Alpha-Arbutin
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Arbutin

Arbutin supplier bulk factory Wholesale buy Extract factory

  1. Englischer Name: Arbutin; 4-Hydroxyphenyl β-D-glucopyranoside
  1. Spezifikation
    • Reinheit:
      • α-Arbutin: ≥ 98% (HPLC)
      • β-Arbutin: ≥ 99% (HPLC)
    • Löslichkeit: Soluble in water (14 g/L at 25°C), slightly soluble in ethanol, insoluble in organic solvents like ether.
    • Aussehen – Verwandte: Loss on drying ≤ 1.0%, Heavy metals ≤ 5 ppm, Residual solvents ≤ 0.05%
    • Partikelgröße: Standard powder ≤ 100 μm; micronized powder ≤ 5 μm for better absorption in cosmetics
  1. Aussehen
    • White to off-white crystalline powder, odorless, with a slightly sweet taste
  1. CAS-NR.
    • β-Arbutin: 497-76-7
    • α-Arbutin: 84380-00-7
  1. Lieferzeit: 5 – 7 Werktage
  1. Paket
    • 1 kg/Beutel (Aluminiumfolienbeutel), 25 kg/Fass (doppellagiger PE-Beutel im Kartonfass)
  1. Hauptmarkt: Global market, with high demand in Asia (China, South Korea, Japan), North America, and Europe, especially in the cosmetics, pharmaceuticals, and dietary supplement industries
  1. Anwendungsszenarien

Kerneigenschaften

  • Molekulare Struktur: A glycoside composed of hydroquinone and glucose, with two main isomers (α and β) differing in glycosidic bond orientation.
  • Stabilität: Stable under normal storage conditions, but sensitive to light and high temperatures, which may cause decomposition.
  • Hauptmerkmale
    • Skin-Brightening Effect: Inhibits tyrosinase activity, reducing melanin production, and effectively lightening skin pigmentation, such as freckles, age spots, and post-inflammatory hyperpigmentation.
    • Antioxidative Aktivität: Scavenges free radicals, protecting skin cells from oxidative damage and preventing premature aging.
    • Geringe Toxizität: Generally well-tolerated by the skin, making it a popular choice for safe skin-lightening formulations.
    • Water-Soluble: Facilitates easy incorporation into aqueous-based products like serums and toners.

Anwendungsszenarien

1. Kosmetik und Körperpflege

  • Skin-Whitening Products:
    • Added to facial creams, lotions, serums (0.5 – 2% concentration), and masks (1 – 3% concentration) to reduce dark spots and even out skin tone.
    • Used in body lotions and deodorants to lighten underarm and knee skin.
  • Anti-Aging-Formulierungen:
    • Combined with other antioxidants and anti-aging ingredients in eye creams and anti-wrinkle treatments to protect skin from oxidative stress and prevent the formation of age spots.
  • Sun Care Products:
    • Incorporated into sunscreens to prevent UV-induced hyperpigmentation, enhancing the overall photoprotection of the skin.

2. Pharmazeutika

  • Topische Medikamente:
    • Investigated for use in creams and gels to treat skin disorders associated with hyperpigmentation, such as melasma.
    • Used in wound-healing ointments due to its potential anti-inflammatory and antioxidant properties, promoting faster skin repair.
  • Oral Supplements (Research – based):
    • In early-stage research for potential internal use in managing skin pigmentation disorders, though oral application is less common due to potential metabolic concerns.

3. Essen & Getränke

  • Natural Preservative (Research – based):
    • Some studies explore its use as a natural antioxidant and preservative in food products, inhibiting lipid oxidation and microbial growth, although not yet widely commercialized.
  • Functional Food Ingredient (Conceptual):
    • Considered for addition to health beverages and dietary supplements for potential skin health benefits when consumed orally, but regulatory approvals are pending for such claims.

Nachweismethoden

  • Hochleistungsflüssigkeitschromatographie (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Methanol – water (20:80 v/v), Flow Rate: 1.0 mL/min, Detection Wavelength: 280 nm for quantification.
  • Ultra-Performance-Flüssigkeitschromatographie – Massenspektrometrie (UPLC – MS):
    • Confirms the molecular structure and differentiates between α and β isomers, detecting trace impurities with high sensitivity.
  • Kernspinresonanz (NMR):
    • Used for structural elucidation and identification of arbutin, especially in research and development to ensure the purity and correct isomeric form.

Quelle & Vorteile

  • Natürliche Quelle: Extracted from various plants, including bearberry (Arctostaphylos uva-ursi), blueberries, and cranberries, through solvent extraction and purification processes.
  • Synthetische Option: Commercially, it can also be synthesized chemically, providing a more consistent supply compared to natural extraction.
  • Marktnachfrage: High consumer demand for skin-lightening products drives its popularity in the cosmetics industry, making it a valuable ingredient for manufacturers.

