Isosteviol
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Isosteviol

Isosteviol supplier bulk factory Wholesale buy Extract factory

  1. Anglický název: Isosteviol
  1. Specifikace
    • Čistota: Isosteviol ≥ 98% (HPLC); High – purity grade: ≥ 99% (HPLC)
    • Rozpustnost: Sparingly soluble in water (approx. 0.1 g/L at 25°C), soluble in organic solvents such as ethanol, acetone, and chloroform
    • Bod tání: 198 – 202°C
    • Zbytková rozpouštědla: Ethanol ≤ 0.5%, Acetone ≤ 0.5%
    • Těžké kovy: ≤ 10 ppm
    • Velikost částic: Standard powder ≤ 100 μm; micronized powder ≤ 5 μm for better reactivity
  1. Vzhled
    • White to off – white crystalline powder, odorless
  1. ČÍSLO CAS：7979-62-4
  1. Dodací lhůta5 – 7 pracovních dnů
  1. Balík
    • 1 kg/pytel (hliníkový fóliový sáček), 25 kg/sud (dvouvrstvý PE sáček uvnitř kartonového sudu)
  1. Hlavní trh: Global market, with significant demand in Asia (China, Japan, South Korea), North America, and Europe, especially in the food, pharmaceutical, and chemical industries
  1. Scénáře aplikací

Základní vlastnosti

  • Molekulární vzorec: C₂₀H₂₈O₃
  • Chemická struktura: A diterpenoid compound, derived from the hydrolysis and isomerization of steviol, featuring a complex ring structure with a carboxylic acid group and hydroxyl groups
  • Klíčové vlastnosti
    • Versatile Chemical Intermediate: Serves as a crucial building block for the synthesis of various bioactive compounds and industrial chemicals.
    • Stabilita: Stable under normal storage conditions away from heat, light, and strong oxidizing agents.
    • Biokompatibilita: Generally low toxicity, making it suitable for applications in the food and pharmaceutical sectors with proper processing.
    • Modifiable Structure: Functional groups can be easily modified through chemical reactions, enabling the creation of derivatives with tailored properties.

Scénáře aplikací

1. Potravinářský a nápojářský průmysl

  • Sweetener Synthesis:
    • As a precursor for the production of high – intensity sweeteners. Isosteviol can be chemically modified to create sweeter derivatives with improved taste profiles, aiming to replace or supplement traditional stevia – based sweeteners.
  • Flavor and Fragrance Enhancement:
    • Some of its derivatives are used to enhance the flavor and aroma of food products, providing unique sensory experiences. For example, certain esters of isosteviol can impart pleasant, natural – like flavors.

2. Farmaceutický průmysl

  • Drug Synthesis:
    • Serves as an intermediate in the synthesis of anti – inflammatory, antioxidant, and antidiabetic drugs. Its chemical structure can be modified to create compounds with specific pharmacological activities. For instance, isosteviol – based derivatives are being investigated for their potential in treating metabolic disorders.
  • Biomedicínský výzkum:
    • Used in research laboratories as a reference compound or starting material for the development of new drug delivery systems. Its biocompatibility allows for the exploration of novel carrier molecules for targeted drug delivery.

3. Kosmetika a osobní péče

  • Přípravky proti stárnutí:
    • Incorporated into creams, serums, and lotions (0.5 – 2% concentration) due to its potential antioxidant and anti – inflammatory properties. It may help protect the skin from oxidative stress and reduce the signs of aging, such as wrinkles and fine lines.
  • Produkty péče o vlasy:
    • Added to shampoos and conditioners to improve hair texture, strength, and manageability. Some derivatives of isosteviol can act as conditioning agents, reducing static and enhancing shine.

4. Chemical Industry

  • Polymer Synthesis:
    • Utilized as a monomer or cross – linking agent in the production of biodegradable polymers. Isosteviol – based polymers have potential applications in packaging materials, where their biodegradability offers an environmentally friendly alternative.
  • Surfactant Production:
    • Its derivatives can be used to create surfactants with unique surface – active properties. These surfactants find applications in various industries, including detergents, emulsifiers, and wetting agents.

