Sodium hyaluronate

Unlock the Power of Sodium Hyaluronate: Your Ultimate Guide from Industry Leader Zhonghong Tech

1. What is Sodium Hyaluronate (SH)?
Sodium Hyaluronate (SH) is the sodium salt form of hyaluronic acid (HA), a naturally occurring glycosaminoglycan polymer essential to the extracellular matrix in humans and animals. Renowned for its exceptional viscoelastic properties and profound hydrophilicity, SH is a high-molecular-weight biopolymer capable of binding over 1000 times its weight in water. This unique hygroscopic nature underpins its critical biological functions in lubrication, shock absorption, ug tissue hydration across connective tissues, synovial fluid, vitreous humor, and skin.

2. Tinubdan sa Produkto, Mga Kinaiya sa Kemikal ug Mga Identifier

• Panguna nga Tinubdan: Traditionally sourced from rooster combs (animal-derived). Modern, high-purity, low-immunogenicity SH, like that produced by Zhonghong Tech, is predominantly derived via microbial fermentation using carefully selected strains of Streptococcus zooepidemicus bacteria. This method ensures superior batch-to-batch consistency, reduced risk of animal-borne pathogens, and aligns with vegan/vegetarian standards.

• Mga Kinaiya sa Kemikal:

  • Chemical Name: Sodium (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate

  • Numero sa CAS: 9067-32-7

  • Pormula sa Molekular (MF): (C14H20NO11Na)n (where ‘n’ represents the number of repeating disaccharide units)

  • Molekular nga Timbang (MW): Variable. Defined by its weight-average molecular weight (Mw). Commercial grades range from Low Molecular Weight (LMW, e.g., 10-50 kDa) for enhanced skin penetration to High Molecular Weight (HMW, >1000 kDa) for superior surface hydration and film-forming.

  • Numero sa EINECS: 618-619-1

  • Panagway: White or off-white, hygroscopic, fibrous powder or granules.

  • Solubility: Highly soluble in water, forming viscous, clear solutions; insoluble in organic solvents.

  • Viscosity: Highly dependent on concentration, molecular weight, pH, and ionic strength. Exhibits pseudoplasticity (shear-thinning behavior).

3. What Defines the “Best” Sodium Hyaluronate? Key Criteria
Selecting premium SH requires scrutiny beyond basic specifications:

• Core Ingredients & Purity: Look for ultra-high purity (>95%), achieved through multi-stage purification (ultrafiltration, ethanol precipitation). Essential to minimize impurities like proteins (<0.1%), nucleic acids, and endotoxins (<0.5 EU/mg). Molecular Weight Distribution control is critical for targeted efficacy.

• Proven Efficacy & Regulatory Compliance:

  • Kosmetiko: Deep hydration, wrinkle reduction, skin barrier repair. Compliant with EU CosIng, FDA OTC monographs (skin protectant), ISO 16128 (Natural Origin Index).

  • Nutraceutical/Pharmaceutical: Supports joint health (OA symptom relief – USP/NF Monograph), wound healing, ophthalmic surgery (viscoelastic agent – USP/NF, Ph. Eur.). Oral Bioavailability of LMW HA is key for systemic effects.

  • Certifications: cGMP, ISO 9001, ISO 13485 (if medical-grade), HALAL, KOSHER, Non-GMO Project Verified, Vegan Certified.

• Sinugdanan ug Paggama: Opt for products manufactured in cGMP-certified facilities with stringent quality management systems. Traceable sourcing of raw materials (e.g., non-GMO fermentation substrates) is vital. Zhonghong Tech leverages its proprietary fermentation and purification technology in its state-of-the-art Chinese facilities.

• Mga Panudlo sa Paggamit:

  • Topical (Cosmetics): 0.1% – 2.0% in serums, creams, lotions. Apply to clean skin.

  • Oral (Nutraceuticals): Typical doses range from 60mg to 200mg daily for joint support/skin health. Often combined with Chondroitin Sulfate ug Glucosamine. Follow product label.

  • Injectable (Medical): Strictly administered by healthcare professionals under sterile conditions.