Einhaltung gesetzlicher Vorschriften

  • US-amerikanische FDA: Regulated as a cosmetic ingredient. There are no specific restrictions on its use in topical cosmetics, but claims related to skin-lightening must comply with FDA regulations.
  • EU-Verordnung: Approved for use in cosmetics under the Cosmetics Regulation (EC) No 1223/2009. It is listed in the Cosmetic Ingredients Database (CosIng) with specific usage limits.
  • China NMPA: Permitted for use in cosmetics and is included in the Cosmetic Raw Materials Safety Information Database. Manufacturers must ensure compliance with safety and quality standards.
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Arbutin: The Gold Commonplace for Protected Pores and skin Brightening & Antioxidant Protection| Supplier & Manufacturer

1. What is Arbutin?

Arbutin (CAS 497-76-7) ist ein natürlich vorkommendes β-D-glucopyranoside spinoff of hydroquinone, famend for its potent tyrosinase-inhibiting properties. Because the premier non-irritating different to hydroquinone, it successfully disrupts melanin synthesis via aggressive enzyme inhibition with out cytotoxic results. Obtainable as alpha-arbutin (artificial) and beta-arbutin (plant-derived), the alpha type displays superior stability and efficacy at decrease concentrations.

2. Versorgung, chemische Eigenschaften und Identifizierung

  • Natürliche Quellen:

    • Wesentlich: Bearberry leaves (Arctostaphylos uva-ursi), Bergenia crassifolia, Pyrus communis (pear) leaves

    • Secondary: Wheat germ, blueberry shoots

  • Synthesis: Enzymatic glycosylation of hydroquinone by way of Aspergillus oryzae β-glucosidase

  • Chemical Specs:

    Parameter Wert
    CAS-Nr. 497-76-7 (β-Arbutin)
    84380-01-8 (α-Arbutin)
    Molekulare Formulierung C₁₂H₁₆O₇
    Molekulargewicht 272.25 g/mol
    EINECS 207-850-3
    Aussehen Weißes kristallines Pulver
    Löslichkeit Water: 50g/100mL (20°C)
    Stabilität pH 3-7; decomposes at >100°C

3. Premium Product Choice & Well being Functions

► Optimum Product Specs

  • Highest Efficiency: Alpha-arbutin >99% (HPLC) outperforms beta-arbutin with 10x better tyrosinase affinity

  • Purity Requirements: Heavy metals (Pb <1 ppm), residual solvents (methanol <50 ppm), microbial limits (TAMC <100 CFU/g)

► Clinically Validated Benefits:

  1. Pores and skin Depigmentation:

    • Inhibits tyrosinase (IC₅₀: 24 μM) by binding copper lively web site

    • Reduces UV-induced melanin by 45.8% at 0.5% focus (vs. 35.2% for β-arbutin)

  2. Antioxidantiensicherheit:

    • Scavenges ROS (IC₅₀: 0.13 mM) and prevents lipid peroxidation

  3. Antibacterial Motion:

    • Efficient towards Propionibacterium acnes (MIC: 1.25 mg/mL)

► Dosage & Security Profile:

Anwendung Fokus Frequenz
Kosmetika 0.5-2% Every day utility
Nutrazeutika 50-200 mg/day Oral, divided doses
Essential Notes:

  • Aspect Results: <0.1% incidence of contact dermatitis (patch check beneficial)

  • Kontraindikationen: Being pregnant (restricted knowledge), hydroquinone sensitivity

  • Stabilität: Formulate at pH 5.5-6.5; keep away from ascorbic acid/retinol combos

4. Shaanxi Zhonghong Biotech: Arbutin Innovation Chief

28 Jahre Erfahrung in botanical actives positions Shaanxi Zhonghong Investment Technology Co., Ltd. as the worldwide accomplice for premium arbutin:

► Kernkompetenzen:

  • Extraction Mastery:

    • CO₂ supercritical extraction (40°C, 250 bar) preserves thermolabile compounds

    • Nanofiltration expertise achieves >99.5% α-arbutin purity

  • Analytical Infrastructure:

    • Chiral HPLC-ELSD for α/β-arbutin isomer quantification

    • ICP-MS heavy steel detection at ppb-level sensitivity

  • Innovation Ecosystem:

    • Patent CN114716386A: Enzymatic synthesis of high-stability α-arbutin

    • College partnerships creating arbutin-peptide conjugates for enhanced dermal supply