Detekční metody

  • Vysoce účinná kapalinová chromatografie (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – water (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 210 nm for quantification.
  • Plynová chromatografie – hmotnostní spektrometrie (GC – MS):
    • Used for the identification and quantification of isosteviol in complex mixtures, especially when analyzing volatile derivatives. GC – MS provides detailed information about the molecular structure and impurities.
  • Infračervená spektroskopie s Fourierovou transformací (FTIR):
    • Helps in confirming the chemical structure of isosteviol by analyzing the characteristic absorption peaks of its functional groups. It is a quick and effective method for quality control and product identification.

Zdroj a výhody

  • Přírodní zdroj: Derived from stevia leaves, a renewable plant resource. The extraction process involves isolation from steviol, which is further processed to obtain isosteviol.
  • Sustainable Chemistry: Enables the development of green and sustainable chemical processes, especially in the production of biodegradable materials and natural – based products.
  • Economic Potential: As a valuable intermediate, it offers opportunities for the creation of high – value – added products, driving innovation in multiple industries.

Dodržování předpisů

  • Americký úřad pro kontrolu potravin a léčiv (FDA): For food and pharmaceutical applications, products containing isosteviol must comply with relevant regulations. As a food additive precursor, it needs to meet safety standards set by the FDA.
  • Nařízení EU: Regulated under REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals) for industrial applications. In the food and cosmetic sectors, it must adhere to specific EU directives regarding safety and labeling.
  • Čínská NMPA: Approved for use in certain industrial and consumer products, with strict quality control and safety requirements in place to ensure compliance with national standards.
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Unlocking the Potential of Isosteviol: Nature’s Zero-Calorie Sweetener Powerhouse | Supplier & Manufacturer

1. What is Isosteviol?

Isosteviol is a diterpenoid carboxylic acid derived from its precursor, steviol glycosides, the intensely candy compounds discovered within the leaves of the Stévie rebaudiana Bertoni plant. Via a selected acid hydrolysis course of, the glucose moieties of stevioside are cleaved off, yielding isosteviol. In contrast to its guardian glycosides, isosteviol itself is non-caloric however possesses solely delicate sweetness. Its significance lies primarily in its function as a key metabolic intermediate and, more and more, in its personal distinct and promising bioaktivní vlastnosti, making it a compound of serious curiosity in meals science, nutraceuticals, and pharmaceutical analysis.

2. Dodávka produktu, chemické vlastnosti a identifikátory

  • Zásobování: Synthesized by way of chemical modification (hydrolysis) of steviol glycosides extracted from Stévie rebaudiana listy.

  • Chemické vlastnosti:

    • Chemický název: ent-16-Ketobeyeran-19-oic acid or 13-Hydroxyent-kaur-16-en-19-oic acid

    • Molekulární složky: C₂₀H₃₀O₃

    • Molekulová hmotnost: 318.45 g/mol

    • Vzhled: Usually a high quality, white to off-white crystalline powder.

    • Rozpustnost: Odhalení lipophilic traits, soluble in organic solvents like ethanol, methanol, chloroform, and dimethyl sulfoxide (DMSO), however displays low solubility in water.

    • Stabilita: Chemically secure beneath typical storage situations. Immune to warmth and pH adjustments encountered in meals processing.

  • Klíčové identifikátory:

    • Množství v registru CAS: 471-80-7

    • Množství ES (EINECS): 207-442-5

    • MF: C₂₀H₃₀O₃

    • MW: 318.45

3. Benefits, Purity, Dosage & Security Issues

  • “Greatest” & Highest Purity: The “finest” isosteviol prioritizes distinctive purity (>98%), rigorous absence of residual solventsa undetectable ranges of contaminants (heavy metals, pesticides, microbes). Respected suppliers like Shaanxi Zhonghong Investment Technology Co., Ltd. obtain this by means of proprietary purification strategies (e.g., multi-stage crystallization, preparative HPLC) exceeding normal {industry} purity benchmarks.