• Target nga mamiminaw: Skincare consumers, individuals with joint discomfort (osteoarthritis), athletes, post-surgical patients (ophthalmic, orthopedic), wound care patients, health-conscious supplement users.

• Kritikal nga Pag-amping:

  • Topical: Generally well-tolerated. Patch test recommended for sensitive skin.

  • Oral: Considered safe at recommended doses. Consult physician if pregnant, breastfeeding, or have autoimmune conditions.

  • Injectable: Risk of injection site reactions, hypersensitivity (rare). Contraindicated in infections near injection site.

• Potensyal nga mga epekto: Topical: Very rare irritation. Oral: Mild GI upset possible. Injectable: Pain, redness, swelling at site; extremely rare granulomatous reactions.

• Mga Kaayohan ug Mekanismo sa Panglawas:

  • Skin Hydration & Anti-Aging: Binds water, plumps skin, reduces TEWL (Transepidermal Water Loss), stimulates fibroblast activity and collagen/elastin synthesis via CD44 receptor interaction.

  • Joint Health (Oral/Injectable): Lubricates synovial fluid, reduces friction, suppresses pro-inflammatory cytokines (IL-1β, TNF-α), protects chondrocytes. LMW HA (<20 kDa) shows enhanced bioavailability ug chondroprotective effects.

  • Wound Healing: Creates moist environment, facilitates cell migration (fibroblasts, keratinocytes), modulates inflammation.

  • Ocular Health: Lubricates dry eyes (topical drops), maintains chamber depth during surgery (injectable viscoelastics).

• Daily Intake (Oral): No universally established RDA. Clinical studies for joint health typically use 60mg to 200mg daily. Adhere strictly to manufacturer’s dosing instructions.

4. Introducing Zhonghong Tech: Your Trusted Sodium Hyaluronate Innovator
Shaanxi Zhonghong Investment Technology Co., Ltd. is a premier high-tech nga negosyo integrating cutting-edge R&D, collaborative innovation, integrated manufacturing, and global marketing. We specialize in serving the chemical, advanced materials, and life science sectors, with a core expertise in the extraction, isolation, purification, and commercial application of potent botanical constituents.

• Panguna nga Pokus: Delivering high-value ingredients including Natural nga mga Ekstrak sa Tanum, Mga Aktibo sa Kosmetiko, Pharmaceutical & Nutraceutical Intermediates, Natural nga mga Pigment, Mga Suplemento sa Pagkaon, Mga Additives sa Pagkaon ug Ilimnon, ug Natural nga mga Patam-is.

• Unrivaled Scientific Expertise (Research Barrier):

  • 5 Strategic University Joint Labs: Collaborating with top-tier academic institutions for breakthrough research.

  • 20+ Patented Technologies: Protecting innovative extraction, purification, and analysis methods.

  • Global Exclusive Compound Library: Offering unique, hard-to-source bioactive molecules.

• Cutting-Edge Infrastructure (Equipment Leadership): Gisangkapan sa HPLC (High-Performance Liquid Chromatography), UPLC (Ultra-Performance LC), GC-MS (Gas Chromatography-Mass Spectrometry), Superconducting NMR (Nuclear Magnetic Resonance), ug FTIR (Fourier Transform Infrared Spectroscopy). Ang among pasalig sa mga sumbanan sa kaputli nga labaw sa mga lagda sa industriya sa 20%+ guarantees unparalleled quality.

• Global Market Reach: An established distribution and partnership network spanning 80+ ka nasod across Asia, Europe, and the Americas. We provide gipahiangay nga mga solusyon sa sangkap sa multinasyunal nga pharmaceutical corporations, leading research institutions, ug innovative manufacturers.

• Proven Legacy: Leveraging 28 years of deep domain expertise sa bioactive compound discovery, production, and application.

5. Benefits of Zhonghong Tech’s Sodium Hyaluronate

• Unmatched Purity & Consistency: Estrikto QC protocols ensure >95% purity, minimal impurities (endotoxins, proteins), and tight molecular weight distribution control (LMW, MMW, HMW options).

• Optimal Bioactivity: Sourced from non-animal, GMO-free microbial fermentation for superior biocompatibility and efficacy.

