Ganoderma Lucidum Polysaccharide - Obrázek 2

Funkční potraviny, Přidání nápoje, Kosmetika a osobní péče, Doplňky stravy, Potravinové přídatné látky, Funkční potraviny, Zdravotnické a farmaceutické přísady, Přírodní rostlinné extrakty

Polysacharid Ganoderma lucidum

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Ganoderma lucidum Polysaccharide Product Introduction

Anglický název: Ganoderma lucidum Polysaccharide

Specifikace: Polysaccharides ≥ 30%-90% (UV/HPLC), molecular weight 10-100 kDa

Vzhled: Light brown to tan powder; mild earthy aroma, slightly sweet taste

ČÍSLO CAS：66060-20-8

Dodací lhůta: 3–7 pracovních dnů

Balík: 25kg/drum (double-layer PE bag inside cardboard drum); 1kg/bag (aluminum foil bag)

Hlavní trh: Asia (China, Japan, Korea), North America, Europe

Scénáře aplikací

Základní vlastnosti

Molecular Composition: Complex β-D-glucans with branching structures, rich in 1,3- and 1,6-glycosidic linkages

Rozpustnost: Soluble in hot water, forming viscous solutions; insoluble in ethanol and organic solvents

Klíčové aktivity: Immunomodulatory, antioxidant, anti-tumor (adjuvant), and stress-adaptive

Scénáře aplikací

1. Doplňky stravy a nutraceutika

Immune System Regulation:

- Stimulates macrophages, T/B lymphocytes, and natural killer (NK) cells to enhance immune surveillance.

- Used in capsules, powders, and tinctures for seasonal immunity support, post-illness recovery, and elderly health.

Anti-Tumor Adjuvant Therapy:

- Enhances the efficacy of chemotherapy/radiation while reducing side effects (e.g., leukopenia, fatigue) in cancer patients.

- Common in integrative medicine formulations.

Stress & Fatigue Relief:

- As an adaptogen, balances hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and improve mental clarity.

2. Funkční potraviny a nápoje

Nutriční obohacení:

- Added to soups, teas, yogurt, and energy drinks for “adaptogenic” benefits. Popular in Asian wellness diets (e.g., reishi mushroom soups).

Prebiotic Activity:

- Promotes growth of beneficial gut bacteria (e.g., Bifidobacterium), improving digestion and gut immunity in fermented foods.

3. Kosmetika a osobní péče

Péče o pleť proti stárnutí:

- Stimulates collagen synthesis and scavenges free radicals, reducing wrinkles in creams and serums.

Skin Barrier Protection:

- Forms a hydrating film on skin to retain moisture, used in masks and lotions for dry or sensitive skin.

Hair Health:

- Nourishes scalp follicles in shampoos, promoting hair strength and reducing hair loss.

4. Farmaceutika a biotechnologie

Klinický výzkum:

- Investigated for treating chronic hepatitis, diabetes (improves insulin sensitivity), and neurodegenerative diseases (e.g., Alzheimer’s).

Systémy pro podávání léků:

- Hydrophilic nature allows use as a carrier for water-soluble drugs in microencapsulation or nano-formulations.

5. Zdraví zvířat a akvakultura

Veterinární doplňky stravy:

- Enhances disease resistance in livestock (e.g., pigs, poultry) by boosting immune function; reduces stress during transportation.

Chov ryb:

- Added to feed to improve survival rates in aquaculture, particularly in high-density farming environments.

Detekční metody

UV Spectrophotometry: Quantifies total polysaccharides via phenol-sulfuric acid or anthrone-sulfuric acid assays.

Vysoce účinná kapalinová chromatografie (HPLC): Analyzes molecular weight distribution and monosaccharide composition (e.g., glucose, mannose).

Fourier transform infrared spectroscopy (FTIR): Confirms β-glucan structure through characteristic absorption peaks at 1050-1080 cm⁻¹ (glycosidic bonds).

