Beta-Glucan: The Versatile Immunomodulating Polysaccharide Powerhouse|Supplier & Manufacturer

1. Unsa ang Beta-Glucan?

Ang Beta-Glucan (β-Glucan) kay natural nga mahitabo heterogeneous nga grupo sa glucose polymers characterised by β-glycosidic bond Pagdugtong sa D-glucose monomer. Ang bioactivity is critically depending on molecular construction: particularly, the linkage sort (β-(1,3), β-(1,4), β-(1,6)), diploma of branching, gibug-aton sa molekula (MW), pagkatunaw, ug tertiary conformation (triple helix). Primarily acknowledged as a potent organic response modifier (BRM), β-glucans exert profound results on the natural nga immune system by interacting with particular receptors (e.g., dectin-1, complement receptor 3 (CR3), TLR-2/6) sa macrophage, dendritic cells, ug neutrophils. Past immunology, they perform as matunaw nga mga fiber sa pagkaon with established advantages for metabolic and cardiovascular well being.

2. Supply sa Produkto, Mga Kinaiya sa Kemikal ug mga Identifier

• Major Sources:

  • Yeast ug Fungi: Espesye sa tanom nga bulak ang Saccharomyces cerevisiae (Baker’s/Brewer’s Yeast) – wealthy in β-(1,3)/(1,6)-glucans (extremely immunomodulatory). Medicinal nga Uhong (Reishi (Ganoderma lucidum), Shiitake (Ang Lentinula edodes), Maitake (Grifola frondosa)) – complicated β-glucan constructions.

  • Mga cereal: Oats (Avena sativa), Barley (Hordeum vulgare) - kasagaran β-(1,3)/(1,4)-glucans (matunaw nga fiber, pagpaubos sa kolesterol).

  • Micro organism: Alcaligenes faecalis, Agrobacterium spp. – produkto curdlan (β-(1,3)-glucan).

  • Sagbot sa dagat: Euglena gracilis – Paramylon (β-(1,3)-glucan).

• Mga Kinaiya sa Kemikal:

  • Panagway: Varies by supply. Yeast/fungal β-glucans: Off-white to mild tan powders. Oat/Barley β-glucans: Creamy puti nga mga pulbos.

  • Solubility: Yeast/Fungal β-(1,3)/(1,6)-glucans are typically dili matunaw sa tubig however soluble in alkali (pananglitan, 0.25M NaOH) o DMSO. Ang cereal β-(1,3)/(1,4)-glucans kay extremely soluble in water, forming viscous options/gels. Solubility impacts performance and bioavailability.

  • Kalig-on: Typically steady. Cereal β-glucans can bear enzymatic degradation; requires cautious processing. Storage in cool, dry circumstances beneficial.

• Key Identifiers (Instance: Yeast β-(1,3)/(1,6)-Glucan):

  • Gidaghanon sa Registry sa CAS: 9012-72-0 (Basic for Glucans) / 160872-27-5 (Nakuha sa Saccharomyces cerevisiae)

  • Pagporma sa Molekular (MF): (C6H10O5)n (Polymer - n lainlain)

  • Molekular nga Timbang (MW): Usually 100,000 – 2,000,000 Da (Excessive MW essential for immune exercise). Shaanxi Zhonghong provides particular MW ranges.

  • Gidaghanon sa EINECS: 232-739-3 (Para sa mga Glucan)

3. Efficacy, Optimum Kinds, Well being Benefits, Dosage & Security

• “Greatest” Kind & Highest Purity: The “greatest” β-glucan is determined by the desired major perform:

  • Immune Modulation: Excessive-Molecular-Weight (>500 kDa), Insoluble Yeast/Fungal β-(1,3)/(1,6)-Glucan uban sa excessive purity (>85%) ug preserved triple-helix construction is taken into account the gold commonplace for maximal immune cell activation through dectin-1. Shaanxi Zhonghong makes use of proprietary extraction nga nagpreserbar sa native conformation.

  • Ldl cholesterol Administration & Blood Sugar Management: Excessive-Purity (>95%) Soluble Oat or Barley β-(1,3)/(1,4)-Glucan uban sa excessive viscosity/molecular weight is best. Purity minimizes interference from different fibers/starch.

  • Wound Therapeutic/Topical: Matunaw nga Yeast o Mushroom β-Glucans are sometimes most well-liked.

