Natriumkupferchlorophyllin
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Natriumkupferchlorophyllin

Sodium Copper Chlorophyllin supplier bulk factory Wholesale buy Extract factory

  1. Englischer Name: Sodium Copper Chlorophyllin
  1. Spezifikation
    • Reinheit: Copper Chlorophyllin ≥ 95% (HPLC), Copper content: 4.0 – 6.0% (atomic absorption spectroscopy)
    • Löslichkeit: Highly water – soluble (≥ 50 g/L at 25°C), insoluble in non – polar solvents like hexane
    • Appearance – Related: Loss on drying ≤ 5%, Heavy metals ≤ 10 ppm, Arsenic ≤ 2 ppm
    • Partikelgröße: Standard powder ≤ 100 μm; micronized versions ≤ 5 μm for better dispersion
  1. Aussehen
    • Dark green to blackish – green powder, odorless or with a faint, characteristic plant – like smell
  1. CAS-NR.：1406-65-1
  1. Lieferzeit: 3 – 5 Werktage
  1. Paket
    • 1 kg/Beutel (Aluminiumfolienbeutel), 25 kg/Fass (doppellagiger PE-Beutel im Kartonfass)
  1. Hauptmarkt: Global market, with significant demand in Asia (China, Japan), North America, and Europe, especially in food, cosmetics, and pharmaceutical industries
  1. Anwendungsszenarien

Kerneigenschaften

  • Molekularstruktur: A semi – synthetic derivative of chlorophyll, with copper ions replacing the central magnesium in chlorophyll and sodium salts enhancing water solubility
  • Chemical Stability: More stable than natural chlorophyll under varying pH and temperature conditions
  • Hauptmerkmale
    • Natural Green Colorant: Provides a vibrant green hue, heat – stable up to 120°C and maintains color in acidic (pH 4 – 8) environments.
    • Antioxidative Aktivität: Fängt freie Radikale wie Hydroxyl- und Superoxidanionen ab und schützt die Zellen vor oxidativen Schäden.
    • Detoxifying Properties: Binds to toxins like indole compounds in the gut, aiding in their elimination.
    • Entzündungshemmend: Inhibits the production of pro – inflammatory cytokines, reducing tissue inflammation.

Anwendungsszenarien

1. Essen & Getränke

  • Natürlicher Farbstoff:
    • Added to confectioneries (e.g., gummies, hard candies), baked goods (cakes, pastries), and dairy products (yogurt, ice cream) at 0.01 – 0.1% concentration to provide a green color.
    • Used in beverages such as green teas, sports drinks, and fruit – flavored drinks to enhance visual appeal without synthetic additives.
  • Geschmacksmodifikator:
    • In some meat products and seasonings, it can help mask off – flavors and improve overall taste.

2. Kosmetik und Körperpflege

  • Hautpflegeprodukte:
    • Incorporated into creams, lotions, and serums (0.5 – 2% concentration) for its antioxidant and anti – inflammatory properties, helping to soothe irritated skin and protect against environmental damage.
    • Used in anti – acne formulations to reduce inflammation and promote skin healing.
  • Haarpflege:
    • Added to shampoos and conditioners to nourish the scalp, strengthen hair follicles, and give hair a natural shine.

3. Pharmazeutika

  • Oral Health Products:
    • Included in toothpaste, mouthwashes, and chewing gum at 0.1 – 0.5% concentration to reduce bad breath by binding to odor – causing compounds in the mouth.
    • Investigated for its potential in preventing oral infections due to its antibacterial properties.
  • Nahrungsergänzungsmittel:
    • Capsules or tablets containing sodium copper chlorophyllin (200 – 500 mg per serving) are sold for detoxification support, immune system enhancement, and as an antioxidant supplement.

4. Tierfutter

  • Futterzusatz:
    • Added to poultry, livestock, and aquaculture feed at 50 – 200 ppm to improve the color of egg yolks, meat, and fish, and to enhance the overall health of animals through its antioxidant and anti – inflammatory effects.
    • Helps reduce the occurrence of digestive disorders in animals by promoting a healthy gut environment.

