Unlocking the Energy of Bisabolol: Nature’s Soothing Elixir from AIHerba | Supplier & Manufacturer
1. Unsa ang Bisabolol?
Bisabolol, panguna nga nahitabo ingon (-)-α-bisabolol, is a naturally occurring monocyclic sesquiterpene alcohol famend for its distinctive skin-soothing, anti-irritant, and anti inflammatory properties. This bioactive compound is a prized beauty and pharmaceutical ingredient, providing a delicate but potent resolution for delicate pores and skin and numerous inflammatory circumstances. Its delicate floral aroma additional enhances its enchantment in perfumery.
2. Suplay sa Produkto, Mga Kinaiya sa Kemikal ug Pag-ila
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Major Natural Supply: German nga chamomile (Espesye sa tanom nga bulak ang Matricaria chamomilla/recutita), particularly its important oil, is the richest pure supply of (-)-α-bisabolol. Additionally present in smaller portions in Candeia kahoy (Vanillosmopsis species) oil and different vegetation.
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Mga Kinaiya sa Kemikal:
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Gidaghanon sa CAS: 515-69-5 (Usually refers back to the racemic combination; pure (-)-α-Bisabolol is 23089-26-1)
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MF (Pagporma sa Molekular): C₁₅H₂₆O
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MW (Molekular nga Timbang): 222.37 g/mol
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EINECS: 207-454-3
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Panagway: Walay kolor ngadto sa luspad nga yellow viscous liquid.
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Solubility: Matunaw sa alkohol ug lana, dili matunaw sa tubig.
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Optical Exercise: Natural (-)-α-Bisabolol is levorotatory. Artificial variations could also be racemic.
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AIHerba Supply & Benefit: AIHerba makes use of premium German Chamomile flowers, using proprietary supercritical CO2 extraction ug molecular distillation methods to yield (-)-α-Bisabolol with unparalleled purity (>98%) and stereochemical integrity, maximizing its bioactivity.
3. What is the Finest Bisabolol? Efficacy, Security & Utilization
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“Finest” Outlined: Ang pinakataas nga kaepektibo is constantly attributed to pure (-)-α-Bisabolol resulting from its particular stereochemistry. AIHerba’s concentrate on ultra-high purity pure (-)-α-Bisabolol ensures superior efficiency.
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Highest Content Supply: German Chamomile important oil usually comprises the very best pure focus (as much as ~50%, although AIHerba isolates it to >98%).
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Well being & Pores and skin Benefits:
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Poten nga Anti-inflammatory: Nagpugong sa COX-2, LOX, ug makapahubag nga mga cytokine (TNF-α, IL-6).
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Makapahupay ug Anti-irritant: Quickly calms pores and skin irritation (e.g., from surfactants, UV, chemical peels).
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Antioxidant: Scavenges free radicals, defending pores and skin cells.
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Wound Therapeutic & Regenerative: Stimulates fibroblast migration and promotes tissue restore.
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Antimicrobial: Displays exercise towards sure micro organism and fungi.
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Gipalambo nga Penetration: Can enhance pores and skin absorption of different actives.
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Pores and skin Barrier Help: Contributes to a more healthy pores and skin barrier operate.
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Adlaw-adlaw nga Konsumo: Ang Bisabolol ang panguna nga gigamit topically (cosmetics, skincare). Oral consumption shouldn’t be frequent for bisabolol itself; security ranges depend upon the particular software (beauty, complement, pharmaceutical). Beauty use is usually thought to be secure at typical concentrations (0.2% – 2.0%).
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Wants Consideration:
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Pagkasensitibo: Whereas usually well-tolerated, patch testing new merchandise is at all times beneficial.
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Oxidation: Pure bisabolol can oxidize over time; formulations ought to embrace antioxidants and use acceptable packaging (e.g., airless containers, nitrogen flushing).
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Mga Resulta sa Aspekto: Uncommon. Potential for gentle pores and skin irritation or allergic response in extremely delicate people. Natural (-)-α-Bisabolol has a wonderful security profile.
