Bisabolol

Unlocking the Energy of Bisabolol: Nature’s Soothing Elixir from AIHerba | Supplier & Manufacturer

1. Was ist Bisabolol?
Bisabolol, vorwiegend als (-)-α-Bisabolol, is a naturally occurring monocyclic sesquiterpene alcohol famend for its distinctive skin-soothing, anti-irritant, and anti inflammatory properties. This bioactive compound is a prized beauty and pharmaceutical ingredient, providing a delicate but potent resolution for delicate pores and skin and numerous inflammatory circumstances. Its delicate floral aroma additional enhances its enchantment in perfumery.

2. Produktversorgung, chemische Eigenschaften und Identifizierung

• Major Natural Supply: Deutsche Kamille (Kamille/recutita), particularly its important oil, is the richest pure supply of (-)-α-bisabolol. Additionally present in smaller portions in Candeia Baum (Vanillosmopsis species) oil and different vegetation.

• Chemische Eigenschaften:

  • CAS-Menge: 515-69-5 (Usually refers back to the racemic combination; pure (-)-α-Bisabolol is 23089-26-1)

  • MF (Molekulare Formulierung): C₁₅H₂₆O

  • MW (Molekulargewicht): 222,37 g/mol

  • EINECS: 207-454-3

  • Aussehen: Farblose bis hellgelbe viskose Flüssigkeit.

  • Löslichkeit: Löslich in Alkoholen und Ölen, unlöslich in Wasser.

  • Optical Exercise: Natural (-)-α-Bisabolol is levorotatory. Artificial variations could also be racemic.

• AIHerba Supply & Benefit: AIHerba makes use of premium German Chamomile flowers, using proprietäre überkritische CO2-Extraktion und Molekulardestillation methods to yield (-)-α-Bisabolol with unparalleled purity (>98%) and stereochemical integrity, maximizing its bioactivity.

3. What is the Finest Bisabolol? Efficacy, Security & Utilization

• “Finest” Outlined: Der höchste Wirksamkeit is constantly attributed to pure (-)-α-Bisabolol resulting from its particular stereochemistry. AIHerba’s concentrate on ultra-high purity pure (-)-α-Bisabolol ensures superior efficiency.

• Highest Content Supply: German Chamomile important oil usually comprises the very best pure focus (as much as ~50%, although AIHerba isolates it to >98%).

• Well being & Pores and skin Benefits:

  • Starkes entzündungshemmendes Mittel: Hemmt COX-2, LOX und entzündliche Zytokine (TNF-α, IL-6).

  • Beruhigend und reizlindernd: Quickly calms pores and skin irritation (e.g., from surfactants, UV, chemical peels).

  • Antioxidans: Scavenges free radicals, defending pores and skin cells.

  • Wound Therapeutic & Regenerative: Stimulates fibroblast migration and promotes tissue restore.

  • Antimikrobiell: Displays exercise towards sure micro organism and fungi.

  • Verbesserte Durchdringung: Can enhance pores and skin absorption of different actives.

  • Pores and skin Barrier Help: Contributes to a more healthy pores and skin barrier operate.

• Täglicher Verbrauch: Bisabolol wird vor allem topisch (cosmetics, skincare). Oral consumption shouldn’t be frequent for bisabolol itself; security ranges depend upon the particular software (beauty, complement, pharmaceutical). Beauty use is usually thought to be secure at typical concentrations (0.2% – 2.0%).

• Wants Consideration:

  • Empfindlichkeit: Whereas usually well-tolerated, patch testing new merchandise is at all times beneficial.

  • Oxidation: Pure bisabolol can oxidize over time; formulations ought to embrace antioxidants and use acceptable packaging (e.g., airless containers, nitrogen flushing).

• Aspektergebnisse: Uncommon. Potential for gentle pores and skin irritation or allergic response in extremely delicate people. Natural (-)-α-Bisabolol has a wonderful security profile.

4. Introducing AIHerba: Your Trusted Bisabolol Companion
Shaanxi Zhonghong Investment Technology Co., Ltd. (AIHerba) ist eine Premiere High-Tech-Unternehmen integrating agile R&D, collaborative innovation, built-in manufacturing, and international advertising. For over 28 Jahre, we have specialised in serving the chemical, supplies, and life sciences sectors, with core experience within the extraction, isolation, purification, and industrial software of bioactive plant constituents.

• Wissenschaftliche Fähigkeiten: 5+ strategic college joint labs, 20+ patented applied sciences, and a globally distinctive proprietäre Verbindungsbibliothek.

• Chopping-Edge High quality: HPLC (Hochleistungsflüssigkeitschromatographie), GC-MS (Gasoline Chromatography-Mass Spectrometry), Und Supraleitende NMR (Kernspinresonanz) guarantee purity requirements exceeding trade norms by 20%+.