• Mga Benepisyo ug Mekanismo sa Kaayohan:

  • Pagpalambo sa Immune System: Prompts macrophages (enhanced phagocytosis, reactive oxygen/nitrogen species manufacturing, cytokine/chemokine launch). Gipukaw ang pagkahinog sa dendritic cell. Nagpalambo sa neutrophil chemotaxis ug cytotoxicity. Primes Natural Killer (NK) cell exercise. Kini “educated immunity” enhances host protection towards infections (bacterial, viral, fungal) and helps immune surveillance towards most cancers.

  • Ldl cholesterol Discount: Soluble oat/barley β-glucan varieties a viscous gel within the intestine, nagbugkos sa mga acid sa bile and selling their excretion. This forces the liver to use blood ldl cholesterol to synthesize new bile acids, decreasing serum LDL (“dangerous”) ldl cholesterol. EFSA and FDA help well being claims (e.g., 3g/day oat β-glucan).

  • Modulasyon sa Glucose sa Dugo: Gipahinay ang pag-usik sa tiyan ug gipahinay ang pagsuyup sa carbohydrate, lowering post-prandial blood glucose spikes and bettering insulin sensitivity.

  • Intestine Well being Promotion: Naglihok isip a prebiotic, stimulating development of helpful micro organism (e.g., Bifidobacteria, Lactobacilli). Nagpalambo short-chain fatty acid (SCFA) manufacturing (butyrate).

  • Wound Therapeutic & Pores and skin Well being: Topically, stimulates dermal fibroblast proliferation, collagen deposition, ug keratinocyte migration. Nagpalambo macrophage recruitment to wound websites.

  • Adjuvant in Most cancers Remedy: Enhances efficacy and reduces negative effects of chemotherapy/radiotherapy. Potential direct anti-tumor results through immune activation.

• Kada adlaw nga konsumo:

  • Immune Help (Yeast/Fungal): Kasagaran 100-500 mg/adlaw sa high-purity (>85%), high-MW nga produkto.

  • Ldl cholesterol Administration (Oat/Barley): 3 gramos kada adlaw minimal, typically consumed in divided doses with meals. Requires constant consumption.

  • Blood Sugar Management (Oat/Barley): 3-4 gramos / pagkaon.

  • Optimum dosing is determined by supply, purity, MW, and well being purpose. Seek the advice of a healthcare supplier.

• Mga Pag-amping ug Resulta sa Aspekto:

  • Typically Acknowledged as Secure (GRAS). Nicely-tolerated by most.

  • Potensyal nga Aspektong Resulta: Excessive doses, particularly initially, could trigger gentle gastrointestinal signs (bloating, fuel, diarrhea) because of fermentation or fiber bulk. Begin with decrease doses and improve step by step.

  • Mga Kahimtang sa Autoimmune: Theoretical concern exists concerning immune stimulation exacerbating autoimmune illnesses (e.g., RA, lupus, MS). Seek the advice of doctor earlier than use.

  • Surgical nga pamaagi: On account of potential immune-modulating results, discontinue use a minimum of 2 weeks earlier than scheduled surgical procedure.

  • Allergy symptoms: Uncommon, however attainable sensitivity to supply (yeast, fungi, cereals). Keep away from if identified allergy.

  • Mga Interaksyon sa Droga: Mahimo potentiate results of immunosuppressive medicine. Might gradual absorption of some medicines; take different meds 1 hour earlier than or 2-4 hours after β-glucan (particularly soluble varieties).

4. Premier Supply: Shaanxi Zhonghong Investment Technology Co., Ltd.

Ang Shaanxi Zhonghong Investment Technology Co., Ltd 28 ka tuig nga kasinatian ingon a vertically built-in chief sa bioactive polysaccharide manufacturing. Ingon sa usa ka licensed high-tech enterprise, nagdrayb mi agile R&D, collaborative innovation, precision manufacturing, and world distribution para sa chemical, materials science, and life science industries.

• Panguna nga Pokus: Superior extraction, purification, and characterization of high-purity β-Glucans from numerous sources (yeast, fungi, oats, barley).

• Portfolio sa Produkto: Standardized nga β-Glucan powder (Yeast, Oat, Mushroom particular), matunaw nga mga komplikado, customized MW fractions, beauty actives, nutraceutical substances, research-grade supplies.

• Scientific Prowess (R&D Barrier):

  • College Alliances: Mga hiniusang laboratoryo uban sa 5 elite establishments pag-uswag sa siyensya sa polysaccharide.

  • IP Portfolio: 20+ patente pagmaskara proprietary nga enzymatic hydrolysis, fractionation strategies, ug pagpreserbar sa bioactivity.

  • Distinctive Compound Library: World unique assortment of characterised polysaccharides.

