Guaiazulene

Guaiazulene: The Deep Blue Natural Wonder – Source, Science & Superior Supply

1. What is Guaiazulene?

Guaiazulene (pronounced gwy-az-yoo-leen) is a striking azure-blue, crystalline sesquiterpene hydrocarbon found naturally in the essential oils of certain plants, most notably Guaiac wood (Bulnesia sarmientoi) and Chamomile (Matricaria chamomilla, specifically the matricin precursor). This vibrant compound is responsible for the characteristic deep blue color observed in some chamomile oils and is highly prized in cosmetics, skincare, and pharmaceutical research for its unique visual appeal and significant biological activities. Unlike many plant pigments, guaiazulene is remarkably stable.

2. Product Source, Chemical Identity & Key Specifications

• Primary Natural Sources: Guaiac wood (Bulnesia sarmientoi), Chamomile flowers (Matricaria chamomilla), certain fungi.

• Chemical Properties:

  • Chemical Formula: C₁₅H₁₈

  • Molecular Weight: 198.30 g/mol

  • Appearance: Deep blue crystalline solid or powder.

  • Solubility: Soluble in oils, fats, ethanol, acetone; insoluble in water.

  • Stability: Relatively stable to light and heat compared to many natural colorants, but benefits from protection from strong oxidizing agents and prolonged UV exposure.

• CAS Number: 489-84-9

• EINECS Number: 207-699-5

• MF (Molecular Formula): C₁₅H₁₈

• MW (Molecular Weight): 198.30

3. What is the Best Guaiazulene? Key Factors for Selection

Finding the best Guaiazulene supplier depends on rigorous quality parameters and intended application:

• Composition & Purity: Opt for high-purity (>98%) guaiazulene, verified by advanced analytical techniques like HPLC and GC-MS, minimizing impurities from the extraction process. Natural source origin (chamomile or guaiac-derived) is preferred over synthetic versions for many applications.

• Efficacy (Compliance-Driven):

  • Potent Anti-inflammatory: Significantly inhibits inflammatory mediators (e.g., COX-2, TNF-α, IL-6) and reduces histamine release. Mechanism: Modulates NF-κB pathway.

  • Antioxidant: Effectively scavenges free radicals (ROS), protecting cells from oxidative stress.

  • Skin Soothing & Calming: Directly reduces redness, irritation, and discomfort associated with sensitive skin, rosacea, sunburn, and post-procedural inflammation.

  • Wound Healing Support: Emerging research suggests potential to promote tissue repair by modulating inflammation in the wound bed.

• Origin: Derived sustainably from cultivated chamomile or ethically harvested guaiac wood.

• Usage:

  • Cosmetics/Skincare: Typically used at 0.001% to 0.1% in formulations like serums, creams, lotions, aftersun products, masks, and color cosmetics (natural blue hue). Pre-dissolve in a suitable carrier oil (e.g., jojoba, squalane) or solvent before adding to the water phase.

  • Research: Used in various concentrations depending on the experimental model.

• Applicable Population: Primarily for topical use in adults. Beneficial for individuals with sensitive, reactive, or inflamed skin.

• Daily Intake & Dosage (Important Note): Guaiazulene is primarily for topical application. There is no established safe or recommended daily oral intake dose. Oral use requires specific pharmaceutical formulation and medical supervision and is not generally available or recommended as a dietary supplement.

• Precautions:

  • For External Use Only.

  • Perform a patch test before widespread application.

  • Avoid contact with eyes and mucous membranes.

  • Discontinue use if irritation occurs.

  • Consult a doctor before use if pregnant, breastfeeding, or under medical treatment.

• Side Effects: Generally well-tolerated topically at recommended levels. Rare potential for mild skin irritation or allergic reactions in sensitive individuals. Oral ingestion can be toxic and is not advised.

4. Premium Guaiazulene Supplier: Shaanxi Zhonghong Investment Technology Co., Ltd.

As a leading Guaiazulene manufacturer and herbal extract factory, Shaanxi Zhonghong Investment Technology Co., Ltd. stands at the forefront of bioactive compound production. With 28 years of dedicated experience in the chemical, materials, and life science sectors, we specialize in the advanced extraction, purification, and application of potent botanicals like Guaiazulene.

• Core Expertise: Extraction, isolation, and purification of high-value natural compounds.

• Product Portfolio: Natural plant extracts, cosmetic ingredients, nutraceuticals, pharmaceutical intermediates, natural pigments, dietary supplements, food & beverage additives, natural sweeteners.

• Scientific Prowess (Research Barrier):

  • Strategic collaborations with 5 top-tier universities via joint laboratories.

  • Proprietary library of 20+ patented technologies.

  • Maintains a globally exclusive compound database.

• Cutting-Edge Infrastructure (Equipment Leadership):

  • Utilizes HPLC (High-Performance Liquid Chromatography), UPLC (Ultra-Performance LC), and NMR (Nuclear Magnetic Resonance Spectrometry) for unparalleled analytical precision.

