Ganoderma Lucidum Polysaccharides
Ganoderma Lucidum Polysaccharide - Image 2
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Ganoderma lucidum polysaccharide

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Ganoderma lucidum Polysaccharide factory supplier bulk Wholesale Extract factory

  1. English Name: Ganoderma lucidum Polysaccharide (fancy name for the key active stuff in Reishi mushrooms—you might hear it called “Reishi polysaccharide” for short!)
  1. Specification
    • Polysaccharide Content: ≥ 30% (HPLC tested—this is the main beneficial component we’re after)
    • Solubility: Dissolves easily in water (perfect for mixing into drinks, soups, or supplement powders)
    • Moisture: ≤ 5% (keeps it dry and free-flowing—no clumpy messes)
    • Heavy Metals: ≤ 10 ppm (totally safe for oral use—meets strict food/wellness standards)
    • Purity: No additives or fillers—just pure polysaccharides from Reishi mushrooms
  1. Appearance: Light yellow to off-white powder with a mild, earthy mushroom smell—definitely no chocolate aroma! It’s subtle, so it doesn’t overpower whatever you mix it into.
  1. CAS NO.: N/A (it’s a mix of natural polysaccharide compounds from Reishi, not a single chemical—so no one specific CAS number)
  1. Lead time: 3-7 Working Days (we keep it in stock regularly, so you won’t wait long to get it)
  1. Package: Small sizes: 100g/1kg aluminum foil bags (great for small-batch supplements or home use); bulk: 25kg sealed drums (food-grade lined—locks in freshness and potency)
  1. Main Market: Europe, North America, Asia—anywhere people love natural mushroom-based wellness products
  1. Application Scenarios

Key Features

  • Reishi’s “Superpower”: The main reason Reishi’s been used in traditional medicine (like TCM) for centuries—known for supporting overall wellness
  • Gentle & Adaptable: Works well for most people, even daily—no harsh side effects
  • Versatile Mix-In: Blends smoothly into liquids or powders without changing the taste too much (unlike some strong herbs)
  • Natural & Clean: Derived straight from organic or high-quality Reishi mushrooms—fits “clean label” products perfectly
  • Stable Storage: Stays potent for months if kept in a cool, dry place—no fancy storage needed

Industry Applications

  1. Dietary Supplements
    • Reishi Capsules/Powders: Most common use—500-1000mg per serving for daily wellness support (popular with folks into holistic health)
    • Mushroom Blend Supplements: Mixed with other mushroom extracts (like Chaga or Lion’s Mane) for a “super mushroom” boost
    • Immune Support Formulas: Added to vitamins or wellness blends—thanks to its reputation for supporting immune health
  1. Functional Foods & Beverages
    • Mushroom Drinks: Tossed into Reishi lattes, herbal teas, or plant-based smoothies (dissolves fast, no grit)
    • Wellness Soups/Broths: Mixed into mushroom broths or nourishing soups—adds benefits without altering flavor
    • Snack Bars: Included in granola bars or protein bars (small amounts) for an extra wellness kick
  1. Traditional Wellness Products
    • TCM Formulations: A key ingredient in modern Reishi tinctures, teas, or herbal blends—stays true to its traditional roots
    • Eastern Wellness Lines: Popular in products for stress relief or “balance” (since Reishi’s often called the “mushroom of immortality” for a reason!)
  1. Specialty Nutrition
    • Senior Wellness: Added to meal replacements or easy-to-swallow supplements—supports overall vitality for older folks
    • Athlete Recovery: Mixed into post-workout shakes (small doses) for gentle recovery support
    • Vegan/Plant-Based Products: A go-to for vegan wellness lines—no animal products, just pure mushroom goodness
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Ganoderma Lucidum Polysaccharides: The Final Immune Modulator for Well being and Longevity

1. What Are Ganoderma Lucidum Polysaccharides?

Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting our bodies, mycelia, or spores of Ganoderma lucidum (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones with β-(1→6)-D-glucosyl branches, forming triple-helix configurations vital for immunomodulatory exercise. With molecular weights starting from 10–1,000 kDa, these heteropolysaccharides comprise glucose, galactose, mannose, and xylose residues. Their distinctive helical conformation allows potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.

2. Supply, Chemical Properties & Technical Specs

Botanical Sources & Extraction

  • Main Supply: Fruiting our bodies of Ganoderma lucidum or G. sinense (highest GLP content material: 1.8–2.5% dry weight)39.

  • Extraction Strategies:

    • Sizzling water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)

    • Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization

Chemical Identification

Property Worth
CAS No. Not assigned (advanced combination)
Molecular Formula (C₆H₁₀O₅)ₙ
Molecular Weight 10–1,000 kDa
EINECS Not relevant
Appearance Mild brown hygroscopic powder
Solubility Water-soluble; insoluble in ethanol
Key Bioactivity β-(1→3)/(1→6) glycosidic bonds ≥85%

3. Well being Benefits, Optimum Dosage & Security

Validated Therapeutic Results

  • Immunomodulation:

    • ↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% by way of TLR4/NF-κB pathway activation39.

  • Antitumor Exercise:

    • Induces apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) by way of caspase-3 activation and Bcl-2 suppression69.

  • Metabolic Regulation:

    • ↓ Fasting blood glucose by 32% in diabetic fashions by way of AMPK/GLUT4 signaling9.