  • Well being Benefits (Rising Analysis):

    • Cardiometabolic Well being: Exhibits potential in modulating glucose homeostasis (enhancing insulin sensitivity), managing dyslipidémie (decreasing triglycerides, LDL), and supporting wholesome blood strain by way of results on vascular tone and endothelial perform. Acts partly by means of Aktivace AMPK a Modulace PPARγ.

    • Protizánětlivé a antioxidační účinky: Reveals important reactive oxygen species (ROS) scavenging skill and modulates key inflammatory pathways (e.g., NF-κB, MAPK signaling).

    • Renal Safety: Analysis suggests protecting results towards renal fibrosis a glomerular injury in experimental fashions, doubtlessly by way of TGF-β/Smad pathway inhibition a oxidative stress discount. (Word: Whereas nattokinase is researched for cardiovascular advantages, its direct affect on kidney well being is much less established in comparison with the rising renal protecting knowledge for isosteviol).

    • Neuroprotektivní potenciál: Preliminary research point out attainable advantages in neurodegenerative situations by decreasing neuroinflammation and oxidative injury.

  • Every day Consumption & Utilization Tips: At present, no established ADI (Acceptable Every day Consumption) exists zejména for isosteviol. Dosing in analysis varies considerably. Crucially seek the advice of a healthcare skilled earlier than supplementation. Utilization relies upon closely on the appliance (meals additive, complement, analysis chemical). Observe particular product labeling or analysis protocols meticulously.

  • Bezpečnostní opatření a výsledky na straně:

    • Restricted Human Security Information: Complete long-term human research are nonetheless wanted.

    • Potential Drug Interactions: Theoretical interactions exist because of results on CYP450 enzymes and blood strain/glucose; warning with antihypertensives, antidiabetics, and anticoagulants.

    • Being pregnant & Lactation: Keep away from use because of inadequate security knowledge.

    • Reported Facet Results: Typically well-tolerated in analysis, however excessive doses might doubtlessly trigger gastrointestinal discomfort. Allergic reactions are uncommon however attainable.

    • Vysoká kvalita je Paramount: Underscores the need of sourcing ultra-pure isosteviol from GMP-compliant producers to attenuate contaminant dangers.

4. Introducing Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Isosteviol Associate

Shaanxi Zhonghong Investment Technology Co., Ltd. stands as a premier high-tech podnik devoted to excellence in bioaktivní sloučenina analysis, growth, and manufacturing. We specialize within the superior extrakce, izolace a čištění of potent phytochemicals, serving world markets in nutraceuticals, prescribed drugs, cosmeceuticals, meals components (pure sweeteners, colours), and analysis chemical substances.

  • Klíčové kompetence a diferenciace:

    • Unmatched Scientific Prowess (The Analysis Barrier): Strategický academic-industry partnerships with 5 elite universities underpin our innovation. We possess a formidable IP portfolio exceeding 20 patents and keep a globálně unikátní knihovna sloučenin, driving cutting-edge discovery.

    • Analytical Management (Gear Dominance): Náš state-of-the-art QC infrastructure možnosti Excessive-Efficiency Liquid Chromatography (HPLC/UHPLC), Gasoline Chromatography-Mass Spectrometry (GC-MS), Superconducting Fourier Rework Nuclear Magnetic Resonance (FT-NMR)a Hmotnostní spektrometrie s indukčně vázaným plazmatem (ICP-MS). This allows stringent purity verification (>98% normal, exceeding {industry} norms by 20%) and complete contaminant profiling.

    • Excelence v mezinárodním dodavatelském řetězci: We reliably serve a various clientele throughout Více než 80 zemí all through Asia, Europe, and the Americas, offering syntéza na míru a možnosti ingrediencí na míru to multinational pharmaceutical companies, analysis establishments, and complement manufacturers.

    • Legacy of Experience: Využití 28 let specializovaných zkušeností within the isolation and software of bioactive pure compounds.

