Quercetin
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Quercetin-tilskud

Quercetin Kosttilskud​ – Overdreven-Purity Flavonoid Compound supplier bulk produktionsenhed Wholesale Extract produktionsenhed

  1. Engelsk navn: Quercetin
  1. Specifikation
    • Renhed: Quercetin ≥ 98% (HPLC)
    • Vandopløselig Slags: Quercetin glycosides (e.g., rutin) or nanoemulsion – primært baseret formulations, solubility enhanced så meget som 10 g/L ved hjælp af indkapsling
    • Partikel Dimension: Almindelig powder ≤100 μm; micronized variationer ≤5 μm for højere biotilgængelighed
  1. Udseende
    • Powder: Yellow to orange – yellow crystalline powder, odorless, knap bitter stil
  1. CAS-nr.：117-39-5
  1. Leveringstid: 3 – 7 arbejdsdage
  1. Pakke
    • 1 kg/pose (aluminiumsfoliepose), 25 kg/tønde (dobbeltlags PE-pose i paptønde)
  1. Hovedmarked: North America, Europe, Asia, South America
  1. Applikationsscenarier

Kerneegenskaber

  • Molekylær Komponenter: C₁₅H₁₀O₇
  • Opløselighed: Sparingly soluble in water (0.1 g/L at 25°C); soluble in ethanol, DMSO; water – soluble derivatives forbedre usability in aqueous programs
  • Nøgle Valgmuligheder
    • Kraftig antioxidant: Scavenges free radicals (e.g., hydroxyl, superoxide), with an ORAC værdi of ~5000 μmol Trolox equivalents/g.
    • Antiinflammatorisk: Hæmmer professionel – inflammatory enzymes (COX – 2, iNOS) and cytokines (TNF – α, IL – 6).
    • Fytoøstrogen Øvelse: Weak estrogen – like resultater, nyttig for menopausale symptomer administration.
    • Antimikrobiel: Skærme øvelse mod mikroorganisme (f.eks. Staphylococcus aureus) og svampe (f.eks. Candida albicans).

Applikationsscenarier

1. Kost Kosttilskud

  • Grundlæggende Velvære Formulering:
    • Capsules or tablets (250 – 500 mg per serving) bought as antioxidant and immune – boosting kosttilskud.
    • Som regel blandet with vitamin C and zinc for enhanced efficacy hele vejen igennem kølig and flu seasons.
  • Specialitet Velvære Varer:
    • Led velvære kosttilskud (500 – 1000 mg/day) at skære ned irritation in arthritis de lidende.
    • Kardiovaskulær hjælp formulering, som det kunne hjælpe formindske blod stress og niveauer af kolesterol.

2. Praktisk Måltider & Drikkevarer

  • Antioxidant – Fortified Varer:
    • Added to juices, teas, and vitalitet drinks at 50 – 100 mg/L at forlænge antioxidant indholdsmateriale.
    • Anvendt i “klar – label” snacks (e.g., granola bars) as a ren preservative and nutrient enhancer.
  • Plant – Hovedsageligt baseret Meat Alternative muligheder:
    • Inhibits lipid oxidation, extending the shelf – levetid på plante – primært baseret proteiner og forbedring smag stability.

3. Kosmetik & Privat Omsorg

  • Anti- bliver ældre Hudpleje:
    • Serum og lotioner (0.5 – 2% fokus) at bevogte mod UV – induced skade, skære tilbage wrinkles, and promote collagen synthesis.
    • Soothing formulations for delikat porer og hud, leveraging its anti – inflammatory properties.
  • Hårpleje:
    • Shampoos and conditioners to strengthen hair follicles and skære tilbage dandruff by combating scalp irritation.

4. Receptpligtig medicin

  • Undersøgelsesterapier:
    • Studied for its potential in treating neurodegenerative sygdomme (e.g., Alzheimer’s, Parkinson’s) som følge af neuroprotective resultater.
    • Investigated as an adjuvant in de fleste kræftformer terapi, enhancing the efficacy of chemotherapy hvorimod sænkning uønskede bivirkninger.
  • Over – the – Counter (OTC) Lægemidler:
    • Anvendt i topical lotioner for mild porer og hud irritations and allergisymptomer, tilbud anti – inflammatory and antioxidant hjælpe.

5. Dyr Velvære

  • Husdyrfoder Komponenter:
    • Added to poultry and swine feed (100 – 500 ppm) at forbedre udvikling effektivitet, skære tilbage oxidative stress, and forbedre kød høj kvalitet.
  • Kæledyr Kosttilskud:
    • Formulated in chewable tablets for hund and cats to hjælp led velvære og immunforsvar udføre.

Opdagelse Strategier

  • Overdreven – Effektivitet Væskekromatografi (HPLC):
    • Kolonne: C18 (250 × 4,6 mm, 5 μm), Celle Afsnit: Acetonitrile – 0.1% phosphoric acid (35:65 v/v), Cirkulation Betaling: 1.0 mL/min, Detection Wavelength: 360 nm.
  • Massespektrometri (MS):
    • Anvendt i blanding med HPLC (HPLC – MS) to substantiate molekylær konstruktion og opdage antydning urenheder.
  • FTIR-spektroskopi:
    • Identifies attribut målbevidst hold (e.g., hydroxyl, carbonyl) to bekræfte produkt identification.

