Icariin
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Icariin

Icariin factory supplier bulk Wholesale Extract factory

  1. English Name: Icariin (pronounced “ick-uh-REEN”—it’s the main active compound in Epimedium plants, also called “Horny Goat Weed” (yes, that’s the real common name!); used in TCM for centuries)
  1. Specification
    • Purity: 10%–98% (HPLC tested—most common for supplements is 20%–40%; higher purity (98%) is for research)
    • Solubility: Slightly soluble in water; dissolves well in ethanol and DMSO (works in capsules, tinctures, or topical gels—no clumps)
    • Moisture: ≤ 8% (keeps it dry, so it doesn’t lose its herbal potency)
    • Heavy Metals: ≤ 10 ppm (safe for oral use—meets TCM and global supplement standards)
    • Form: Fine powder (easy to mix into supplements or herbal blends)
  1. Appearance: Light yellow to pale yellow powder with a mild, earthy, slightly bitter herbal aroma—not a yellowish-white solid with chocolate scent! It smells like dried Epimedium leaves—subtle, classic herbal smell.
  1. CAS NO.: 489-32-7
  1. Lead time: 3–7 Working Days (we stock common purities (20%–40%) and high-purity (98%)—fast for supplement brands and TCM suppliers)
  1. Package:
    • Small sizes: 10g/100g amber glass jars (light-proof to protect potency) or 1kg resealable foil bags (great for small-batch products)
    • Bulk: 25kg food-grade drums (lined with plastic—27 drums per tray; includes desiccants to keep moisture out)
  1. Main Market: Global—Asia (TCM markets in China, Japan), Europe (herbal supplements), North America (men’s wellness and sports nutrition). Popular with people into traditional herbs or natural performance support.
  1. Applications & Main Benefits
    • Dietary Supplements
      • Men’s Wellness Capsules: 500–1000mg per serving (paired with tribulus or maca—traditional use for vitality support)
      • Joint Health Blends: Mixed with glucosamine or chondroitin (eases joint discomfort—thanks to anti-inflammatory effects)
      • Sports Performance Powders: Small doses (250–500mg) in pre-workout mixes (supports energy and endurance—popular with gym-goers)
    • Traditional Wellness Products
      • TCM Decoctions: Added to herbal soups or teas (simmered with ginseng or goji berries—customized for vitality)
      • Herbal Tinctures: Diluted in ethanol (fast-acting—drops under the tongue for quick support)
    • Cosmetics (Natural Brands)
      • Anti-Aging Serums: 0.1%–0.5% concentration (boosts collagen production—fades fine lines; great for mature skin)
      • Hair Growth Oils: Mixed into scalp oils (nourishes follicles—reduces mild hair thinning; safe for daily use)
    • Research Uses
      • Bone Health Studies: Tested for supporting bone density (may help with osteoporosis—still in lab stages)
      • Cognitive Research: Explored for memory support (crosses the blood-brain barrier—early results look promising)

Key Benefits (Why It’s a TCM Staple!)

  • Vitality Support: Traditional use for men’s wellness—helps maintain healthy energy levels and performance (no harsh stimulants)
  • Joint Comfort: Reduces inflammation in joints—great for people with mild stiffness from exercise or aging
  • Anti-Aging: Fights free radicals and boosts collagen—keeps skin firm and reduces signs of aging (natural alternative to harsh chemicals)
  • Bone Health: May support bone strength—helps with calcium absorption (useful for older adults or those at risk of bone loss)
  • Cognitive Boost: Early research shows it may support memory and focus—crosses the blood-brain barrier to target brain cells

Quick Tip

For supplements: Take icariin with a small amount of fat (like avocado or nuts)—it’s fat-soluble, so this helps your body absorb more of its benefits. If you’re new to it, start with a lower dose (500mg) to see how your body reacts—most people tolerate it well!
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Icariin: Premium Natural Compound for Nutraceutical & Pharmaceutical Applications – Manufacturer & Exporter Guide

1. What is Icariin?
For manufacturers seeking advanced natural compounds with proven biological activity, Icariin represents a premium flavonoid glycoside derived from Epimedium species (Horny Goat Weed). As the primary active compound responsible for Epimedium’s traditional uses, this sophisticated molecule offers significant potential in various health applications. Our high-purity Icariin provides consistent quality and reliable efficacy for nutraceutical, pharmaceutical, and cosmetic formulations where evidence-based natural ingredients are essential.

2. Source, Chemistry & Specifications

  • Source: Extracted from leaves of Epimedium brevicornum and related species

  • Chemical Identity: 3,5,7-Trihydroxy-4′-methoxy-8-(3-hydroxy-3-methylbutyl)flavone-3-β-D-rhamnoside

  • Chemical Profile:

    • CAS No.: 489-32-7

    • MF: C₃₃H₄₀O₁₅

    • MW: 676.67 g/mol

    • EINECS: 610-101-1

  • Appearance: Light yellow to white crystalline powder

  • Solubility: Soluble in methanol, ethanol; slightly soluble in water

  • Purity Grades: 10%-98% HPLC purity available

3. The Premium Standard: Why Our Icariin Excels
For B2B clients requiring scientifically-backed natural compounds, our Icariin offers exceptional quality:

  • Key Advantages:

    • Standardized Potency: Consistent biological activity batch-to-batch

    • Multiple Purity Options: Various concentrations for different applications

    • Research-Backed: Substantial scientific literature supporting mechanisms

  • Documented Benefits:

    • Bone Health Support: Promotes osteoblast activity and bone formation

    • Physical Performance: Supports endurance and energy metabolism

    • Neuroprotective Effects: Demonstrates protective effects on neural cells

    • Cardiovascular Support: Exhibits vasodilatory and protective properties

  • Recommended Usage: 50-200 mg daily in supplements; 0.1-1% in cosmetic formulations

  • Certifications Available: cGMP, ISO 9001, Kosher, Halal

  • Target Applications: Bone health supplements, sports nutrition, cognitive support, cardiovascular health

  • Safety Profile: Generally well-tolerated at recommended dosages

4. Zhonghong Biotech: Your Natural Compounds Specialist
Sourcing high-purity Icariin requires specialized botanical expertise.Shaanxi Zhonghong Investment Technology Co., Ltd. combines 28 years of botanical extraction experience with advanced purification technology to deliver premium ingredients to global markets.

  • Technical Capabilities:

    • Advanced Extraction: Optimized extraction protocols for maximum yield

    • Purification Expertise: Chromatographic separation for high purity grades

    • Quality Assurance: Comprehensive analytical testing and validation

  • Global Compliance: Full documentation meeting international standards

5. Scientific Excellence: Mechanism of Action
Icariin’s biological activity stems from multiple mechanisms:

  • Modulates BMP-2 and Wnt/β-catenin signaling pathways for bone formation

  • Inhibits PDE5 activity similar to conventional approaches

  • Exhibits antioxidant and anti-inflammatory properties

  • Shows neuroprotective effects through multiple pathways

6. Pharmaceutical-Grade Quality Assurance
Our rigorous quality control ensures every batch meets the highest standards:

Certificate of Analysis (COA) Summary – Icariin (98%)

Category Parameter Specification Test Method
Identity HPLC Fingerprint Matches Reference HPLC-UV
Assay Icariin Content ≥ 98.0% HPLC-UV
Purity Total Impurities ≤ 2.0% HPLC-UV
Safety Heavy Metals ≤ 10 ppm ICP-MS
Pesticide Residues Meet EPA Standards GC-MS/MS
Microbiology Total Plate Count ≤ 1000 CFU/g USP <61>
Yeast/Mold ≤ 100 CFU/g USP <61>

7. Advanced Manufacturing Process
Our optimized production ensures maximum quality:

  1. Raw Material Selection: Premium Epimedium leaves from certified sources

  2. Extraction: Optimized solvent extraction for maximum yield

  3. Concentration: Low-temperature vacuum concentration

  4. Purification: Multi-stage chromatographic purification

  5. Crystallization: Precision crystallization for purity enhancement

  6. Quality Control: Comprehensive analytical testing

8. Professional Applications & Usage

  • Nutraceuticals: Bone health supplements, sports nutrition, vitality formulas

  • Pharmaceuticals: Osteoporosis prevention, cardiovascular health

  • Cosmetics: Anti-aging skincare, hair growth formulations

  • Research: Biochemical studies, pharmacological research

Usage Guidelines:

  • Dietary Supplements: 5-15% of formulation weight

  • Cosmetic Products: 0.5-2% in final formulations

  • Research Applications: Study-specific concentrations

  • Functional Foods: As per regulatory allowances

9. Global Supply Chain Excellence

  • Packaging: 1kg double-bagged with oxygen scavengers, 25kg fiber drums

  • Storage: Cool, dry conditions away from light

  • Shelf Life: 24 months when stored properly

  • Logistics: Global shipping with full documentation support

10. Partnership Opportunities
We offer:

  • Custom purity grades (10%, 50%, 98%)

  • Private labeling and custom packaging

  • Technical support for formulation development

  • Regulatory documentation for global markets

Contact Our Technical Team:

11. Technical FAQ

  • Q: What’s the difference between Icariin and Epimedium extract?
    A: Icariin is the single active compound, while Epimedium extract contains multiple compounds

  • Q: Can you provide different purity levels?
    A: Yes, we offer from 10% to 98% purity for different applications

  • Q: Is your production GMP certified?
    A: Yes, we are a GMP certified plant extract manufacturer

  • Q: Do you offer OEM services?
    A: Absolutely, we are an experienced OEM API supplier China

  • Q: What’s your minimum order quantity?
    A: MOQ is 1kg for samples, 25kg for production quantities

12. Final Call to Action
Experience the superior quality of our Icariin for your formulations. As a leading dietary supplement raw material manufacturer and cosmetic raw material supplier bulk, we guarantee quality and consistency. Contact us today to discuss your specific requirements.

Contact us now for technical specifications and samples:

References:

  1. Chinese Pharmacopoeia Commission. (2020). Epimedium Monograph

  2. Journal of Ethnopharmacology. (2021). Therapeutic Applications of Icariin

  3. FDA. (2023). Dietary Supplement Ingredient Directory

  4. European Medicines Agency. (2022). Herbal Medicine Compendium

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