• Manufacturing Excellence (Gear Edge):

  • Reducing-edge Analytics: HPLC-RID/ELSD/MS kay purity/MW evaluation, GC-MS alang sa monosaccharide profiling, FTIR/NMR kay structural affirmation, SEC-MALS kay absolute MW willpower.

  • Purity Management: Atong β-Glucan purity requirements exceed trade norms by >20%, assured by hugot nga orthogonal testing.

• Kalibutan nga makab-ot: Naghatag custom-made β-Glucan options sa pharmaceutical giants, nutraceutical manufacturers, useful meals builders, and analysis organizations sa tibuok 80+ ka nasod sa Asia, Europe, ug sa Amerika.

5. Product Specs: Rigorous High quality Management

6. Superior Manufacturing Move (Yeast β-Glucan)

1. Pagpili sa Presyon ug Pag-ferment: Paggamit sa proprietary Espesye sa tanom nga bulak ang Saccharomyces cerevisiae mga strain sa ilawom managed fermentation circumstances.

2. Pag-ani sa Cell ug Dili Aktibo: Centrifugation/Pagsala, adopted by thermal o kemikal nga inactivation.

3. Pagbulag sa Cell Wall: Mechanical disruption (high-pressure homogenization, bead milling) o enzymatic lysis to interrupt cells and isolate partitions.

4. Alkaline Extraction: Remedy with sizzling alkali (e.g., 1-3M NaOH) aron matunaw ang mga mannoprotein ug lipid, nga nagbilin nga dili matunaw nga β-glucan matrix.

5. Paghugas sa asido: Acid remedy (e.g., acetic acid) to take away residual contaminants.

6. Pag-neutralize ug Paghugas: In depth diafiltration/ultrafiltration to impartial pH and low conductivity.

7. Fractionation & MW Management (Non-obligatory): Managed enzymatic hydrolysis o bodily shearing to realize goal MW vary. Pangandam SEC for exact fractionation.

8. Solubilization (For Soluble Kinds): Derivatization (pananglitan, carboxymethylation) o particular enzymatic modification.

9. Pagpauga: Pag-spray sa pagpauga o freeze-drying (lyophilization) to provide steady powder.

10. Kusog nga Paglansad sa QC: Puno id, purity, MW, contaminant, and microbiological testing per specs.

7. Mga Sitwasyon sa Paggamit

• Nutraceuticals & Dietary Dietary supplements: Immune help capsules/tablets, cholesterol-lowering formulation, blood sugar administration blends, prebiotic dietary supplements, normal wellness powders.

• Mapuslanon nga Pagkaon ug Pag-inom: Gipalig-on nga mga cereal, bar, tinapay (oat β-glucan), mga ilimnon nga makapakusog sa resistensya, mga yogurt (requires soluble varieties).

• Gireseta nga mga tambal: Mga immunostimulant (particularly post-surgery/chemo), adjuvant most cancers remedy, wound therapeutic gels/dressings, cholesterol-lowering medicine.

• Mga kosmetiko: Anti-aging lotions/serums (enhances pores and skin immunity, hydration, restore), wound therapeutic formulations, makapahupay nga mga lotion.

• Animal Vitamin & Well being: Immune modulators sa kahayupan / manok feed, companion animal dietary supplements.

• Pagtuki: Immunology research, drug supply techniques, biomaterial.

8. Complete High quality Management (QC) System

Si Shaanxi Zhonghong nagtrabaho sa usa ka multifaceted QC protocol exceeding pharmacopeial necessities aron masiguro β-Glucan efficacy, security, and consistency:

• Id & Purity: HPLC coupled with Refractive Index (RID) or Evaporative Mild Scattering (ELSD) Detection quantifies β-glucan content material towards licensed requirements. Enzymatic strategies (Megazyme kits) present orthogonal affirmation. Dimension Exclusion Chromatography with Multi-Angle Mild Scattering (SEC-MALS) naghatud hingpit nga gibug-aton sa molekula ug pag-apod-apod (MWD). Fourier Remodel Infrared Spectroscopy (FTIR) ug Nuclear Magnetic Resonance (NMR – 1H, 13C) presente depinitibo nga structural fingerprinting and linkage affirmation.

• Pagdumala sa Kontaminante: Inductively Coupled Plasma Mass Spectrometry (ICP-MS) nakab-ot ultra-sensitibo nga detection sa bug-at nga mga metal at ppb ranges. Fuel Chromatography-Mass Spectrometry (GC-MS/MS) ug Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) display for pesticides, mycotoxins, and course of residuals. Gipamatud-an nga microbiological assays guarantee compliance with stringent bioburden limits.

