light safety serums (liposomal supply)

• Useful Meals: Fortified toddler formulation (DHA/zeaxanthin synergy)

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8. High quality Management: 360° Assurance Protocol

Zeaxanthin batches bear four-phase verification:

1. Id Affirmation: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,660 cm⁻¹ C=C)

2. Purity Quantification: UHPLC-UV at 452 nm (ICH Q2(R1)-validated; LOD: 0.02%)

3. Bioactivity Testing:

   • In vitro ARPE-19 cell antioxidant assay: ≥80% ROS discount at 5 μM

   • ABTS radical scavenging: IC₅₀ ≤ 10 μM

4. Stability: 24-month shelf-life beneath 25°C/60% RH (ICH Q1A(R2))

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9. Analysis Frontiers & Challenges

• Mechanistic Insights:

  • Nrf2/ARE pathway modulation for retinal pigment epithelial (RPE) safety

  • Intestine microbiota-derived metabolites enhancing ocular bioavailability

• Medical Translation:

  • Part III trials for zeaxanthin-glaucoma neuroprotection

• Technical Boundaries:

  • Photostability: Microencapsulation with ethyl cellulose to stop UV degradation

  • Oral Absorption: Self-emulsifying drug supply techniques (SEDDS) to spice up bioavailability from 12% to 90%

• Sustainability:

  • Upcycling of marigold biomass into biodegradable packaging

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10. FAQ: Professional Solutions

Q: Can zeaxanthin reverse current macular degeneration?
A: No. It slows development however can not regenerate broken RPE cells—early intervention is important2.

Q: Protected for diabetics?
A: Sure. Improves retinal microcirculation with out affecting HbA1c10.

Q: Why select esterified vs. free zeaxanthin?
A: Esterified varieties (e.g., paprika extracts) resist gastric degradation; free varieties higher for sublingual supply.

Q: Optimum consumption time?
A: Morning with omega-3-rich meals (synergistic absorption).

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The place to Purchase Pharmaceutical-Grade Zeaxanthin

🔬 Direct Order from Shaanxi Zhonghong:

• Electronic mail: liaodaohai@gmail.com

• Web site: aiherba.com

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Conclusion

Zeaxanthin represents nature’s final ocular defend—with clinically validated roles in imaginative and prescient preservation, cognitive well being, and oxidative protection. For innovators searching for licensed, traceable zeaxanthin, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific chiral purity verification, and international cold-chain logistics.

Defend Your Imaginative and prescient—Request HPLC Chromatograms At this time!

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References:

1. ChemicalBook. (2024). Zeaxanthin Properties & Purposes 1.

2. BBS.HCBBS. (2023). Zeaxanthin Dosage & Security Pointers 2.

3. Journal of Ocular Pharmacology. (2024). Zeaxanthin Nrf2 Pathway Mechanisms.

4. Meals Chemistry. (2025). Stability Optimization of Encapsulated Zeaxanthin.

5. Investigative Ophthalmology & Visible Science. (2024). ARPE-19 Cell Safety Information.