Ganoderma Lucidum Polysaccharides: The Final Immune Modulator for Well being and Longevity
1. What Are Ganoderma Lucidum Polysaccharides?
Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting our bodies, mycelia, or spores of Ganoderma lucidum (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones s β-(1→6)-D-glucosyl branches, forming triple-helix configurations vital for immunomodulatory exercise. With molecular weights starting from 10–1,000 kDa, these heteropolysaccharides comprise glucose, galactose, mannose, and xylose residues. Their distinctive helical conformation allows potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.
2. Dodávka, chemické vlastnosti a technické specifikace
Botanické zdroje a extrakce
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Hlavní napájení: Fruiting our bodies of Ganoderma lucidum nebo G. sinense (highest GLP content material: 1.8–2.5% dry weight)39.
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Strategie extrakce:
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Sizzling water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)
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Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization
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Chemical Identification
Vlastnictví | Hodnota |
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Číslo CAS | Not assigned (advanced combination) |
Molekulární vzorec | (C₆H₁₀O₅)ₙ |
Molekulová hmotnost | 10–1,000 kDa |
EINECS | Not relevant |
Vzhled | Mild brown hygroscopic powder |
Rozpustnost | Water-soluble; insoluble in ethanol |
Key Bioactivity | β-(1→3)/(1→6) glycosidic bonds ≥85% |
3. Přínosy pro zdraví, optimální dávkování a bezpečnost
Validated Therapeutic Results
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Imunomodulace:
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↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% by way of TLR4/NF-κB pathway activation39.
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Antitumor Exercise:
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Vyvolává apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) by way of caspase-3 activation and Bcl-2 suppression69.
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Metabolická regulace:
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↓ Fasting blood glucose by 32% in diabetic fashions by way of AMPK/GLUT4 signaling9.
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Hepatoprotekce:
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Snižuje ALT/AST ranges by 65% in ethanol-induced liver damage fashions3.
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Návrhy na dávkování
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Obecné zdraví: 100–300 mg/day (20–30% GLPs)
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Terapeutické použití:
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Immune help: 500 mg/day (≥40% GLPs)
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Adjuvant most cancers remedy: 1,000–1,500 mg/day
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Security Threshold: ≤3,000 mg/day (no noticed toxicity)9.
Vital Precautions
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Autoimmune Circumstances: Might overstimulate Th1 responses (keep away from in lupus/RA).
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Chirurgický zákrok: Discontinue 2 weeks pre-operation (potential immunostimulatory results).
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Lékové interakce: Might potentiate immunosuppressants (e.g., cyclosporine).
4. Firm Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.
A 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with international provide chain excellence to ship cGMP-grade GLPs exceeding pharmacopeial requirements.
Základní schopnosti:
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Patentově chráněná extrakce: 20+ patents overlaying ultrasonic-microwave synergy (CN201810023456.7).
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Analytická důslednost: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS making certain Čistota >99,51 TP3T (exceeding USP/EP monographs).
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Mezinárodní shodaCertifikace ISO 9001, FDA-GMP, EFSA, JECFA.
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Zajistěte zvládnutí řetězceLogistika chladírenského řetězce ve více než 80 zemích.
5. Product Specs: Pharmaceutical-Grade GLP QC
Contaminant Testing Requirements
Třída | Parametr | Omezit | Zkontrolujte techniku |
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Pesticidy | Chlorpyrifos | ≤0,01 ppm | GC-MS/MS (EU 396/2005) |
Glyfosát | ≤0,05 ppm | HPLC-MS/MS (ISO 16308) | |
Těžké kovy | Olovo (Pb) | ≤0,5 ppm | ICP-MS (USP <233>) |
Arsen (As) | ≤0,5 ppm | AAS (EP 2.4.27) | |
Mikrobiologie | Závisí na celém talíři | ≤1 000 KTJ/g | USP <61> |
E. coli | Nepřítomný | ISO 16654 | |
Salmonela druhů | Nepřítomný | FDA BAM Kapitola 5 |
6. Vynikající výrobní postup
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Sourcing: Natural G. lucidum fruiting our bodies (OOP-certified).
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Extrakce: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).
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Deproteinization: Sevag reagent (chloroform:butanol 4:1).
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Čištění: DEAE-Sepharose FF chromatography → lyophilization.
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Standardizace: Phenol-sulfuric acid assay to 40% GLP content material.
7. Účely v různých odvětvích
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Nutraceutika: Immune-boosting capsules (GLP + β-glucan synergy).
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Léky na předpis: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).
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Kosmeceutika: Anti-aging serums (↑ collagen synthesis by 200%).
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Useful Meals: Glycemic management drinks (GLP + berberine).
8. High quality Management: 360° Assurance Protocol
GLP batches bear čtyřfázové ověření:
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Potvrzení totožnosti: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).
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Kvantifikace čistoty: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).
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Testování bioaktivity:
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RAW 264.7 macrophage NO manufacturing: ≥50% stimulation at 100 μg/mL
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α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL
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Stabilita: 24-month shelf-life underneath 25°C/60% RH (ICH Q1A(R2)).
9. Analýza hranic a výzev
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Mechanistické poznatky:
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Intestine microbiota modulation (↑ Bifidobacterium ↑ SCFA manufacturing).
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STING pathway activation for antitumor immunity.
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Medical Translation:
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Part II trials for GLP-COVID-19 immunity synergy.
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Technical Boundaries:
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Perorální biologická dostupnost: Chitosan nanoparticles to reinforce absorption from 12% to 91%.
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Structural Heterogeneity: Batch-to-batch reproducibility optimization.
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Udržitelnost:
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Mycelial fermentation to preserve wild Ganoderma populations.
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10. Často kladené otázky: Kvalifikovaná řešení
Q: Can GLPs change chemotherapy?
A: No. Use as adjuvant remedy—enhances NK cell exercise with out interfering with cisplatin9.
Q: Secure throughout being pregnant?
A: Restricted information. Keep away from until authorized by a doctor.
Q: Why select 40% vs 95% GLPs?
A: 40% extracts swimsuit useful meals; 95%+ grades goal pharmaceutical purposes.
Otázka: Optimální doba spotřeby?
A: Morning on empty abdomen (enhances macrophage uptake).
The place to Purchase Pharmaceutical-Grade GLPs
🔬 Přímý příkaz od Shaanxi Zhonghong:
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E-mail: liaodaohai@gmail.com
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Webové stránky: aiherba.com
Závěr
Ganoderma lucidum polysaccharides redefine precision immunonutrition—with sturdy proof supporting roles in oncology, virology, and metabolic well being. For innovators in search of licensed, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and international cold-chain logistics.
Harness Reishi’s Millennium Legacy—Request Your NMR Report As we speak!
Reference:
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Časopis etnofarmakologie (2019). GLP mechanisms in most cancers apoptosis9.
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Sacharidové polymery (2020). Structural characterization of immunomodulatory GLPs6.
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Chemie jídel (2021). Ultrasonic-microwave extraction optimization3.
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USP-NF (2023). Polysaccharide identification/purity testing tips.
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Frontiers in Immunology (2024). STING pathway activation by GLPs.
James Oli*** –
“As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”