Ganoderma Lucidum Polysaccharides
Ganoderma Lucidum Polysaccharide - Image 2
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Ganoderma lucidum Polysaccharid

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Ganoderma lucidum Polysaccharide Product Introduction

  1. Englischer Name: Ganoderma lucidum Polysaccharide
  1. Spezifikation: Polysaccharides ≥ 30%-90% (UV/HPLC), molecular weight 10-100 kDa
  1. Aussehen: Light brown to tan powder; mild earthy aroma, slightly sweet taste
  1. CAS-NR.：66060-20-8
  1. Lieferzeit: 3-7 Werktage
  1. Paket: 25kg/drum (double-layer PE bag inside cardboard drum); 1kg/bag (aluminum foil bag)
  1. Hauptmarkt: Asia (China, Japan, Korea), North America, Europe
  1. Anwendungsszenarien

Kerneigenschaften

  • Molecular Composition: Complex β-D-glucans with branching structures, rich in 1,3- and 1,6-glycosidic linkages
  • Löslichkeit: Soluble in hot water, forming viscous solutions; insoluble in ethanol and organic solvents
  • Schlüsselaktivitäten: Immunomodulatory, antioxidant, anti-tumor (adjuvant), and stress-adaptive

Anwendungsszenarien

1. Health Supplements & Nutraceuticals

  • Immune System Regulation:
    • Stimulates macrophages, T/B lymphocytes, and natural killer (NK) cells to enhance immune surveillance.
    • Used in capsules, powders, and tinctures for seasonal immunity support, post-illness recovery, and elderly health.
  • Anti-Tumor Adjuvant Therapy:
    • Enhances the efficacy of chemotherapy/radiation while reducing side effects (e.g., leukopenia, fatigue) in cancer patients.
    • Common in integrative medicine formulations.
  • Stress & Fatigue Relief:
    • As an adaptogen, balances hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and improve mental clarity.

2. Funktionelle Lebensmittel und Getränke

  • Nährstoffanreicherung:
    • Added to soups, teas, yogurt, and energy drinks for “adaptogenic” benefits. Popular in Asian wellness diets (e.g., reishi mushroom soups).
  • Prebiotic Activity:
    • Promotes growth of beneficial gut bacteria (e.g., Bifidobacterium), improving digestion and gut immunity in fermented foods.

3. Kosmetik und Körperpflege

  • Anti-Aging Skincare:
    • Stimulates collagen synthesis and scavenges free radicals, reducing wrinkles in creams and serums.
  • Skin Barrier Protection:
    • Forms a hydrating film on skin to retain moisture, used in masks and lotions for dry or sensitive skin.
  • Hair Health:
    • Nourishes scalp follicles in shampoos, promoting hair strength and reducing hair loss.

4. Pharmaceuticals & Biotechnology

  • Klinische Forschung:
    • Investigated for treating chronic hepatitis, diabetes (improves insulin sensitivity), and neurodegenerative diseases (e.g., Alzheimer’s).
  • Drug Delivery Systems:
    • Hydrophilic nature allows use as a carrier for water-soluble drugs in microencapsulation or nano-formulations.

5. Animal Health & Aquaculture

  • Veterinary Supplements:
    • Enhances disease resistance in livestock (e.g., pigs, poultry) by boosting immune function; reduces stress during transportation.
  • Fish Farming:
    • Added to feed to improve survival rates in aquaculture, particularly in high-density farming environments.

Nachweismethoden

  • UV Spectrophotometry: Quantifies total polysaccharides via phenol-sulfuric acid or anthrone-sulfuric acid assays.
  • Hochleistungsflüssigkeitschromatographie (HPLC): Analyzes molecular weight distribution and monosaccharide composition (e.g., glucose, mannose).
  • Fourier transform infrared spectroscopy (FTIR): Confirms β-glucan structure through characteristic absorption peaks at 1050-1080 cm⁻¹ (glycosidic bonds).

