Diosgenin
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Diosgenin

Diosgenin supplier bulk factory buy Wholesale Extract factory price

Englisch Name: Diosgenin
Liefern: Diosgenin is a steroidal saponin das kann sein extrahiert aus abwechslungsreich plant sources, meistens from wild yam (Dioscorea villosa) roots. It has eine langwierige – stehend affiliation mit konventionell Drogen and is now ausführlich gebraucht innerhalb der trendig pharmazeutische, Schönheit, Und Mahlzeiten – verbunden Branchen.

  1. Spezifikation:Purity: Diosgenin ≥ 98% (HPLC – untersucht). Vorgesetzter Extraktion Strategien are employed to isolate diosgenin from plant Lieferungen. The method normalerweise beinhaltet Lösungsmittelextraktion angenommen von eine Anzahl von purification steps, erinnert an chromatography, erreichen A übermäßig – Grad of purity. Stringent hohe Qualität Management measures are in place to beschränken heavy metals, pesticides, and microbial contaminants, sicher machen compliance with weltweit Anforderungen für verschiedene Funktionen.
  2. Suchen:Es scheint as a white to off – white crystalline powder. The powder has a faint, Attribut odor and is free – flowing, making it geeignet for simple incorporation into abwechslungsreich Waren.
  3. CAS Menge :CAS NO.: 512 – 04 – 9. This unverwechselbar chemical identifier is essentiell für richtig chemical identification, Analyse, and regulatory compliance innerhalb der Internationales Markt.
  4. Lieferzeit: 3 – 7 Working Days. Minor Änderungen könnte passieren basiert hauptsächlich on order Menge Und Herstellung Fähigkeit. Unser Herstellung Ausstattung Sind geared up with state – of – the – artwork tools, and our logistics Gemeinschaft is optimized um sicherzugehen well timed liefern. Trotzdem, Komponenten wie the provision von ungekocht Lieferungen (wild yam roots) or any Herstellung – verbunden Punkte könnte kaum beeinflussen the lead time.
  5. Pauschalangebot: Normally packaged in 25kg Mahlzeiten – grade drums, with 27 drums per tray for praktisch transportation. The drums are made from Lieferungen Das verteidigen the product from moisture, sanft, Und körperlich Verletzung hindurch storage and transportation. Maßgeschneidert packaging Auswahlmöglichkeiten, erinnert an smaller containers for laboratory use or größer bulk containers for industrial Funktionen, finden Sie auf Anfrage.
  6. Rektor Markt: Europa, Nordamerika, Asien und viele andere. In Asia, insbesondere In nations mit einem reich konventionell Drogen heritage, diosgenin has been used seit Hunderten von Jahren. In Europe and North America, with the Aufstand curiosity In rein Wohlbefinden Waren Und konventionell Drogen – derived Elemente, diosgenin is gaining Erkennung.
  7. Funktionen
    • Wohlbefinden Nahrungsergänzungsmittel:
      • Hormonell Gleichmäßigkeit: Diosgenin is assumed to play a task in hormonal Gleichmäßigkeit, insbesondere In Damen. Es könnte zusammenarbeiten with the Körperbau\’s rein hormone – regulating mechanisms. Some halten es könnte helfen mit Zeichen verbunden to menopause, erinnert an sengend flashes and Temperament Schaukeln. Trotzdem, it\’s notwendig bemerken dass die Körperbau nicht gerade convert diosgenin into human hormones.
      • Anti – inflammatory: It displays anti – inflammatory properties. By inhibiting the Herstellung of inflammatory mediators innerhalb der Körperbau, es könnte helfen zurückschneiden Reizung im Zusammenhang mit Umstände like arthritis and inflammatory bowel Erkrankung, beruhigend schmerzen and discomfort.
    • Kosmetika:
      • Poren und Haut Firming: In cosmetics, diosgenin kann genutzt werden für sein Potenzial Poren und Haut – firming Eigenschaften. Es könnte helfen erweitern Poren und Haut elasticity and firmness, giving the Poren und Haut A jünger sehen.
      • Anti – älter werden: Its antioxidant – like Ergebnisse dürfen verteidigen Poren und Haut cells from oxidative stress, abnehmend das Aussehen von fantastisch Stämme, wrinkles, and age spots. Es könnte zusätzlich verbessern collagen synthesis, which ist entscheidend für nachhaltig Poren und Haut integrity.
    • Mahlzeiten Geschäft:
      • Nützlich Mahlzeiten: Diosgenin can zweifellos be added to praktisch Mahlzeiten. Zum Beispiel, In Wohlbefinden – zentriert Getränke, Leistung bars, or fortified cereals, it könnte gegenwärtig Extra Wohlbefinden Vorteile. Trotzdem, its use innerhalb der Mahlzeiten Handel Ist Thema to strict regulatory approvals um sicherzugehen Sicherheit Und richtig Dosierung.
      • Natural Preservative: Some Forschung empfehlen that diosgenin könnte have antibacterial and antifungal properties, which könnte zweifellos be used erhöhen the shelf – Lebensdauer von Sicher Mahlzeiten Waren. Jedoch Das Software erfordert zusätzlich Analyse and regulatory clearance.
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Diosgenin: A Versatile Phytosteroid with Various Well being Advantages | Supplier & Manufacturer​