• Versatility: Available in multiple grades (Cosmetic, Food, Pharmaceutical) and MW profiles tailored for specific applications (deep penetration, surface film-forming, viscoelasticity).

• Regulatory Assurance: Fully documented to meet cGMP, ISO, USP/NF, EP, JP standards as applicable. Comprehensive Dossiers (RS, CoA, CoO, Stability) gihatag.

• Sustainable & Ethical: Animal-free production, commitment to environmentally responsible manufacturing processes.

6. Product Specification & Certificate of Analysis (CoA)
Zhonghong Tech guarantees adherence to the strictest quality parameters. A typical CoA includes:

Table: Zhonghong Tech Sodium Hyaluronate – Key CoA Specifications

7. Advanced nga Pag-agos sa Produksyon
Zhonghong Tech’s SH production leverages aseptic microbial fermentation ug multi-step purification:

1. Strain Cultivation: Activation of proprietary Streptococcus zooepidemicus master cell bank under controlled conditions.

2. Precision Fermentation: Large-scale fermentation in computer-controlled bioreactors optimizing temperature, pH, dissolved oxygen, and nutrient feed (non-GMO substrates).

3. Broth Clarification: Removal of bacterial cells via tangential flow microfiltration (TFF).

4. Panguna nga Pagputli: Precipitation of HA using food-grade ethanol o isopropanol.

5. Secondary Purification: Depth filtration ug activated carbon treatment to remove impurities, pigments, and endotoxins.

6. Ultrafiltration/Diafiltration (UF/DF): Critical step for molecular weight fractionation (using specific MWCO membranes) and removal of salts/small molecules. Enables precise LMW, MMW, HMW production.

7. Sterile Filtration: 0.22μm membrane filtration under aseptic conditions.

8. Controlled Drying: Pag-spray sa pagpauga o lyophilization (freeze-drying) to obtain powder with optimal moisture content and particle size.

9. Stringent Quality Control: Matag batch moagi full suite analytical testing (HPLC for MW/assay, ICP-MS for metals, GC/LC-MS for residues, BET for endotoxins, microbiological testing) against predefined specs.

10. GMP Packaging: Powder filled into multi-layered, moisture-proof bags (e.g., aluminum foil with PE inner liner) with desiccant, within mga tambol sa fiber or cartons, in ISO-certified cleanrooms.

8. Nagkalainlain nga mga Sitwasyon sa Paggamit

• Mga Kosmetiko ug Pag-atiman sa Panit: Serums, moisturizers, masks, eye creams, foundations (humectant, plumping, anti-aging, barrier repair).

• Mga Nutraceutical ug Mga Suplemento sa Pagkaon: Capsules, tablets, powders for joint health, skin hydration, gut health support.

• Pharmaceuticals: Injectable viscoelastic supplements for osteoarthritis (e.g., knee injections), ophthalmic surgery aids (viscoelastic devices), wound dressings (hydrogels), drug delivery systems.

• Medical Devices: Coatings for implants, catheters, surgical aids.

• Pagkaon ug Ilimnon: Functional beverages, supplements, moisture retention agent in foods (limited use).

9. Rigorous Quality Control
Zhonghong Tech implements a comprehensive, phase-appropriate Quality by Design (QbD) framework for Sodium Hyaluronate, exceeding pharmacopeial standards. Our cGMP-aligned Quality Management System (QMS) governs every stage.

• Kwalipikasyon sa Hilaw nga Materyal: Strict vendor approval and umaabot nga inspeksyon of fermentation substrates and chemicals using HPLC, GC, ICP-MS against pharmacopeial standards (USP, EP, CP). Identity testing (FTIR, NMR) ensures traceability.

• In-Process Controls (IPC): Real-time monitoring of critical process parameters (CPPs) during fermentation (pH, DO, temp, nutrient levels) and purification (TFF/UF pressures, fluxes, conductivity, ethanol concentration). HPLC sampling monitors HA concentration and potential degradation. Bioburden testing ensures aseptic processing integrity.