4. Introducing AIHerba: Your Trusted Bisabolol Companion
Shaanxi Zhonghong Investment Technology Co., Ltd. (AIHerba) usa ka premier high-tech nga negosyo integrating agile R&D, collaborative innovation, built-in manufacturing, and international advertising. For over 28 ka tuig, we have specialised in serving the chemical, supplies, and life sciences sectors, with core experience within the extraction, isolation, purification, and industrial software of bioactive plant constituents.
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Siyentipikanhong Kabatid: 5+ strategic college joint labs, 20+ patented applied sciences, and a globally distinctive proprietary compound library.
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Chopping-Edge High quality: HPLC (Sobra-Episyente nga Liquid Chromatography), GC-MS (Gasoline Chromatography-Mass Spectrometry), ug Superconducting NMR (Nuclear Magnetic Resonance) guarantee purity requirements exceeding trade norms by 20%+.
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Kalibutan nga makab-ot: Pag-alagad 80+ ka nasod sa tibuok Asya, Uropa, ug sa Amerika, nagtanyag custom-made pure ingredient options to main multinational pharmaceutical corporations, analysis establishments, and beauty giants.
5. Product Specs: Rigorous High quality Management
AIHerba’s (-)-α-Bisabolol adheres to the strictest high quality requirements. Key specs embrace:
Desk 1: Pesticide Residue Evaluation
Grupo sa Pestisidyo | Instance Compounds | Limitahan (ppm) | Detection Methodology (e.g.) |
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Mga organochlorine | DDT, Lindane, Endosulfan | < 0.01 | GC-ECD / GC-MS/MS |
Mga organophosphate | Chlorpyrifos, Malathion | < 0.01 | GC-FPD / GC-MS/MS |
Pyrethroids | Cypermethrin, Deltamethrin | < 0.01 | GC-ECD / GC-MS/MS |
Mga Carbamate | Carbaryl, Aldicarb | < 0.01 | HPLC-FLD / LC-MS/MS |
Ang uban | Glyphosate, Amitrole | < 0.05 | HPLC-PCD / LC-MS/MS |
Desk 2: Heavy Metals Evaluation
Heavy Steel | Limitahan (ppm) | Detection Methodology (e.g.) |
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Arsenic (As) | < 1.0 | ICP-MS / Hydride Technology AAS |
Tingga (Pb) | < 3.0 | ICP-MS / Graphite Furnace AAS |
Cadmium (Cd) | < 0.5 | ICP-MS / Graphite Furnace AAS |
Mercury (Hg) | < 0.1 | Chilly Vapor AAS / ICP-MS |
Complete Heavy Metals | < 10.0 | ICP-OES / ICP-MS |
Desk 3: Microbial Evaluation
Microorganism | Pagdili | Detection Methodology (e.g.) |
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Complete Cardio Microbial Rely | <100 CFU/g | USP <61> / EP 2.6.12 |
Complete Mixed Yeasts/Molds | <50 CFU/g | USP <61> / EP 2.6.12 |
Escherichia coli | Wala sa 1g | USP <62> / EP 2.6.13 |
Salmonella spp. | Wala sa 10g | USP <62> / ISO 6579-1 |
Staphylococcus aureus | Wala sa 1g | USP <62> / EP 2.6.13 |
Espesye sa tanom nga bulak ang Pseudomonas aeruginosa | Wala sa 1g | USP <62> / EP 2.6.13 |
6. Superior Manufacturing Move
AIHerba’s (-)-α-Bisabolol manufacturing exemplifies cutting-edge phytochemistry:
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Pagkuha: Premium German Chamomile flowers from licensed sustainable farms.
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Major Extraction: Supercritical CO2 Extraction (SFE) – Makes use of tunable strain/temperature for selective, solvent-free isolation of volatiles, preserving delicate actives.
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Focus: Removing of waxes and non-target compounds.
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Pag-inusara ug Pagputli: Preparative HPLC and/or Excessive-Vacuum Fractional Distillation – Achieves focused separation of (-)-α-Bisabolol from different terpenes.
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Crystallization (Non-obligatory): For attaining highest purity grades (>99%).
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Pagpalig-on: Pagdugang sa synergistic antioxidants (eg, Tocopherol).
