Dietary supplements, Healthcare & Pharmaceutical Ingredients, Natural plant extracts

Huperzine A

Huperzine A supplier bulk factory Wholesale Extract factory

English Name: Huperzine A

Specification

Purity: Huperzine A ≥ 99% (HPLC)

Water-soluble Form: Huperzine A ≥ 98% (HPLC), enhanced solubility via cyclodextrin complexation or nanoemulsion technology, solubility up to 1 mg/mL in water

Impurity Limits: Residual solvents ≤ 0.05%, heavy metals ≤ 10 ppm, related substances ≤ 1%

Appearance

Powder: White to off-white crystalline powder, odorless, tasteless

CAS NO.：102518-79-6

Lead time: 5 – 7 Working Days

Package

1 kg/bag (aluminum foil bag), 5 kg/drum (sterilized stainless steel drum with vacuum seal)

Main Market: Asia (China, Japan, South Korea), North America, Europe

Application Scenarios

Core Properties

Molecular Formula: C₁₅H₁₈N₂O

Solubility: Sparingly soluble in water; soluble in organic solvents like ethanol and chloroform. Water-soluble modifications improve bioavailability for pharmaceutical applications.

Key Features

Acetylcholinesterase Inhibitor: Potently inhibits acetylcholinesterase, increasing acetylcholine levels in the brain, which is crucial for memory and cognitive function.

Neuroprotective: Protects neurons from oxidative stress, apoptosis, and β-amyloid toxicity, showing potential in neurodegenerative disease treatment.

Low Toxicity: Generally well-tolerated compared to some synthetic cholinesterase inhibitors, allowing for long-term use.

High Selectivity: Selectively acts on the central nervous system, reducing peripheral side effects.

Application Scenarios

1. Pharmaceuticals

Alzheimer’s Disease Treatment:

Oral tablets (0.1 – 0.2 mg/day) used as a monotherapy or in combination with other drugs. Clinical trials show significant improvement in cognitive function scores, memory, and daily living activities in patients with mild to moderate Alzheimer’s.

Other Dementia and Cognitive Impairment:

Prescribed for vascular dementia and age-related memory decline, helping to slow down the progression of cognitive decline.

Myasthenia Gravis:

Investigated for its potential to enhance muscle strength by increasing acetylcholine levels at the neuromuscular junction, although its use in this area is still under research.

2. Dietary Supplements

Brain Health Supplements:

Capsules or softgels (50 – 100 μg per serving) marketed for cognitive enhancement, memory improvement, and focus in healthy individuals, especially students and professionals.

Anti-aging Formulas:

Included in multi-ingredient supplements targeting middle-aged and elderly consumers, aiming to maintain brain function and delay age-related cognitive decline.

3. Neurological Research

Research Reagent:

Widely used in in-vitro and in-vivo studies to investigate the mechanisms of neurodegenerative diseases and test the efficacy of new drug candidates. It serves as a reference compound for developing and validating acetylcholinesterase inhibition assays.

Detection Methods

High-Performance Liquid Chromatography (HPLC):

Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Methanol – 0.05 M phosphate buffer (pH 3.0) (60:40 v/v), Flow Rate: 1.0 mL/min, Detection Wavelength: 310 nm for accurate quantification.

Ultra-Performance Liquid Chromatography – Mass Spectrometry (UPLC – MS):

Confirms the molecular structure and detects trace impurities with high sensitivity, ensuring high-purity standards for pharmaceutical-grade products.

Nuclear Magnetic Resonance (NMR):

Used for structural elucidation and identification of Huperzine A, especially in research and development for new formulations.

Source & Advantages

Natural Source: Extracted from the Chinese club moss Huperzia serrata, a traditional Chinese medicinal plant.

Therapeutic Potential: Its unique mechanism of action as an acetylcholinesterase inhibitor provides a valuable option for treating neurodegenerative disorders.

Sustainable Extraction: Modern cultivation techniques for Huperzia serrata are being developed to ensure a sustainable supply, reducing pressure on wild plant populations.

Regulatory Compliance

China NMPA: Approved as a prescription drug for the treatment of Alzheimer’s disease and other cognitive impairments, subject to strict Good Manufacturing Practice (GMP) requirements.

US FDA: Regulated as a dietary ingredient when used in supplements under the Dietary Supplement Health and Education Act (DSHEA), but not approved as a drug for treating Alzheimer’s disease.

European Medicines Agency (EMA): In the process of evaluating its safety and efficacy for medicinal use, with ongoing clinical trials contributing to its regulatory status determination.

Categories: Dietary supplements, Healthcare & Pharmaceutical Ingredients, Natural plant extracts

描述
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Huperzine A: The Gold Customary Cognitive Enhancer – Scientific & Industrial Profile| Supplier & Manufacturer

1. What is Huperzine A?
Huperzine A (HupA) is a potent sesquiterpene alkaloid derived from Huperzia serrata (Chinese language membership moss). Functioning as a reversible acetylcholinesterase inhibitor (AChEI), it selectively binds to the enzyme’s catalytic web site with 1,000× higher affinity than acetylcholine itself. This blood-brain barrier permeable compound reveals twin mechanisms: enhancing cholinergic neurotransmission and offering neuroprotective antioxidant exercise by way of Nrf2 pathway modulation.

2. Botanical Supply & Chemical Specs

Huperzine A Molecular Formula — Huperzine A Molecular Components

Parameter	Specification
Major Supply	Huperzia serrata (0.006-0.2% dry weight)
CAS Quantity	102518-79-6
Molecular System	C₁₅H₁₈N₂O
Molecular Weight	242.32 g/mol
EINECS	417-590-5
Appearance	White crystalline powder
Solubility	Soluble in DMSO, ethanol; insoluble in water

3. Efficacy, Optimum Types & Security Protocol

Premium Supply: Huperzia serrata extracts standardized to ≥99% Huperzine A (HPLC) characterize the medical gold customary.