5. Specifikace produktu: Přísné zajištění vysoké kvality

Třída kontaminantů Parametr Omezení specifikace Podívejte se na Metodologii
Zbytky pesticidů Glyfosát ≤ 0,05 mg/kg LC-MS/MS
Chlorpyrifos ≤ 0,01 mg/kg GC-MS/MS
Cypermethrin ≤ 0,05 mg/kg GC-ECD
Whole Different Pesticides ≤ 0.1 mg/kg (every) Multi-residue Strategies (GC/LC)
Těžké kovy Olovo (Pb) ≤ 1,0 mg/kg ICP-MS / AAS
Arsen (As) ≤ 0,5 mg/kg ICP-MS / HG-AAS
Kadmium (Cd) ≤ 0,5 mg/kg ICP-MS / GFAAS
Rtuť (Hg) ≤ 0,1 mg/kg ICP-MS / CVAAS
Mikrobiologické Spolehněte se na celý talíř ≤ 1000 KTJ/g USP <61>
Kvasinky a plísně ≤ 100 KTJ/g USP <61>
E. coli Destructive in 10g USP <62>
Salmonela druhů Destructive in 375g USP <62>
Zlatý stafylokok Destruktivní v 1g USP <62>
Normální Isosteviol Purity ≥ 98.0% (HPLC) HPLC-ELSD/UV
Úbytek hmotnosti sušením ≤ 2,0% USP <731>
Zbytky po zapálení ≤ 0.2% USP <281>
Zbytková rozpouštědla Meets ICH Q3C Tips GC-FID/HS-GC

6. Vynikající výrobní kurz
Our isosteviol manufacturing employs a vertically built-in, GMP-compliant workflow:

  1. Zdroje a ověřování: Pojistné Stévie rebaudiana leaves bear botanical verification (macroscopic/microscopic, DNA barcoding).

  2. Hlavní extrakce: Supercritical CO2 extraction nebo food-grade solvent extraction yields crude steviol glycosides.

  3. Hydrolysis: Managed acid-catalyzed hydrolysis selectively cleaves glycosidic bonds, changing stevioside/rebaudioside A to isosteviol.

  4. Čištění: Vícestupňový liquid-liquid extraction, adopted by activated carbon decolorization a multi-step fractional crystallization beneath exact temperature management. Preparativní HPLC is employed for ultra-high purity (>99%) batches.

  5. Sušení a mletí: Lyofilizace (lyofilizace) nebo vacuum belt drying ensures stability, adopted by mikronizace to desired particle measurement distribution.

  6. Strict High quality Management: Each batch undergoes complete analytical profiling towards stringent specs earlier than launch.

7. Numerous Application Scenarios

  • Nutraceutika a dietní doplňky stravy: Formulated in capsules, tablets, softgels, and powders concentrating on metabolic well being, cardiovascular assist, antioxidant protection, and anti-aging.

  • Praktická jídla a nápoje: Integrated as a non-caloric practical ingredient in health-focused drinks, snacks, and meal replacements, leveraging its bioactivity past sweetness.

  • Farmaceutická analýza: An important reference normal, pharmacophorea sloučenina olova in drug discovery for diabetes, hypertension, irritation, and neurodegeneration.

  • Kosmeceutika: Explored in topical formulations for proti stárnutí (combating oxidative stress/irritation) and skin-brightening výsledky.

  • Sweetener Intermediate: Key precursor within the synthesis of next-generation steviol glycosides with improved style profiles.

8. Přísné řízení vysoké kvality (QC)
High quality is embedded at each stage. Our ISO 9001 and cGMP-aligned QC system mandates:

  • Identification Affirmation: FT-NMR a HPLC-UV/ELSD fingerprint matching towards reference requirements.

  • Čistota a účinnost: HPLC-ELSD/UV quantification of isosteviol content material (≥98%), monitoring for associated compounds (steviol, steviol glycosides).

  • Contaminant Management: GC-MS/MS/LC-MS/MS screens for >500 pesticide residues. ICP-MS ensures heavy metals compliance. Mikrobiologické testování (cardio depend, pathogens) follows validated USP/EP strategies.

  • Zbytková rozpouštědla: GC-FID/HS-GC evaluation per ICH Q3C pointers.

  • Bodily & Chemical Assessments: Úbytek hmotnosti sušením (LOD), Zbytek po žíhání (síranový popel), pH, Zvláštní rotace.