• Weltweite Reichweite: Portion 80+ Nationen in ganz Asien, Europa und Amerika und bietet custom-made pure ingredient options to main multinational pharmaceutical corporations, analysis establishments, and beauty giants.

5. Produktspezifikationen: Strenges Qualitätsmanagement
AIHerba’s (-)-α-Bisabolol adheres to the strictest high quality requirements. Key specs embrace:

Desk 1: Pesticide Residue Evaluation

Desk 2: Heavy Metals Evaluation

Desk 3: Microbial Evaluation

6. Superior Manufacturing Move
AIHerba’s (-)-α-Bisabolol manufacturing exemplifies cutting-edge phytochemistry:

1. Beschaffung: Premium German Chamomile flowers from licensed sustainable farms.

2. Major Extraction: Überkritische CO2-Extraktion (SFE) – Makes use of tunable strain/temperature for selective, solvent-free isolation of volatiles, preserving delicate actives.

3. Fokus: Removing of waxes and non-target compounds.

4. Isolierung und Reinigung: Preparative HPLC and/or Excessive-Vacuum Fractional Distillation – Achieves focused separation of (-)-α-Bisabolol from different terpenes.

5. Crystallization (Non-obligatory): For attaining highest purity grades (>99%).

6. Stabilisierung: Zugabe synergistischer Antioxidantien (z. B. Tocopherol).

7. Strenge Qualitätskontrolle: HPLC-DAD/ELSD, Chirale GC/HPLC, GC-MS, NMR for identification, purity (>98%), enantiomeric extra, and residual solvent evaluation. ICP-MS auf Schwermetalle. Mikrobiologische Prüfung gemäß Arzneibuch.

8. Verpackung: Underneath inert environment (Nitrogen) in light-protected, food-grade HDPE or glass containers.

7. Verschiedene Anwendungsszenarien

• Kosmetik & Hautpflege: Calming serums, delicate pores and skin lotions, after-sun merchandise, anti-redness remedies, child care, post-procedure formulations (laser, peels), zits remedies (mitigates irritation), pure deodorants.

• Verschreibungspflichtige Medikamente: Topical anti-inflammatory and wound therapeutic ointments/gels, mucoadhesive formulations, dental care merchandise (anti-gingivitis).

• Parfümerie: Gives a tender, candy, floral notice with fixative properties.

• Nutrazeutika: Included into topical wellness merchandise (e.g., muscle soothing balms).

8. Complete High quality Management (QC)
AIHerba’s QC paradigm is constructed on Pharmaceutical cGMP ideas und Hebel modernste analytische Instrumente. Identification affirmation makes use of FTIR (Fourier Remodel Infrared Spectroscopy) Fingerabdrücke und Chirale Chromatographie to confirm the (-)-enantiomer. Purity is quantified by way of validated HPLC-UV/ELSD strategies calibrated towards licensed reference requirements, constantly guaranteeing >98% (-)-α-Bisabolol content material. Residual Solvent Evaluation (Headspace GC-MS) ensures compliance with ICH Q3C tips. Stabilitätsforschung (ICH Q1A) underneath accelerated and long-term circumstances decide shelf-life and optimum storage parameters. Each batch undergoes full spectroscopic (NMR for structural elucidation if wanted), chromatographic, and microbiological testing, dokumentiert in einem Bewertungszertifikate (CoA) traceable to worldwide requirements (USP, EP, CP). Our ISO 9001-zertifiziert high quality administration system ensures traceability and steady enchancment.

9. Sichere Verpackung und weltweite Logistik

• Verpackung: 1 kg, 5 kg lebensmittelechte HDPE-Flaschen; 25 kg HDPE-Fässer. Alle Stickstoff gespült Und Aluminiumbeutel ausgekleidet for max oxidation safety. Customized packaging obtainable.

• Lagerung: Retailer tightly sealed in unique packaging, shielded from mild and moisture at 2-8°C (gekühlt) for long-term stability. Quick-term (<6 months) at <25°C acceptable.

• Logistik: Shipped globally by way of temperaturgeführte Logistik (chilly chain the place required). Compliant with all worldwide rules (REACH, FDA, COSMOS and so on.). Complete documentation offered.

10. Deep Dive: Well being Mechanisms, Purposes & Innovation

• Bewegungsmechanismus: (-)-α-Bisabolol exerts results by way of a number of pathways:

  • Modulates NF-κB and MAPK signaling cascades, suppressing pro-inflammatory cytokine manufacturing.

  • Hemmt wichtige Enzyme: Cyclooxygenase-2 (COX-2), 5-Lipoxygenase (5-LOX).

  • Demonstrates antioxidant exercise by quenching ROS/RNS.

  • Enhances penetration by way of lipid bilayer interplay.

  • Fördert die Reepithelisierung und Bildung von Granulationsgewebe in Wunden.

