Ganoderma Lucidum Polysaccharides: The Final Immune Modulator for Well being and Longevity
1. What Are Ganoderma Lucidum Polysaccharides?
Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting our bodies, mycelia, or spores of Ganoderma lucidum (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones gyda β-(1→6)-D-glucosyl branches, forming triple-helix configurations vital for immunomodulatory exercise. With molecular weights starting from 10–1,000 kDa, these heteropolysaccharides comprise glucose, galactose, mannose, and xylose residues. Their distinctive helical conformation allows potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.
2. Cyflenwad, Priodweddau Cemegol a Manylebau Technegol
Ffynonellau Botanegol ac Echdynnu
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Main Supply: Fruiting our bodies of Ganoderma lucidum neu G. sinense (highest GLP content material: 1.8–2.5% dry weight)39.
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Strategaethau Echdynnu:
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Sizzling water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)
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Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization
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Chemical Identification
Eiddo | Gwerth |
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Rhif CAS | Not assigned (advanced combination) |
Fformiwla Foleciwlaidd | (C₆H₁₀O₅)ₙ |
Pwysau Moleciwlaidd | 10–1,000 kDa |
EINECS | Not relevant |
Ymddangosiad | Mild brown hygroscopic powder |
Hydoddedd | Water-soluble; insoluble in ethanol |
Key Bioactivity | β-(1→3)/(1→6) glycosidic bonds ≥85% |
3. Manteision Llesiant, Dos Gorau Posibl a Diogelwch
Validated Therapeutic Results
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Imiwno-fodiwleiddio:
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↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% by way of TLR4/NF-κB pathway activation39.
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Antitumor Exercise:
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Induces apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) by way of caspase-3 activation and Bcl-2 suppression69.
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Rheoleiddio Metabolaidd:
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↓ Fasting blood glucose by 32% in diabetic fashions by way of AMPK/GLUT4 signaling9.
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Amddiffyniad hepato:
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Yn lleihau ALT/AST ranges by 65% in ethanol-induced liver damage fashions3.
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Awgrymiadau Dos
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Llesiant Cyffredinol: 100–300 mg/day (20–30% GLPs)
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Defnydd Therapiwtig:
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Immune help: 500 mg/day (≥40% GLPs)
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Adjuvant most cancers remedy: 1,000–1,500 mg/day
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Security Threshold: ≤3,000 mg/day (no noticed toxicity)9.
Vital Precautions
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Autoimmune Circumstances: Might overstimulate Th1 responses (keep away from in lupus/RA).
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Gweithdrefn lawfeddygol: Discontinue 2 weeks pre-operation (potential immunostimulatory results).
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Rhyngweithiadau Cyffuriau: Might potentiate immunosuppressants (e.g., cyclosporine).
4. Firm Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.
A 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with international provide chain excellence to ship cGMP-grade GLPs exceeding pharmacopeial requirements.
Galluoedd Craidd:
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Echdynnu wedi'i Warchod gan Batent: 20+ patents overlaying ultrasonic-microwave synergy (CN201810023456.7).
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Trylwyredd Dadansoddol: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS making certain purdeb >99.5% (yn rhagori ar fonograffau USP/EP).
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Cydymffurfiaeth RyngwladolArdystiadau ISO 9001, FDA-GMP, EFSA, JECFA.
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Provide Chain MasteryLogisteg cadwyn oer ledled 80+ o wledydd.
5. Product Specs: Pharmaceutical-Grade GLP QC
Contaminant Testing Requirements
Dosbarth | Paramedr | Cyfyngu | Techneg Gwirio |
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Plaladdwyr | Clorpyrifos | ≤0.01 ppm | GC-MS/MS (EU 396/2005) |
Glyffosad | ≤0.05 ppm | HPLC-MS/MS (ISO 16308) | |
Metelau Trwm | Plwm (Pb) | ≤0.5 ppm | ICP-MS (USP <233>) |
Arsenig (As) | ≤0.5 ppm | AAS (EP 2.4.27) | |
Microbioleg | Plât Cyfan yn Dibynnu | ≤1,000 CFU/g | USP <61> |
E. coli | Absennol | ISO 16654 | |
Salmonela rhywogaethau | Absennol | FDA BAM Pennod 5 |
6. Llif Gwaith Gweithgynhyrchu Rhagorol
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Cyrchu: Natural G. lucidum fruiting our bodies (OOP-certified).
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Echdynnu: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).
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Deproteinization: Sevag reagent (chloroform:butanol 4:1).
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Puro: DEAE-Sepharose FF chromatography → lyophilization.
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Safoni: Phenol-sulfuric acid assay to 40% GLP content material.
7. Dibenion Ar Draws y Diwydiannau
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Maeth-fferyllol: Immune-boosting capsules (GLP + β-glucan synergy).
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Cyffuriau presgripsiwn: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).
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Cosmeceuticals: Anti-aging serums (↑ collagen synthesis by 200%).
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Useful Meals: Glycemic management drinks (GLP + berberine).
8. High quality Management: 360° Assurance Protocol
GLP batches bear dilysu pedwar cam:
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Cadarnhad Adnabod: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).
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Mesur Purdeb: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).
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Profi Bioactifedd:
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RAW 264.7 macrophage NO manufacturing: ≥50% stimulation at 100 μg/mL
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α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL
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Sefydlogrwydd: 24-month shelf-life underneath 25°C/60% RH (ICH Q1A(R2)).
9. Dadansoddi Ffiniau a Heriau
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Mewnwelediadau Mecanyddol:
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Intestine microbiota modulation (↑ Bifidobacterium ↑ SCFA manufacturing).
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STING pathway activation for antitumor immunity.
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Medical Translation:
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Part II trials for GLP-COVID-19 immunity synergy.
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Technical Boundaries:
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Bioargaeledd Llafar: Chitosan nanoparticles to reinforce absorption from 12% to 91%.
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Structural Heterogeneity: Batch-to-batch reproducibility optimization.
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Cynaliadwyedd:
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Mycelial fermentation to preserve wild Ganoderma populations.
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10. Cwestiynau Cyffredin: Datrysiadau Medrus
Q: Can GLPs change chemotherapy?
A: No. Use as adjuvant remedy—enhances NK cell exercise with out interfering with cisplatin9.
Q: Secure throughout being pregnant?
A: Restricted information. Keep away from until authorized by a doctor.
Q: Why select 40% vs 95% GLPs?
A: 40% extracts swimsuit useful meals; 95%+ grades goal pharmaceutical purposes.
C: Yr amser defnydd gorau posibl?
A: Morning on empty abdomen (enhances macrophage uptake).
The place to Purchase Pharmaceutical-Grade GLPs
🔬 Gorchymyn Uniongyrchol gan Shaanxi Zhonghong:
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E mail: liaodaohai@gmail.com
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Gwefan: aiherba.com
Casgliad
Ganoderma lucidum polysaccharides redefine precision immunonutrition—with sturdy proof supporting roles in oncology, virology, and metabolic well being. For innovators in search of licensed, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and international cold-chain logistics.
Harness Reishi’s Millennium Legacy—Request Your NMR Report As we speak!
Cyfeiriadau:
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Cylchgrawn Ethnopharmacoleg (2019). GLP mechanisms in most cancers apoptosis9.
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Polymerau Carbohydrad (2020). Structural characterization of immunomodulatory GLPs6.
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Cemeg Prydau Bwyd (2021). Ultrasonic-microwave extraction optimization3.
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USP-NF (2023). Polysaccharide identification/purity testing tips.
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Frontiers in Immunology (2024). STING pathway activation by GLPs.
James Oli*** –
“As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”