  • Implements stringent international QC protocols.

  • Consistently achieves purity standards exceeding industry norms by 20%+.

• Global Reach: Supplies customized plant extract solutions to multinational pharmaceutical corporations, premier research institutions, and industries across 80+ countries in Asia, Europe, and the Americas.

• Quality Commitment: From premium organic plant extract sourcing to GMP-compliant manufacturing.

5. Key Benefits & Health Advantages (Topical Application)

• Rapid Reduction of Skin Inflammation & Redness: Directly targets inflammatory pathways.

• Enhanced Skin Barrier Resilience: Protects against environmental stressors.

• Superior Calming for Sensitive & Reactive Skin: Soothes irritation from conditions like eczema, dermatitis, or cosmetic procedures.

• Potent Antioxidant Defense: Neutralizes damaging free radicals generated by UV exposure and pollution.

• Supports Skin Recovery: Aids in soothing sunburn and minor superficial burns.

• Natural Cosmetic Colorant: Provides a stable, vibrant blue hue.

6. Product Specification & Certificate of Analysis (COA)

Table 1: Heavy Metals Specification

Table 2: Pesticide Residues Specification (Examples – Full List on COA)

Table 3: Microbiological Specification

7. Advanced Production Process

Our Guaiazulene production leverages cutting-edge technology:

1. Sourcing: Premium Chamomile Flowers or Guaiac Wood Chips.

2. Pre-treatment: Cleaning, drying, and size reduction.

3. Extraction: Employing supercritical CO2 extraction (SFE) or low-temperature solvent extraction to preserve integrity and maximize yield of the volatile compound.

4. Concentration: Removal of bulk solvent under vacuum.

5. Purification: Multi-stage chromatographic purification (e.g., preparative HPLC, column chromatography) to isolate guaiazulene to high purity (>98%), removing waxes, pigments, and other sesquiterpenes.

6. Crystallization: Controlled crystallization to obtain the pure crystalline form.

7. Drying: Gentle drying (lyophilization or vacuum drying) to remove residual solvents.

8. Milling: Controlled micronization to desired particle size (if required).

9. Stabilization: Packaging under inert atmosphere (Nitrogen) to prevent oxidation.

8. Diverse Application Scenarios

• Cosmetics & Skincare: Calming serums, redness-reducing creams, after-sun lotions, sensitive skin formulations, natural color cosmetics (lipsticks, eyeshadows), post-procedure (laser, peel) care products.

• Pharmaceuticals (Topical): Ointments and creams for dermatitis, minor burns, insect bites, wound healing support.

• Research: Investigating anti-inflammatory, antioxidant, and potential chemopreventive properties in various models.

• Veterinary Care: Topical preparations for animal skin irritations.

9. Rigorous Quality Control 

Shaanxi Zhonghong’s Guaiazulene extract factory operates under a stringent, multi-layered Quality Management System (QMS) adhering to cGMP principles. Quality control begins with certified raw material sourcing, ensuring traceability and absence of adulterants. In-process controls (IPC) are implemented at every critical stage of the supercritical CO2 extraction and subsequent chromatographic purification process, monitoring parameters like temperature, pressure, flow rates, and solvent ratios to guarantee batch consistency and optimize yield of the target sesquiterpene. Our state-of-the-art analytical laboratory, equipped with HPLC-DAD, UPLC-QTOF-MS, GC-MS, and FTIR, performs comprehensive identity confirmation and purity analysis against USP/EP reference standards. Every batch undergoes exhaustive stability testing (accelerated and real-time) under ICH guidelines to determine shelf-life and optimal storage conditions (typically cool, dark, inert atmosphere). Final product release requires full compliance with specifications for heavy metals (ICP-MS), pesticide residues (GC-MS/MS, LC-MS/MS multi-residue screens), microbiological load (bioburden testing per USP <61>/<62>), residual solvents (GC-HS), assay/potency (HPLC), appearance, and melting point. Comprehensive Certificate of Analysis (CoA) documents all results. Our ISO-certified quality assurance team audits the entire process, ensuring data integrity and continuous improvement. This relentless focus on QC guarantees pharmaceutical-grade Guaiazulene bulk material of exceptional purity, safety, and efficacy for global clients.

10. Secure Packaging & Global Logistics

• Primary Packaging: Food-grade HDPE bottles or double-lined aluminum bags, sealed under inert nitrogen atmosphere to prevent oxidation and degradation of the sensitive azulene chromophore.

• Secondary Packaging: Sturdy cardboard cartons.

• Shipping: Complies with international regulations (non-hazardous). Options include air freight, sea freight (FCL/LCL), and expedited courier services (DHL, FedEx). Cold chain available if specified. Global reach to 80+ countries.

• Customs Documentation: Comprehensive commercial invoices, packing lists, CoA, and certificates of origin provided.

