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Alpha-Arbutin

α-Arbutin supplier bulk factory Wholesale Extract factory

  1. Enw Saesneg: α-Arbutin,Alpha-Arbutin
  1. Manyleb
    • General Powder: α-Arbutin ≥ 99% (HPLC), optical purity ≥ 98%
    • Water-soluble Powder: α-Arbutin ≥ 98% (HPLC), with a water-soluble darparwr (e.g., cyclodextrin), solubility ≥ 100 g/L at 25°C
  1. Ymddangosiad
    • General Powder: White crystalline powder, odorless
    • Water-soluble Powder: Off-white free-flowing powder
  1. RHIF CAS:84380-01-8
  1. Amser arweiniol: 3 – 7 Diwrnod Gwaith
  1. Pecyn
    • 1 kg/bag (bag ffoil alwminiwm), 25 kg/drwm (bag PE dwy haen y tu mewn i'r drwm cardbord)
  1. Prif Farchnad: Asia (yn arbennig yn Iawn-beauty and J-beauty markets), North America, Europe
  1. Senarios Cais

Priodweddau Craidd

  • Moleciwlaidd Formula: C₁₂H₁₆O₇
  • Hydoddedd: Soluble in water, ethanol, and propylene glycol; the water-soluble formulation exhibits enhanced dissolution cyflymder
  • Allwedd Dewisiadau:
    • Potent tyrosinase inhibitor, blocking melanin synthesis ychwanegol yn llwyddiannus than β-Arbutin (IC₅₀ = 0.2 mM)
    • Antioxidant properties, amddiffyn mandyllau a chroen from UV-induced oxidative stress
    • Cyson mewn asidig sefyllfaoedd (optimwm pH 4 – 6), fodd bynnag degrades in alkaline environments or at gormodol temperatures (> 60°C)

Senarios Cais

1. Cosmetigau a Preifat Gofal

  • Mandyllau a chroen Lightening Nwyddau:
    • Serums and Essences: Yn gyffredinol formulated at 2 – 5% ffocws, gostwng tywyll spots, melasma, and post-inflammatory hyperpigmentation. Meddygol ymchwil presennol a 30% disgownt in pigmentation after 8 weeks of use.
    • Eli haul: Added at 1 – 2% i gyflenwi pob un solar diogelwch and anti-pigmentation manteision, stopio UV-induced melanin gweithgynhyrchu.
    • Whitening Lotions: Cymysg gyda gwahanol bywiog sylweddau like niacinamide and hyaluronic acid, canolbwyntio ar cyffredinol mandyllau a chroen brightening and hydration.
  • Gwrth-Mynd yn hen Fformwleiddiadau:
    • Inhibits collagen degradation wedi'i ddwyn ymlaen gan free radicals, gostwng yr edrychiadau o manteisiol straenau and wrinkles when included in anti-aging masks and eli.

2. Cyffuriau wedi'u rhagnodi

  • Dermatological Therapies:
    • Wedi'i ddefnyddio yn prescription-strength eli (cymaint â 4% ffocws in some ardaloedd) for treating eithafol pigmentation problemau atgoffa rhywun o melasma and freckles.
    • Submit-surgical and post-peel swyddogaethau rhagflaenu neu graddio'n ôl post-treatment hyperpigmentation, fel arfer cymysg with vitamin E.

3. Pwrpasol Prydau bwyd a Diodydd

  • Oral Atchwanegiadau dietegol:
    • Capsules or tablets containing 500 mg of α-Arbutin, fel arfer paired with vitamin C i hybu collagen synthesis and promote mandyllau a chroen lles o y tu mewn.
  • Magnificence Diodydd:
    • Added to low-calorie diodydd at 0.5 – 1% ffocws, marketed as “beauty-from-within” nwyddau ar gyfer cyffredinol mandyllau a chroen brightening.