• Advanced Finished Product Testing: Every batch undergoes exhaustive analysis per our gi-validate nga mga pamaagi: HPLC-ELSD/RID for precise molecular weight distribution (Mw, Mn, PDI) and assay; UPLC-MS/MS for impurity profiling; ICP-MS kay bug-at nga metal; GC-MS/MS ug LC-MS/MS kay mga salin sa pestisidyo; LAL Kinetic Chromogenic kay endotoxins; compendial (USP <61>/<62>, EP 2.6.12/13) microbiological testing; viscosity; pH; loss on drying; residue on ignition. Mga pagtuon sa kalig-on (ICH Q1A) support shelf-life claims.

• Dokumentasyon ug Pagsubay: Electronic Batch Records (EBR), Laboratory Information Management System (LIMS), and full analytical method validation (ICH Q2) ensure data integrity, compliance, and complete traceability from raw material to finished product. Annual product reviews guarantee continuous quality.

10. Luwas nga Packaging & Global Logistics

• Pagputos: 25 kg net weight in robust, multi-layer packaging: High-grade polyethylene (PE) inner liner heat-sealed inside an aluminum foil bag, containing oxygen absorber & silica gel desiccant, placed within a fiberboard drum or heavy-duty carton. Smaller quantities (1kg, 5kg) available in double-sealed foil bags within cartons. All packaging meets ISTA 3A standards for transit protection.

• Pagtipig: Store unopened in a cool (<25°C), dry (RH <60%) environment, protected from light. Shelf life typically 24 ka bulan from manufacturing date under recommended conditions.

• Global Logistics: Leveraging partnerships with major freight forwarders (DHL, FedEx, UPS for samples; sea/air freight for bulk), we ensure efficient, compliant global shipping. Expertise in customs clearance documentation (CoA, CoO, MSDS) for seamless import into 80+ ka nasod. Cold chain options available if required.

11. Health Benefits: Mechanisms, Applications & Innovation

• Mechanism of Action: SH exerts effects via receptor-mediated signaling (primarily CD44 and RHAMM). Binding triggers intracellular cascades influencing cell proliferation, migration, differentiation, and inflammation. Ang physicochemical properties provide direct biomechanical lubrication ug osmotic hydration.

• Joint Health: HMW SH injections supplement synovial fluid, improving viscoelasticity and reducing pain/stiffness in OA. Oral LMW SH is absorbed intestinally, modulates synovial macrophage activity, reduces pro-inflammatory cytokines (IL-1β, TNF-α, PGE2), stimulates endogenous HA synthesis, and protects cartilage (inhibition of MMPs, ADAMTS5). Clinical Benefit: Reduced WOMAC/VAS pain scores.

• Skin Health: Penetrates depending on MW (LMW penetrates deeper). Hydrates via water-binding, stimulates dermal fibroblast proliferation ug collagen I/III, elastin, fibrillin synthesis pinaagi sa CD44/TGF-β1 signaling. Reduces matrix metalloproteinase (MMP-1, -3) expression. Clinical Benefit: Improved skin hydration, elasticity, reduced wrinkle depth.

• Wound Healing: Creates moist environment, facilitates keratinocyte/fibroblast migration, modulates inflammation (M1/M2 macrophage shift), promotes angiogenesis, and organizes ECM deposition.

• Ocular Health: Topical: Lubricates, protects ocular surface. Injectable: Maintains anterior chamber, protects corneal endothelium during surgery.

• Industrial Applications & Innovation: Zhonghong Tech drives innovation via MW engineering (ultra-LMW fragments for enhanced absorption, novel cross-linked HMW for sustained release), conjugation technologies (HA-drug conjugates for targeted delivery), berde nga chemistry in fermentation/purification, and exploring novel applications in regenerative medicine (bioinks, scaffolds) and precision diagnostics.

• Mga Frontier ug Hagit sa Pagpanukiduki: Key areas include elucidating HA fragment-specific signaling (oligo-HA vs. poly-HA), enhancing oral bioavailability strategies, developing longer-acting injectable formulations, pagsabot HA microbiome interactions (gut-joint axis), and scaling complex bioengineered HA production cost-effectively.