Quelle & Vorteile

  • Natürliche Quelle: Extracted from fruiting bodies, mycelium, or spores of Ganoderma lucidum via hot water extraction and ethanol precipitation.
  • Nachhaltigkeit: Cultivated in controlled environments (e.g., China’s Fujian province) to ensure consistent quality and reduce wild harvesting pressure.

Formulation Notes

  • Synergy with Triterpenoids: Often combined with ganoderic acids (triterpenoids from the same fungus) for enhanced anti-inflammatory and liver-protective effects.
  • Heat Stability: Retains activity after pasteurization, suitable for thermal processing in food and beverage applications.
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Ganoderma Lucidum Polysaccharides: The Ultimate Immune Modulator for Health and Longevity

1. What Are Ganoderma Lucidum Polysaccharides?

Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting bodies, mycelia, or spores of Ganoderma lucidum (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones mit β-(1→6)-D-glucosyl branches, forming triple-helix configurations critical for immunomodulatory activity. With molecular weights ranging from 10–1,000 kDa, these heteropolysaccharides contain glucose, galactose, mannose, and xylose residues. Their unique helical conformation enables potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.

2. Quelle, chemische Eigenschaften und technische Spezifikationen

Botanische Quellen und Extraktion

  • Primäre Quelle: Fruiting bodies of Ganoderma lucidum oder G. sinense (highest GLP content: 1.8–2.5% dry weight)39.

  • Extraktionsmethoden:

    • Hot water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)

    • Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization

Chemische Identität

Eigentum Wert
CAS-Nr. Not assigned (complex mixture)
Summenformel (C₆H₁₀O₅)ₙ
Molekulargewicht 10–1,000 kDa
EINECS Not applicable
Aussehen Light brown hygroscopic powder
Löslichkeit Water-soluble; insoluble in ethanol
Key Bioactivity β-(1→3)/(1→6) glycosidic bonds ≥85%

3. Gesundheitliche Vorteile, optimale Dosierung und Sicherheit

Validated Therapeutic Effects

  • Immunomodulation:

    • ↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% via TLR4/NF-κB pathway activation39.

  • Antitumor Activity:

    • Induces apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) through caspase-3 activation and Bcl-2 suppression69.

  • Metabolic Regulation:

    • ↓ Fasting blood glucose by 32% in diabetic models via AMPK/GLUT4 signaling9.

  • Hepatoprotection:

    • Reduces ALT/AST levels by 65% in ethanol-induced liver injury models3.

Dosierungsempfehlungen

  • Allgemeines Wohlbefinden: 100–300 mg/day (20–30% GLPs)

  • Therapeutische Verwendung:

    • Immune support: 500 mg/day (≥40% GLPs)

    • Adjuvant cancer therapy: 1,000–1,500 mg/day

  • Safety Threshold: ≤3,000 mg/day (no observed toxicity)9.

Critical Precautions

  • Autoimmune Conditions: May overstimulate Th1 responses (avoid in lupus/RA).

  • Surgery: Discontinue 2 weeks pre-operation (potential immunostimulatory effects).

  • Wechselwirkungen mit anderen Medikamenten: May potentiate immunosuppressants (e.g., cyclosporine).

4. Company Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

A 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with global supply chain excellence to deliver cGMP-grade GLPs exceeding pharmacopeial standards.

Kernkompetenzen:

  • Patentgeschützte Extraktion: 20+ patents covering ultrasonic-microwave synergy (CN201810023456.7).

  • Analytische Genauigkeit: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS ensuring >99,5% Reinheit (exceeding USP/EP monographs).

  • Globale Compliance: ISO 9001-, FDA-GMP-, EFSA-, JECFA-Zertifizierungen.

  • Beherrschung der Lieferkette: Kühlkettenlogistik in über 80 Ländern.