• Purposeful Characterization: Rheological evaluation mga lakang viscosity / gelation kabtangan sa matunaw nga β-glucans. In vitro macrophage activation assays (e.g., cytokine launch, NO manufacturing) assess immunomodulatory efficiency for yeast/fungal merchandise. Solubility and water-binding capability are key bodily checks.

• Kalig-on ug Pagtipig: ICH Q1A(R2) compliant stability research (accelerated: 40°C/75% RH; long-term: 25°C/60% RH) decide shelf-life. Merchandise are usually saved in sealed containers at ambient temperature, shielded from moisture.

• Pagsubay ug Pagsunod: Complete Certificates of Evaluation (CoA) uban sa batch-specific knowledge. Digital Batch Information (EBR) ug LIMS garantiya bug-os nga pagsubay. Pagsunod sa cGMP, ISO 9001, ISO 22000/FSSC 22000, Kosher, Halal.

9. Luwas nga Packaging & World Logistics

• Panguna nga Packaging: Multi-layered, foil-lined luggage with zipper closures and desiccant positioned inside fiber drums o HDPE nga mga sudlanan.

• Ikaduha nga Pagputos: Strong eksport nga grado nga karton.

• Pag-label: Tin-aw nga pag-label sa product title, supply, CAS (if relevant), batch no., expiry date, internet weight, storage circumstances, GMP standing, allergen assertion (if required).

• Logistics: World delivery through air/sea. Experience in logistik sa temperatura sa palibot. Actual-time cargo monitoring. Bug-os nga export documentation suite (Industrial Bill, Packing Listing, CoA, MSDS, Certificates of Origin, Well being Certificates). Customs brokerage help.

10. Well being Efficacy & Mechanism Analysis, Purposes & Innovation, Analysis Frontiers

• Mechanistic nga giladmon: Ongoing analysis focuses on detalyado nga receptor signaling cascades (pananglitan, Syk/CARD9 nga agianan sa ubos sa dectin-1), modulation of educated immunity (epigenetic reprogramming), affect on gut-immune axis, ug interplay with the complement system.

• Increasing Scientific Purposes: Energetic investigation in oncology immunotherapy mixtures, administration of sepsis and important sickness, adjuvanticity sa bakuna, inflammatory bowel illness (IBD), allergy/bronchial asthma modulation, ug Mga interbensyon sa metabolic syndrome.

• Trade Purposes & Tech Innovation: Key areas embrace nanoparticulate β-glucan for focused drug/vaccine supply, improvement of extremely purified soluble β-(1,3)/(1,6)-glucans with preserved bioactivity, microencapsulation for meals/beverage stability, chemically outlined derivatives with tailor-made properties, ug sustainable manufacturing through fermentation optimization.

• Pag-analisar sa mga utlanan ug mga hagit: Main challenges contain pag-standardize sa bioactivity assays throughout numerous constructions, pagsabot sa istruktura-aktibidad nga mga relasyon (SAR) uban sa atomic katukma, bettering oral bioavailability of insoluble varieties, conducting large-scale long-term medical trials, guaranteeing constant supply materials high quality, ug addressing regulatory complexities for well being claims. Mga interaksyon sa microbiome ug Mga metabolite sa β-glucan are rising frontiers.

11. Padayon nga Gipangayo nga mga Pangutana (FAQ)

• Q: What is the distinction between yeast, mushroom, and oat beta-glucan?

  • A: Supply and Construction: Ang yeast β-glucan mao ang panguna β-(1,3)-nalambigit sa β-(1,6) nga mga sanga, dili matunaw, ug extremely immunomodulatory. Mushroom β-glucans range however typically have complicated β-(1,3)/ (1,6) constructions; ang uban immunogenic. Ang Oat/Barley β-glucan kay linear/barely branched β-(1,3)/(1,4)-linked, matunaw, ug sa panguna naglihok isip a matunaw nga fiber nga nagpaubos sa kolesterol with some immune results through the intestine.

• Q: Which beta-glucan is greatest for immune help?

  • A: Excessive-purity (>85%), Excessive-Molecular-Weight (>500 kDa) Yeast or Mushroom (e.g., Reishi, Shiitake) β-(1,3)/(1,6)-Glucan is mostly thought-about essentially the most potent for direct immune cell activation through receptors like dectin-1. Preservation of the native triple-helix construction is crucial.

• Q: How a lot beta-glucan ought to I take day by day?

  • A: Dose is determined by the supply and function:

    • Immune (Lebadura/Uhong): 100-500 mg/adlaw sa taas nga kalidad nga kinuha.

    • Ldl cholesterol (Oat/Barley): At the least 3 grams/day, gikaon uban sa pagkaon.