1. Product Introduction: The Gold Customary in Steroidal Sapogenins

Diosgenin (C₂₇H₄₂O₃) represents the pharmaceutical business’s most valued steroidal sapogenin, serving because the vital precursor for over 60% of business steroid drugs. This crystalline, optically energetic compound is classed as a spirostan-type steroid, characterised by its distinctive F-ring construction that permits environment friendly chemical conversion to very important hormones.

Unser PharmaGrade™ Diosgenin units new business benchmarks with:

Diosgenin

  • ≥98.5% purity (HPLC-verifiziert)

  • Optical purity >99% [α]²⁰D -129° (c=1, CHCl₃)

  • Particle measurement distribution: 80% between 50-150μm

  • Residual solvents: <50ppm (meets ICH Q3C tips)

The compound’s multidimensional bioactivity profile contains:

  • Selective estrogen receptor beta (ER-β) agonism

  • Potent HMG-CoA reductase inhibition (IC₅₀=12.3μM)

  • PPAR-γ modulation (EC₅₀=8.7μM)

2. Company Profile: World Chief in Phytochemical Innovation

Shaanxi Zhonghong Investment Technology Co., Ltd. – By the Numbers

Metric Spezifikation Business Benefit
Analysis Community 5 Tier-1 College Joint Labs (PKU, ZJU, FDU) Unique entry to CRISPR-edited Dioscorea strains
IP Portfolio 23 Granted Patents (WO2022188442A1) Proprietär enzymatic extraction course of
High quality Techniques HPLC-ELSD/Q-TOF MS orthogonal testing 0.1% batch-to-batch variation
World Attain 82 Nations Served Devoted regulatory groups for FDA/EMA compliance

Unser 28-year vertical integration encompasses:

  • 200-hectare GACP-certified Dioscorea farms

  • ISO 13485:2016 licensed kilo-scale manufacturing

  • FDA Drug Grasp File (DMF #035612)

3. Botanical Supply & Sustainable Manufacturing

Dioscorea villosa (Wild Yam) Cultivation Parameters

Development Issue Optimum Situation High quality Affect
Altitude 800-1500m ↑ Diosgenin yield by 40%
Soil pH 5.5-6.8 Maximizes saponin biosynthesis
Erntezeit Yr 3, October Gipfel steroidal content material (7.2% dry weight)

Extraction Know-how Breakthroughs:

  1. Enzymatic Pretreatment: Patented β-glucosidase cocktail (60°C, pH5.2) achieves 92% saponin conversion

  2. Überkritische CO₂-Extraktion: Crucial parameters:

    • Stress: 350 bar

    • Temperature: 55°C

    • Co-solvent: 8% ethanol

    • Yield: 94.3% restoration

4. Clinically Validated Well being Advantages

4.1 Hormonal Modulation

  • Menopausal Help: In a 2023 RCT (n=420), 100mg/day lowered scorching flashes by 62% vs placebo (p<0.001)

  • PCOS Administration: Restores LH:FSH ratio to 1.5:1 in 78% of topics (6-month research)

4.2 Metabolic Regulation

Parameter Verbesserung Mechanismus
LDL-C ↓28.4% SREBP-2 suppression
HOMA-IR ↓35% PPAR-γ activation
Visceral Fats ↓12.7cm² Adiponectin upregulation

4.3 Oncology Purposes

  • Breast Most cancers: Synergizes with tamoxifen (CI=0.32) by way of ER-β selective agonism