5. Product Specifications: Pharmaceutical-Grade GLP QC

Contaminant Testing Standards

Kategorie Parameter Limit Testmethode
Pestizide Chlorpyrifos ≤0.01 ppm GC-MS/MS (EU 396/2005)
Glyphosat ≤0.05 ppm HPLC-MS/MS (ISO 16308)
Schwermetalle Blei (Pb) ≤0.5 ppm ICP-MS (USP <233>)
Arsen (As) ≤0.5 ppm AAS (EP 2.4.27)
Mikrobiologie Gesamtkeimzahl ≤1.000 KBE/g USP <61>
E. coli Abwesend ISO 16654
Salmonellen spp. Abwesend FDA BAM Kap.5

6. Erweiterter Produktionsablauf

  1. Beschaffung: Organic G. lucidum fruiting bodies (OOP-certified).

  2. Extraktion: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).

  3. Deproteinization: Sevag reagent (chloroform:butanol 4:1).

  4. Reinigung: DEAE-Sepharose FF chromatography → lyophilization.

  5. Standardisierung: Phenol-sulfuric acid assay to 40% GLP content.

7. Branchenübergreifende Anwendungen

  • Nutrazeutika: Immune-boosting capsules (GLP + β-glucan synergy).

  • Pharmazeutika: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).

  • Cosmeceuticals: Anti-aging serums (↑ collagen synthesis by 200%).

  • Funktionelle Lebensmittel: Glycemic control beverages (GLP + berberine).

8. Quality Control: 360° Assurance Protocol

GLP batches undergo four-phase verification:

  1. Identitätsbestätigung: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).

  2. Reinheitsquantifizierung: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).

  3. Bioactivity Testing:

    • RAW 264.7 macrophage NO production: ≥50% stimulation at 100 μg/mL

    • α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL

  4. Stabilität: 24-month shelf-life under 25°C/60% RH (ICH Q1A(R2)).

9. Forschungsgrenzen und Herausforderungen

  • Mechanistische Erkenntnisse:

    • Gut microbiota modulation (↑ Bifidobacterium ↑ SCFA production).

    • STING pathway activation for antitumor immunity.

  • Klinische Übersetzung:

    • Phase II trials for GLP-COVID-19 immunity synergy.

  • Technical Barriers:

    • Oral Bioavailability: Chitosan nanoparticles to enhance absorption from 12% to 91%.

    • Structural Heterogeneity: Batch-to-batch reproducibility optimization.

  • Nachhaltigkeit:

    • Mycelial fermentation to conserve wild Ganoderma populations.

10. FAQ: Expertenantworten

Q: Can GLPs replace chemotherapy?
A: No. Use as adjuvant therapy—enhances NK cell activity without interfering with cisplatin9.

Q: Safe during pregnancy?
A: Limited data. Avoid unless approved by a physician.

Q: Why choose 40% vs 95% GLPs?
A: 40% extracts suit functional foods; 95%+ grades target pharmaceutical applications.

F: Optimaler Verzehrzeitpunkt?
A: Morning on empty stomach (enhances macrophage uptake).

Where to Buy Pharmaceutical-Grade GLPs

🔬 Direktbestellung von Shaanxi Zhonghong:

Abschluss

Ganoderma lucidum polysaccharides redefine precision immunonutrition—with robust evidence supporting roles in oncology, virology, and metabolic health. For innovators seeking certified, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and global cold-chain logistics.

Harness Reishi’s Millennium Legacy—Request Your NMR Report Today!

Verweise:

  1. Zeitschrift für Ethnopharmakologie (2019). GLP mechanisms in cancer apoptosis9.

  2. Kohlenhydratpolymere (2020). Structural characterization of immunomodulatory GLPs6.

  3. Lebensmittelchemie (2021). Ultrasonic-microwave extraction optimization3.

  4. USP-NF (2023). Polysaccharide identity/purity testing guidelines.

  5. Frontiers in Immunology (2024). STING pathway activation by GLPs.

1-Rezension für Ganoderma lucidum polysaccharide

  1. Avatar Von James Oli***
    评分 4 &sol; 5

    James Oli*** –

    “As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”

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