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Rebaudioside A

Rebaudioside A supplier bulk factory Wholesale buy Extract factory

1.English Name: Rebaudioside A

  1. Specification
    • Purity: Rebaudioside A ≥ 95% (HPLC); Excessive – purity grade: ≥ 98% (HPLC)
    • Particle Measurement: Normal powder ≤ 100 μm; Micronized powder ≤ 5 μm for enhanced dissolution
    • Solubility: Soluble in water (5 – 10 g/L at 25°C), ethanol; water – soluble formulations optimized for beverage functions
  2. Appearance
    • Powder: White to off – white high quality powder, odorless, intensely candy style
  3. CAS NO.:58543-16-1
  4. Lead time: 3 – 7 Working Days
  5. Package
    • 1 kg/bag (aluminum foil bag), 25 kg/drum (double – layer PE bag inside cardboard drum)
  6. Main Market: North America, Europe, Asia, South America (particularly in low – calorie meals and beverage industries)
  7. Application Scenarios

Core Properties

  • Molecular Method: C₄₄H₇₀O₂₂
  • Style Profile: 200 – 400 instances sweeter than sucrose with minimal bitter aftertaste (in comparison with different steviol glycosides)
  • Key Options
    • Low – Calorie Sweetener: Zero – calorie various to sugar, appropriate for diabetic and weight – administration diets.
    • Thermostability: Secure below excessive temperatures (as much as 120°C), enabling use in baked items and processed meals.
    • pH Stability: Stays secure throughout pH 3 – 9, splendid for drinks and acidic merchandise.
    • Natural Origin: Extracted from Stevia rebaudiana leaves, assemblyclear label” client calls for.

Application Scenarios

1. Meals & Drinks

  • Drinks:
    • Added to delicate drinks, juices, teas, and power drinks at 0.01 – 0.1% focus to exchange or cut back sugar content material.
    • Utilized in sports activities drinks to offer sweetness with out energy, sustaining electrolyte steadiness.
  • Bakery & Confectionery:
    • Incorporate into truffles, cookies, and candies, sustaining texture and shelf – life whereas decreasing sugar by 30 – 50%.
    • Perfect for sugar – free chocolate merchandise, enhancing sweetness with out affecting melting properties.
  • Dairy Merchandise:
    • Fortify yogurt, ice cream, and milkshakes, interesting to well beingacutely aware shoppers looking for low – calorie choices.

2. Dietary Dietary supplements

  • Weight Administration Formulation:
    • Capsules or powders containing Rebaudioside A mixed with fiber and probiotics, marketed for urge for food suppression and calorie discount.
  • Diabetic – Pleasant Dietary supplements:
    • Included in glucose – management dietary supplements, offering sweetness with out elevating blood sugar ranges.

3. Cosmetics & Private Care

  • Oral Care:
    • Added to toothpaste, mouthwash, and chewing gum to offer sweetness whereas decreasing sugar – associated dental points.
  • Skincare:
    • Utilized in lip balms and moisturizers for a candy taste with out the chance of attracting bugs (not like sugar – primarily based sweeteners).

4. Animal Feed

  • Pet Meals:
    • Incorporate into pet treats and kibble to boost palatability with out including energy, helpful for chubby pets.
  • Livestock Feed:
    • Utilized in poultry and swine feed to enhance feed consumption, doubtlessly growing development effectivity.

Detection Strategies

  • ExcessiveEfficiency Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Cell Part: Acetonitrile – water (gradient elution), Stream Charge: 1.0 mL/min, Detection Wavelength: 210 nm.
  • ExtremelyEfficiency Liquid Chromatography – Mass Spectrometry (UPLC – MS):
    • Confirms molecular construction and detects hint impurities, making certain excessive – purity requirements.
  • Refractive Index Detection (RID):
    • Used for quantifying Rebaudioside A in complicated mixtures, offering correct focus information.

Supply & Benefits

  • Natural Supply: Extracted from the leaves of Stevia rebaudiana, a plant native to South America and now cultivated globally.
  • Sustainability: Renewable crop with low water necessities, supporting eco – pleasant manufacturing.
  • PriceEffectivity: Reduces lengthytime period healthcare prices related to sugar – associated illnesses (e.g., diabetes) via calorie discount.