Levere & Fordele

  • Naturlig LevereUddrag fra talrige vegetation, sammen med Sophora japonica flowers, onions, apples, and grapes.
  • Bæredygtighed: Might be sourced from agricultural by – varer (e.g., onion skins), sænkning spild.
  • Multi – målbevidstDens forskellige bioactivities make it passende for funktioner hele vejen igennem et antal industrier.

Overholdelse af regler

  • Det amerikanske FDA: Regulated as a dietary supplement ingrediens under DSHEA (Dietary Komplement Velvære og Uddannelse Act).
  • EU-forordningTilladt som en måltider additive and dietary supplement ingredient, emne til sikkerhed evaluations.
  • Kinas NMPA: Tilladt at blive brugt i målbevidst måltider og kost kosttilskud, med særlig udnyttelse grænser.
Kategorier: , , , , ,

Quercetin Dietary supplements​: The Premier Flavonoid Powerhouse – Final Information & Premium Supply| Supplier & Manufacturer

1. Hvad er quercetin?
Quercetin er en flavonol i kosten belonging to the polyphenolic compounds subclass. As a potent plant pigment, it serves vital roles in UV safety and stress response in botanicals. In human physiology, it displays multifunctional bioactivity, appearing as a grasp antioxidant, anti-inflammatory agent, og mobile signaling modulator. Its distinctive catechol construction og α,β-unsaturated carbonyl group allow distinctive free radical scavenging and metallic chelation capabilities.

2. Forsyning, kemiske egenskaber og identifikation

  • Main Natural Sources (Highest Concentrations):

    • Sophora japonica Buds: Richest supply (as much as 20% dry weight)

    • Onion Skins (Allium cepa): Significantly purple onions (1-1.5%)

    • Ginkgo biloba Leaves: Standardized extracts (22-26%)

    • Apple Peel (Malus domestica): Key supply of quercetin glycosides

    • Different Sources: Capers, lovage, elderberries, buckwheat, tea

  • Kemiske egenskaber:

    • CAS-mængde: 117-39-5

    • Molekylære komponenter: C₁₅H₁₀O⇇

    • Molekylvægt: 302,24 g/mol

    • EINECS-mængde: 204-187-1

    • Udseende: Gult krystallinsk pulver

    • Opløselighed: Insoluble in water; soluble in ethanol, DMSO, lipids (when complexed)

    • Stabilitet: Delicate to UV mild and alkaline circumstances; degrades above 160°C

3. Benefits, Efficacy, Dosage & Security

  • Optimum Sources & Bioavailability: Sophora japonica extracts ship the very best pure concentrations (95-98% purity). Bioavailability is enhanced by phospholipid complexation (Quercetin Phytosome®) or liposomal encapsulation, growing absorption by 5-20x vs. commonplace powder.

  • Validated Well being Benefits & Mechanisms:

    • Systemic Antioxidant Protection: Modulerer Nrf2/ARE-signalvejen, upregulating glutathione synthesis og superoxide dismutase (SOD)

    • Antiinflammatorisk bevægelse: Hæmmer COX-2, LOX, og NF-κB signaling pathways, decreasing pro-inflammatory cytokines (TNF-α, IL-6)

    • Immunmodulation: Stabilizes mast cells, reduces histamine launch through cAMP phosphodiesterase inhibition

    • Cardiometabolic Assist: Improves endothelial perform by eNOS activation, inhibits LDL oxidation

    • Viral Protection: Demonstrated 3CL protease inhibition in opposition to coronaviruses in vitro

  • Medical Dosage:

    Formulering Daglig dosis Length
    Commonplace Powder 500-1000 mg 8-12 uger
    Phytosome® 250-500 mg Stabil
    Acute Immune Assist As much as 3000 mg ≤5 days

  • Security Profile:

    • GRAS standing (FDA)

    • Keep away from concomitant use with CYP3A4 substrates (cyclosporine, warfarin)

    • Potential renal toxicity at >5g/day

    • Being pregnant Class C

4. Shaanxi Zhonghong: Quercetin Excellence
Udnyttelse 28 years in bioactive phytochemistry, Shaanxi Zhonghong Investment Technology Co., Ltd. pioneers quercetin manufacturing by:

  • Core Improvements:

    • Glycoside-to-Aglycone Conversion: Patented enzymatic hydrolysis for >98% aglycone purity

    • Nanocrystallization Know-how: 200nm particle measurement for enhanced solubility

    • Phytosome® Manufacturing: Validated complexation with sunflower phospholipids

  • Infrastruktur af høj kvalitet:

    • UPLC-QTOF-MS for isomer profiling

    • cGMP og ISO 22000 licensed amenities

    • Batch traceability through blockchain expertise

5. Product Specification (Pharmaceutical Grade)

Klasse Parameter Specifikation Tjekteknik
Renhed Quercetin Aglycone ≥98.0% HPLC-DAD (EP 10.0)
Tungmetaller Bly (Pb) ≤1,0 ppm ICP-MS (USP <233>)
Cadmium (Cd) ≤0,5 ppm ICP-MS
Arsen (As) ≤1,0 ppm ICP-MS
Pesticider Chlorpyrifos ≤0,01 ppm GC-MS/MS
Cypermethrin ≤0,02 ppm GC-MS/MS
Complete 186 Pesticides Skadelig EU SANTE/11813/2017
Mikrobiologi Komplet cardio-afhængighed ≤1000 CFU/g USP <61>
Gær og meldug ≤100 CFU/g USP <61>
Enterobacteriaceae Fraværende/10 g ISO 21528-2

6. Overlegen produktionsarbejdsgang

  1. Botanical Sourcing: DNA-authenticated Sophora japonica buds

  2. Multistage Extraction: Ethanol/water (70:30) at 45°C with microwave help

  3. Macroporous Resin Chromatography: AB-8 resin for flavonoid isolation

  4. Enzymatic Bioconversion: β-glucosidase remedy (45°C, pH 5.0)

  5. Crystallization Management: Anti-solvent precipitation at 4°C

  6. Nanomilling: Moist-milling to D90 < 250nm

  7. Phospholipid Complexation (Optionally available): 1:1 ratio with phosphatidylcholine

  8. Frysetørring: -40°C main drying

7. Application Matrix

Forretning Formulation Examples Useful Position
Nutraceuticals Immune complexes, sports activities formulation Oxidative stress discount
Receptpligtig medicin Antiviral adjuvants, cardioprotectives Endothelial perform modulation
Kosmeceutiske produkter Anti-pollution serums, UV protectants MMP inhibition
Nyttige måltider Stability-enhanced drinks Shelf-life extension

8. Mechanism & Medical Proof

  • Mitokondriel biogenese: Prompter SIRT1/PGC-1α-signalvejen (5-15% improve in ATP manufacturing)

  • Senescence Modulation: Reducerer p16INK4a expression in human fibroblasts

  • Viral Inhibition: IC₅₀ = 7.6 μM in opposition to SARS-CoV-2 3CL protease

  • Cardiometabolic Results: 12% LDL discount in hyperlipidemic sufferers (500mg/day, 8 weeks)

9. Technological Frontiers

  • Bioavailability Options:

    • Quercetin-β-cyclodextrin complexes (water solubility: 35 mg/mL)

    • Strong lipid nanoparticles (90% oral bioavailability)

  • Uerfaren kemi:

    • Subkritisk vandudvinding (SWE) at 120°C/50 bar

    • Enzyme-assisted deep eutectic solvent teknikker

10. Analysis Challenges

  • Pharmacokinetics: Quick plasma half-life (3-4 hours)

  • Medicinsk oversættelse: Restricted Part III trials for immune claims

  • Reguleringsmæssig status: Novel Meals authorization required in EU

11. Ofte stillede spørgsmål

  1. Q: Why select Sophora japonica-derived quercetin?
    EN: Superior focus profile (98% vs. 70% in onion extracts) and decrease pesticide danger.

  2. Q: The best way to overcome bioavailability limitations?
    EN: Our phytosome expertise achieves Cₘₐₓ 4.3x greater than commonplace powder.

  3. Q: Validated immune help dosage?
    EN: 500-1000mg/day prophylactic; 3000mg/day acute part (max 5 days).

  4. Q: Stability in formulations?
    EN: Nanoencapsulated type retains >90% efficiency at 25°C/60% RH for twenty-four months.

  5. Q: GMP compliance?
    EN: Manufactured underneath ICH Q7 pointers with ISO 17025 accredited QC.

12. Procurement Info

  • Technical Dossiers: liaodaohai@gmail.com

  • Order Portal: aiherba.com/quercetin

  • MOQ: 1kg (R&D), 10kg (business)

  • Logistik: -20°C validated chilly chain transport

13. Konklusion
Quercetin repræsenterer apex of flavonoid bioactivity with clinically validated impacts on immune competence, metabolisk velvære, og oxidative resilience. Shaanxi Zhonghongs vertikalt indbygget produktion—from DNA-verified Sophora japonica til nanoparticle-enhanced supply techniques—ensures unprecedented purity (≥98%) and bioavailability. Our patented enzymatic conversion expertise and cGMP-compliant manufacturing ship benchmark materials compliant with USP, EP, and JP monographs. Accomplice with our 28 års erfaring for quercetin options powering next-generation nutraceuticals, prescription drugs, and useful meals.

14. Referencer

  1. Li Y, et al. (2021). Molekyler. 26(9):2507. [Bioavailability]

  2. Colunga Biancatelli RML, et al. (2020). Indgangsimmunologi. 11:1451. [Antiviral]

  3. EFSA Panel (2020). EFSA Tidsskrift. 18(1):e05993.

  4. Anand David AV, et al. (2016). J Meals Sci. 81(10):R2501. [Metabolism]

  5. Zhonghong Technical File QRC-2024. aiherba.com/docs/QRC-Spec

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