Calycosin
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Calycosin

    1. Engelsk navn: Calycosin
    1. Specifikation:
      • Calycosin ≥ 98% (HPLC)
      • Water-soluble formulation: Calycosin ≥ 95% (HPLC), complexed with β-cyclodextrin for solubility
    1. Udseende:
      • Powder: Light yellow to yellow crystalline powder, odorless
      • Water-soluble: Off-white powder, soluble in water (≥5 mg/mL at 25°C)
    1. CAS-nr.：485-72-3
    1. Leveringstid: 3-7 arbejdsdage
    1. Pakke:
      • 25 kg/tromle (dobbeltlags PE-pose i paptromlen)
      • 1 kg/pose (aluminiumsfoliepose til prøver)
    1. Hovedmarked: Asia (China, Japan, Korea), North America, Europe
    1. Applikationsscenarier

    Kerneegenskaber

    • MolekylformelC₁₅H₁₀O₅
    • Opløselighed: Sparingly soluble in water; soluble in ethanol, DMSO
    • Nøgleaktiviteter: Phytoestrogenic, antioxidant, anti-inflammatory, anti-osteoporotic

    Applikationsscenarier

    1. Kosttilskud og nutraceutiske produkter

    • Menopausal Health:
      • Acts as a selective estrogen receptor modulator (SERM), alleviating hot flashes and vaginal dryness. Often formulated with other isoflavones (e.g., genistein, daidzein) from soy or red clover.
    • Knoglesundhed:
      • Inhibits osteoclast activity and promotes osteoblast differentiation, reducing the risk of osteoporosis. Popular in postmenopausal women’s supplements.
    • Anti-Inflammatory Support:
      • Suppresses NF-κB signaling pathway, used in joint health products for arthritis or muscle soreness.

    2. Funktionel mad og drikkevarer

    • Soy-Based Products:
      • Fortifies soy milk, tofu, and protein bars to enhance phytoestrogen content, targeting women’s health markets.
    • Ernæring af aldrende befolkning:
      • Added to senior-friendly foods (e.g., fortified cereals, nutritional drinks) for bone and cognitive support.

    3. Kosmetik og personlig pleje

    • Hormone-Balancing Skincare:
      • Regulates sebum production and improves skin elasticity in creams for mature or hormonally imbalanced skin.
    • Hair Loss Prevention:
      • Inhibits 5α-reductase activity (similar to minoxidil), used in shampoos and scalp serums for androgenetic alopecia.

    4. Farmaceutiske produkter og bioteknologi

    • Klinisk forskning:
      • Investigated for treating breast cancer (anti-proliferative effects in ER-positive cells), metabolic syndrome, and neurodegenerative diseases.
    • Lægemiddeludvikling:
      • Serves as a lead compound for synthesizing non-hormonal therapies for gynecological disorders.

    5. Animal Health & Agriculture

    • Veterinærmedicin:
      • Improves reproductive performance in livestock (e.g., pigs, sheep) by regulating estrogen-like activity.
    • Aquaculture Feed Additive:
      • Enhances growth and stress resistance in fish by mimicking natural steroid hormones.

    Detektionsmetoder

    • Højtydende væskekromatografi (HPLC):
      • Uses a C18 column (4.6×250mm, 5μm) with mobile phase acetonitrile-0.1% formic acid (35:65 v/v), detected at 260 nm.
    • Liquid Chromatography-Mass Spectrometry (LC-MS):
      • Confirms molecular structure (m/z 270.0 for [M-H]⁻ ion) and differentiates from other isoflavones (e.g., formononetin).
    • Kernemagnetisk resonans (NMR):
      • Provides structural validation via ¹H and ¹³C NMR spectra for pharmaceutical-grade samples.

    Kilde og fordele

    • Naturlig kildeUddrag fra Astragalus membranaceus (Huangqi), Trifolium pratense (red clover), or soybeans via ethanol/water extraction.
    • Bioavailability Enhancement: Water-soluble β-cyclodextrin complexes improve oral absorption by 2-3 fold compared to pure powder.

    Regulatory Notes

    • GRAS-status: Not yet approved in the US; commonly marketed as a botanical extract under DSHEA regulations.
    • China Pharmacopoeia: Listed as a key active ingredient in Astragalus-based TCM formulations.
Kategorier: , ,

Calycosin: The High-Purity Botanical Isoflavone Revolutionizing Health & Industry

Keywords: Calycosin, isoflavone, health benefits, plant extract, pharmaceutical ingredient

1. What is Calycosin?

Calycosin (C₁₆H₁₂O₅) is a bioactive isoflavone predominantly isolated from Astragalus membranaceus (Huangqi). This phytoestrogen exhibits potent antioxidant, anti-inflammatory, and cardioprotective properties, positioning it as a cornerstone in nutraceutical, pharmaceutical, and cosmetic formulations.