  • Výzkum stability: Ongoing ICH Q1A(R2) compliant zrychlený a long-term stability research to outline shelf life and storage situations. Dokumentace a sledovatelnost: Plný Certifikáty o hodnocení (CoA) per batch, adhering to ALCOA+ rules for knowledge integrity.

9. Bezpečné balení a mezinárodní logistika

  • Obal: Meals-grade double HDPE baggage s integrity liners, sealed inside strong, tamper-evident fiber drums (25kg normal). Smaller R&D portions use glass bottles. Customized packaging (vacuum-sealed, nitrogen-flushed) out there.

  • Skladování: Prodejce v cool, dry place (<25°C), protected against gentle and moisture. Preserve unique sealed packaging.

  • Logistika: Environment friendly world delivery by way of air freight, sea freight, or categorical couriers. Experience in dealing with celní odbavení a regulatory documentation for worldwide markets. Chilly chain choices out there.

10. Well being Efficacy, Mechanism & Analysis

  • Mechanism Insights: Isosteviol exerts results by way of a number of pathways:

    • AMPK Activation: Enhances glucose uptake, fatty acid oxidation.

    • PPARγ Modulation: Influences adipogenesis, insulin sensitivity, irritation.

    • Okay+ Channel Activation (Vascular): Promotes vasodilation, reducing blood strain.

    • TGF-β1/Smad Pathway Inhibition: Key mechanism in decreasing renal fibrosis.

    • NF-κB & MAPK Suppression: Reduces pro-inflammatory cytokine manufacturing (TNF-α, IL-6).

    • ROS Scavenging: Direct antioxidant exercise and upregulation of endogenous antioxidants (SOD, GSH).

  • Business Purposes & Innovation: Podpora inovací v practical sweeteners, metabolic syndrome therapeutics, pure preservativesa cosmeceutical actives. Zhonghong’s patented enzymatic bioconversion a steady chromatography applied sciences improve yield and purity.

  • Hranice a výzvy analýzy:

    • Hranice: Exploring isosteviol derivatives for enhanced bioavailability/exercise; medical translation of preclinical advantages; mixture therapies.

    • Výzvy: Establishing human-specific ADI; definitive large-scale human medical trials; optimizing supply methods for poor water solubility; navigating advanced world regulatory landscapes (GRAS, Novel Meals, and so forth.).

11. Often Requested Questions (FAQ)

  • Q1: Is Isosteviol the identical as Stevia?

    • A: No. Stevia refers back to the plant or its candy leaf extracts (steviol glycosides like stevioside, rebaudioside A). Isosteviol is a particular metabolite/spinoff produced by chemically modifying these glycosides. It has completely different properties (mildly candy/non-sweet, distinct bioactivity).

  • Q2: Is Isosteviol secure?

    • A: Present preclinical and restricted human knowledge counsel security profile at researched doses. Nonetheless, long-term, large-scale human research are ongoing. All the time select high-purity (>98%) isosteviol from respected suppliers adhering to GMP and seek the advice of your healthcare supplier earlier than use, particularly if pregnant, breastfeeding, taking treatment, or have underlying situations.

  • Q3: What are the primary well being advantages of Isosteviol?

    • A: Analysis highlights potential for supporting wholesome blood sugar metabolism, cardiovascular perform (blood strain, lipids), decreasing irritation and oxidative stress, and defending kidney well being. Extra human trials are wanted to verify efficacy for particular situations.

  • This autumn: What is the really useful each day dosage of Isosteviol?

    • A: Může existovat no universally established each day consumption (ADI). Dosages utilized in analysis fluctuate broadly. Crucially, seek the advice of your physician or a certified healthcare practitioner for customized recommendation primarily based in your well being targets and circumstances. Observe product-specific labeling.

  • Q5: How does Isosteviol examine to Nattokinase for kidney well being?

    • A: Whereas each are researched for well being advantages, their mechanisms differ. Isosteviol reveals direct anti-fibrotic and antioxidant results in kidney tissue in preclinical fashions, primarily by way of TGF-β inhibition. Nattokinase is a fibrinolytic enzyme primarily studied for cardiovascular advantages (blood move, clot prevention); its direct affect on kidney construction/perform is much less established. Neither replaces medical therapy for kidney illness.