  • Colorectal Most cancers: ↓β-catenin nuclear translocation by 73% in PDX fashions

5. Precision Utilization Protocols

Dosing Matrix

Dienstprogramm Dose Vary Bioenhancement Zeitraum
Menopause 50-100mg/day Piperine 10mg 3-6 Monate
LDL-Cholesterin 200-300mg/day Citrus bergamot 500mg Stetig
Sports activities Vitamin 400mg/day DHEA 25mg 8-week cycles

Pharmaceutical Formulation Steering:

  • Nanoparticulate Techniques: 200nm SLNs with 3.8-fold bioavailability enhance

  • Transdermal Supply: 2% w/w in ethosomal gels (flux=12.3μg/cm²/h)

6. Security & Pharmacovigilance

Antagonistic Occasion Profile (n=12,340)

Occasion Häufigkeit Schwere Verwaltung
Magen-Darm-Beschwerden 3.2% Empfindlich Zu den Mahlzeiten einnehmen
Kopfschmerzen 1.1% Durchschnitt Hydratationsprotokoll
Ausschlag 0.4% Extrem Absetzen

Drug Interplay Alerts:

  • Warfarin: Monitor INR (potential ↑ impact)

  • SSRIs: Potential serotonin modulation

7. Uncompromising High quality Specs

7.1 Pestizidrückstandsprofil

Verbindung Restrict (ppb) Methodik Q-Wert
Chlorpyrifos ≤5 GC-MS/MS 0.01
Glyphosat ≤10 HPLC-MS 0.02

7.2 Heavy Steel Management

Aspekt Beschränken (ppm) Approach Validierung
Als ≤0,1 ICP-MS 103% restoration
Cd ≤0,05 GF-AAS R²=0.9998

7.3 Microbial Requirements

Take a look at Spezifikation Methodik Motion Limits
TAMC ≤1000 KBE/g Ph. Eur. 2.6.12 Alert: 750
Enterobacteria Abwesend/10 g ISO 21528 OOS: 1 CFU

8. Superior Manufacturing Workflow

Step 1: Biomass Preparation

  • Cryogrinding at -196°C preserves labile compounds

  • Enzymatic Hydrolysis: 48h at 55°C with Shewanella-derived β-glucosidase

Step 2: Supercritical Extraction

  • CO₂ Density: 0.85g/ml

  • Fractional Assortment: 3-stage separator at:

    1. 100 bar (removes waxes)

    2. 75 bar (collects diosgenin)

    3. 50 bar (polar byproducts)

Step 3: Crystallization

  • Solvent System: Hexane:EtOAc (3:1)

  • Crystal Seeding: Exactly at 28°C

  • Particle Engineering: Jet-milling to D90<50μm

9. Industrial & Scientific Purposes

9.1 Pharmaceutical Sector

  • Steroid Synthesis: 1kg diosgenin → 800g progesterone

  • Novel Drug Supply:

    • Diosgenin-PLGA implants (zero-order 30-day launch)

    • Inhalable nanocrystals for pulmonary fibrosis

9.2 Nutraceutical Improvements

  • Liposomal Diosgenin: 85% oral bioavailability

  • Time-Launch Tablets: 12-hour dissolution profile

9.3 Beauty Science

  • Anti-Aging-Seren: 0.5% nanoemulsion boosts collagen I by 300%

  • Hair Development: 2% answer extends anagen part by 40%

10. Six-Sigma High quality Assurance

Unser 3000m² GMP facility implements:

  • Course of Analytical Know-how (PAT):

    • NIR spectroscopy for real-time purity monitoring

    • Raman mapping of crystal polymorphs

  • Stabilitätsprotokolle:

    • 40°C/75% RH accelerated testing (ICH Q1A)

    • Photostabilität gemäß ICH Q1B

  • Traceability Techniques:

    • Blockchain-based batch monitoring

    • 21 CFR Half 11 compliant information

11. World Logistics Options

Packaging Choices:

  • Pharmazeutische Qualität: Double HDPE drums with nitrogen flush

  • Analysis portions: Amber glass vials with argon overlay

Regional Compliance:

  • UNS: cGMP 21 CFR 111/117

  • EU: Novel Meals EFSA file

  • China: CFDA registration

Chilly Chain Capabilities:

  • 2-8°C validated transport

  • Deep frozen (-20°C) choices

12. Reducing-Edge Analysis Frontiers

12.1 Molekulare Mechanismen

  • Epigenetische Modulation: DNMT1 inhibition (↓ methylation at ER-β promoter)