Regulatory Compliance

  • US FDA: Typically Acknowledged As Protected (GRAS) for meals use since 2008, permitting inclusion in varied meals classes.
  • EU Regulation: Permitted as a meals additive (E960) with particular utilization limits in numerous merchandise.
  • China NMPA: Permitted as a sweetener in meals and drinks, topic to nationwide security requirements.

Rebaudioside A: The Premium Natural Sweetener Powering More healthy Formulations| Supplier & Manufacturer

1. What is Rebaudioside A?

Rebaudioside A (Reb A) is a extremely prized steviol glycoside, the first sweet-tasting compound remoted from the leaves of the Stevia rebaudiana Bertoni plant. Famend for its distinctive sweetness depth (roughly 200-400 instances sweeter than sucrose) and superior sensory profile in comparison with different steviol glycosides, Reb A delivers a clear, sugar-like style with considerably decreased bitterness and lingering aftertaste. Its zero-calorie, zero-glycemic index nature makes it a cornerstone ingredient within the world shift in the direction of pure, health-conscious sugar discount methods throughout meals, beverage, and nutraceutical industries.

2. Product Supply, Chemical Properties & Key Identifiers

  • Supply: Extracted and purified from the leaves of the Stevia rebaudiana Bertoni plant, native to South America and now cultivated globally.

  • Chemical Properties:

    • Sort: Diterpene glycoside.

    • Molecular Components: C₄₄H₇₀O₂₃

    • Molecular Weight: 967.03 g/mol

    • CAS Quantity: 58543-16-1

    • EINECS Quantity: 261-342-2

    • Appearance: Usually a positive, white to off-white crystalline powder.

    • Solubility: Extremely soluble in water and ethanol.

    • Stability: Steady beneath excessive temperatures (baking, pasteurization) and throughout a large pH vary, making it extremely versatile for processing.

3. Why Rebaudioside A is the Finest & Its Well being Profile

  • “The Finest” & Highest Purity: Amongst steviol glycosides, Rebaudioside A (Reb A) is broadly thought to be having essentially the most favorable sensory profile, characterised by its clear sweetness onset and minimal bitterness/licorice aftertaste. Merchandise labeled “Excessive-Purity Reb A” (e.g., 95%, 97%, 98%+) comprise the best focus of this fascinating glycoside, providing superior style efficiency. Reb M can also be famous for a clear profile however is much less considerable naturally and sometimes extra expensive to provide at excessive purity.

  • Well being Benefits & Efficacy:

    • Zero Energy & Zero Glycemic Influence: Essential for weight administration and blood sugar management, notably helpful for diabetics and prediabetics.

    • Dental Well being: Non-cariogenic – doesn’t promote tooth decay.

    • Antioxidant Properties: Some analysis suggests steviol glycosides possess gentle antioxidant exercise.

    • Blood Stress Help: Restricted research point out potential gentle vasodilatory results, although extra analysis is required for conclusive well being claims.

  • Day by day Consumption & ADI: The Acceptable Day by day Consumption (ADI) for steviol glycosides (expressed as steviol equivalents) established by JECFA (FAO/WHO) and EFSA is 4 mg per kg of physique weight per day. For a 70kg grownup, this equates to roughly 280 mg of steviol equivalents. Excessive-purity Reb A merchandise sometimes specify their Reb A content material and steviol equal conversion issue.

  • Security & Facet Results: Rebaudioside A is Usually Acknowledged As Protected (GRAS) by the US FDA and accredited for meals use globally (EU, JECFA, and so on.). In depth security evaluations assist its use. Potential unintended effects are uncommon however might embrace gentle gastrointestinal discomfort (bloating, nausea) in delicate people when consumed in very massive portions, considerably exceeding the ADI. No important allergenic potential is thought.

  • Precautions: Whereas secure for the overall inhabitants, people with extreme kidney illness ought to seek the advice of a physician. At all times adhere to beneficial utilization ranges in formulations.

4. Introducing Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Supply for Premium Reb A
Shaanxi Zhonghong Investment Technology Co., Ltd. stands as a frontrunner within the bioactive compounds business, leveraging 28 years of experience. As a vertically built-in high-tech enterprise, we concentrate on agile R&D, built-in manufacturing, and world distribution, serving the demanding wants of the chemical, supplies, and life science sectors. Our core competency lies within the superior extraction, isolation, and purification of high-value plant constituents, together with premium-grade Rebaudioside A.