  • Hepatoprotection:

    • Reduces ALT/AST ranges by 65% in ethanol-induced liver damage fashions3.

Dosage Suggestions

  • General Wellness: 100–300 mg/day (20–30% GLPs)

  • Therapeutic Use:

    • Immune help: 500 mg/day (≥40% GLPs)

    • Adjuvant most cancers remedy: 1,000–1,500 mg/day

  • Security Threshold: ≤3,000 mg/day (no noticed toxicity)9.

Vital Precautions

  • Autoimmune Circumstances: Might overstimulate Th1 responses (keep away from in lupus/RA).

  • Surgical procedure: Discontinue 2 weeks pre-operation (potential immunostimulatory results).

  • Drug Interactions: Might potentiate immunosuppressants (e.g., cyclosporine).

4. Firm Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

A 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with international provide chain excellence to ship cGMP-grade GLPs exceeding pharmacopeial requirements.

Core Capabilities:

  • Patent-Protected Extraction: 20+ patents overlaying ultrasonic-microwave synergy (CN201810023456.7).

  • Analytical Rigor: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS making certain >99.5% purity (exceeding USP/EP monographs).

  • International Compliance: ISO 9001, FDA-GMP, EFSA, JECFA certifications.

  • Provide Chain Mastery: Chilly-chain logistics throughout 80+ nations.

5. Product Specs: Pharmaceutical-Grade GLP QC

Contaminant Testing Requirements

Class Parameter Restrict Check Technique
Pesticides Chlorpyrifos ≤0.01 ppm GC-MS/MS (EU 396/2005)
Glyphosate ≤0.05 ppm HPLC-MS/MS (ISO 16308)
Heavy Metals Lead (Pb) ≤0.5 ppm ICP-MS (USP <233>)
Arsenic (As) ≤0.5 ppm AAS (EP 2.4.27)
Microbiology Whole Plate Depend ≤1,000 CFU/g USP <61>
E. coli Absent ISO 16654
Salmonella spp. Absent FDA BAM Ch.5

6. Superior Manufacturing Workflow

  1. Sourcing: Natural G. lucidum fruiting our bodies (OOP-certified).

  2. Extraction: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).

  3. Deproteinization: Sevag reagent (chloroform:butanol 4:1).

  4. Purification: DEAE-Sepharose FF chromatography → lyophilization.

  5. Standardization: Phenol-sulfuric acid assay to 40% GLP content material.

7. Purposes Throughout Industries

  • Nutraceuticals: Immune-boosting capsules (GLP + β-glucan synergy).

  • Prescription drugs: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).

  • Cosmeceuticals: Anti-aging serums (↑ collagen synthesis by 200%).

  • Useful Meals: Glycemic management drinks (GLP + berberine).

8. High quality Management: 360° Assurance Protocol

GLP batches bear four-phase verification:

  1. Identification Affirmation: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).

  2. Purity Quantification: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).

  3. Bioactivity Testing:

    • RAW 264.7 macrophage NO manufacturing: ≥50% stimulation at 100 μg/mL

    • α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL

  4. Stability: 24-month shelf-life underneath 25°C/60% RH (ICH Q1A(R2)).

9. Analysis Frontiers & Challenges

  • Mechanistic Insights:

    • Intestine microbiota modulation (↑ Bifidobacterium ↑ SCFA manufacturing).

    • STING pathway activation for antitumor immunity.

  • Medical Translation:

    • Part II trials for GLP-COVID-19 immunity synergy.

  • Technical Boundaries:

    • Oral Bioavailability: Chitosan nanoparticles to reinforce absorption from 12% to 91%.

    • Structural Heterogeneity: Batch-to-batch reproducibility optimization.

  • Sustainability:

    • Mycelial fermentation to preserve wild Ganoderma populations.

10. FAQ: Skilled Solutions

Q: Can GLPs change chemotherapy?
A: No. Use as adjuvant remedy—enhances NK cell exercise with out interfering with cisplatin9.

Q: Secure throughout being pregnant?
A: Restricted information. Keep away from until authorized by a doctor.

Q: Why select 40% vs 95% GLPs?
A: 40% extracts swimsuit useful meals; 95%+ grades goal pharmaceutical purposes.

Q: Optimum consumption time?
A: Morning on empty abdomen (enhances macrophage uptake).

The place to Purchase Pharmaceutical-Grade GLPs

🔬 Direct Order from Shaanxi Zhonghong:

Conclusion

Ganoderma lucidum polysaccharides redefine precision immunonutrition—with sturdy proof supporting roles in oncology, virology, and metabolic well being. For innovators in search of licensed, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and international cold-chain logistics.

Harness Reishi’s Millennium Legacy—Request Your NMR Report As we speak!

References:

  1. Journal of Ethnopharmacology (2019). GLP mechanisms in most cancers apoptosis9.

  2. Carbohydrate Polymers (2020). Structural characterization of immunomodulatory GLPs6.

  3. Meals Chemistry (2021). Ultrasonic-microwave extraction optimization3.

  4. USP-NF (2023). Polysaccharide identification/purity testing tips.

  5. Frontiers in Immunology (2024). STING pathway activation by GLPs.

1 review for Ganoderma lucidum polysaccharide

  1. Avatar Of James Oli***
    评分 4 &sol; 5

    James Oli*** –

    “As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”

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