4. Diwydiannol Dibenion

  • Textile Dyeing:
    • Fel pur mordant, α-Arbutin gellir ei ddefnyddio to repair dyes on deunyddiau, producing ysgafn a cyson coloration hues heb allan gan ddefnyddio harsh cyfansoddion cemegol.
  • Bioblaladdwyr:
    • Aqueous opsiynau of α-Arbutin (0.1 – 0.5%) presennol antifungal properties, making it priodol i'w ddefnyddio in eco-friendly agricultural pest rheolaeth.

Canfod Strategaethau

  • GormodolEffeithlonrwydd Cromatograffeg Hylif (HPLC):
    • Colofn: C18 (250 × 4.6 mm, 5 μm), Cellog Adran: Acetonitrile – Water (15:85, v/v), Ffrwd Tâl: 1.0 mL/min, Detection Wavelength: 280 nm
  • Sbectrometreg Màs (MS):
    • Wedi'i ddefnyddio i wirio y moleciwlaidd adeiladu and purity, yn arbennig for pharmaceutical-grade α-Arbutin nwyddau.
  • Calorimetreg Sganio Gwahaniaethol (DSC):
    • Determines the melting level (195 – 198°C for α-Arbutin), yn gwasanaethu i i cadarnhau cynnyrch ansawdd uchel and authenticity.

Cyflenwad a Manteision

  • Gweithgynhyrchu: Yn bennaf synthesized drwy gyfrwng enzymatic or chemical processes, darparu mwy purity and consistency mewn cymhariaeth â pur echdynnu strategaethau.
  • EffeithiolrwyddEi cadarn ataliol effaith on tyrosinase cynigion cyflym and visual ends in mandyllau a chroen lightening, making it a mwyaf poblogaidd ingredient for high-end gwychder nwyddau.
  • Diogelwch: Yn nodweddiadol well-tolerated by most mandyllau a chroen mathau, gyda lleihau bygythiad of irritation mewn cymhariaeth â another 美白 broceriaid.

Cydymffurfiaeth Rheoleiddiol

  • NMPA Tsieina: Wedi'i ganiatáu fel harddwch ingredient with a y rhan fwyaf ffocws o ddau% (requiring diogelwch gwerthusiad ar gyfer mwy ystodau).
  • UE Harddwch Regulation (EC 1223/2009): Accredited i'w ddefnyddio in cosmetics, with a cyfyngu of three% in leave-on nwyddau.
  • FDA yr Unol Daleithiau: Tentatively labeled as an OTC ingredient for mandyllau a chroen lightening, with ffocws limits oddi tano asesiad.

Alpha-Arbutin: The Gold Normal in Pores and skin Lightening and Antioxidant Safety| Supplier & Manufacturer

1. What is Alpha-Arbutin?

Alpha-arbutin is a glycosylated hydroquinone spinoff famend for its potent pores and skin – lightening properties. In contrast to its counterpart, beta – arbutin, alpha – arbutin displays a better affinity for tyrosinase, the important thing enzyme concerned in melanin synthesis. This makes it simpler at decreasing hyperpigmentation, comparable to age spots, freckles, and melasma, with out inflicting important pores and skin irritation. Extensively used within the cosmetics business, alpha – arbutin has additionally proven antioxidant and anti – inflammatory results, positioning it as a multifunctional bioactive ingredient.

Alpha-Arbutin Applications
Alpha-Arbutin Purposes

2. Tarddiad y Cynnyrch a'i Briodweddau Cemegol

2.1 Supply

Alpha-arbutin could be extracted from varied crops, together with bearberry (Arctostaphylos uva-ursi), blueberries (Vaccinium spp.), and cranberries (Vaccinium macrocarpon). Nevertheless, as a result of low pure content material in crops, most business alpha – arbutin is produced by way of biocatalysis or chemical synthesis. At Shaanxi Zhonghong Investment Technology Co., Ltd., we make the most of superior biocatalytic processes to make sure excessive – purity, sustainable manufacturing with minimal environmental influence.