  • Unmatched Scientific Prowess: We keep strategic collaborations with 5 top-tier universities by way of joint analysis laboratories, driving innovation. Our technological edge is protected by over 20 patents and consists of entry to a proprietary world compound library.

  • Chopping-Edge High quality Infrastructure: Our dedication to purity is enforced by state-of-the-art analytical instrumentation, together with Excessive-Efficiency Liquid Chromatography (HPLC), Extremely-Excessive-Efficiency Liquid Chromatography (UHPLC), and Superconducting Nuclear Magnetic Resonance (NMR) spectrometers. This allows us to constantly obtain purity requirements exceeding business norms by 20% or extra.

  • International Provide Chain Excellence: We possess a strong worldwide distribution community spanning Asia, Europe, and the Americas (80+ international locations), offering custom-made ingredient options to multinational pharmaceutical firms, analysis establishments, and premium nutraceutical/meals producers.

5. Rebaudioside A Benefits: Past Sweetness

  • Well being & Wellness: Allows important sugar discount with out sacrificing sweetness, supporting calorie management, blood sugar administration, and dental well being.

  • Clear Label Attraction: A pure, plant-derived ingredient extremely wanted by customers demanding transparency.

  • Formulation Versatility: Distinctive stability beneath warmth and throughout pH ranges permits use in drinks, baked items, dairy, confectionery, and tabletop sweeteners.

  • Value-Effectiveness: Excessive sweetness efficiency means very low utilization ranges are required, typically making it economically viable regardless of the next per-kg worth than sugar.

6. Utilizing Rebaudioside A: Tips

  • Utilization Ranges: Extremely potent; typical utilization ranges vary from 0.01% to 0.05% in drinks and meals, relying on the goal sweetness and the particular product matrix. Alternative ranges for sucrose differ considerably.

  • Synergies: Usually blended with different sweeteners (e.g., erythritol, allulose, monk fruit extract) or flavors to optimize style profile, masks any slight aftertaste, and supply bulk.

  • Application: Simply integrated into each aqueous and lipid-based techniques. Pre-dissolving in water or a water-miscible solvent is widespread for uniform distribution.

7. Product Specs: Rigorous High quality Assurance
Shaanxi Zhonghong ensures Reb A gathering the best worldwide requirements. Our specs embrace complete testing for purity, residues, heavy metals, and microbiology:

Desk 1: Pesticide Residue Limits

Pesticide Residue Venture Specification (Max mg/kg) Take a look at Technique
Acephate < 0.01 GC-MS, LC-MS/MS
Aldrin + Dieldrin < 0.01 GC-MS
BHC (α, β, γ, δ isomers) < 0.01 GC-MS
Chlordane (Complete) < 0.01 GC-MS
DDT (Complete) < 0.01 GC-MS
Endrin < 0.01 GC-MS
Fenvalerate < 0.01 GC-MS
Heptachlor + Epoxide < 0.01 GC-MS
Hexachlorobenzene < 0.01 GC-MS
Malathion < 0.01 GC-MS
Methoxychlor < 0.01 GC-MS
Parathion < 0.01 GC-MS
Pyrethrins (Complete) < 0.01 GC-MS

Desk 2: Heavy Steel Limits

Heavy Steel Venture Specification (Max ppm) Take a look at Technique
Arsenic (As) ≤ 1.0 ICP-MS, USP <232>/EP 2.4.27
Cadmium (Cd) ≤ 1.0 ICP-MS, USP <232>/EP 2.4.27
Lead (Pb) ≤ 1.0 ICP-MS, USP <232>/EP 2.4.27
Mercury (Hg) ≤ 0.1 ICP-MS, USP <232>/EP 2.4.27

Desk 3: Microbiological Requirements

Microbiological Venture Specification Take a look at Technique
Complete Cardio Microbial Depend ≤ 1,000 CFU/g USP <61>, EP 2.6.12
Complete Mixed Yeasts & Molds ≤ 100 CFU/g USP <61>, EP 2.6.12
Escherichia coli Absent in 10g USP <62>, EP 2.6.13
Salmonella spp. Absent in 25g USP <62>, EP 2.6.13
Staphylococcus aureus Absent in 1g USP <62>, EP 2.6.13
Pseudomonas aeruginosa Absent in 1g USP <62>, EP 2.6.13