  • Q6: Why select Zhonghong’s Isosteviol?

    • A: Zhonghong delivers ultra-high purity (>98%), industry-leading contaminant management, konzistence mezi jednotlivými dávkami, podporovaný 20+ patents, cutting-edge analytical capabilities (HPLC, NMR, ICP-MS), Soulad s GMPa 28 let zkušeností s bioaktivními látkami. We provide přizpůsobení a world regulatory assist.

12. The place to Purchase Excessive-Purity Isosteviol?
Supply premium Isosteviol instantly from the producer:

  • Webové stránky: Discover merchandise and specs at aiherba.com

  • Kontakt: Attain our gross sales staff by way of e-mail: liaodaohai@gmail.com

  • Inquiry: Request an in depth Certifikáty o hodnocení (CoA), MSDSa aggressive citation on your particular wants (bulk, analysis samples).

13. Conclusion: Isosteviol – A Versatile Bioactive with Important Promise
Isosteviol, derived from the pure sweetener stevia, transcends its origins as a metabolic intermediate. Its compelling portfolio of bioactivities – spanning cardiometabolic regulation, renoprotection, anti-inflammation, and antioxidant protection – positions it as a extremely promising compound for the nutraceutical, practical meals, and pharmaceutical industries. Whereas additional strong human medical validation is crucial, the prevailing scientific basis is powerful. The vital issue for efficacy and security lies in sourcing ultra-pure, meticulously characterised isosteviol. Shaanxi Zhonghong Investment Technology Co., Ltd., with its scientific rigor, superior purification know-how, and unwavering dedication to high quality, stands because the premier world accomplice for unlocking the complete potential of this exceptional diterpenoid. Contact us right this moment to debate your isosteviol necessities.

14. Odkazy

  1. Wang, J., et al. (2014). Isosteviol reduces plasma glucose ranges in diabetic Goto-Kakizaki rats by enhancing insulin sensitivity and enhancing glucose metabolism. Evropský časopis farmakologie, 734, 50-55. DOI: 10.1016/j.ejphar.2014.03.036

  2. Liu, J. C., et al. (2010). Antihypertensive results of isosteviol in spontaneously hypertensive rats. Molecular and Mobile Biochemistry, 340(1-2), 55-60. DOI: 10.1007/s11010-010-0401-1

  3. Mizushina, Y., et al. (2005). Structural evaluation of isosteviol and associated compounds as DNA polymerase and DNA topoisomerase inhibitors. Biologické vědy, 77(17), 2127-2140. DOI: 10.1016/j.lfs.2005.03.022

  4. Chen, T. H., et al. (2016). Isosteviol protects towards endotoxin-induced acute kidney harm by inhibiting NF-κB and MAPK signaling pathways. Časopis zemědělské a potravinářské chemie, 64(34), 6669-6677. DOI: 10.1021/acs.jafc.6b02895

  5. Worldwide Stevia Council. (2023). Stevia Manufacturing & Science. https://internationalsteviacouncil.org/

  6. EFSA Panel on Meals Components and Flavourings (FAF). (2021). Security of use of steviol glycosides. Časopis EFSA, 19(1), e06336. DOI: 10.2903/j.efsa.2021.6336

  7. FDA GRAS Notices: GRN No. 252 (Steviol Glycosides), GRN No. 667 (Reb M). https://www.fda.gov/food/gras-notice-inventory

  8. JECFA (Joint FAO/WHO Skilled Committee on Meals Components). (2016). Steviol glycosides. WHO Meals Components Sequence 71. https://apps.who.int/food-additives-contaminants-jecfa-database/

  9. ICH High quality Tips (Q1A(R2), Q2(R1), Q3C). https://www.ich.org/page/quality-guidelines

  10. USP-NF Normal Chapters: <61> Microbiological Examination, <62> Microbiological Procedures, <731> Loss on Drying, <281> Residue on Ignition. https://www.usp.org/

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