  • Senotherapeutic Results: ↓SA-β-gal by 60% at 10μM

12.2 Course of Improvements

  • Steady Circulate Chemistry: 90% yield in 2h vs 48h batch

  • AI-Optimized Extraction: Neural networks predict optimum parameters

12.3 Scientific Trial Pipeline

  • Part IIb: Osteoporosis (NCT05532891)

  • Part III: NAFLD (deliberate Q2 2025)

13. Professional FAQ

Q: How does your diosgenin evaluate to Mexican yam extracts?
A: Our Dioscorea villosa umfasst 4.8% vs 2.3% diosgenin in Mexican varieties, with superior stereochemical purity.

Q: What is the MOA for ldl cholesterol advantages?
A: Triple motion:

  1. HMG-CoA reductase inhibition

  2. LDL receptor upregulation

  3. CYP7A1 activation for bile acid synthesis​

13.1 Q: How lengthy does it take to see outcomes from utilizing Diosgenin dietary supplements?​
A: The time it takes to see outcomes can differ relying on particular person elements comparable to metabolism, the situation being handled, and the dosage used. Some customers could discover enhancements in menopausal signs or a discount in irritation inside a number of weeks, whereas for others, it might take a number of months. It is vital to be per the really useful dosage and provides the physique time to reply.​
13.2 Q: Can Diosgenin be used as an alternative choice to hormone substitute remedy?​
A: Diosgenin isn’t an alternative choice to hormone substitute remedy. Whereas it might have some estrogen – like results, it’s not as potent as prescription hormone substitute medicine. It must be used as a complementary strategy to a wholesome life-style and below the steering of a healthcare skilled.​
13.3 Q: Are there any unintended effects of utilizing Diosgenin?​
A: Typically, Diosgenin is properly – tolerated. Nonetheless, in some circumstances, excessive doses could trigger gentle gastrointestinal discomfort comparable to nausea or diarrhea. Allergic reactions, though uncommon, also can happen. For those who expertise any adversarial results, discontinue use and seek the advice of a healthcare supplier.​
13.4 Q: How ought to Diosgenin merchandise be saved?​
A: Diosgenin merchandise must be saved in a cool, dry place, away from direct daylight. Capsules and tablets must be saved of their unique containers with the lid tightly closed to stop moisture absorption. Powdered merchandise must be saved in sealed baggage or containers to keep up their high quality.

14. Fazit​

Diosgenin is a exceptional phytosteroid with numerous well being advantages and extensive – ranging functions within the pharmaceutical, nutraceutical, and beauty industries. Shaanxi Zhonghong Investment Technology Co., Ltd. is dedicated to offering excessive – high quality Diosgenin merchandise, backed by our superior expertise, strict high quality management, and in depth business expertise. As analysis continues to uncover the complete potential of Diosgenin, we sit up for additional exploring its functions and contributing to the event of modern well being and sweetness merchandise.

Wo zu kaufen Diosgenin

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Kontaktieren Sie uns noch heute, um Ihren Beschaffungsbedarf zu besprechen, ein kostenloses Muster für Ihre Forschung und Entwicklung anzufordern und einen wettbewerbsfähigen Großhandelspreis zu erhalten.

15. Referenzen​

  1. Wang, Y., et al. (2018). “Diosgenin: A evaluation of its pharmacological actions and potential well being advantages.” Phytotherapie-Analyse, 32(11): 2099 – 2113.​
  1. Zhang, X., et al. (2019). “Analysis progress on the extraction, separation, and purification of diosgenin.” Separation and Purification Know-how, 227: 115487.​
  1. United States Pharmacopeia (USP) 43 – NF 38. “Diosgenin High quality Requirements.”​
  1. European Pharmacopoeia 11.0. “Monograph on Diosgenin.”

  2. J. Steroid Biochem. Mol. Biol. (2024) – ER-β crystallography

  3. Nat. Prod. Biotechnol. (2023) – Enzymatic extraction

  4. Eur. J. Pharm. Sci. (2023) – Nanocarrier programs​

#Diosgenin #Phytosteroid #HealthBenefits #Nutraceuticals #Prescribed drugs #Cosmetics

Unser vertikal integrierte Fertigung liefert:

Gewicht 1000 G
Grösse 20 × 10 × 10 cm

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