• Industrial Purposes & AIHerba Innovation: Past cosmetics, bisabolol enhances transdermal drug supply programs. AIHerba innovates by way of enantioselektive Synthesewege (für ultrareines (-)-Isomer), neuartige Co-Kristallformulierungen für verbesserte Stabilität/Löslichkeit und sustained-release supply programs (e.g., lipid nanoparticles) built-in with our proprietäre Verbindungsbibliothek screening for synergistic combos.

• Grenzen und Herausforderungen der Analyse:

  • Grenzen: Untersuchung der Wirksamkeit in neuroinflammatory circumstances, gastroprotective results, anti-cancer adjunct remedy (enhancing chemo efficacy/lowering negative effects), superior biomaterials (entzündungshemmende Beschichtungen für Implantate).

  • Herausforderungen: Scaling sustainable cultivation of high-bisabolol chamomile strains, cost-effective large-scale chiral purification, definitive medical dose-response research for particular therapeutic endpoints, long-term stability optimization in advanced formulations.

11. Häufig gestellte Fragen (FAQ)

• Q: Is pure (-)-α-Bisabolol higher than artificial?

  • A: Sure, quite a few research point out pure (-)-α-Bisabolol possesses superior entzündungshemmende und hautberuhigende Wirkung in comparison with artificial racemic mixtures or different isomers resulting from its particular stereochemistry.

• Q: What focus of Bisabolol is efficient in cosmetics?

  • A: Typical efficient concentrations vary from 0,2% bis 2,0%. Efficacy relies on the formulation and desired impact; AIHerba gives software assist.

• Q: Is Bisabolol secure for delicate pores and skin?

  • A: Completely. Natural (-)-α-Bisabolol is famend for its distinctive tolerance and efficacy in calming delicate, irritated, and reactive pores and skin.

• Q: Does Bisabolol have any identified drug interactions?

  • A: Topical use has no vital reported interactions. Seek the advice of a doctor for potential interactions with oral medicines if used systemically (uncommon).

• Q: How ought to I retailer AIHerba Bisabolol?

  • A: For optimum long-term stability and to stop oxidation, retailer tightly sealed, shielded from mild, and refrigerated (2-8°C). See CoA for particular batch suggestions.

• Q: Is AIHerba Bisabolol compliant with worldwide requirements?

  • A: Sure. Our product meets or exceeds specs outlined in related USP/EP monographs (the place relevant), COSMOS, ISO, and is REACH/FDA compliant. Certificates obtainable.

12. The place to Purchase Premium (-)-α-Bisabolol
Supply the very best purity, naturally derived (-)-α-Bisabolol straight from the producer:

• Website: www.aiherba.com

• Kontakt: Herr Liao Daohai

• E-Mail: liaodaohai@gmail.com

• Anfragen für: Bulk pricing, samples, technical knowledge sheets (TDS), certificates of research (CoA), and formulation assist.

13. Fazit
(-)-α-Bisabolol stands as a cornerstone bioactive ingredient for light but highly effective soothing and anti inflammatory efficacy. AIHerba, Nutzung 28 years of experience in phytochemistry and superior purification applied sciences, liefert ultra-pure (>98%) pure (-)-α-Bisabolol. Nachhaltig bezogen und validiert durch supraleitende NMR, HPLC und ICP-MS, our ingredient meets the stringent calls for of worldwide beauty, pharmaceutical, and analysis markets. Select AIHerba for unparalleled high quality, scientific assist, and a dedication to innovation in pure actives.

14. Referenzen

1. Kamatou, G. P. P., & Viljoen, A. M. (2010). A evaluation of the applying and pharmacological properties of α-bisabolol and α-bisabolol-rich oils. Zeitschrift der American Oil Chemists' Society, 87(1), 1-7.

2. European Medicines Company (EMA) Evaluation Report on Matricaria recutita L., flos. (2015).

3. Cavalieri, E., et al. (2004). Professional-apoptotic exercise of α-bisabolol in preclinical fashions of major human acute leukemia cells. The Journal of Medical Investigation, 114(3).

4. Worldwide Group for Standardization (ISO). ISO 16128 – Tips on technical definitions and standards for pure and organic beauty substances.

5. United States Pharmacopeia (USP) Normal Chapters: <561> Articles of Botanical Origin, <2023> Microbiological Examination of Nonsterile Merchandise.

6. European Pharmacopoeia (Ph. Eur.) Monographs: 2.8.12 Microbiological examination of non-sterile merchandise, 2.4.8 Heavy Metals.

7. Current Analysis (e.g., search PubMed.gov for “alpha-bisabolol mechanism”, “bisabolol pores and skin”, “bisabolol wound therapeutic” – 2023/2024 publications). AIHerba Inner Analysis & Stability Information.