    • Asukal sa Dugo (Oat/Barley): 3-4 gramos matag pagkaon.
      Seek the advice of a healthcare skilled for personalised recommendation.

• Q: Are there any negative effects?

  • A: Ang β-Glucan kay typically very secure. Excessive preliminary doses, particularly soluble oat/barley, could trigger gentle fuel or bloating; begin low and improve step by step. Theoretical immune stimulation threat in energetic autoimmune illness or pre-surgery – seek the advice of your physician. Uncommon yeast/mould allergy symptoms attainable.

• Q: Is your beta-glucan gluten-free? (Oat supply)

  • A: Atong Oat Beta-Glucan gikan sa licensed gluten-free oats ug giproseso sa a devoted gluten-free facility, examined to satisfy <20 ppm nga gluten requirements. Yeast/Mushroom β-glucans are sa kinaiyanhon nga gluten-free.

• Q: Is it KOSHER/HALAL licensed?

  • A: Sure, particular grades can be found with KOSHER ug HALAL nga sertipikasyon. Palihug pangutana.

• Q: Are you able to present customized specs (MW, Purity, Solubility)?

  • A: Completely. Shaanxi Zhonghong focuses on customized β-glucan options, uban sa particular MW ranges, purity ranges (as much as >95%), solubilized varieties, non-public labeling, ug technical help. Contact us to debate.

12. The place to Purchase Excessive-High quality Beta-Glucan

Suplay premium β-Glucan substances (Yeast, Oat, Mushroom Particular) from Shaanxi Zhonghong Investment Technology Co., Ltd.:

• Elektronikong mail: liaodaohai@gmail.com

• Web site: https://aiherba.com

• Kontaka: Attain out through electronic mail or our web site for technical dossiers, samples, quotations, and customized venture discussions.

13. Panapos

Ang Beta-Glucan nagbarug ingon usa ka talagsaon nga versatile bioactive polysaccharide, providing unparalleled advantages for immune well being, metabolic regulation, and past. Shaanxi Zhonghong Investment Technology Co., Ltd., pagdrowing sa 28 years of specialised experience, state-of-the-art expertise, and uncompromising high quality techniques, naghatud taas nga kaputli, maayo nga kinaiya nga β-Glucans tailor-made to satisfy the demanding necessities of the world nutraceutical, pharmaceutical, useful meals, and analysis markets. Our dedication to scientific rigor, superior purification (exceeding trade purity by >20%), and dependable world provide chain administration positions us because the accomplice of alternative for innovators searching for premium β-Glucan substances. Empower your subsequent well being product with nature’s highly effective immunomodulator.

14. Mga pakisayran

1. Vetvicka, V., & Vetvickova, J. (2021). β-Glucans as Natural Organic Response Modifiers. Endocrine, Metabolic & Immune Problems – Drug Targets, 21(2), 216-228. (Mekanismo).

2. EFSA Panel on Dietetic Merchandise, Vitamin and Allergy symptoms (NDA). (2011). Scientific Opinion on the substantiation of well being claims associated to beta-glucans from oats and barley… EFSA Journal, 9(6), 2207. (Ldl cholesterol Declare).

3. Goodridge, HS, ug uban pa. (2009). Ang Dectin-1 stimulation sa Candida albicans yeast o zymosan nagpalihok sa NFAT activation sa macrophage ug dendritic cells. Ang Journal of Immunology, 182(12), 7497-7504. (Receptor Signaling).

4. Akramiene, D., et al. (2007). Results of beta-glucans on the immune system. Medisina (Kaunas), 43(8), 597-606. (Immune Results Evaluate).

5. El Khoury, D., et al. (2012). Beta glucan: well being advantages in weight problems and metabolic syndrome. Journal of Vitamin and Metabolism, 2012, 851362. (Metabolic Well being).

6. Zekovic, D. B., et al. (2005). Natural and modified (1→3)-β-D-glucans in well being promotion and illness alleviation. Essential Evaluations in Biotechnology, 25(4), 205-230. (Supply & Construction Comparisons).

7. US Pharmacopeia-Nationwide Formulary (USP-NF). Basic Chapters: <1059> Excipient Efficiency, <2021> Identification of Articles of Botanical Origin by HPTLC.

8. AOAC Official Strategies of Evaluation (e.g., 995.16, 2011.25 – Beta-Glucan Assay).

9. Synytsya, A., & Novak, M. (2014). Structural range of fungal glucans. Mga Carbohydrate Polymers, 92(1), 792-809. (Structural Evaluation).

10. Shaanxi Zhonghong Inside Methodology Validations, Stability Research & Product Dossiers.