Berberin

Berberine Extract | High-Purity Botanical Ingredient Supplier | AIHerba® 

---

1. Produktübersicht

Englischer Name: Berberin-Extrakt
Botanische Quelle: Berberis aristata, Coptis chinensis (Coptis root), or Phellodendron amurense bark
Wirkstoff: Berberine Hydrochloride / Berberine Sulfate
Spezifikation: 97% Berberine (HPLC)
Aussehen: Gelbes kristallines Pulver
CAS-Nr.: 633-65-8
Molekularformel: C₂₀H₁₈NO₄⁺
Hersteller: Shaanxi Zhonghong Investment Technology Co., Ltd. (AIHerba®)
Zertifikate: GMP, ISO 9001, ISO 22000, HACCP, Halal, Koscher

Berberine is a natural isoquinoline alkaloid extracted from Coptis chinensis and other Berberis plants. With potent bioactivity and a long history in traditional Chinese medicine, it is widely used in pharmaceuticals, dietary supplements, and functional food formulations for its glucose-regulating, antimicrobial, and metabolic benefits.

---

2. Source & Production

AIHerba® sources premium Coptis chinensis roots and Berberis aristata barks from pollution-free mountain regions in China.
Production utilizes modern water-ethanol extraction, überkritische CO₂-Reinigung, Und membrane separation um Folgendes sicherzustellen:

• ≥97% purity (HPLC verified)
• Low heavy metal and pesticide residue levels
• Consistent batch-to-batch quality
• Full traceability from raw herb to final extract

---

3. Health Benefits & Functions

(1) Key Bioactive Benefits

• Blutzuckerregulation: Supports insulin sensitivity and lowers fasting glucose levels.
• Fettstoffwechsel: Reduces LDL cholesterol and triglycerides while increasing HDL.
• Gut Microbiome Support: Balances intestinal flora and improves digestive function.
• Entzündungshemmend & antioxidativ: Reduces systemic inflammation and oxidative stress.
• Herz-Kreislauf-Gesundheit: Promotes endothelial function and circulation.

(2) Scientifically Supported Health Effects

Clinical studies (NIH, PubMed) have shown berberine’s comparable effects to metformin in managing Type 2 diabetes and metabolic syndrome.

• NIH Study on Berberine & Glucose Control
• FDA Reference on Herbal Alkaloids

---

4. Traditionelle Anwendungen

Wird seit Jahrhunderten verwendet in Traditionelle Chinesische Medizin (TCM) as “Huang Lian,” berberine was prescribed to treat gastrointestinal infections, fever, and inflammation. In Ayurveda, Berberis aristata (Tree Turmeric) was known for its cleansing and antimicrobial effects.

---

5. Recommended Dosage & Usage

Anwendung	Typische Dosierung	Usage Form
Nahrungsergänzungsmittel	500–1500 mg/Tag	Capsules, Tablets, Powders
Funktionelle Getränke	100–300 mg/serving	Dissolved or mixed in drink bases
Pharmazeutische Formulierungen	Maßgeschneidert	Per regulatory and formulation requirements

---

6. Best Formulation Combinations

Berberine is often combined with:

• Milk Thistle Extract (Silymarin): Enhances liver detoxification.
• Alpha Lipoic Acid: Boosts glucose metabolism.
• Cinnamon Extract: Improves insulin sensitivity.
• Probiotics: Supports microbiota balance and absorption efficiency.

---

7. Safety & Precautions

• Avoid during pregnancy or lactation without medical supervision.
• May interact with diabetic medications—consult a physician before use.
• An einem kühlen, trockenen Ort, vor direkter Sonneneinstrahlung und Feuchtigkeit geschützt lagern.

