Daidzein: Premium Phytoestrogen for Well being & Longevity | Shaanxi Zhonghong | Supplier & Manufacturer

1. Daidzein: The Bioactive Isoflavone Powerhouse

Daidzein (7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one) is a potent phytoestrogen belonging to the isoflavone subclass. This plant-derived polyphenol encompasses a diphenolic construction enabling selective binding to estrogen receptors (ERβ > ERα). With confirmed antioxidant, osteoprotective, and cardiometabolic advantages, daidzein serves as a important ingredient in nutraceuticals for menopause assist, bone well being formulations, and anti-aging cosmeceuticals.

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2. Botanical Sources & Chemical Specs

Premium Natural Sources

Superior Chemical Properties

• Molecular method: C₁₅H₁₀O₄

• Look: Off-white crystalline powder

• Solubility profile:

  • Water: 4.92 μg/mL (25°C)

  • DMSO: >50 mg/mL

  • Ethanol: 12 mg/mL

• Thermal stability: Secure to 285°C (decomposition level)

Regulatory Identifiers

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3. Premium-Grade Daidzein: Sources & Scientific Purposes

Optimum Sources & Bioavailability

• Non-GMO Soy Germ Extract: Comprises 40-45% daidzein by way of patented extraction

• Enhanced Types:

  • β-Cyclodextrin Complexes: 8x water solubility

  • Nanoemulsions: 92% oral bioavailability

• Equol Conversion:

  • 30-50% of populations are equol-producers

  • Equol displays 100x greater ERβ affinity

Proof-Based mostly Well being Advantages

1. Menopausal Symptom Aid

   • Reduces scorching flash frequency by 52% (50mg/day)

   • Improves vaginal epithelial maturation index

2. Bone Well being Preservation

   • Will increase osteocalcin by 23% (scientific trial)

   • Inhibits osteoclastogenesis by way of RANKL suppression

3. Cardiometabolic Safety

   • Improves arterial elasticity by 26%

   • Reduces LDL oxidation susceptibility

4. Oncoprotective Results

   • Modulates ERβ-mediated apoptosis in breast tissue

   • Downregulates AR signaling in prostate cells

Scientific Dosage Protocol

Security Concerns

• GRAS Standing: FDA affirmed (GRN No. 879)

• Drug Interactions:

  • Might improve tamoxifen efficacy

  • Potentiates warfarin (monitor INR)

• Contraindications:

  • ER+ breast most cancers with out medical supervision

  • Thyroid problems (monitor TSH)

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4. Shaanxi Zhonghong: International Isoflavone Specialists

Technical Capabilities

• 28-year experience in phytoestrogen isolation

• Proprietary Applied sciences:

  • Enzymatic bioconversion (daidzein → equol)

  • Molecular distillation purification

• High quality Infrastructure:

  • UPLC-PDA-ELSD quantification

  • 500MHz NMR structural affirmation

International Compliance

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5. Pharmaceutical-Grade Specs

Complete High quality Management

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6. Superior Manufacturing Workflow

1. Botanical Sourcing

   • Id-preserved non-GMO soybeans (IP certification)

   • Wild-harvested kudzu root (HPLC pre-tested)

2. Extraction Optimization

   • Subcritical water extraction (120°C, 30 MPa)

   • Enzyme-assisted liberation (β-glucosidase therapy)

3. Chromatographic Purification

   • Simulated shifting mattress (SMB) chromatography

   • Hydrophilic interplay chromatography (HILIC)

4. Crystallization & Formulation

   • Anti-solvent crystallization (ethanol/water)

   • Cyclodextrin inclusion complexation

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7. Reducing-Edge Purposes

Pharmaceutical Improvements

• Osteoporosis Therapeutics: Combines with ipriflavone (3:1 ratio)

• Oncology Adjuvants: Enhances radiation sensitivity in prostate most cancers

Nutraceutical Breakthroughs

• Equol-Precursor Formulation: With Lactobacillus probiotics

• Cardio-Menopause Complexes: Synergized with resveratrol

Cosmeceutical Advances

• Dermal Matrix Help: Stimulates collagen I synthesis (87% enhance)

• Hair Regrowth Serums: 5α-reductase inhibition (IC₅₀ = 28μM)

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8. Analysis Frontiers

Mechanistic Discoveries

• Epigenetic Regulation: DNMT3b suppression at 10μM

• Mitochondrial Biogenesis: PGC-1α activation by way of SIRT1

Technological Improvements

• Biocatalytic Conversion: Engineered Escherichia coli for equol manufacturing

• Cocrystal Know-how: With nicotinamide for enhanced solubility

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9. FAQ: Knowledgeable Insights

Q: Does daidzein have an effect on thyroid perform?
A: In vitro research present TPO inhibition at >100μM; scientific significance requires monitoring at >100mg/day doses

Q: Optimum equol conversion methods?
A: Probiotic co-administration (Slackia isoflavoniconvertens) will increase conversion to 82%

Q: Stability in last merchandise?
A: Nitrogen-flushed packaging maintains >95% efficiency for 36 months; keep away from alkaline excipients (pH >8.0)

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10. International Provide Specs

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11. Scientific References

1. Menopause. 2024 – RCT on vasomotor signs

2. J Bone Miner Res. 2023 – Osteoblast activation mechanisms

3. USP-NF 2024 Monograph: Daidzein

4. EFSA Panel (2022) – Cardiovascular declare evaluation

5. ICH Q3D R2 Guideline – Elemental impurities

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12. Conclusion: Pharmaceutical-Grade Daidzein Options

Daidzein represents the gold customary in selective phytoestrogen remedy with clinically validated advantages for menopausal well being, bone integrity, and cardiometabolic safety. Shaanxi Zhonghong delivers 98.5% HPLC-verified daidzein by way of proprietary SMB chromatography, that includes:

• Non-GMO Mission Verification

• Equol-conversion optimized formulations

• cGMP manufacturing (FDA DMF #028741)

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