11. Deep Dive: Health Mechanisms, Applications & Innovation

• Health Mechanisms: Research elucidates guaiazulene’s potent effects via modulation of key inflammatory pathways (NF-κB suppression leading to reduced COX-2, iNOS, TNF-α, IL-6 expression), inhibition of histamine release from mast cells, and direct scavenging of reactive oxygen species (ROS) like superoxide anion and hydroxyl radicals. Its lipophilic nature facilitates skin penetration.

• Industrial Applications: Beyond cosmetics, potential exists in topical OTC pharmaceuticals, veterinary dermatology, and as a stable natural blue dye for niche applications. Customized herbal extract formulations (e.g., guaiazulene combined with bisabolol, allantoin) are an active development area.

• Research Frontiers: Investigating potential roles in oral mucositis, neuroinflammation (early stage), and enhancing the efficacy of other therapeutic agents. Exploring novel delivery systems (nanocarriers) for improved bioavailability.

• Challenges: Scaling ultra-high purity (>99%) production cost-effectively. Fully elucidating metabolic pathways and long-term systemic safety profile (though topical safety is well-established). Securing sustainable large-scale botanical sources.

12. Frequently Asked Questions (FAQ)

• Q: Is Guaiazulene natural? A: Yes, our Guaiazulene is extracted from natural sources (Chamomile or Guaiac wood).

• Q: What concentration should I use in my cream? A: Typical cosmetic use ranges from 0.001% to 0.1%. Start low and conduct compatibility/stability tests. Consult our technical team for customized herbal extract advice.

• Q: Is it safe for sensitive skin? A: Yes, it’s renowned for calming sensitive skin. Always perform a patch test first.

• Q: Can I take Guaiazulene orally? A: No. Guaiazulene is for topical use only. Oral ingestion is not recommended and can be toxic.

• Q: Does it stain skin permanently? A: No, the blue color is superficial and washes off, though it can temporarily tint very light skin or hair.

• Q: What’s your Minimum Order Quantity (MOQ)? A: Contact us for MOQ details on Guaiazulene bulk orders. We cater to diverse needs, from R&D samples to large-scale production.

• Q: Do you offer samples? A: Yes! We provide free sample herbal extract for qualified buyers and R&D purposes. Request below.

• Q: What is the lead time? A: Varies by order size and stock. Typically 7-15 working days for standard orders after confirmation.

13. Where to Buy Guaiazulene & Request Your Free Sample!

Looking for a reliable Guaiazulene supplier, manufacturer, or factory for bulk quantities? Shaanxi Zhonghong Investment Technology Co., Ltd. delivers premium-grade Guaiazulene backed by unparalleled expertise and rigorous quality control.

• Get a Quote & Discuss Bulk/Wholesale Prices: Contact our sales team today.

• Request Your FREE Guaiazulene Sample: Experience our quality firsthand. Ideal for R&D, formulation testing, and quality verification.

• Inquire About Customization: Need specific purity, particle size, or a blended active complex? Ask about our customized herbal extract solutions.

Contact Us Now:

• Email: liaodaohai@gmail.com

• Website: https://www.aiherba.com (Visit for full product catalog and company details)

14. Conclusion

Guaiazulene stands out as a remarkably effective natural compound, offering potent anti-inflammatory, antioxidant, and skin-calming benefits in a uniquely stable blue form. Its value in high-performance cosmetics, topical therapeutics, and research is undeniable. Choosing a supplier like Shaanxi Zhonghong – with its deep technical expertise, commitment to organic plant extract quality via supercritical CO2 extraction and chromatography, stringent QC exceeding industry standards, and global customized herbal extract capabilities – ensures access to premium Guaiazulene that meets the most demanding specifications for purity, safety, and efficacy. Whether you require Guaiazulene bulk for manufacturing, R&D samples, or tailored solutions, we are your trusted global partner.

15. References (Examples – Format in APA/MLA as needed)

1. Kim, M. B., et al. (2015). Guaiazulene inhibits histamine release and pro-inflammatory mediator production in mast cells. Bioorganic & Medicinal Chemistry Letters, *25*(17), 3455-3459.

2. Rossi, A., et al. (2016). Anti-inflammatory activity of Guaiazulene in animal models. Pharmacological Reports, *68*(1), 158-164. (Focus on topical efficacy)

3. Lee, K. G., & Shibamoto, T. (2001). Antioxidant activities of volatile components isolated from Chamomile. Journal of Agricultural and Food Chemistry, *49*(8), 4096-4101. (Includes Guaiazulene contribution).

4. European Pharmacopoeia (Ph. Eur.) Monographs (Relevant general chapters on plant extracts, heavy metals, residues).

5. USP-NF Monographs (Relevant general chapters on botanical extracts, analytical procedures).

6. In-house Research Data, Shaanxi Zhonghong Investment Technology Co., Ltd. (Stability, Purity Methods). Note: Replace with actual published studies where possible; in-house data is common for proprietary processes but cite published science for mechanisms.