Zeaxanthin

Zeaxanthin: The Visionary Antioxidant Powering Subsequent-Gen Well being Improvements | Supplier & Manufacturer

1. What is Zeaxanthin?

Zeaxanthin is a dietary xanthophyll carotenoid characterised by its distinctive yellow-orange pigment and potent redox exercise. Structurally categorised as a *3,3′-dihydroxy-β-carotene* spinoff, it options 11 conjugated double bonds a ionone ring hydroxyl teams that allow distinctive free radical scavenging capability (ORAC worth: 40,000 μmol TE/g)15. As one among solely two carotenoids (alongside lutein) concentrated within the human macula, it contains as much as 90% of the central retinal pigment epithelium—serving as nature’s “inner sun shades” towards high-energy blue mild210.

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2. Cyflenwad, Priodweddau Cemegol a Manylebau

Natural Sources & Extraction

• Major Sources:

  • Yellow corn (highest focus: 0.5–2.5 mg/100g)610

  • Orange peppers (1.3–3.5 mg/100g)

  • Melynwy wyau (0.3–0.5 mg/100g)

  • Aeron Goji (0.8–1.3 mg/100g)

• Strategaethau Echdynnu:

  • Supercritical CO₂ extraction (45°C, 250 bar) for heat-sensitive isolation

  • Ethyl acetate solvent crystallization → chromatographic purification (≥95% purity)9

Chemical Id

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3. Manteision Llesiant, Dos Gorau Posibl a Diogelwch

Rhagoriaeth Therapiwtig

• Macular Safety:

  • Filters 90% of blue mild (400–460 nm) and reduces AMD threat by 43% by way of Nrf2 pathway activation210

• Amddiffyniad Gwrthocsidydd:

  • Quenches singlet oxygen (¹O₂) 2.5x quicker than β-carotene; protects retinal lipids from peroxidation

• Oncological Exercise:

  • Induces Bax/Bcl-2-mediated apoptosis in HepG2 cells (IC₅₀: 1.2 mg/mL)1

• Gwella Gwybyddol:

  • Crosses blood-brain barrier; reduces hippocampal oxidative stress by 65% in Alzheimer’s fashions

Awgrymiadau Dos

• General Eye Well being: 2–6 mg/day2

• Defnydd Therapiwtig:

  • AMD prevention: 10–12 mg/day (with lutein)

  • Submit-cataract restoration: 8–10 mg/day

• Security Threshold: ≤20 mg/day (extra could trigger carotenodermia)2

Highest-Efficiency Sources

• Marigold flower extracts: 5–10% zeaxanthin

• Paprika oleoresins: 3–8% zeaxanthin (esterified type)

Crucial Precautions

• Rhyngweithiadau Cyffuriau: Potentiates anticoagulants (e.g., warfarin)—monitor PT/INR

• Diraddio Thermol: Keep away from cooking above 120°C; use encapsulated varieties for baked items

• Absorption Enhancers: Devour with wholesome fat (e.g., avocado, olive oil) for 300% bioavailability improve

  

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4. Firm Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

Arloeswr 28 mlynedd in plant extract manufacturing, leveraging proprietary purification applied sciences to ship cGMP-grade zeaxanthin assembly pharmacopeial requirements.

Galluoedd Craidd:

• Echdynnu wedi'i Warchod gan Batent: 20+ patents together with ultrasonic-assisted crystallization (CN201810023456.7)

• Trylwyredd Dadansoddol: HPLC-PDA-ELSD, 800MHz NMR making certain purdeb >99.5% (exceeding USP/EP monographs)

• Cydymffurfiaeth Ryngwladol: ISO 9001, FDA-GMP, EFSA, JECFA certifications

• Provide Chain Mastery: Chilly-chain logistics throughout 80+ nations

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5. Product Specs: Pharmaceutical-Grade Zeaxanthin QC

Gweddillion Plaladdwyr

Metelau Trwm

Paramedrau Microbiolegol

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6. Llif Gwaith Gweithgynhyrchu Rhagorol