Nachweismethoden

  • Hochleistungsflüssigkeitschromatographie (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% formic acid (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 405 nm for quantification.
  • Atomabsorptionsspektroskopie (AAS):
    • Used to determine the copper content accurately, ensuring compliance with specification limits.
  • UV – Visible Spectroscopy:
    • Utilized for quick identification and quantification by analyzing the characteristic absorption peaks of the pigment in the UV – Vis range (around 400 – 700 nm).

Quelle & Vorteile

  • Natürliche Quelle: Derived from chlorophyll extracted from plants such as alfalfa, nettles, or mulberry leaves through a chemical modification process.
  • Nachhaltige Produktion: The raw materials are renewable, and the manufacturing process can be optimized for environmental friendliness.
  • Versatile Use: Its multi – functional properties make it valuable across multiple industries, from food coloring to health – promoting applications.

Einhaltung gesetzlicher Vorschriften

  • US-amerikanische FDA: Generally Recognized As Safe (GRAS) for use as a food color additive and dietary supplement ingredient.
  • EU-Verordnung: Approved as a food additive (E141ii) with specific usage limits in different food categories. Also compliant with cosmetic regulations for use in personal care products.
  • China NMPA: Permitted for use in food, cosmetics, and pharmaceuticals, subject to strict quality control standards.
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Sodium Copper Chlorophyllin: The Science-Backed Inexperienced Biomolecule for Well being & Trade | Supplier & Manufacturer

1. What is Sodium Copper Chlorophyllin?

Sodium Copper Chlorophyllin (SCC) is a semi-synthetic, water-soluble by-product of pure chlorophyll, the place the central magnesium ion is changed by copper and the phytol tail is eliminated by way of saponification. This transformation yields a steady, shiny inexperienced advanced (CIE 75810) proof against mild/warmth degradation189. In contrast to pure chlorophyll—which degrades quickly—SCC maintains its bioactive construction, enabling purposes in prescription drugs, meals expertise, and cosmetics. Its distinctive porphyrin-based construction permits electron switch reactions crucial for antioxidant and antiviral features59.

2. Versorgung, chemische Eigenschaften und Identifizierung

  • Liefern: Primarily extracted from spinach, alfalfa, oder silkworm excrement (referred to as “silkworm sand” or Cansha in conventional drugs)18. Uncooked supplies bear solvent extraction (ethanol/acetone), adopted by alkaline saponification Und copper substitution to exchange Mg²⁺ with Cu²⁺9.

  • Chemische Eigenschaften:

    • CAS-Nr.: 11006-34-1 (commonest), 65963-40-8, or 28302-36-5459

    • Molekulare Formulierung: C₃₄H₃₁CuN₄Na₃O₆ (main kind)4

    • Molekulargewicht: 724.15 g/mol4

    • EINECS: 234-242-54

    • Aussehen: Darkish inexperienced, metallic-lustered powder or liquid9

    • Löslichkeit: Extremely water-soluble; insoluble in lipids9

    • Stabilität: Degrades below sturdy mild/acidic situations; retailer at -20°C in darkish, hermetic containers5

3. Therapeutic Benefits, Dosage & Security

Highest Purity & Scientific Purposes

The “greatest” Natriumkupferchlorophyllin SCC prioritizes >95% purity (HPLC-verified), low heavy metals (Pb ≤3 ppm), and authorized low pesticide residues. Pharmaceutical-grade SCC (e.g., in Chlorophyllin Copper Sodium Capsules) incorporates standardized 20mg/capsule for exact dosing36.

Vorteile und Mechanismen für das Wohlbefinden:

  • Leberschützend: Prompts liver reticuloendothelial cells, reduces hepatomegaly, and accelerates regeneration in continual hepatitis (30-day course, 20mg TID)36.

  • Hematopoietic: Stimulates bone marrow stem cells (CFU-S, CFU-E) to extend RBCs, platelets, and neutrophils in leukopenia/radiation-induced anemia36.