12. Kanunayng Gipangutana nga mga Pangutana (FAQ)

• Q1: Is Zhonghong Tech’s Sodium Hyaluronate animal-derived?

  • A: No. Our premium SH is produced exclusively via non-animal, microbial fermentation naggamit Streptococcus zooepidemicus, pagsiguro vegan compliance, high purity, ug reduced immunogenic risk.

• Q2: What molecular weight (MW) is best for my application?

  • A: It depends:

    • Deep Skin Penetration & Systemic Effects (Oral/Nutra): Low MW (10-50 kDa)

    • Surface Hydration & Film-Forming (Cosmetics): Medium (100-500 kDa) to High MW (>1000 kDa)

    • Viscoelasticity/Joint Injection/Lubrication: High MW (>1000 kDa)

    • Contact us for specific formulation advice.

• Q3: Is Oral Sodium Hyaluronate effective?

  • A: Yes, particularly Low MW HA. Scientific studies demonstrate oral LMW HA is absorbed, distributed to skin and joints, reducing osteoarthritis symptoms (pain, stiffness) and improving skin hydration/elasticity. Efficacy depends on dose, MW, and quality.

• Q4: What certifications do your products hold?

  • A: We manufacture under cGMP, certified to ISO 9001, and relevant grades meet USP/NF, EP, JP monographs. Products are HALAL, KOSHER, Non-GMO Project Verified, Vegan Certified. Specific certifications per product/grade available upon request.

• Q5: Are there allergens or GMOs in your SH?

  • A: Our microbial fermentation SH is gluten-free, soy-free, dairy-free, shellfish-free. We use non-GMO substrates and hold Non-GMO Project Verification.

• Q6: What is the shelf life and storage condition?

  • A: Standard shelf life is 24 ka bulan from date of manufacture when stored sealed in the original packaging in a cool (<25°C), dry (RH<60%), dark place. Avoid freezing.

• Q7: Can I get a sample for testing?

  • A: Yes! We encourage evaluation. See “Where to Buy” below for free sample request.

13. Where to Buy & Contact for Free Samples
Experience the Zhonghong Tech difference. We supply Pharmaceutical Grade, Cosmetic Grade, and Food Grade Sodium Hyaluronate globally.

• Request Your FREE Sample Today!

  • Email: liaodaohai@gmail.com

  • Website: www.aiherba.com

• Visit our website (www.aiherba.com) to explore our full portfolio of premium botanical extracts and bioactive ingredients. Contact us for bulk quotes, technical dossiers, and custom synthesis inquiries.

14. Panapos
Sodium Hyaluronate is a remarkably versatile biomolecule with proven benefits spanning cosmetics, nutraceuticals, and advanced medicine. Choosing a supplier like Shaanxi Zhonghong Investment Technology Co., Ltd. guarantees access to ultra-pure, precisely characterized HA produced under stringent cGMP pinaagi sa non-animal fermentation. Backed by 28 ka tuig nga kahanas, university partnerships, proprietary nga teknolohiya, and a global distribution network, Zhonghong Tech is your premier partner for innovative, high-performance Sodium Hyaluronate solutions. Contact us today to elevate your product formulations.

15. Mga pakisayran

• USP-NF Monograph: Hyaluronate Sodium. United States Pharmacopeia.

• European Pharmacopoeia Monograph: Sodium Hyaluronate (1466). European Directorate for the Quality of Medicines.

• Japanese Pharmacopoeia Monograph: Sodium Hyaluronate.

• Balazs EA, Denlinger JL. Clinical uses of hyaluronan. Ciba Found Symp. 1989.

• *Jegasothy SM, et al. Efficacy of a New Topical Nano-hyaluronic Acid in Humans. J Clin Aesthet Dermatol. 2014.*

• Nelson FR, et al. The effects of an oral preparation containing hyaluronic acid (Oralvisc®) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses. Rheumatol Int. 2015.

• *Tashiro T, et al. Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period. Sci World J. 2012.*

• International Council for Harmonisation (ICH) Guidelines: Q1A(R2), Q2(R1), Q8, Q9, Q10.

• *ISO 16128-1:2016: Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products.*