2.2 Proffil Cemegol

  • Maint CAS: 84380 – 01 – 8
  • Fformiwla Foleciwlaidd (MF): C₁₂H₁₆O₇
  • Pwysau Moleciwlaidd (MW): 272.25 g/mol
  • EINECS: 282 – 776 – 3
  • Bodily State: White to off – white crystalline powder
  • Hydoddedd: Soluble in water (5 – 10 g/L at 25°C), barely soluble in ethanol

3. Optimum Product, Well being Benefits, Dosage, Precautions and Aspect Results

3.1 Finest Merchandise and Content

The best – high quality alpha – arbutin merchandise sometimes have a purity of 98% or increased. Our firm leverages state – of – the – artwork purification methods, comparable to excessive – efficiency liquid chromatography (HPLC) and crystallization processes, to realize a purity stage 20% above the business common. This ensures most efficacy in pores and skin – lightening purposes and minimizes the danger of impurities inflicting antagonistic reactions.

3.2 Well being Benefits

3.2.1 Pores and skin Lightening

Alpha-arbutin inhibits tyrosinase exercise, blocking the conversion of tyrosine to melanin. By decreasing melanin manufacturing, it successfully lightens current darkish spots and prevents new pigmentation, resulting in a extra even pores and skin tone.

3.2.2 Antioxidant Safety

It acts as a free – radical scavenger, neutralizing reactive oxygen species (ROS) comparable to hydroxyl and superoxide radicals. This antioxidant property helps defend pores and skin cells from oxidative harm, which is related to untimely ageing, effective strains, and wrinkles.

3.2.3 Anti – Inflammatory Results

Alpha-arbutin can cut back the manufacturing of professional – inflammatory cytokines, soothing irritated pores and skin and selling a more healthy pores and skin barrier perform. This makes it appropriate for delicate pores and skin sorts vulnerable to irritation.

3.3 Beneficial Dosage

In beauty formulations, the standard focus of alpha – arbutin ranges from 0.5% to 2%. For direct software merchandise like serums or lotions, making use of a pea – sized quantity (roughly 1 – 2 grams) containing the suitable focus to the affected pores and skin areas a couple of times every day is widespread. Nevertheless, it is vital to comply with product – particular directions.

3.4 Precautions and Aspect Results

Alpha-arbutin is mostly nicely – tolerated. Nevertheless, in uncommon instances, it might trigger delicate pores and skin irritation, comparable to redness or itching, particularly in people with extremely delicate pores and skin. Extended publicity to daylight can cut back its effectiveness and enhance the danger of pores and skin harm, so sunscreen use is advisable when utilizing alpha – arbutin merchandise. Keep away from contact with eyes, and if unintended ingestion happens, search medical recommendation instantly.

4. Firm Introduction

With 28 years of expertise within the bioactive compound business, Shaanxi Zhonghong Investment Technology Co., Ltd. is a number one excessive – tech enterprise. Our operations span agile analysis and improvement, collaborative innovation, built-in manufacturing, and international advertising and marketing, serving the chemical, supplies, and life science sectors.
  • Analysis Edge: Our partnerships with 5 prime – tier universities by way of joint laboratories, together with over 20 patented applied sciences and a singular international compound library, drive steady innovation in alpha – arbutin manufacturing and software.
  • Technological Superiority: Outfitted with state – of – the – artwork services, together with excessive – efficiency liquid chromatography (HPLC) and superconducting nuclear magnetic resonance spectrometers, we guarantee product purity requirements 20% increased than the business common.
  • Cyrhaeddiad y Byd: Our intensive community covers greater than 80 nations throughout Asia, Europe, and the Americas. We provide custom-made uncooked materials options for multinational pharmaceutical firms, analysis establishments, and beauty producers.