  • Virostatikum: Hemmt HIV and influenza A (IC₅₀: 50–100 μM) by blocking viral fusion5.

  • Antioxidant/Wound Therapeutic: Neutralizes ROS and upregulates collagen synthesis in continual ulcers10.

Täglicher Verbrauch und Sicherheit:

  • Dosierung:

    • Therapeutisch: 20mg capsules TID for 30 days6

    • Dietary (coloring agent): ≤1g/kg in meals (e.g., drinks, gums)9

  • Facettenergebnisse:

    • Inexperienced stool/urine (benign)

    • Gentle belly discomfort or urticaria-like rashes3

  • Kontraindikationen:

    • Copper metabolism issues (Wilson’s illness)

    • Salicylate allergy (in carbazochrome formulations)36

  • Vorsichtsmaßnahmen: Renal impairment sufferers require dose changes; keep away from throughout being pregnant as a result of restricted security information6.

4. Shaanxi Zhonghong: Innovating Sodium Copper Chlorophyllin SCC Manufacturing

Shaanxi Zhonghong Investment Technology Co., Ltd. Hebelwirkungen 28 Jahre of experience in bioactive compound manufacturing to ship GMP-certified SCC. Our built-in strategy combines botanical extraction with cutting-edge purification:

  • Core Applied sciences:

    • Überkritische CO₂-Extraktion: Preserves heat-sensitive alkaloids

    • Preparative HPLC/UHPLC: Achieves >98% purity (vs. trade avg. 80%)

  • Hochwertige Infrastruktur:

    • Joint Labs with 5 High Universities: Centered on chlorophyll-derivative optimization

    • 20+ Patents: Together with SCC stabilization and nano-encapsulation methods

    • International Compound Library: 10,000+ pure molecules for customized formulations

  • International Provide: Serves 80+ international locations with tailor-made APIs for pharma (e.g., hemostats, antivirals), nutraceuticals, and cosmetics.

5. Strenge Produktspezifikationen

Klasse Parameter Spezifikation Technik prüfen
Pestizide Chlorpyrifos ≤0,01 mg/kg GC-MS/MS
Cypermethrin ≤0,05 mg/kg GC-MS/MS
Schwermetalle Blei (Pb) ≤3,0 mg/kg ICP-MS
Arsen (As) ≤2,0 mg/kg ICP-MS
Cadmium (Cd) ≤1,0 mg/kg ICP-MS
Mikrobiologie Whole Cardio Depend ≤1000 KBE/g USP <61>
E. coli Fehlt in 1 g USP <62>
Salmonellen spp. Fehlt in 10 g USP <62>
Lively Assay SCC (by HPLC) ≥95.0% HPLC-DAD/ELSD

6. Überlegener Fertigungsablauf

Shaanxi Zhonghongs cGMP-compliant course of ensures traceability from farm to API:

  1. Beschaffung: Natural spinach/alfalfa from audited farms.

  2. Extraktion: Ethanol/acetone leaching below nitrogen environment.

  3. Verseifung: NaOH therapy to hydrolyze ester bonds.

  4. Copper Substitution: React with CuSO₄ at pH 9.5–10.5.

  5. Reinigung: Chromatographie (adsorption → prep-HPLC) to take away phytol/byproducts.

  6. Crystallization & Drying: Lyophilization yields steady powder (moisture ≤5%)9[citation:用户输入].

7. Multisector Purposes

  • Verschreibungspflichtige Medikamente:

    • Tablets/capsules for hepatitis Und chemotherapy-induced leukopenia6.

    • Topical gels for diabetic ulcers (1–2% SCC)10.

  • Meals Know-how: Natural inexperienced coloring in drinks, yogurts, and gums (E141(ii))9.

  • Cosmeceuticals: Anti-aging lotions leveraging antioxidant properties1.

  • Analyse: Antiviral research (e.g., SARS-CoV-2 entry inhibition)5.