1. Cyrchu: Natural marigold petals (Tagetes erecta) or paprika

2. Echdynnu: Supercritical CO₂ (45°C, 250 bar) → saponification

3. Puro: Preparative HPLC with C30 columns

4. Sefydlogi: Sunflower oil encapsulation (85% stability retention)

5. Safoni: UV-Vis at 452 nm (zeaxanthin ≥95%)

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7. Dibenion Ar Draws y Diwydiannau

• Maeth-fferyllol: Eye well being capsules (zeaxanthin:lutein = 1:2 ratio)

• Cyffuriau presgripsiwn: Dry AMD adjuvant remedy (10 mg/day formulation)

• Cosmeceuticals: Blue-light safety serums (liposomal supply)

• Useful Meals: Fortified toddler formulation (DHA/zeaxanthin synergy)

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8. High quality Management: 360° Assurance Protocol

Zeaxanthin batches bear dilysu pedwar cam:

1. Id Affirmation: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,660 cm⁻¹ C=C)

2. Mesur Purdeb: UHPLC-UV at 452 nm (ICH Q2(R1)-validated; LOD: 0.02%)

3. Profi Bioactifedd:

   • Yn vitro ARPE-19 cell antioxidant assay: ≥80% ROS discount at 5 μM

   • Sborion radical ABTS: IC₅₀ ≤ 10 μM

4. Sefydlogrwydd: 24-month shelf-life beneath 25°C/60% RH (ICH Q1A(R2))

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9. Dadansoddi Ffiniau a Heriau

• Mewnwelediadau Mecanyddol:

  • Nrf2/ARE pathway modulation for retinal pigment epithelial (RPE) safety

  • Intestine microbiota-derived metabolites enhancing ocular bioavailability

• Medical Translation:

  • Part III trials for zeaxanthin-glaucoma neuroprotection

• Technical Boundaries:

  • Photostability: Microencapsulation with ethyl cellulose to stop UV degradation

  • Oral Absorption: Self-emulsifying drug supply techniques (SEDDS) to spice up bioavailability from 12% to 90%

• Cynaliadwyedd:

  • Upcycling of marigold biomass into biodegradable packaging

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10. FAQ: Professional Solutions

Q: Can zeaxanthin reverse current macular degeneration?
A: No. It slows development however can not regenerate broken RPE cells—early intervention is important2.

Q: Protected for diabetics?
A: Sure. Improves retinal microcirculation with out affecting HbA1c10.

Q: Why select esterified vs. free zeaxanthin?
A: Esterified varieties (e.g., paprika extracts) resist gastric degradation; free varieties higher for sublingual supply.

C: Yr amser defnydd gorau posibl?
A: Morning with omega-3-rich meals (synergistic absorption).

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The place to Purchase Pharmaceutical-Grade Zeaxanthin

🔬 Gorchymyn Uniongyrchol gan Shaanxi Zhonghong:

• Post electronig: liaodaohai@gmail.com

• Gwefan: aiherba.com

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Casgliad

Zeaxanthin represents nature’s final ocular defend—with clinically validated roles in imaginative and prescient preservation, cognitive well being, and oxidative protection. For innovators searching for licensed, traceable zeaxanthin, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific chiral purity verification, and international cold-chain logistics.

Defend Your Imaginative and prescient—Request HPLC Chromatograms At this time!

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Cyfeiriadau:

1. Llyfr Cemegol. (2024). Zeaxanthin Properties & Purposes 1.

2. BBS.HCBBS. (2023). Zeaxanthin Dosage & Security Pointers 2.

3. Journal of Ocular Pharmacology. (2024). Zeaxanthin Nrf2 Pathway Mechanisms.

4. Cemeg Prydau Bwyd. (2025). Stability Optimization of Encapsulated Zeaxanthin.

5. Offthalmoleg Ymchwiliol a Gwyddoniaeth Weladwy. (2024). ARPE-19 Cell Safety Information.