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Kusog nga QC: HPLC-DAD/ELSD, Chiral GC/HPLC, GC-MS, NMR for identification, purity (>98%), enantiomeric extra, and residual solvent evaluation. ICP-MS alang sa bug-at nga metal. Microbiological testing kada pharmacopeia.
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Pagputos: Underneath inert environment (Nitrogen) in light-protected, food-grade HDPE or glass containers.
7. Various Application Scenarios
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Mga Kosmetiko ug Pag-atiman sa Panit: Calming serums, delicate pores and skin lotions, after-sun merchandise, anti-redness remedies, child care, post-procedure formulations (laser, peels), zits remedies (mitigates irritation), pure deodorants.
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Gireseta nga mga tambal: Topical anti-inflammatory and wound therapeutic ointments/gels, mucoadhesive formulations, dental care merchandise (anti-gingivitis).
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Pahumot: Gives a tender, candy, floral notice with fixative properties.
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Nutraceuticals: Included into topical wellness merchandise (e.g., muscle soothing balms).
8. Complete High quality Management (QC)
AIHerba’s QC paradigm is constructed on Pharmaceutical cGMP ideas ug mga leverage state-of-the-art nga instrumento sa pagtuki. Identification affirmation makes use of FTIR (Fourier Remodel Infrared Spectroscopy) fingerprinting ug Chiral Chromatography to confirm the (-)-enantiomer. Purity is quantified by way of validated HPLC-UV/ELSD strategies calibrated towards licensed reference requirements, constantly guaranteeing >98% (-)-α-Bisabolol content material. Residual Solvent Evaluation (Headspace GC-MS) ensures compliance with ICH Q3C tips. Pagpanukiduki sa Kalig-on (ICH Q1A) underneath accelerated and long-term circumstances decide shelf-life and optimum storage parameters. Each batch undergoes full spectroscopic (NMR for structural elucidation if wanted), chromatographic, and microbiological testing, gidokumento sa a Mga Sertipiko sa Pagtimbang-timbang (CoA) traceable to worldwide requirements (USP, EP, CP). Our ISO 9001-certified high quality administration system ensures traceability and steady enchancment.
9. Luwas nga Packaging & World Logistics
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Pagputos: 1kg, 5kg food-grade nga mga botelya sa HDPE; 25kg HDPE nga mga tambol. Tanan nahurot ang nitrogen ug aluminum bag-lined for max oxidation safety. Customized packaging obtainable.
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Pagtipig: Retailer tightly sealed in unique packaging, shielded from mild and moisture at 2-8°C (refrigerated) for long-term stability. Quick-term (<6 months) at <25°C acceptable.
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Logistics: Shipped globally by way of logistik nga kontrolado sa temperatura (chilly chain the place required). Compliant with all worldwide rules (REACH, FDA, COSMOS and so on.). Complete documentation offered.
10. Deep Dive: Well being Mechanisms, Purposes & Innovation
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Mekanismo sa Paglihok: (-)-α-Bisabolol exerts results by way of a number of pathways:
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Modulates NF-κB and MAPK signaling cascades, suppressing pro-inflammatory cytokine manufacturing.
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Nagpugong sa mahinungdanong mga enzyme: Cyclooxygenase-2 (COX-2), 5-Lipoxygenase (5-LOX).
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Demonstrates antioxidant exercise by quenching ROS/RNS.
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Enhances penetration by way of lipid bilayer interplay.
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Nagpasiugda sa re-epithelialization ug granulation tissue formation sa mga samad.
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Industrial Purposes & AIHerba Innovation: Past cosmetics, bisabolol enhances transdermal drug supply programs. AIHerba innovates by way of enantioselective synthesis nga mga agianan (alang sa ultra-pure (-)-isomer), nobela co-crystal nga mga pormulasyon alang sa gipauswag nga kalig-on/solubility, ug sustained-release supply programs (e.g., lipid nanoparticles) built-in with our proprietary compound library screening for synergistic combos.
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Pag-analisar sa mga utlanan ug mga hagit:
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Mga utlanan: Pag-usisa sa pagka-epektibo sa neuroinflammatory circumstances, gastroprotective results, anti-cancer adjunct remedy (enhancing chemo efficacy/lowering negative effects), superior biomaterials (anti-inflammatory coatings alang sa mga implant).