---

8. Technical Specifications (COA Summary)

Kategorie	Artikel	Spezifikation	Testmethode
Aussehen	Gelbes kristallines Pulver	Konform	Visuell
Assay (Berberine)	≥97.0%	HPLC
Trocknungsverlust	≤5,0%	105°C, 2h
Aschegehalt	≤2,0%	Gravimetrisch
Lösungsmittelrückstand	≤5000 ppm	GC

---

Pestizidrückstandsprüfung

Artikel	Grenzwert (ppm)	Verfahren
DDT	<0,05	GC-ECD
BHC	<0,05	GC-ECD
Parathion	<0,05	GC-MS
Carbofuran	<0,05	LC-MS/MS
Chlorpyrifos	<0,05	GC-MS

---

Schwermetalltests

Metall	Limit	Verfahren
Blei (Pb)	≤3,0 mg/kg	ICP-MS
Arsen (As)	≤2,0 mg/kg	ICP-MS
Quecksilber (Hg)	≤0,1 mg/kg	ICP-MS
Cadmium (Cd)	≤1,0 mg/kg	ICP-MS

---

Mikrobiologische Tests

Parameter	Limit	Verfahren
Gesamtkeimzahl	≤1000 KBE/g	USP <61>
Hefe und Schimmel	≤100 KBE/g	USP <61>
E. coli	Negativ	USP <62>
Salmonellen	Negativ	USP <62>
Staphylococcus aureus	Negativ	USP <62>

---

9. Herstellungsprozess

1. Rohstoffauswahl →
2. Crushing & Pre-treatment →
3. Wasser-Ethanol-Extraktion →
4. Filtration & Konzentration →
5. Purification (Membrane & Chromatography) →
6. Drying (Spray or Vacuum Drying) →
7. Mahlen & Sieben →
8. Quality Inspection & Packaging

All steps follow GMP, ISO und HACCP standards with full traceability.

---

10. Lagerung, Haltbarkeit und Verpackung

• Lagerung: Store below 25°C, in a tightly sealed container, protected from light and humidity.
• Haltbarkeit: 24 Monate ab Produktionsdatum.
• Verpackung: 25 kg/drum (inner double PE bag + outer fiber drum).
• Proben: Free 20–50 g samples available upon request.
• Mindestbestellmenge: 1 kg (for trial order).

---

11. Logistics & Delivery

• Vorlaufzeit: 3–7 working days for standard specifications.
• Versandarten: DHL, FedEx, UPS, or air/sea freight.
• Zolldokumentation: COA, MSDS, TDS, Non-GMO statement, and Origin Certificate available.

---

12. Application Industries

Industrie	Anwendungen
Nutrazeutika	Blood sugar control, lipid management supplements
Pharmazeutika	Metabolic and anti-inflammatory formulations
Funktionelle Lebensmittel	Metabolic health beverages, herbal tonics
Kosmetika	Antibacterial and anti-inflammatory skin formulations
Veterinary & Feed Additives	Natural antimicrobial ingredient

---

13. Why Choose AIHerba®?

✅ Professional Factory: Über 28 Jahre of production experience in botanical extracts.
✅ Zertifizierungen: GMP, ISO9001, ISO22000, HALAL, KOSHER.
✅ OEM/ODM Solutions: Custom formulations for global brands.
✅ Global Clients: Trusted by 1,000+ health and cosmetic companies.
✅ Vollständige Rückverfolgbarkeit: Raw material to final batch with transparent quality control.

---

14. Häufig gestellte Fragen (FAQ)

Q1: Is berberine water-soluble?
A1: Berberine hydrochloride is slightly soluble in water but dissolves better in ethanol and methanol.

Q2: Can I get customized specifications (e.g., 85% Berberine)?
A2: Yes. We provide tailored purity levels and formulation bases according to client needs.

Q3: What is the lead time for bulk orders?
A3: Typically 5–10 days depending on quantity and specification.

Q4: Can AIHerba provide third-party testing reports?
A4: Yes. We can provide SGS, Eurofins, or Intertek reports upon request.

---

15. Referenzen

1. Yin, J. et al. “Efficacy of Berberine in Type 2 Diabetes Mellitus: A Meta-analysis.” Stoffwechsel (2008). PubMed Link
2. NIH: Berberine — Herbal Supplement Information. NIH.gov
3. FDA Botanical Drug Development Guidance. FDA.gov

---

Kontaktieren Sie uns
📧 E-Mail: sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 Webseite: www.aiherba.com
🏭 Fabrik: Shaanxi Zhonghong Investment Technology Co., Ltd.
AIHerba® – Your Trusted GMP-Certified Natural Plant Extract Supplier in China