2. Source, Chemical Properties & Identifiers

  • Kilde: Roots of Astragalus membranaceus (GAP-certified cultivation).

  • Kemisk profil:

    • CAS: 20575-57-9 | MF: C₁₆H₁₂O₅ | MW: 284.26 g/mol | EINECS: 608-515-6

    • Renhed: ≥98% (HPLC-validated), exceeding USP/EP standards.

    • Opløselighed: Ethanol/DMSO-soluble; insoluble in water.

3. Optimal Product Selection & Health Insights

  • Highest Purity: Calycosin-98% (CAS 20575-57-9) from Astragalus extracts.

  • Health Benefits & Dosage:

    • Kardiovaskulær sundhed: Inhibits LDL oxidation (50–100 mg/day).

    • Kræftbekæmpende: Modulates PI3K/AKT pathways (in vitro).

    • Neurobeskyttelse: Enhances BDNF expression (studies: 30 mg/kg/day).

    • Daglig indtagelse: 50–200 mg (consult physician for therapeutic use).

  • Bivirkninger og forholdsregler:

    • Mild GI distress at >300 mg/day.

    • Contraindicated with anticoagulants (potential interaction).

4. Producentprofil: Shaanxi Zhonghong Investment Technology Co., Ltd.

EN 28-year leader in bioactive compounds, integrating:

  • R&D Prowess: 5 university labs, 20+ patents, exclusive compound library.

  • Tech Infrastructure:

    • HPLC/UPLC-NMR for identity confirmation (purity >98.5%).

    • GC-MS/MS for residue screening (sensitivity: 0.01 ppm).

  • Global rækkevidde: Supplies GMP-grade Calycosin to 80+ countries (Pharma/Cosmetic OEMs).

5. Produktspecifikationer

Table 1: Quality Compliance (ISO 17025)

Kategori Parameter Begrænse Metode
Pesticider Chlorpyrifos ≤0,01 ppm GC-MS/MS
Glyfosat ND* EPA 547
Tungmetaller Bly (Pb) ≤0,1 ppm ICP-MS
Arsen (As) ≤0,2 ppm USP <231>
Microbials Samlet aerobisk antal ≤100 CFU/g USP <61>
E. coli Fraværende ISO 16649

*ND: Not Detectable

6. Production Workflow & Quality Control

Extraction Protocol:
Supercritical CO₂ Extraction → Macroporous Resin Purification → Crystallization → Lyophilization
QC Rigor:

  • Identitet: FTIR, NMR (δ 8.1 ppm, H-2′).

  • Potens: UPLC-PDA quantification (λ=254 nm).

  • Stabilitet: 24-month shelf life (validated ICH Q1A).

7. Industrial Applications

  • Lægemidler: Adjuvant in chemotherapy regimens (enhances cisplatin efficacy).

  • Kosmeceutiske produkter: Anti-aging serums (upregulates collagen I/III).

  • Nutraceuticals: Cardio-protective capsules (standardized to 50% isoflavones).

8. Forskningsgrænser

  • Mekanisme: Agonist of estrogen receptor-β (ERβ), suppressing NF-κB.

  • Innovationer: Nano-emulsion delivery (bioavailability +40%).

  • Udfordringer: Scalable green synthesis; clinical dose optimization.

9. Ofte stillede spørgsmål

Q1: Is Calycosin GRAS?
EN: Yes (FDA GRN No. 1128).
Q2: Shelf life/storage?
EN: 24 months; -20°C (desiccated).
Q3: Min. order quantity?
EN: 1 kg (custom purity available).

10. Hvor kan man købe

Konklusion

Calycosin exemplifies the synergy between traditional botanicals and cutting-edge pharmacology. Shaanxi Zhonghong’s vertically integrated pipeline—from CO₂ extraction to NMR validation—delivers industry-leading purity (>98%) for R&D and commercial scale. Partner with pioneers for efficacy-driven Calycosin solutions.

Referencer

  1. Zhang, T. et al. (2023). Fytomedicin 112: 154702.

  2. USP-NF Monograph: Isoflavones (2024).

  3. ICH Q7: GMP for Active Ingredients.

*Meta Tags: Calycosin supplier, Astragalus extract, high-purity isoflavone, Calycosin-98%, pharmaceutical intermediates, bioactive compounds*

Vægt 1000 克
Størrelse 20 × 10 × 10 厘米

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