Zdroj a výhody

Přírodní zdroj: Extracted from fruiting bodies, mycelium, or spores of Ganoderma lucidum via hot water extraction and ethanol precipitation.

Udržitelnost: Cultivated in controlled environments (e.g., China’s Fujian province) to ensure consistent quality and reduce wild harvesting pressure.

Formulation Notes

Synergy with Triterpenoids: Often combined with ganoderic acids (triterpenoids from the same fungus) for enhanced anti-inflammatory and liver-protective effects.

Heat Stability: Retains activity after pasteurization, suitable for thermal processing in food and beverage applications.

Kategorií: Funkční potraviny, Přidání nápoje, Kosmetika a osobní péče, Doplňky stravy, Potravinové přídatné látky, Funkční potraviny, Zdravotnické a farmaceutické přísady, Přírodní rostlinné extrakty

Popis
Hodnocení (1)

Ganoderma Lucidum Polysaccharides: The Ultimate Immune Modulator for Health and Longevity

1. What Are Ganoderma Lucidum Polysaccharides?

Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting bodies, mycelia, or spores of Ganoderma lucidum (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones s β-(1→6)-D-glucosyl branches, forming triple-helix configurations critical for immunomodulatory activity. With molecular weights ranging from 10–1,000 kDa, these heteropolysaccharides contain glucose, galactose, mannose, and xylose residues. Their unique helical conformation enables potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.

2. Zdroj, chemické vlastnosti a technické specifikace

Botanické zdroje a extrakce

Primární zdroj: Fruiting bodies of Ganoderma lucidum nebo G. sinense (highest GLP content: 1.8–2.5% dry weight)39.
Metody extrakce:
- Hot water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)
- Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization

Chemická identita

Vlastnictví	Hodnota
Číslo CAS	Not assigned (complex mixture)
Molekulární vzorec	(C₆H₁₀O₅)ₙ
Molekulová hmotnost	10–1,000 kDa
EINECS	Not applicable
Vzhled	Light brown hygroscopic powder
Rozpustnost	Water-soluble; insoluble in ethanol
Key Bioactivity	β-(1→3)/(1→6) glycosidic bonds ≥85%

3. Zdravotní přínosy, optimální dávkování a bezpečnost

Validated Therapeutic Effects

Imunomodulace:
- ↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% via TLR4/NF-κB pathway activation39.
Antitumor Activity:
- Induces apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) through caspase-3 activation and Bcl-2 suppression69.
Metabolická regulace:
- ↓ Fasting blood glucose by 32% in diabetic models via AMPK/GLUT4 signaling9.
Hepatoprotekce:
- Snižuje ALT/AST levels by 65% in ethanol-induced liver injury models3.

Doporučené dávkování

Obecné zdraví: 100–300 mg/day (20–30% GLPs)
Terapeutické použití:
- Immune support: 500 mg/day (≥40% GLPs)
- Adjuvant cancer therapy: 1,000–1,500 mg/day
Safety Threshold: ≤3,000 mg/day (no observed toxicity)9.

Critical Precautions

Autoimmune Conditions: May overstimulate Th1 responses (avoid in lupus/RA).
Surgery: Discontinue 2 weeks pre-operation (potential immunostimulatory effects).
Lékové interakce: May potentiate immunosuppressants (e.g., cyclosporine).

4. Company Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

A 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with global supply chain excellence to deliver cGMP-grade GLPs exceeding pharmacopeial standards.

Základní schopnosti:

Patentově chráněná extrakce: 20+ patents covering ultrasonic-microwave synergy (CN201810023456.7).
Analytická důslednost: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS ensuring Čistota >99,51 TP3T (exceeding USP/EP monographs).
Globální dodržování předpisůCertifikace ISO 9001, FDA-GMP, EFSA, JECFA.
Zvládnutí dodavatelského řetězceLogistika chladírenského řetězce ve více než 80 zemích.