5. Rigorous High quality Specs

Klasse Parameter Spezifikation Prüfmethodik
Pestizide Chlorpyrifos ≤0,01 mg/kg GC-MS/MS
Cypermethrin ≤0,05 mg/kg GC-MS/MS
Schwermetalle Blei (Pb) ≤1,0 mg/kg ICP-MS
Quecksilber (Hg) ≤0,1 mg/kg Lebenslauf-AAS
Mikrobiologie Komplette Cardio-Rely ≤100 KBE/g ISO 4833-1
Candida albicans Fehlt in 1 g ISO 18416
Staphylococcus aureus Fehlt in 1 g ISO 22718
Key Analytics α-Arbutin Assay ≥99,0% HPLC-ELSD
β-Arbutin Impurity ≤0,5% Chirale HPLC
Hydroquinone ≤1 ppm HPLC-DAD

6. Überlegener Fertigungsablauf

  1. Biomasseverarbeitung: Cryogenic milling of Arctostaphylos uva-ursi leaves (-196°C)

  2. Selective Extraction: Ethanol-water (70:30) at 50°C, pH 4.5

  3. Enzymatic Conversion: β-Glucosidase remedy (40°C, 24h) for α-arbutin isomerization

  4. Reinigung:

    • Macroporous resin chromatography (AB-8 resin)

    • Recrystallization from acetone/water (3:1)

  5. Lyophilisierung: -50°C vacuum drying for crystal construction preservation

7. Chopping-Edge Functions & Analysis

► Geschäftsfunktionen:

  • Cosmeceuticals: Brightening serums (2% α-arbutin + 5% niacinamide), pimples spot remedies

  • Medical Dermatology: Melasma remedy (mixed with 1064nm Q-switched Nd:YAG laser)

  • Praktische Mahlzeiten: Antioxidant capsules (100mg arbutin + selenium)

► Innovation Frontiers:

  1. Transdermale Versorgung:

    • Ethosomal carriers (entrapment effectivity: 92.3%) improve stratum corneum penetration

  2. Multi-Goal Inhibitors:

    • Arbutin-kojic acid hybrids present synergistic tyrosinase inhibition (IC₅₀: 3.7 μM)

  3. Nachhaltige Produktion:

    • CRISPR-edited E. coli strains producing arbutin from glycerol (yield: 28.7 g/L)

Present Challenges:

  • Regulatory divergence (Japan: quasi-drug vs. EU: beauty ingredient)

  • Stability in O/W emulsions (>40°C)

8. Important FAQs

Q: Does arbutin trigger pores and skin photosensitivity?
A: No – in contrast to hydroquinone, arbutin doesn’t improve UV sensitivity and offers intrinsic photoprotection.

Q: What focus is perfect for hyperpigmentation?
A: Scientific research present 2% α-arbutin reduces melanin index by 22.3% after 8 weeks (vs. 16.7% for 7% β-arbutin).

Q: Is plant-derived arbutin superior to artificial?
A: Artificial α-arbutin delivers greater purity (>99.5%), batch consistency, and efficacy at decrease doses.

Q: Can arbutin be used with vitamin C?
A: Formulate at pH 5.5-6.0; keep away from direct mixture with L-ascorbic acid (stability points).

9. World Provide Data

Contact Shaanxi Zhonghong for Pharmaceutical-Grade Arbutin:

  • E-Mail: liaodaohai@gmail.com

  • Website: https://www.aiherba.com

  • Verpackung: Nitrogen-flushed amber glass vials (1-5kg) or HDPE drums (25kg)

  • Lagerung: 2-8°C; 24-month stability

  • Logistik: World cold-chain transport (2-8°C) with IATA-compliant documentation

10. Fazit

Arbutin stays the gold-standard melanogenesis inhibitor for moral pores and skin brightening formulations. Shaanxi Zhonghong Investment Technology Co., Ltd. Hebelwirkungen proprietary enzymatic bioconversion expertise, cGMP-compliant nanofiltration, Und chiral separation experience to ship >99% pure α-arbutin – outperforming typical extracts in efficacy and security. With Über 20 Patente in lively supply techniques and ISO 22716 beauty GMP certification, we empower manufacturers to develop clinically efficient, regulatory-compliant depigmenting options. Accomplice with us to formulate the subsequent era of evidence-based pores and skin therapies.

Verweise

  1. Zhu, W. et al. (2021). α-Arbutin: Superior Manufacturing Methods & Scientific Efficacy. J. Cosmet. Dermatol. 20(7):2145-2156.

  2. EU SCCS Opinion on Alpha-Arbutin (SCCS/1642/22).

  3. Chen, L. et al. (2023). CRISPR-based Metabolic Engineering for Arbutin Biosynthesis. Metab. Eng. 76:146-158.

  4. JECFA Specs for Arbutin (JECFA/89/SC).

  5. Shaanxi Zhonghong Patent CN114716386A: Methodology for Excessive-Yield α-Arbutin Manufacturing.

  6. ICH Pointers: Q3C (Residual Solvents), Q3D (Elemental Impurities).

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