8. High quality Management & Stability

Unser High quality-by-Design (QbD) protocol exceeds pharmacopeial requirements:

  • Identifikation: FT-IR/NMR spectroscopy matched to USP reference requirements.

  • Reinheit: UHPLC-MS/MS detects impurities ≤0.1% (e.g., pheophytins).

  • Kontaminanten: ICP-MS screens for 14 heavy metals per ICH Q3D; LC-QTOF displays 500+ pesticides.

  • Stabilität: 24-month shelf life at -20°C validated by way of ICH Q1A(R2) accelerated/real-time research4[citation:用户输入].

9. Packaging & International Logistics

  • Hauptverpackung: Amber glass vials (R&D) or HDPE drums with desiccants (bulk).

  • Lagerung: -20°C ± 5°C; shield from mild.

  • Haltbarkeit: 24 months (powder), 12 months (resolution).

  • Transport: Dry ice (analysis grades) or climate-controlled freight (GMP batches) with GDP-compliant documentation.

10. Analysis Frontiers & Challenges

  • Rising Alternatives:

    • Nanocarrier Programs: Liposomal SCC for enhanced bioavailability in tumor concentrating on.

    • Antimicrobial Coatings: SCC-integrated polymers for wound dressings.

  • Key Challenges:

    • Dose Standardization: Assorted bioactivity throughout plant sources.

    • Regulatorische Hürden: SCC classification as “artificial” limits pure product claims.

    • Copper Bioaccumulation: Lengthy-term security in renal-impaired populations59.

11. Often Requested Questions (FAQ)

Q: Is SCC protected for every day consumption?
A: Sure—in regulated doses. Meals-grade SCC is GRAS at ≤15 mg/kg/day; therapeutic use requires medical supervision79.

Q: Why does SCC flip urine inexperienced?
A: This benign impact stems from incomplete metabolism of the porphyrin ring—no toxicity issues3.

Q: Can SCC change artificial dyes?
A: Completely. Its stability (>90% shade retention at 100°C) and security make it preferrred for clean-label meals9.

Q: How does SCC differ from chlorophyll?
A: SCC replaces Mg²⁺ with Cu²⁺ and removes lipophilic phytol, enabling water solubility and enhanced stability8.

12. Ordering Data

Supply premium, GMP-certified Sodium Copper Chlorophyllin instantly:

13. Fazit

Sodium Copper Chlorophyllin bridges pure biochemistry and industrial utility—delivering validated advantages in hepatoprotection, hematopoiesis, and antimicrobial motion. Shaanxi Zhonghong Investment Technology Co., Ltd. combines 28 years of plant extract experience, universitätsgestützte Forschung und Entwicklung, Und cGMP analytical rigor (NMR/HPLC-MS/MS) to provide international companions with high-purity SCC. Our vertically built-in course of ensures batch-to-batch consistency for prescription drugs, nutraceuticals, and revolutionary purposes like antiviral coatings. Contact us to leverage our portfolio in your next-generation well being options.

14. Referenzen

  1. Nationwide Well being Analysis Institutes (Taiwan). Copper Chlorophyllin Q&A. (2013).

  2. European Meals Security Authority. *Re-evaluation of Chlorophyllins (E 141(ii)) as Meals Components*. (2015).

  3. Guangdong Xin Feng Pharma. Chlorophyllin Copper Sodium Capsules Package Insert. (2021).

  4. J&Ok Scientific. Sodium Copper Chlorophyllin Product Knowledge Sheet. (2023).

  5. Beijing BioLab. SCC Antiviral Mechanism Examine. (2022).

  6. Tencent Medical Dictionary. Scientific Use of SCC Capsules. (2023).

  7. Taiwan FDA. Regulatory Requirements for Meals Colorants. (2024).

  8. Chen, C. Copper Chlorophyll in Cosmetics. Dermatologist Weblog. (2021).

  9. Shenghua Chemical. SCC Manufacturing and Purposes. (2024).

  10. McCook, J.P. et al. Wound Restore with Topical SCC. Journal of Medicine in Dermatology. (2016).

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