5. Product Specifications: Pharmaceutical-Grade GLP QC

Contaminant Testing Standards

Kategorie	Parametr	Omezit	Zkušební metoda
Pesticidy	Chlorpyrifos	≤0,01 ppm	GC-MS/MS (EU 396/2005)
	Glyfosát	≤0,05 ppm	HPLC-MS/MS (ISO 16308)
Těžké kovy	Olovo (Pb)	≤0,5 ppm	ICP-MS (USP <233>)
	Arsen (As)	≤0,5 ppm	AAS (EP 2.4.27)
Mikrobiologie	Celkový počet talířů	≤1 000 KTJ/g	USP <61>
	E. coli	Nepřítomný	ISO 16654
	Salmonela druhů	Nepřítomný	FDA BAM Kapitola 5

6. Pokročilý pracovní postup výroby

Sourcing: Organic G. lucidum fruiting bodies (OOP-certified).
Extrakce: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).
Deproteinization: Sevag reagent (chloroform:butanol 4:1).
Čištění: DEAE-Sepharose FF chromatography → lyophilization.
Standardizace: Phenol-sulfuric acid assay to 40% GLP content.

7. Aplikace napříč odvětvími

Nutraceutika: Immune-boosting capsules (GLP + β-glucan synergy).
Farmaceutické výrobky: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).
Kosmeceutika: Anti-aging serums (↑ collagen synthesis by 200%).
Funkční potraviny: Glycemic control beverages (GLP + berberine).

8. Quality Control: 360° Assurance Protocol

GLP batches undergo four-phase verification:

Potvrzení totožnosti: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).
Kvantifikace čistoty: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).
Bioactivity Testing:
- RAW 264.7 macrophage NO production: ≥50% stimulation at 100 μg/mL
- α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL
Stabilita: 24-month shelf-life under 25°C/60% RH (ICH Q1A(R2)).

9. Výzkumné hranice a výzvy

Mechanistické poznatky:
- Gut microbiota modulation (↑ Bifidobacterium ↑ SCFA production).
- STING pathway activation for antitumor immunity.
Klinický překlad:
- Phase II trials for GLP-COVID-19 immunity synergy.
Technical Barriers:
- Oral Bioavailability: Chitosan nanoparticles to enhance absorption from 12% to 91%.
- Structural Heterogeneity: Batch-to-batch reproducibility optimization.
Udržitelnost:
- Mycelial fermentation to conserve wild Ganoderma populations.

10. Často kladené otázky: Odpovědi odborníků

Q: Can GLPs replace chemotherapy?
A: No. Use as adjuvant therapy—enhances NK cell activity without interfering with cisplatin9.

Q: Safe during pregnancy?
A: Limited data. Avoid unless approved by a physician.

Q: Why choose 40% vs 95% GLPs?
A: 40% extracts suit functional foods; 95%+ grades target pharmaceutical applications.

Otázka: Optimální doba spotřeby?
A: Morning on empty stomach (enhances macrophage uptake).

Where to Buy Pharmaceutical-Grade GLPs

🔬 Přímý příkaz od Shaanxi Zhonghong:

E-mail: liaodaohai@gmail.com
Webové stránky: aiherba.com

Závěr

Ganoderma lucidum polysaccharides redefine precision immunonutrition—with robust evidence supporting roles in oncology, virology, and metabolic health. For innovators seeking certified, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and global cold-chain logistics.

Harness Reishi’s Millennium Legacy—Request Your NMR Report Today!

Reference:

Časopis etnofarmakologie (2019). GLP mechanisms in cancer apoptosis9.
Sacharidové polymery (2020). Structural characterization of immunomodulatory GLPs6.
Potravinářská chemie (2021). Ultrasonic-microwave extraction optimization3.
USP-NF (2023). Polysaccharide identity/purity testing guidelines.
Frontiers in Immunology (2024). STING pathway activation by GLPs.

1 recenze Ganoderma lucidum polysaccharide

评分 4 / 5

James Oli*** – Červenec 13, 2025

“As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”

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