8. Superior Manufacturing Course of
Shaanxi Zhonghong employs a classy, multi-stage cGMP-compliant course of to make sure the best purity Reb A:

  1. Sourcing & Pre-treatment: Choice of premium Stevia rebaudiana leaves; washing, drying, and milling.

  2. Extraction: Sizzling water or food-grade solvent extraction to solubilize steviol glycosides.

  3. Major Purification: Filtration and centrifugation to take away insoluble plant materials.

  4. Decolorization & Deionization: Elimination of pigments, organic acids, and salts utilizing activated carbon and ion-exchange resins.

  5. Superior Chromatographic Separation: Macroporous adsorption resin chromatography and/or preparative HPLC are critically employed to isolate and extremely purify Rebaudioside A from different glycosides (e.g., Stevioside, Reb C, Reb D).

  6. Crystallization: Managed crystallization to acquire high-purity Reb A crystals.

  7. Drying: Spray drying or vacuum drying to attain the ultimate powder type.

  8. Mixing & Standardization: Guaranteeing constant Reb A content material and efficiency.

  9. Rigorous High quality Management: Complete analytical testing at each important stage (HPLC, UHPLC, NMR, GC-MS, ICP-MS, microbiology).

  10. Packaging: Sealed in food-grade, multi-layer moisture-barrier packaging (e.g., aluminum foil luggage inside cartons).

9. Key Application Scenarios

  • Meals & Beverage: Smooth drinks, juices, flavored waters, yogurt, ice cream, confectionery (chocolate, candies), baked items, sauces, dressings.

  • Nutraceuticals & Dietary Dietary supplements: Tablets, capsules, powders, gummies for weight administration, blood sugar assist.

  • Prescription drugs: Sweetening agent in syrups, chewable tablets, and liquid formulations.

  • Tabletop Sweeteners: Liquid drops, sachets, and granulated blends.

  • Oral Care Merchandise: Toothpaste, mouthwash (non-cariogenic profit).

  • Cosmetics: Sometimes utilized in lip merchandise.

10. Stringent High quality Management (QC)
High quality is paramount at Shaanxi Zhonghong. Our multi-tiered QC protocol begins with incoming uncooked materials inspection of stevia leaves for authenticity, moisture, and preliminary contaminants. In-process controls (IPC) are rigorously utilized all through extraction, purification, chromatography, and crystallization, using real-time HPLC/UHPLC monitoring to trace glycoside profiles and guarantee goal purity ranges are met earlier than continuing. Ultimate product launch requires full conformance testing in opposition to all specs outlined in Part 7 (Purity by HPLC/UHPLC, Residues by GC-MS/LC-MS/MS, Heavy Metals by ICP-MS, Microbiology per USP/EP). Our cutting-edge analytical capabilities, together with quantitative NMR (qNMR) for absolute purity affirmation, Mass Spectrometry (MS) for structural elucidation and hint contaminant identification, and accelerated stability research, assure batch-to-batch consistency, security, and efficacy. We adhere strictly to ISO, HACCP, and cGMP ideas, sustaining complete documentation for full traceability.

11. Safe Packaging & International Logistics

  • Packaging: 1kg, 5kg, 10kg, 25kg food-grade aluminum foil luggage with HDPE inside lining, vacuum-sealed or flushed with nitrogen, positioned inside fiberboard drums or corrugated cartons. Customized packaging accessible.

  • Storage: Retailer in a cool, dry place (<25°C, <65% RH) in authentic, unopened packaging. Shelf life sometimes 24 months.

  • Logistics: Shipped by way of air freight or sea freight globally. Certificates of Evaluation (CoA), Certificates of Origin (CoO), and Materials Security Knowledge Sheet (MSDS) accompany all shipments. Compliant with worldwide customs and meals security laws.

12. Deep Dive: Well being Mechanisms, Innovation & Analysis

  • Well being Mechanisms: Reb A interacts with candy style receptors (T1R2/T1R3) on the tongue. In contrast to sugar, it’s not metabolized for vitality within the physique; it passes by way of unmetabolized or is metabolized by intestine micro organism into steviol, which is absorbed, glucuronidated within the liver, and excreted in urine. This pathway underpins its zero-calorie standing and lack of affect on blood glucose.