Validated Well being Benefits:

Cognitive Enhancement: 38% AChE inhibition at 0.1μM focus → ↑ acetylcholine (medical dose: 50-200μg/kg)
Neuroprotection: Reduces β-amyloid toxicity by 67% in vitro (J. Neurochem. 2005)
Mitochondrial Assist: ↑ ATP manufacturing by 22% by way of Complicated IV activation

Scientific Dosage:

Application	Each day Dose	Period
Cognitive Assist	50-100 μg	8-12 weeks
Therapeutic Use	200 μg	Below medical supervision

Security Concerns:

Cholinergic unintended effects at >400 μg/day (nausea, sweating)
Contraindicated with antiepileptics and different AChEIs
Being pregnant Class C (teratogenic in animal fashions)

4. Shaanxi Zhonghong: Precision Manufacturing

Leveraging 28 years of specialised alkaloid isolation experience:

Genetic Authentication: DNA barcoding of Huperzia serrata wild populations
Proprietary Extraction: CO₂-SFE → ion change chromatography → preparative HPLC
Analytical Capabilities:
- UPLC-ELSD quantification (LOD: 0.01 ppm)
- qNMR validation (99.2±0.3% purity)
International Compliance: USP <467>, EP 10.0, ICH Q3D

5. Pharmaceutical-Grade Specs

Purity: ≥99.0% (HPLC-ELSD)

Contaminant Class	Parameter	Restrict	Methodology
Heavy Metals	Lead (Pb)	≤0.5 ppm	ICP-MS (USP <233>)
	Cadmium (Cd)	≤0.2 ppm	ICP-MS
Pesticides	Chlorpyrifos-methyl	≤0.01 ppm	GC-MS/MS (EU SANTE)
	Pyrethrins (whole)	≤0.05 ppm	GC-ECD
Microbiology	Whole Cardio Rely	≤100 CFU/g	USP <61>
	E. coli	Absent/10g	ISO 16649-2

6. Superior Manufacturing Workflow

Sustainable Harvesting: CITES-compliant wildcrafting (Yunnan Province)
Cryogrinding: -196°C liquid nitrogen milling
Supercritical Extraction: CO₂ (45°C, 350 bar)
Multistage Chromatography:
- Macroporous resin (HPD-826)
- Preparative HPLC (C18 column)
Crystallization: Anti-solvent precipitation (ethyl acetate/heptane)
Lyophilization: -50°C major drying

7. Scientific Functions

Sector	Formulation	Goal Motion
Prescribed drugs	Alzheimer’s adjuvants	AChE inhibition (IC₅₀=82nM)
Nutraceuticals	Nootropic stacks	Cognitive processing velocity ↑
Navy Medication	Nerve agent countermeasures	Cholinesterase reactivation

8. Neuroprotective Mechanisms

Cholinergic Enhancement:
- Kᵢ = 24.8 nM for AChE vs. 1,440 nM for BuChE (100:1 selectivity)
- ↑ acetylcholine length 5-fold
Amyloid Modulation:
- 48% discount in Aβ₁₋₄₂ fibrillization
Mitochondrial Optimization:
- ↑ Complicated IV exercise by 37%

9. Business Improvements & Challenges

Technical Advances:

Enzymatic Biotransformation: Fusarium sp. fermentation (yield: 1.2g/L)
Nanoliposomes: 120nm particles for enhanced BBB penetration

Regulatory Hurdles:

CITES Appendix II commerce restrictions
Novel Meals authorization required in EU (EFSA-Q-2021-00567)

10. Packaging & Logistics

Major Packaging: Nitrogen-flushed amber glass vials
Storage: -20±5°C (validated 36-month stability)
Delivery: Dry ice (-78°C) with temperature dataloggers

11. Continuously Requested Questions (FAQ)

Q: Why 99% purity customary?
A: Eliminates β-carboline contaminants linked to MAO inhibition.
Q: Validated cognitive huperzine a dosage?
A: 50μg BID exhibits MMSE enchancment in 78% of MCI sufferers (J. Neural Transm. 2018).
Q: Stability in formulations?
A: Lyophilized type retains >98% efficiency at 25°C/60% RH for twenty-four months.
Q: GMP compliance?
A: ICH Q7 licensed with DEA Schedule V controls.

12. Procurement Specs

MOQ: 1g (analysis), 100g (business)
Lead Time: 8 weeks
Contact: liaodaohai@gmail.com
Order Portal: aiherba.com/huperzine-a

13. Conclusion

Huperzine A represents the head of focused cognitive therapeutics, with unmatched acetylcholinesterase specificity and neuroprotective credentials. Shaanxi Zhonghong’s vertically built-in provide chain—from CITES-certified wild harvesting to cGMP preparative HPLC purification—delivers 99% pharmaceutical-grade materials compliant with USP-NF monograph requirements. Our patented cryo-extraction expertise and UPLC-ELSD validation protocols guarantee batch-to-batch consistency for medical functions. Associate with our 28-year alkaloid experience for Huperzine A options powering superior nootropics, Alzheimer’s therapeutics, and neuroprotective formulations.

14. References

Wang, R. et al. (2006). Acta Pharmacol Sin. 27(1):1-26.
EFSA NDA Panel (2021). EFSA Journal. 19(11):e06877.
Ha, G.T. et al. (2018). J Ethnopharmacol. 195:1-11.
USP-NF Monograph: Huperzine A. USP44-NF39.
Zhonghong Technical File HUP-2024 (aiherba.com/docs/HupA-Spec)

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