5. Product Specs

Venture
Enw
Dangosydd
Techneg Canfod
Gweddillion Plaladdwyr
Clorpyrifos
< 0.01 ppm
Gasoline Chromatography – Mass Spectrometry (GC – MS)
Cypermethrin
< 0.02 ppm
GC – MS
Carbendasim
< 0.05 ppm
Excessive – Efficiency Liquid Chromatography – Mass Spectrometry (HPLC – MS/MS)
Metelau Trwm
Plwm (Pb)
< 0.5 ppm
Plasma Cyplysedig Anwythol – Sbectrometreg Màs (ICP – MS)
Mercwri (Hg)
< 0.01 ppm
Sbectrosgopeg Amsugno Atomig Anwedd Oer (CVAAS)
Cadmiwm (Cd)
< 0.05 ppm
ICP – MS
Halogiad Microbaidd
Whole viable depend
< 100 CFU/g
Normal microbiological plating methods
Escherichia coli
Absennol
Ymateb Cadwyn Polymerase (PCR) a phlatio
Salmonela
Absennol
PCR a phlatio
Listeria monocytogenes
Absennol
PCR a phlatio

6. Cwrs Gweithgynhyrchu

  1. Uncooked Materials Preparation: For biocatalytic manufacturing, choose excessive – high quality enzymes or microorganisms with excessive exercise for alpha – arbutin synthesis. Guarantee correct cultivation and activation of those organic catalysts.
  1. Biocatalysis or Chemical Synthesis: In biocatalysis, use enzymes to catalyze the response between hydroquinone and glucose to kind alpha – arbutin. In chemical synthesis, rigorously management response situations comparable to temperature, pH, and response time to advertise the formation of alpha – arbutin whereas minimizing by – product technology.
  1. Puro: Make use of a number of purification steps, together with filtration, extraction, and chromatography. HPLC is used to separate alpha – arbutin from impurities, guaranteeing excessive – purity product. Crystallization processes might also be utilized to additional refine the product.
  1. Sychu a Fformiwleiddio: Dry the purified alpha – arbutin beneath managed situations to take away moisture. Then, formulate it into completely different varieties in keeping with buyer necessities, comparable to effective powders, granules, or pre – blended options for cosmetics.
  1. High quality Inspection: Conduct complete high quality testing on the completed product, together with purity willpower, identification, and inspection of pesticide residues, heavy metals, and microbial contamination.

7. Senarios Cais

7.1 Cosmetics

  • Pores and skin – Lightening Merchandise: Alpha-arbutin is a key ingredient in serums, lotions, masks, and lotions designed to cut back hyperpigmentation and obtain a brighter, extra even complexion.
  • Anti – Growing old Formulations: Mixed with different antioxidants and anti – ageing substances, it helps fight oxidative stress and enhance pores and skin texture, decreasing the looks of effective strains and wrinkles.
  • Sunscreen and After – Solar Care: Its antioxidant properties make it appropriate for inclusion in sunscreens to boost UV safety and in after – solar merchandise to appease solar – broken pores and skin.

7.2 Prescribed drugs (Analysis – based mostly)

At the moment, alpha – arbutin is beneath investigation for potential purposes in treating pores and skin illnesses associated to irregular pigmentation, comparable to melasma and publish – inflammatory hyperpigmentation. Its anti – inflammatory and antioxidant results might also contribute to wound – therapeutic analysis.

8. Rheoli Ansawdd Uchel

High quality management is the cornerstone of our alpha – arbutin manufacturing. On the uncooked materials stage, we conduct strict inspections on enzymes, microorganisms, or chemical precursors, verifying their purity and exercise by way of biochemical assays and spectroscopic evaluation. Through the manufacturing course of, actual – time monitoring of response parameters (temperature, pH, response time) ensures constant product high quality. Within the purification part, HPLC is used for exact separation and purity willpower, with every batch of merchandise present process a number of rounds of study to make sure the absence of impurities. For ultimate product inspection, we carry out complete exams on chemical purity, microbial security, and heavy metallic content material, adhering to strict worldwide requirements. Our high quality management laboratory is licensed to ISO 9001 and follows Good Manufacturing Follow (GMP) pointers. By implementing a multi – step high quality management system, we assure that each batch of alpha – arbutin meets the very best high quality and security necessities, offering dependable merchandise to our prospects worldwide.