  • Business Purposes & Tech Innovation: Demand drives innovation in extraction effectivity (ultrasound, microwave-assisted), purification selectivity (novel adsorbents, simulated transferring mattress chromatography), style modulation (enzymatic glycosylation to create next-gen molecules like Reb D, M; mixing science), and purposes (bettering solubility/stability in advanced matrices).

  • Analysis Frontiers & Challenges: Ongoing analysis explores metabolic results past sweetness (intestine microbiome modulation, anti-inflammatory potential), refined sensory prediction fashionscost-effective large-scale manufacturing of minor, cleaner-tasting glycosides (Reb M, D), regulatory harmonization, and shopper schooling on style notion.

13. Rebaudioside A FAQs

  • Q: Is Rebaudioside A secure? A: Sure, main world well being authorities (FDA, EFSA, JECFA, FSANZ) approve high-purity steviol glycosides, together with Reb A, as secure for consumption throughout the established ADI.

  • Q: Does Reb A have an effect on blood sugar? A: No, Rebaudioside A has a zero glycemic index and doesn’t increase blood glucose or insulin ranges, making it appropriate for diabetics.

  • Q: Why select Reb A over Stevioside? A: Reb A usually has a cleaner, sweeter style profile with much less bitterness and licorice aftertaste in comparison with Stevioside.

  • Q: Can I bake with Reb A? A: Sure, Reb A is warmth secure, making it appropriate for baking and cooking purposes.

  • Q: Are there any unintended effects? A: Reb A is well-tolerated. Consuming quantities vastly exceeding the ADI may trigger gentle digestive upset in delicate people, however that is unusual at typical utilization ranges.

  • Q: Is Reb A pure? A: Sure, it’s extracted and purified straight from the Stevia leaf, qualifying as a pure sweetener.

  • Q: How is it completely different from synthetic sweeteners? A: In contrast to synthetic sweeteners (e.g., aspartame, sucralose), Reb A is derived from a plant supply and is mostly perceived extra favorably by customers searching for pure substances.

14. The place to Purchase Excessive-High quality Rebaudioside A?
Supply premium, high-purity Rebaudioside A straight from the producer, Shaanxi Zhonghong Investment Technology Co., Ltd.:

15. Conclusion
Rebaudioside A stands because the gold commonplace throughout the pure high-intensity sweetener market, pushed by its distinctive purity, superior style profile, zero-calorie nature, and confirmed security. As shopper demand for sugar discount and clear labels continues to surge, Reb A provides an indispensable resolution for revolutionary meals, beverage, and well being product formulators. Shaanxi Zhonghong Investment Technology Co., Ltd., with its 28-year legacy, cutting-edge purification expertise, unwavering dedication to high quality exceeding business benchmarks (20%+ purity benefit), and strong world provide chain, is your strategic companion for securing a dependable provide of premium-grade Rebaudioside A. Associate with us to raise your product formulations and meet the evolving calls for of the health-conscious world market.

16. References

  1. European Meals Security Authority (EFSA). (2010). Scientific Opinion on the protection of steviol glycosides for the proposed makes use of as a meals additive. EFSA Journal, 8(4), 1537.

  2. Meals and Agriculture Group / World Well being Group (FAO/WHO) Joint Skilled Committee on Meals Components (JECFA). (2016). Specs for Steviol Glycosides. Monograph 21.

  3. U.S. Meals and Drug Administration (FDA). GRAS Notices: GRN No. 252 (Steviol Glycosides), GRN No. 732 (Reb M). [Access via FDA website].

  4. Purkayastha, S., et al. (2016). Steviol Glycosides in Industrial Stevia Merchandise: Compositional Evaluation and Their Relationship to Sweetness. Journal of Agricultural and Meals Chemistry, 64(4), 678–686.

  5. Ashwell, M. (2015). Stevia, Nature’s Zero-Calorie Sustainable Sweetener: A New Participant within the Combat Towards Weight problems. Vitamin As we speak, 50(3), 129–134.

  6. Shankar, P., et al. (2013). Non-nutritive sweeteners: evaluation and replace. Vitamin, 29(11–12), 1293–1299. (PubMed ID: 23845273)

  7. Worldwide Stevia Council (ISC). [Industry resources & science summaries].

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