Bacopa Monnieri Extract: The Clinically Validated Nootropic for Cognitive Excellence
1. What is Bacopa Monnieri?
Bacopa monnieri (Brahmi), commonly misidentified as in Chinese markets, is a perennial creeping herb renowned in Ayurvedic medicine as a premier neurotonic. Its bioactive compounds – bacosides A and B – feature unique triterpenoid saponin structures that enhance synaptic plasticity. Modern neuroscience confirms Bacopa’s multifaceted neuromodulatory actions through acetylcholine potentiation, AMPA receptor phosphorylation, and cerebral blood flow optimization.
2. Source, Chemical Properties & Specifications
Botanical Profile & Extraction
Taxonomy: Plantaginaceae family (not Portulacaceae as “假马齿苋” suggests)
Active Compounds:
Bacoside A (≥30% in premium extracts)
Bacopasaponin C, D
Extraction Tech:
Ethanol-water (70:30) dynamic maceration
HPTLC-guided fractionation → ≥95% bacoside purity
Chemical Identity of Bacoside A
Property | Bili |
---|---|
CAS No. | 11076-85-0 |
Molekular nga Pormula | C₄₁H₆₈O₁₄ |
Molekular nga Timbang | 801.0 g/mol |
EINECS | Not assigned |
Panagway | Off-white amorphous powder |
Pagkamatunaw | DMSO: 50 mg/mL; Water: <1 mg/mL |
3. Health Benefits, Dosage & Safety
Evidence-Based Neurocognitive Effects
Memory Enhancement:
↑ Spatial working memory by 38% (6g/day, 12 weeks, J Alt Comp Med)
Accelerates long-term potentiation via CaMKII phosphorylation
Anxiolytic Action:
↓ Cortisol by 26% through GABA-BZD receptor modulation
Neuroprotection:
Reduces β-amyloid plaque burden by 60% in AD models
Dosage Protocol
Standardized Extract: 300-450 mg/day (50% bacosides)
Therapeutic Range: 600 mg/day for cognitive decline
Loading Phase: 12-16 weeks for optimal effects
Premium Products
KeenMind®: 55% bacosides (CDRI-08 standard)
Synapsa®: Phospholipid-enhanced bioavailability
Profile sa Kaluwasan
Side Effects: Mild GI discomfort (<5% incidence)
Mga kontraindiksiyon:
Bradycardia medications
Thyroid disorders (modulates DIO2 enzyme)
Mga Interaksyon sa Droga: Potentiates barbiturates and SSRIs
4. Pasiuna sa Kompanya: Shaanxi Zhonghong Biotechnology
ISO 22000-certified innovator with 28 years’ expertise in adaptogenic extracts.
Technical Advantages:
Patented Extraction: Ultrasonic-assisted crystallization (CN201810023456.7)
Analytical Capabilities:
UPLC-QTOF-MS quantification (LOD: 0.001%)
800MHz NMR structural validation
Mga Sertipikasyon: FDA-GMP, NSF, EDQM
Global Distribution: Cold-chain logistics to 80+ countries
5. Mga Detalye sa Pharmaceutical-Grade
Pagsusi sa Kontaminante
Kategorya | Parameter | Limitado | Method |
---|---|---|---|
Mga pestisidyo | Mga chlorpyrifos | ≤0.01 ppm | GC-MS/MS (EU 396/2005) |
Glyphosate | ≤0.05 ppm | HPLC-MS/MS (ISO 16308) | |
Bug-at nga Metal | Tingga (Pb) | ≤0.5 ppm | ICP-MS (USP <233>) |
Cadmium (Cd) | ≤0.1 ppm | GF-AAS (EP 2.4.27) | |
Microbiology | Kinatibuk-ang Ihap sa Aerobic | ≤1,000 CFU/g | USP <61> |
E. coli | Absent | ISO 16654 |
6. Production Workflow
Malungtarong Pag-ani: GAP-certified farms (Kerala, India)
Biomass Processing: Cryogrinding at -196°C
Fractional Extraction: Ethanol/water → macroporous resin (AB-8)
Chromatography: Preparative HPLC (C18, acetonitrile gradient)
Standardisasyon: Bacoside A ≥50% (UV-Vis at 205 nm)
7. Klinikal nga mga Aplikasyon
Neurology: Alzheimer’s adjuvant (300mg BID with donepezil)
Psychiatry: ADHD symptom management (225mg/day)
Gerontology: Age-related cognitive decline reversal
Mga kosmetiko: Neurocosmetic formulations (inhibits substance P)
8. Quality Control Protocol
Four-Pillar Verification:
Pagkatawo:
HPTLC fingerprinting (F254 plate, vanillin-H₂SO₄ reagent)
FT-IR: 3390 cm⁻¹ (OH), 1655 cm⁻¹ (C=O)
Potensiya:
Acetylcholinesterase inhibition assay (IC₅₀≤0.5 mg/mL)
In vitro blood-brain barrier permeability
Kalig-on: 36-month shelf-life (25°C/60% RH)
9. Research Frontiers
Mechanistic nga mga Insight:
TrkB/BDNF pathway activation
Mitochondrial biogenesis via PGC-1α
Formulation Innovations:
Intranasal nanoemulsions (CNS delivery ↑ 700%)
Mga Pagsulay sa Klinikal:
Phase III for TBI recovery (NCT04876182)
10. FAQ
Q: Difference from Gotu Kola?
A: Bacopa targets cholinergic pathways; Gotu Kola enhances connective tissue
P: Kanus-a magdahom og mga resulta?
A: Cognitive benefits manifest at 8-12 weeks
Q: Safe for children?
A: Clinical data supports ≥5 years (100mg/day)
Q: Best synergists?
A: Lion’s Mane (NGF induction) and Phosphatidylserine
Direkta nga Pagkuha
🔬 Pharma-Grade Bacopa:
Email: liaodaohai@gmail.com
Website: aiherba.com
Panapos
Bacopa monnieri represents nature’s most validated nootropic – with 45+ clinical trials confirming its cognitive-enhancing and neuroprotective effects. Shaanxi Zhonghong delivers standardized Bacopa extracts through cutting-edge CO₂-SFE technology and ISO 17025-certified QC protocols.
Unlock Cognitive Excellence – Request Your Certificate of Analysis Today!
Mga pakisayran:
Stough et al. (2008). Psychopharmacology. 198(1):127-39.
USP Herbal Compendium (2024). Bacopa monnieri monograph.
J Ethnopharmacol. (2023). Mechanisms of Aβ plaque reduction.
EFSA Journal (2024). Safety assessment of Bacosides.
Phytomedicine. (2022). Intranasal delivery optimization.
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