9. Pecynnu a Logisteg

  • Pecynnu: Our alpha – arbutin merchandise are packaged in air – tight, moisture – resistant containers. For small orders, we use aluminum foil luggage or amber glass bottles, whereas for bulk orders, fiber drums are utilized. Every bundle is labeled with detailed data, together with product identify, batch quantity, purity, expiration date, and storage directions.
  • Storio: Retailer in a cool, dry place, away from direct daylight, at temperatures between 2 – 8°C. Below correct storage situations, the shelf lifetime of our alpha – arbutin merchandise can attain as much as 36 months.
  • Trafnidiaeth: We accomplice with dependable worldwide logistics suppliers to make sure quick and safe supply. Samples could be shipped through specific providers like DHL or FedEx inside 3 – 5 enterprise days, whereas bulk orders are transported by sea or air freight in keeping with buyer necessities.

10. Well being Efficacy Analysis, Industrial Application Innovation, and Challenges

10.1 Analysis Frontiers

  • Nano – Supply Techniques: Scientists are exploring nanoencapsulation methods to enhance the steadiness and bioavailability of alpha – arbutin, enabling higher penetration into the pores and skin and extra focused supply.
  • Mixture Therapies: Analysis is underway to research the synergistic results of alpha – arbutin when mixed with different pores and skin – lively substances, comparable to vitamin C and niacinamide, for enhanced pores and skin – lightening and anti – ageing outcomes.

10.2 Heriau

  • Sefydlogrwydd: Alpha-arbutin could be unstable beneath sure situations, comparable to excessive temperature or publicity to gentle. Creating extra secure formulations with out compromising its efficacy stays a problem.
  • Cydymffurfiaeth Rheoleiddiol: As a beauty ingredient, alpha – arbutin should adjust to varied worldwide rules relating to security, labeling, and efficacy claims. Guaranteeing constant compliance throughout completely different markets is essential for its widespread adoption.

11. Cwestiynau Cyffredin

11.1 The place can I purchase Alpha-Arbutin?

  • We provide quite a lot of alpha – arbutin merchandise with completely different purity ranges and packaging choices to satisfy various buyer wants.

11.2 Is Alpha-Arbutin secure for all pores and skin sorts?

Alpha-arbutin is mostly secure for many pores and skin sorts. Nevertheless, people with extremely delicate pores and skin could expertise delicate irritation. It is advisable to carry out a patch check earlier than utilizing new merchandise containing alpha – arbutin.

11.3 Can Alpha-Arbutin be used throughout being pregnant?

There may be restricted analysis on the security of alpha – arbutin throughout being pregnant. Pregnant or nursing girls ought to seek the advice of a health care provider earlier than utilizing merchandise containing alpha – arbutin.

11.4 How lengthy does it take to see outcomes?

Seen pores and skin – lightening outcomes could take 4 – 8 weeks of constant use, because the pores and skin’s pure renewal cycle wants time to exchange pigmented cells with new, lighter – coloured ones.

12. Casgliad

Alpha-arbutin stands as a revolutionary ingredient within the magnificence and skincare business, providing efficient pores and skin – lightening, antioxidant, and anti – inflammatory advantages. As a number one producer, Shaanxi Zhonghong Investment Technology Co., Ltd. is dedicated to offering excessive – high quality alpha – arbutin merchandise, backed by superior expertise, strict high quality management, and intensive international attain. Whether or not for creating modern beauty merchandise or advancing dermatological analysis, our alpha – arbutin choices set the usual for excellence.

13. Cyfeiriadau

  1. Kameyama, Okay., et al. (1995). Alpha – arbutin: A novel reversible tyrosinase inhibitor from the leaves of Vaccinium ashei. Cylchgrawn Cemeg Amaethyddol a Phrydau Bwyd, 43(11), 2807 – 2810.
  1. Wang, Y., et al. (2018). Advances within the manufacturing and software of arbutin. Moleciwlau, 23(6), 1461.
  1. European Fee. (2019). Beauty Substances Database (CosIng). Retrieved from [CosIng official website]

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