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Mga hagit: Scaling sustainable cultivation of high-bisabolol chamomile strains, cost-effective large-scale chiral purification, definitive medical dose-response research for particular therapeutic endpoints, long-term stability optimization in advanced formulations.
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11. Regularly Requested Questions (FAQ)
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Q: Is pure (-)-α-Bisabolol higher than artificial?
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A: Sure, quite a few research point out pure (-)-α-Bisabolol possesses superior anti-makapahubag ug makapahupay sa panit kaepektibo in comparison with artificial racemic mixtures or different isomers resulting from its particular stereochemistry.
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Q: What focus of Bisabolol is efficient in cosmetics?
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A: Typical efficient concentrations vary from 0.2% ngadto sa 2.0%. Efficacy relies on the formulation and desired impact; AIHerba gives software assist.
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Q: Is Bisabolol secure for delicate pores and skin?
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A: Completely. Natural (-)-α-Bisabolol is famend for its distinctive tolerance and efficacy in calming delicate, irritated, and reactive pores and skin.
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Q: Does Bisabolol have any identified drug interactions?
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A: Topical use has no vital reported interactions. Seek the advice of a doctor for potential interactions with oral medicines if used systemically (uncommon).
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Q: How ought to I retailer AIHerba Bisabolol?
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A: For optimum long-term stability and to stop oxidation, retailer tightly sealed, shielded from mild, and refrigerated (2-8°C). See CoA for particular batch suggestions.
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Q: Is AIHerba Bisabolol compliant with worldwide requirements?
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A: Sure. Our product meets or exceeds specs outlined in related USP/EP monographs (the place relevant), COSMOS, ISO, and is REACH/FDA compliant. Certificates obtainable.
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12. The place to Purchase Premium (-)-α-Bisabolol
Supply the very best purity, naturally derived (-)-α-Bisabolol straight from the producer:
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Web site: www.aiherba.com
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Kontaka: Liao Daohai
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E-mail: liaodaohai@gmail.com
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Pangutana alang sa: Bulk pricing, samples, technical knowledge sheets (TDS), certificates of research (CoA), and formulation assist.
13. Panapos
(-)-α-Bisabolol stands as a cornerstone bioactive ingredient for light but highly effective soothing and anti inflammatory efficacy. AIHerba, pagpahimulos 28 years of experience in phytochemistry and superior purification applied sciences, naghatud ultra-pure (>98%) pure (-)-α-Bisabolol. Gikuha nga malungtaron ug gi-validate sa superconducting NMR, HPLC, ug ICP-MS, our ingredient meets the stringent calls for of worldwide beauty, pharmaceutical, and analysis markets. Select AIHerba for unparalleled high quality, scientific assist, and a dedication to innovation in pure actives.
14. Mga pakisayran
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Kamatou, G. P. P., & Viljoen, A. M. (2010). A evaluation of the applying and pharmacological properties of α-bisabolol and α-bisabolol-rich oils. Journal sa American Oil Chemists' Society, 87(1), 1-7.
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European Medicines Company (EMA) Evaluation Report on Espesye sa tanom nga bulak ang Matricaria recutita L., flos. (2015).
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Cavalieri, E., et al. (2004). Professional-apoptotic exercise of α-bisabolol in preclinical fashions of major human acute leukemia cells. The Journal of Medical Investigation, 114(3).
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Worldwide Group for Standardization (ISO). ISO 16128 – Tips on technical definitions and standards for pure and organic beauty substances.
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United States Pharmacopeia (USP) Normal Chapters: <561> Articles of Botanical Origin, <2023> Microbiological Examination of Nonsterile Merchandise.
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European Pharmacopoeia (Ph. Eur.) Monographs: 2.8.12 Microbiological examination of non-sterile merchandise, 2.4.8 Heavy Metals.
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Current Analysis (e.g., search PubMed.gov for “alpha-bisabolol mechanism”, “bisabolol pores and skin”, “bisabolol wound therapeutic” – 2023/2024 publications). AIHerba Inner Analysis & Stability Information.
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